New insights in the pathogenesis and genetics of leprosy

F1000 Medicine Reports

Volumn 2, Issue 1, 2010, Pages

  Gulia, Andrea ^a   Fried, Isabella ^b   Massone, Cesare ^b  

^a UNIVERSITY OF L'AQUILA   (Italy)

^b MEDICAL UNIVERSITY OF GRAZ   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

GENE LOCUS; GENETICS; HELMINTHIASIS; HUMAN; IMMUNE RESPONSE; IMMUNOPATHOGENESIS; LEPROSY; MIXED INFECTION; MYCOBACTERIUM LEPRAE; NEUTROPHIL; NONHUMAN; PHYLOGEOGRAPHY; REVIEW;

EID: 77955085316     PISSN: None     EISSN: 17575931     Source Type: Journal    
DOI: 10.3410/M2-30     Document Type: Review

References (26)

1. Massone C, Nunzi E: Leprology. Bologna: AIFO; 2009.
2. Scollard DM, Adams LB, Gillis TP, Krahenbuhl JL, Truman RW, Williams DL: The continuing challenges of leprosy. Clin Microbiol Rev 2006, 19:338-81.
3. Cole ST, Eiglmeier K, Parkhill J, James KD, Thomson NR, Wheeler PR, Honoré N, Garnier T, Churcher C, Harris D, Mungall K, Basham D, Brown D, Chillingworth T, Connor R, Davies RM, Devlin K, Duthoy S, Feltwell T, Fraser A, Hamlin N, Holroyd S, Hornsby T, Jagels K, Lacroix C, Maclean J, Moule S, Murphy L, Oliver K, Quail MA, et al.: Massive gene decay in the leprosy bacillus. Nature 2001, 22:1007-11. (Pubitemid 32204045)
4. Maeda Y, Gidoh M, Ishii N, Mukai C, Makino M: Assessment of cell mediated immunogenicity of Mycobacterium leprae-derived antigens. Cell Immunol 2003, 222:69-77.
5. Krutzik SR, Ochoa MT, Sieling PA, Uematsu S, Ng YW, Legaspi A, Liu PT, Cole ST, Godowski PJ, Maeda Y, Sarno EN, Norgard MV, Brennan PJ, Akira S, Rea TH, Modlin RL: Activation and regulation of Toll-like receptors 2 and 1 in human leprosy. Nat Med 2003, 9:525-32.
6. Massone C, Nunzi E, Ribeiro-Rodrigues R, Talhari C, Talhari S, Schettini AP, Parente JN, Brunasso AM, Puntoni M, Clapasson A, Noto S, Cerroni L: T Regulatory Cells and Plasmocytoid Dentritic Cells in Hansen Disease: A New Insight Into Pathogenesis? Am J Dermatopathol 2010, [Epub ahead of print].
7. Resende Co T, Hirsch CS, Toossi Z, Dietze R, Ribeiro-Rodrigues R: Intestinal helminth co-infection has a negative impact on both anti-Mycobacterium tuberculosis immunity and clinical response to tuberculosis therapy. Clin Exp Immunol 2007, 147:45-52.
8. Diniz LM, Zandonade E, Dietze R, Pereira FE, Ribeiro-Rodrigues R: Short report: do intestinal nematodes increase the risk for multibacillary leprosy? Am J Trop Med Hyg 2001, 65:852-4.
9. Diniz LM, Magalhães EF, Pereira FE, Dietze R, Ribeiro-Rodrigues R: Presence of intestinal helminthes decreases Th1 responses in tuberculoid leprosy patients and may increase the risk for multibacillary leprosy. Clin Exp Immunol, in press.
10. Rodrigues LS, da Silva Maeda E, Moreira ME, Tempone AJ, Lobato LS, Ribeiro-Resende VT, Alves L, Rossle S, Lopes UG, Pessolani MC: Mycobacterium leprae induces insulin-like growth factor and promotes survival of Schwann cells upon serum withdrawal. Cell Microbiol 2010, 12:42-54.
11. Mattos KA, D'Avila H, Rodrigues LS, Oliveira VG, Sarno EN, Atella GC, Pereira GM, Bozza PT, Pessolani MC: Lipid droplet formation in leprosy: Toll-like receptor-regulated organelles involved in eicosanoid formation and Mycobacterium leprae pathogenesis. J Leukoc Biol 2010, 87:371-84.
12. Lee DJ, Li H, Ochoa MT, Tanaka M, Carbone RJ, Damoiseaux R, Burdick A, Sarno EN, Rea TH, Modlin RL: Integrated pathways for neutrophil recruitment and inflammation in leprosy. J Infect Dis 2010, 201:558-69.
13. Gupta N, Shankernarayan NP, Dharmalingam K: alpha1-acid glycoprotein as a putative biomarker for monitoring the development of the type II reactional stage of leprosy. J Med Microbiol 2010, 59:400-7.
14. Alter A, Alcaïs A, Abel L, Schurr E: Leprosy as a genetic model for susceptibility to common infectious diseases. Hum Genet 2008, 123:227-35.
15. Mira MT: Genetic host resistance and susceptibility to leprosy. Microbes Infect 2006, 8:1124-31.
16. Mira MT, Alcais A, di Pietrantonio T, Thuc NV, Phuong MC, Abel L, Schurr E: Segregation of HLA//TNF region is linked to leprosy clinical spectrum in families displaying mixed leprosy subtypes. Genes Immun 2003, 4:67-73.
17. Alcaïs A, Alter A, Antoni G, Orlova M, Nguyen VT, Singh M, Vanderborght PR, Katoch K, Mira MT, Vu HT, Ngyuen TH, Nguyen NB, Moraes M, Mehra N, Schurr E, Abel L: Stepwise replication identifies a low-producing lymphotoxin-[alpha] allele as a major risk factor for early-onset leprosy. Nat Genet 2007, 39:517-22. (Pubitemid 46514779)
18. Alcaïs A, Sanchez FO, Thuc NV, Lap VD, Oberti J, Lagrange PH, Schurr E, Abel L: Granulomatous reaction to intradermal injection of lepromin (Mitsuda reaction) is linked to the human NRAMP1 gene in Vietnamese leprosy sibships. J Infect Dis 2000, 181:302-8. (Pubitemid 30049061)
19. Pereira AC, Brito-de-Souza VN, Cardoso CC, Dias-Baptista IM, Parelli FP, Venturini J, Villani-Moreno FR, Pacheco AG, Moraes MO: Genetic, epidemiological and biological analysis of interleukin-10 promoter single-nucleotide polymorphisms suggests a definitive role for -819C/T in leprosy susceptibility. Genes Immun 2009, 10:174-80.
20. Mira MT, Alcaïs A, Nguyen VT, Moraes MO, Di Flumeri C, Vu HT, Mai CP, Nguyen TH, Nguyen NB, Pham XK, Sarno EN, Alter A, Montpetit A, Moraes ME, Moraes JR, Doré C, Gallant CJ, Lepage P, Verner A, Van De Vosse E, Hudson TJ, Abel L, Schurr E: Susceptibility to leprosy is associated with PARK2 and PACRG. Nature 2004, 427:636-40.
21. Alter A, de Léséleuc L, Van Thuc N, Thai VH, Huong NT, Ba NN, Cardoso CC, Grant AV, Abel L, Moraes MO, Alcaïs A, Schurr E: Genetic and functional analysis of common MRC1 exon 7 polymorphisms in leprosy susceptibility. Hum Genet 2010, 127:337-48.
22. Zhang FR, Huang W, Chen SM, Sun LD, Liu H, Li Y, Cui Y, Yan XX, Yang HT, Yang RD, Chu TS, Zhang C, Zhang L, Han JW, Yu GQ, Quan C, Yu YX, Zhang Z, Shi BQ, Zhang LH, Cheng H, Wang CY, Lin Y, Zheng HF, Fu XA, Zuo XB, Wang Q, Long H, Sun YP, Cheng YL, et al.: Genomewide association study of leprosy. N Engl J Med 2009, 361:2609-18.
23. Schurr E, Gros P: A common genetic fingerprint in leprosy and Crohn's disease? N Engl J Med 2009, 361:2666-8.
24. Bochud PY, Hawn TR, Siddiqui MR, Saunderson P, Britton S, Abraham I, Argaw AT, Janer M, Zhao LP, Kaplan G, Aderem A: Toll-like receptor 2 (TLR2) polymorphisms are associated with reversal reaction in leprosy. J Infect Dis 2008, 197:253-61.
25. Misch EA, Macdonald M, Ranjit C, Sapkota BR, Wells RD, Siddiqui MR, Kaplan G, Hawn TR: Human TLR1 deficiency is associated with impaired mycobacterial signaling and protection from leprosy reversal reaction. PLoS Negl Trop Dis 2008, 2:e231. (Pubitemid 352002910)
26. Monot M, Honoré N, Garnier T, Zidane N, Sherafi D, Paniz-Mondolfi A, Matsuoka M, Taylor GM, Donoghue HD, Bouwman A, Mays S, Watson C, Lockwood D, Khamispour A, Dowlati Y, Jianping S, Rea TH, Vera-Cabrera L, Stefani MM, Banu S, Macdonald M, Sapkota BR, Spencer JS, Thomas J, Harshman K, Singh P, Busso P, Gattiker A, Rougemont J, Brennan PJ, et al.: Comparative genomic and phylogeographic analysis of Mycobacterium leprae. Nat Genet 2009, 41:1282-9.