Kinetics of satratoxin G tissue distribution and excretion following intranasal exposure in the mouse

Toxicological Sciences

Volumn 116, Issue 2, 2010, Pages 433-440

  Amuzie, Chidozie J ^a   Islam, Zahidul ^b   Kim, Jae Kyung ^b   Seo, Ji Hyun ^b   Pestka, James J ^a,b,c  

^a MICHIGAN STATE UNIVERSITY   (United States)

^b Michigan State University   (United States)

^c Michigan State University   (United States)

Author keywords

ELISA; Mycotoxin; Stachybotrys; Toxicokinetics; Trichothecene

Indexed keywords

MYCOTOXIN; SATRATOXIN G; UNCLASSIFIED DRUG; TRICHOTHECENE DERIVATIVE;

ANIMAL TISSUE; ARTICLE; BRAIN; C57BL 6 MOUSE; CONTROLLED STUDY; FECES ANALYSIS; FEMALE; HEART; KIDNEY; LIVER; LUNG; MOUSE; NONHUMAN; OLFACTORY BULB; SPLEEN; THYMUS; TISSUE DISTRIBUTION; TOXICOKINETICS; TOXIN ANALYSIS; TURBINATE; URINALYSIS; ANIMAL; APOPTOSIS; C57BL MOUSE; DRUG EFFECTS; INTRANASAL DRUG ADMINISTRATION; METABOLIC CLEARANCE RATE; METABOLISM; NOSE;

ADMINISTRATION, INTRANASAL; ANIMALS; APOPTOSIS; BRAIN; FEMALE; METABOLIC CLEARANCE RATE; MICE; MICE, INBRED C57BL; NOSE; TISSUE DISTRIBUTION; TRICHOTHECENES;

EID: 77955082538     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfq142     Document Type: Article

References (57)

1. Amuzie, C.J., Harkema, J.R., and Pestka, J.J. (2008). Tissue distribution and proinflammatory cytokine induction by the trichothecene deoxynivalenol in the mouse: comparison of nasal vs. oral exposure. Toxicology 248, 39-44.
2. Andersen, B., Nielsen, K.F., and Jarvis, B.B. (2002). Characterization of Stachybotrys from water-damaged buildings based on morphology, growth, and metabolite production. Mycologia 94, 392-403.
3. Azcona-Olivera, J.I., Ouyang, Y., Murtha, J., Chu, F.S., and Pestka, J.J. (1995). Induction of cytokine mRNAs in mice after oral exposure to the trichothecene vomitoxin (deoxynivalenol): relationship to toxin distribution and protein synthesis inhibition. Toxicol. Appl. Pharmacol. 133, 109-120.
4. Bae, H.K., Shinozuka, J., Islam, Z., and Pestka, J.J. (2009). Satratoxin G interaction with 40S and 60S ribosomal subunits precedes apoptosis in the macrophage. Toxicol. Appl. Pharmacol. 237, 137-145.
5. Bamburg, J.R. (1983). Biological and biochemical actions of trichothecene mycotoxins. Prog. Mol. Subcell. Biol. 8, 41-110.
6. Barel, S., Yagen, B., and Bialer, M. (1990). Pharmacokinetics of the trichothecene mycotoxin verrucarol in dogs. J. Pharm. Sci. 79, 548-551.
7. Bloom, E., Nyman, E., Must, A., Pehrson, C., and Larsson, L. (2009). Molds and mycotoxins in indoor environments-a survey in water-damaged buildings. J. Occup. Environ. Hyg. 6, 671-678.
8. Brasel, T.L., Douglas, D.R., Wilson, S.C., and Straus, D.C. (2005). Detection of airborne Stachybotrys chartarum macrocyclic trichothecene mycotoxins on particulates smaller than conidia. Appl. Environ. Microbiol. 71, 114-122.
9. Brown, R.P., Delp, M.D., Lindstedt, S.L., Rhomberg, L.R., and Beliles, R.P. (1997). Physiological parameter values for physiologically based pharma-cokinetic models. Toxicol. Ind. Health. 13, 407-484.
10. Cheng, K.H., Cheng, Y.S., Yeh, H.C., and Swift, D.L. (1997a). An experimental method for measuring aerosol deposition efficiency in the human oral airway. Am. Ind. Hyg. Assoc. J. 58, 207-213.
11. Cheng, K.H., Cheng, Y.S., Yeh, H.C., and Swift, D.L. (1997b). Measurements of airway dimensions and calculation of mass transfer characteristics of the human oral passage. J. Biomech. Eng. 119, 476-482.
12. Cheng, Y.S., Hansen, G.K., Su, Y.F., Yeh, H.C., and Morgan, K.T. (1990). Deposition of ultrafine aerosols in rat nasal molds. Toxicol. Appl. Pharmacol. 106, 222-233.
13. Cho, S.-H., Seo, S.-C., Schmechel, D., Grinshpun, S.S., and Reponen, T. (2005). Aerodynamic characteristics and respiratory deposition of fungal fragments. Atmos. Environ. 39, 5454-5465.
14. Chung, Y.J., Jarvis, B.B., Tak, H., and Pestka, J.J. (2003). Immunochemical assay for satratoxin G and other macrocyclic trichothecenes associated with indoor air contamination by Stachybotrys chartarum. Toxicol. Mech. Methods 13, 247-252.
15. Cowan, C.M., and Roskams, A.J. (2002). Apoptosis in the mature and developing olfactory neuroepithelium. Microsc. Res. Tech. 58, 204-215.
16. Demarquay, G., Ryviln, P., and Royet, J.P. (2007). Olfaction and neurological diseases: a review of the literature. Rev. Neurol. 163, 155-167.
17. Gregory, L., Pestka, J.J., Dearborn, D.G., and Rand, T.G. (2004). Localization of satratoxin-G in Stachybotrys chartarum spores and spore-impacted mouse lung using immunocytochemistry. Toxicol. Pathol. 32, 26-34.
18. Grove, J.F. (1988). Non-macrocyclic trichothecenes. Nat. Prod. Rep. 5, 187-209.
19. Grove, J.F. (1993). Macrocyclic trichothecenes. Nat. Prod. Rep. 10, 429-448.
20. Grove, J.F. (2000). Non-macrocyclic trichothecenes. Part 2. Prog. Chem. Org. Nat. Prod. 69, 1-70.
21. Harkema, J.R. (1991). Comparative aspects of nasal airway anatomy: relevance to inhalation toxicology. Toxicol. Pathol. 19, (Pt 1), 321-336.
22. Hawkes, C. (2003). Olfaction in neurodegenerative disorder. Mov. Disord. 18, 364-372.
23. Institute of Medicine. (2004). Damp Indoor Spaces and Health, pp. 1-355. National Academies Press, Washington, DC.
24. Islam, Z., Amuzie, C.J., Harkema, J.R., and Pestka, J.J. (2007). Neurotoxicity and inflammation in the nasal airways of mice exposed to the macrocyclic trichothecene mycotoxin roridin A: kinetics and potentiation by bacterial lipopolysaccharide co-exposure. Toxicol. Sci. 98, 526-541.
25. Islam, Z., Harkema, J.R., and Pestka, J.J. (2006). Satratoxin G from the black mold Stachybotrys chartarum evokes olfactory sensory neuron loss and inflammation in the murine nose and brain. Environ. Health Perspect. 114, 1099-1107.
26. Islam, Z., Hegg, C.C., Bae, H.K., and Pestka, J.J. (2008). Satratoxin G-induced apoptosis in PC-12 neuronal cells is mediated by PKR and caspase independent. Toxicol. Sci. 105, 142-152.
27. Islam, Z., Nagase, M., Yoshizawa, T., Yamauchi, K., and Sakato, N. (1998). T-2 toxin induces thymic apoptosis in vivo in mice. Toxicol. Appl. Pharmacol. 148, 205-214.
28. Islam, Z., Shinozuka, J., Harkema, J.R., and Pestka, J.J. (2009). Purification and comparative neurotoxicity of the trichothecenes satratioxin G and roridin L2 from Stachybotrys chartarum. J. Toxicol. Environ. Health A 72, 1242-1251.
29. Jarvis, B.B., Yatawara, C.S., Greene, S.L., and Vrudhula, V.M. (1984). Production of Verrucarol. Appl. Environ. Microbiol. 48, 673-674.
30. Lake, B.G., Phillips, J.C., Walters, D.G., Bayley, D.L., Cook, M.W., Thomas, L.V., Gilbert, J., Startin, J.R., Baldwin, N.C., and Bycroft, B.W. (1987). Studies on the metabolism of deoxynivalenol in the rat. Food Chem. Toxicol. 25, 589-592.
31. Li, S., Marquardt, R.R., Frohlich, A.A., Vitti, T.G., and Crow, G. (1997). Pharmacokinetics of ochratoxin A and its metabolites in rats. Toxicol. Appl. Pharmacol. 145, 82-90.
32. Lun, A.K., Moran, E.T., Jr., Young, L.G., and McMillan, E.G. (1989). Absorption and elimination of an oral dose of 3H-deoxynivalenol in colostomized and intact chickens. Bull. Environ. Contam. Toxicol. 42, 919-925.
33. Meky, F.A., Turner, P.C., Ashcroft, A.E., Miller, J.D., Qiao, Y.L., Roth, M.J., and Wild, C.P. (2003). Development of a urinary biomarker of human exposure to deoxynivalenol. Food Chem. Toxicol. 41, 265-273.
34. Miura, K., Nakajima, Y., Yamanaka, N., Terao, K., Shibato, T., and Ishino, S. (1998). Induction of apoptosis with fusarenon-X in mouse thymocytes. Toxicology 127, 195-206.
35. Nikula, K.J., Novak, R.F., Chang, I.Y., Dahl, A.R., Kracko, D.A., Zangar, R.C., Kim, S.G., and Lewis, J.L. (1995). Induction of nasal carboxylesterase in F344 rats following inhalation exposure to pyridine. Drug Metab. Dispos. 23, 529-535.
36. Olson, M.J., Martin, J.L., LaRosa, A.C., Brady, A.N., and Pohl, L.R. (1993). Immunohistochemical localization of carboxylesterase in the nasal mucosa of rats. J. Histochem. Cytochem. 41, 307-311.
37. Pestka, J.J. (1988). Enhanced surveillance of foodborne mycotoxins by immunochemical assay. J Assoc. Off. Anal. Chem. 71, 1075-1081.
38. Pestka, J.J., and Amuzie, C.J. (2008). Tissue distribution and proinflammatory cytokine gene expression following acute oral exposure to deoxynivalenol: comparison of weanling and adult mice. Food Chem. Toxicol. 46, 2826-2831.
39. Pestka, J.J., and Forsell, J.H. (1988). Inhibition of human lymphocyte transformation by the macrocyclic trichothecenes roridin A and verrucarin A. Toxicol. Lett. 41, 215-222.
40. Pestka, J.J., Islam, Z., and Amuzie, C.J. (2008a). Immunochemical assessment of deoxynivalenol tissue distribution following oral exposure in the mouse. Toxicol. Lett. 178, 83-87.
41. Pestka, J.J., Yike, I., Dearborn, D.G., Ward, M.D., and Harkema, J.R. (2008b). Stachybotrys chartarum, trichothecene mycotoxins, and damp building-related illness: new insights into a public health enigma. Toxicol. Sci. 104, 4-26.
42. Pestka, J.J., Zhou, H.R., Moon, Y., and Chung, Y.J. (2004). Cellular and molecular mechanisms for immune modulation by deoxynivalenol and other trichothecenes: unraveling a paradox. Toxicol. Lett. 153, 61-73.
43. Poapolathep, A., Kumagai, S., Suzuki, H., and Doi, K. (2004). Development of early apoptosis and changes in T-cell subsets in mouse thymocyte primary cultures treated with nivalenol. Exp. Mol. Pathol. 77, 149-152.
44. Prelusky, D.B., Hamilton, R.M., Trenholm, H.L., and Miller, J.D. (1986). Tissue distribution and excretion of radioactivity following administration of 14C-labeled deoxynivalenol to White Leghorn hens. Fundam. Appl. Toxicol. 7, 635-645.
45. Prelusky, D.B., Hartin, K.E., and Trenholm, H.L. (1990). Distribution of deoxynivalenol in cerebral spinal fluid following administration to swine and sheep. J. Environ. Sci. Health B 25, 395-413.
46. Prelusky, D.B., Veira, D.M., and Trenholm, H.L. (1985). Plasma pharmacokinetics of the mycotoxin deoxynivalenol following oral and intravenous administration to sheep. J. Environ. Sci. Health B 20, 603-624.
47. Schneider, E., Curtui, V., Seidler, C., Dietrich, R., Usleber, E., and Martlbauer, E. (2004). Rapid methods for deoxynivalenol and other trichothecenes. Toxicol. Lett. 153, 113-121.
48. Shargel, L., Wu-pong, S., and Yu, A.B.C. (2004). In Applied Biopharma-ceutics and Pharmacokinetics. McGraw-Hill Medical, New York.
49. Sorenson, W.G., Frazer, D.G., Jarvis, B.B., Simpson, J., and Robinson, V.A. (1987). Trichothecene mycotoxins in aerosolized conidia of Stachybotrys atra. Appl. Environ. Microbiol. 53, 1370-1375.
50. Sugita-Konishi, Y., Kumagai, S., and Mizuochi, T. (1994). The cytotoxicity of macrocyclic trichothecenes, roridin A and verrucarin A, on murine T-cells is reduced by Ia-negative splenic adherent cells. Toxicon 32, 1051-1057.
51. Takeda, A., Kikuchi, A., Matsuzaki-Kobayashi, M., Sugeno, N., and Itoyama, Y. (2007). Olfactory dysfunction in Parkinson's disease. J. Neurol. 254, 2-7.
52. Thompson, W.L., and Wannemacher, R.W., Jr. (1986). Structure-function relationships of 12,13-epoxytrichothecene mycotoxins in cell culture: comparison to whole animal lethality. Toxicon 24, 985-994.
53. Vesper, S., Dearborn, D.G., Yike, I., Allan, T., Sobolewski, J., Hinkley, S.F., Jarvis, B.B., and Haugland, R.A. (2000). Evaluation of Stachybotrys chartarum in the house of an infant with pulmonary hemorrhage: quantitative assessment before, during, and after remediation. J. Urban Health 77, 68-85.
54. Wu, Q., Dohnal, V., Huang, L., Kuca, K., and Yuan, Z. (2010). Metabolic pathways of trichothecenes. Drug Metab. Rev. 42, 250-267.
55. Yang, G.H., Jarvis, B.B., Chung, Y.J., and Pestka, J.J. (2000). Apoptosis induction by the satratoxins and other trichothecene mycotoxins: relationship to ERK, p38 MAPK, and SAPK/JNK activation. Toxicol. Appl. Pharmacol. 164, 149-160.
56. Yeh, H.C., and Schum, G.M. (1980). Models of human lung airways and their application to inhaled particle deposition. Bull. Math. Biol. 42, 461-480.
57. Yike, I., and Dearborn, D.G. (2004). Pulmonary effects of Stachybotrys chartarum in animal studies. Adv. Appl. Microbiol. 55, 241-273.