HLA-B, DR and DQ antigens polymorphism in Tunisian patients with ankylosing spondylitis (a case-control study)

Rheumatology International

Volumn 30, Issue 7, 2010, Pages 933-939

  Kchir, Mohamed Montacer ^a   Hamdi, Wafa ^a   Laadhar, Lilia ^b   Kochbati, Samir ^a   Kaffel, Dhia ^a   Saadellaoui, Kaouthar ^a   Lahmar, Houria ^b   Ghannouchi, Mohamed Mehdi ^a   Azzouz, Dhouha ^a   Daoud, Lilia ^a   Hamida, Abdelmajid Ben ^c   Zouari, Béchir ^c   Zitouni, Mondher ^b   Makni, Sondes ^b  

^a Institut Kassab   (Tunisia)

^b LA RABTA HOSPITAL   (Tunisia)

^c UNIVERSITY OF TUNIS EL MANAR   (Tunisia)

Author keywords

Ankylosing spondylitis; HLA class II; HLA B polymorphism; HLA b27 subtypes; PCR SSP; Tunisian population

Indexed keywords

HLA B27 ANTIGEN; HLA DQ ANTIGEN; HLA DR ANTIGEN;

ADULT; ANKYLOSING SPONDYLITIS; ARTICLE; CASE CONTROL STUDY; CONTROLLED STUDY; CORRELATION ANALYSIS; DNA POLYMORPHISM; FEMALE; GENE AMPLIFICATION; GENE SEQUENCE; GENETIC PREDISPOSITION; HUMAN; MAJOR CLINICAL STUDY; MALE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SEQUENCE ANALYSIS; STATISTICAL SIGNIFICANCE; TUNISIA;

ADOLESCENT; ADULT; AGED; BIOLOGICAL MARKERS; CASE-CONTROL STUDIES; DNA MUTATIONAL ANALYSIS; FEMALE; GENE FREQUENCY; GENETIC MARKERS; GENETIC PREDISPOSITION TO DISEASE; GENETIC TESTING; GENOTYPE; HLA-B ANTIGENS; HLA-B27 ANTIGEN; HLA-DQ ANTIGENS; HLA-DR ANTIGENS; HUMANS; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC; PREDICTIVE VALUE OF TESTS; RNA, MESSENGER; SPONDYLITIS, ANKYLOSING; TUNISIA; YOUNG ADULT;

EID: 77955092842     PISSN: 01728172     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00296-009-1079-0     Document Type: Article

References (40)

1. Scholostein L, Terasaki PI, Bluestone R, Pearson CM (1973) High association of HLA antigen W27 with ankylosing spondylitis. N Engl J Med 288:704-706.
2. Khan MA (2000) HLA-B27 polymorphism and association with disease. J Rheumatol 27:1110-1114.
3. Gonzales-Roces S, Alvarez MV, Gonzalez S, Dieye A, Makni H, Woodfield DG et al (1997) HLA-B27 polymorphism and worldwide susceptibility to ankylosing spondylitis. Tissue Antigens 49:116-123.
4. Khan MA (1995) HLA B27 and its subtypes in world populations. Curr Opin Rheumatol 7:263-269.
5. Khan MA (1997) Prevalence of HLA-B27 in world populations. In: Lopez Larrea C (ed) HLA B27 in the development of spondylarthropathies. Springer, Austin, pp 1-16.
6. Voorter Cem Swelsen WTN, Van den Berg-Loonen EM (2002) B*27 in molecular diagnostics: Impact of new alleles on polymorphism outside exon 2 and 3. Tissue Antigens 60:25-35.
7. Blanco-Gelaz MA, Lopez-Vasquez A, Garcia-Fernandez S et al (2001) Genetic variability, molecular evolution, and geographic diversity of HLA B27. Hum Immunol 62:1042-1050.
8. Reveille JD, Ball EJ, Khan MA (2001) HLA-B27 and genetic predisposing factors in spondylarthropathies. Curr Opin Rheumatol 13:265-272.
9. Breban WTN, Miceli-Richard C, Zineviova E (2006) The genetics of spondylarthropathies. Joint Bone Spine 73:355-362.
10. Brown MA (2008) Breakthroughs in genetic studies of ankylosing spondylitis. Rheumatology 47:132-137.
11. Sims AM, Bamardo M, Herzberg I et al (2007) Non-B27 MHC associations of ankylosing spondylitis. Genes Immun 8:115-123.
12. Hamida S, Gauthier A, Dridi A et al (1995) HLA class II gene polymorphism in Tunisians. Tissue Antigens 54:63-68.
13. Ayed K, Ayed-Jendoubi S, Sfar I, Labonne MP, Gebuhrer L (2004) HLA class I and HLA class II phenotypic, gene and haplotypic frequencies in Tunisians by using molecular typing data. Tissue Antigens 64:520-532.
14. Hajjej A, Hmida S, Kaabi H et al (2006) HLA genes in Southern Tunisians (Ghannouch area) and their relationship with other Mediterraneans. Eur J Med Genet 49:43-56.
15. Ben Radhia K, Ayed-Jendoubi S, Sfar I et al (2008) Distribution of HLA-B27 subtypes in Tunisians and their association with ankylosing spondylitis. Joint Bone Spine 75:172-175.
16. Siala M, Mahfoudh N, Gdoura R et al (2009) Distribution of HLA-B27 and its alleles in patients with reactive arthritis and with ankylosing spondylitis. Rheumatol Int (on line) (PMID 19152094).
17. Moll JM (1987) New criteria for the diagnosis of ankylosing spondylitis. Scand J Rheumatol Suppl 65:12-24.
18. Almanos Y, Papadopoulos NG, Voulgari PV et al (2004) Epidemiology of ankylosing spondylitis in Northwest Greece, 1983-2002. Rheumatology 43:615-618.
19. Gunal EK, Sarvan FO, Kamali S et al (2008) Low frequency of HLA-B27 in ankylosing spondylitis patients from Turkey. Joint Bone Spine 75:299-302.
20. Fernandez-Sueiro JL, Alonso C, Blanco FJ, Rodriguez-Gomez M, Galdo F, Gonzalez-Gay MA (2004) Prevalence of HLA-B27 and subtypes of HLA-B27 associated with ankylosing spondylitis in Galicia, Spain. Clin Exp Rheumatol 22(4):465-468.
21. Brown MA, Jepson A, Young A et al (1997) Ankylosing spondylitis in West Africans: evidence for non HLA-B27 protective effect. Ann Rheum Dis 56:68-70.
22. Varnaviou-Nicolaidou Karpasitou K, Georgiou D et al (2004) HLA B27 in the Greek Cypriot population distribution of subtypes in patients with ankylosing spondylitis and other HLA B27 related diseases: the possible protective role of B*2707. Hum Immunol 65:1451-1454.
23. Tamouza R, Awada H, Marzais F (1997) HLA B27 in the Lebanese population: subtypes analysis and association with ankylosing spondylitis. In: Charron D (ed) Genetic diversity of HLA: functional and medical implications. EDK, Paris, p 649.
24. Yamaguchi A, Tsuchiva N, Mitsui H et al (1995) Association of HLA-B39 with HLA-B27 negative ankylosing spondylitis and pauciarticular juvenile rheumatoid polyarthritis in Japanese patients. Arthritis Rheum 38:1672-1677.
25. Vargas-Alarcon G, Londono JD, Hernandez-Pacheco G et al (2002) Effect of HLA-B and HLA-DR genes on susceptibility to and severity of spondylarthropathies in Mexican patients. Ann Rheum Dis 61:714-717.
26. Robinson WP, van der Linden SM, Khan MA et al (1989) HLA-BW60 increases susceptibility to ankylosing spondylitis in HLA-B27+ patients. Arthritis Rheum 32:1135-1141.
27. Brown MA, Pile KD, Kennedy LG et al (1996) HLA class I associations of ankylosing spondylitis in the white population in the United Kingdom. Ann Rheum Dis 55:268-270.
28. Wei JC, Tsai WC, Lin HS et al (2004) HLA-B60 and B61 are strongly associated with ankylosing spondylitis in HLA-B27- negative Taiwan Chinese patients. Rheumatology 43:839-842.
29. Harjacek M, Margetic T, Kerhin-Brkljacic V, Martinez N, Grubic Z (2008) HLA-B*27/HLA-B*07 in combination with D6S273-134 allele is associated with increased susceptibility to juvenile spondylarthropathies. Clin Exp Rheumatol 26(3):498-504.
30. Merino E, Montserrat V, Paradela A, Lopez de Castro JA (2005) Two HLA-B14subtypes B*1402 and B14*03 differentially associated with ankylosing spondylitis differ substantially in peptide specificity but have limited peptide and T-cell epitope sharing with HLA-B27. J Biol Chem 280(43):35868-35880.
31. Silva-Ramirez B, Vargas-Alarcon G, Granados J, Burgos-Vargas R (2005) HLA antigens and juvenile onset spondyloarthritides: negative association with non-B27 alleles. Clin Exp Rheumatol 23(5):721-723.
32. Cipriani A, Rivera S, Hassanhi M et al (2003) HLA-B27 subtypes determination in patients with ankylosing spondylitis from Zulia Venezuela. Hum Immunol 64:745-749.
33. Brown MA, Wordworth BP, Reveille JD (2002) Genetics of ankylosing spondylitis. Clin Exp Rheumatol 20(Suppl 28):S43-S49.
34. Madhavan R, Parthiban M, Panchapakesa Rajendran C et al (2002) HLA class I and class II in Southern Indian population. Ann N Y Acad Sci 958:403-407.
35. Clayton J, Lonjou C (1997) Allele and haplotype frequencies for HLA loci in various ethnic groups. In: Charron D (ed) Genetic diversity of HLA: functional and medical implications, vol. EDK, Paris, pp 665-820.
36. Brown MA, Kennedy LG, Darke C et al (1998) The effect of HLADR genes on susceptibility to and severity of ankylosing spondylitis. Arthritis Rheum 41:460-465.
37. Brown MA, Kennedy LG, MacGregor AJ et al (1997) Susceptibility to AS in twins: the role of genes, HLA, and the environment. Arthritis Rheum 40:1823-1828.
38. Said-Nahal R, Miceli-Richard C, Goutreau C, Tamouza R, Borot N, Porcher R et al (2006) The role of HLA genes in familial spondylarthropathy: a comprehensive study of 70 multiplex families. Ann Rheum Dis 61:201-206.
39. Maksymowych WP, Gorodezky C, Olivo A, Alaez C, Wong C, Burgos-Vargas R et al (1997) HLA-DRB1*08 influences the development of disease in Mexican mestizo with spondylarthropathy. J Rheumatol 24:904-907.
40. Martinez-Lazo J, Gazit E, Gomez-Casado E, Morale P (1996) HLA-DR and DQ polymorphism in Ashkenazi and non-Ashkenazi Jews: comparison with other Mediterraneans. Tissue Antigens 47:63-71.