Nestin is a novel marker for renal tubulointerstitial injury in immunoglobulin A nephropathy

Nephrology

Volumn 15, Issue 5, 2010, Pages 568-574

  Tomioka, Mai ^a   Hiromura, Keiju ^a   Sakairi, Toru ^a   Takeuchi, Shigeru ^a   Maeshima, Akito ^a   Kaneko, Yoriaki ^a   Kuroiwa, Takashi ^a   Takeuchi, Toshiyuki ^b   Nojima, Yoshihisa ^a  

^a GUNMA UNIVERSITY   (Japan)

^b GUNMA UNIVERSITY   (Japan)

Author keywords

immunoglobulin A nephropathy; myofibroblasts; nestin; peritubular endothelial cells; tubulointerstitial injury

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; CD34 ANTIGEN; NESTIN; ACTIN; BIOLOGICAL MARKER; CREATININE; INTERMEDIATE FILAMENT PROTEIN; NERVE PROTEIN; NES PROTEIN, HUMAN;

ADULT; ARTICLE; CLINICAL ARTICLE; FEMALE; GLOMERULONEPHRITIS; HUMAN; HUMAN TISSUE; IMAGE ANALYSIS; IMMUNOGLOBULIN A NEPHROPATHY; IMMUNOHISTOCHEMISTRY; INTERSTITIUM; KIDNEY BIOPSY; KIDNEY DEVELOPMENT; KIDNEY DYSFUNCTION; KIDNEY INJURY; KIDNEY INTERSTITIUM; KIDNEY TUBULE CELL; LEYDIG CELL; MALE; MYOFIBROBLAST; PHENOTYPE; PODOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RENAL TUBULOINTERSTITIAL INJURY; BIOPSY; BLOOD; CHEMISTRY; FIBROSIS; FLUORESCENT ANTIBODY TECHNIQUE; GLOMERULUS FILTRATION RATE; JAPAN; KAPLAN MEIER METHOD; KIDNEY TUBULE; METABOLISM; MIDDLE AGED; PATHOLOGY; PATHOPHYSIOLOGY; PREDICTIVE VALUE; PROGNOSIS; PROTEINURIA; SIGNAL PROCESSING; STATISTICAL MODEL; TIME;

ACTINS; ADULT; ANTIGENS, CD34; BIOLOGICAL MARKERS; BIOPSY; CREATININE; FEMALE; FIBROSIS; FLUORESCENT ANTIBODY TECHNIQUE; GLOMERULAR FILTRATION RATE; GLOMERULONEPHRITIS, IGA; HUMANS; IMMUNOHISTOCHEMISTRY; INTERMEDIATE FILAMENT PROTEINS; JAPAN; KAPLAN-MEIER ESTIMATE; KIDNEY TUBULES; LINEAR MODELS; MALE; MIDDLE AGED; NERVE TISSUE PROTEINS; NESTIN; PREDICTIVE VALUE OF TESTS; PROGNOSIS; PROTEINURIA; SIGNAL PROCESSING, COMPUTER-ASSISTED; TIME FACTORS;

EID: 77955083644     PISSN: 13205358     EISSN: 14401797     Source Type: Journal    
DOI: 10.1111/j.1440-1797.2010.01342.x     Document Type: Article

References (30)

1. Cattaneo E, McKay R. Proliferation and differentiation of neuronal stem cells regulated by nerve growth factor. Nature 1990 347 : 762 765.
2. Michalczyk K, Ziman M. Nestin structure and predicted function in cellular cytoskeletal organisation. Histol. Histopathol. 2005 20 : 665 671.
3. Wiese C, Rolletschek A, Kania G et al. Nestin expression - a property of multi-lineage progenitor cells? Cell. Mol. Life Sci. 2004 61 : 2510 2522.
4. Chen J, Boyle S, Zhao M et al. Differential expression of the intermediate filament protein nestin during renal development and its localization in adult podocytes. J. Am. Soc. Nephrol. 2006 17 : 1283 1291.
5. Zou J, Yaoita E, Watanabe Y et al. Upregulation of nestin, vimentin, and desmin in rat podocytes in response to injury. Virchows Arch. 2006 448 : 485 492.
6. Wagner N, Wagner KD, Scholz H, Kirschner KM, Schedl A. The intermediate filament protein nestin is expressed in the developing kidney and heart and might be regulated by the Wilms' tumor suppressor Wt1. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2006 291 : R779 87.
7. Sakairi T, Hiromura K, Yamashita S et al. Nestin expression in the kidney with an obstructed ureter. Kidney Int. 2007 72 : 307 318.
8. Eddy AA. Molecular insights into renal interstitial fibrosis. J. Am. Soc. Nephrol. 1996 7 : 2495 2508.
9. Nangaku M. Chronic hypoxia and tubulointerstitial injury: A final common pathway to end-stage renal failure. J. Am. Soc. Nephrol. 2006 17 : 17 25.
10. D'Amico G. The commonest glomerulonephritis in the world: IgA nephropathy. Q. J. Med. 1987 64 : 709 727.
11. D'Amico G. Natural history of idiopathic IgA nephropathy: Role of clinical and histological prognostic factors. Am. J. Kidney Dis. 2000 36 : 227 237.
12. Matsuo S, Imai E, Horio M et al. Revised equations for estimated GFR from serum creatinine in Japan. Am. J. Kidney Dis. 2009 53 : 982 992.
13. Su W, Chen J, Yang H et al. Expression of nestin in the podocytes of normal and diseased human kidneys. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2007 292 : R1761 7.
14. Patschan D, Michurina T, Shi HK et al. Normal distribution and medullary-to-cortical shift of Nestin-expressing cells in acute renal ischemia. Kidney. Int. 2007 71 : 744 754.
15. Lardon J, Rooman I, Bouwens L. Nestin expression in pancreatic stellate cells and angiogenic endothelial cells. Histochem. Cell Biol. 2002 117 : 535 540.
16. Mokry J, Cizkova D, Filip S et al. Nestin expression by newly formed human blood vessels. Stem. Cells Dev. 2004 13 : 658 664.
17. Aihara M, Sugawara K, Torii S et al. Angiogenic endothelium-specific nestin expression is enhanced by the first intron of the nestin gene. Lab. Invest. 2004 84 : 1581 1592.
18. Amoh Y, Yang M, Li L et al. Nestin-linked green fluorescent protein transgenic nude mouse for imaging human tumor angiogenesis. Cancer Res. 2005 65 : 5352 5357.
19. Kang DH, Hughes J, Mazzali M, Schreiner GF, Johnson RJ. Impaired angiogenesis in the remnant kidney model: II. Vascular endothelial growth factor administration reduces renal fibrosis and stabilizes renal function. J. Am. Soc. Nephrol. 2001 12 : 1448 1457.
20. Lindenmeyer MT, Kretzler M, Boucherot A et al. Interstitial vascular rarefaction and reduced VEGF-A expression in human diabetic nephropathy. J. Am. Soc. Nephrol. 2007 18 : 1765 1776.
21. Ohashi R, Shimizu A, Masuda Y et al. Peritubular capillary regression during the progression of experimental obstructive nephropathy. J. Am. Soc. Nephrol. 2002 13 : 1795 1805.
22. Hwang HS, Maeng YS, Kim YH, Kwon YG, Park YW, Kim IK. Nestin expression during differentiation of fetal endothelial progenitor cells and hypoxic culture of human umbilical vein endothelial cells. Acta Obstet. Gynecol. Scand. 2008 87 : 643 651.
23. Zeisberg EM, Potenta SE, Sugimoto H, Zeisberg M, Kalluri R. Fibroblasts in kidney fibrosis emerge via endothelial-to-mesenchymal transition. J. Am. Soc. Nephrol. 2008 19 : 2282 2287.
24. Strutz F, Zeisberg M. Renal fibroblasts and myofibroblasts in chronic kidney disease. J. Am. Soc. Nephrol. 2006 17 : 2992 2998.
25. Qi W, Chen X, Poronnik P, Pollock CA. The renal cortical fibroblast in renal tubulointerstitial fibrosis. Int. J. Biochem. Cell Biol. 2006 38 : 1 5.
26. Zeisberg M, Strutz F, Muller GA. Role of fibroblast activation in inducing interstitial fibrosis. J. Nephrol. 2000 13 (Suppl 3 S111 20.
27. Bascands JL, Klein J, Schanstra JP. A nest in renal fibrosis? Kidney Int. 2007 72 : 242 244.
28. Chang L, Goldman RD. Intermediate filaments mediate cytoskeletal crosstalk. Nat. Rev. Mol. Cell Biol. 2004 5 : 601 613.
29. Omary MB, Coulombe PA, McLean WH. Intermediate filament proteins and their associated diseases. N. Engl. J. Med. 2004 351 : 2087 2100.
30. Kleeberger W, Bova GS, Nielsen ME et al. Roles for the stem cell associated intermediate filament Nestin in prostate cancer migration and metastasis. Cancer Res. 2007 67 : 9199 9206.