5-HTTLPR polymorphism influences prefrontal neurochemical metabolites in autism spectrum disorder

Psychiatry Research - Neuroimaging

Volumn 183, Issue 2, 2010, Pages 170-173

  Endo, Taro ^a   Kitamura, Hideaki ^a   Tamura, Ryu ^a   Egawa, Jun ^a   Sugai, Takuro ^a   Fukui, Naoki ^a   Suzuki, Yutaro ^a   Someya, Toshiyuki ^a  

^a NIIGATA UNIVERSITY GRADUATE SCHOOL OF MEDICAL AND DENTAL SCIENCES   (Japan)

Author keywords

Allele; Proton magnetic resonance spectroscopy (1H MRS); Serotonin transporter gene

Indexed keywords

CREATININE; N ACETYLASPARTIC ACID; SEROTONIN 5 RECEPTOR; SEROTONIN TRANSPORTER;

ADOLESCENT; ADULT; ARTICLE; AUTISM; CHILD; CLINICAL ARTICLE; CREATININE BLOOD LEVEL; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; FEMALE; GENETIC POLYMORPHISM; GENOTYPE; GENOTYPE PHENOTYPE CORRELATION; HUMAN; MALE; PREFRONTAL CORTEX; PRIORITY JOURNAL; PROMOTER REGION; PROTON NUCLEAR MAGNETIC RESONANCE;

ADOLESCENT; ANALYSIS OF VARIANCE; ASPARTIC ACID; CHILD; CHILD DEVELOPMENT DISORDERS, PERVASIVE; CREATINE; FEMALE; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; NEUROCHEMISTRY; POLYMORPHISM, GENETIC; PREFRONTAL CORTEX; PROTONS; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS;

EID: 77955050934     PISSN: 09254927     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pscychresns.2010.04.015     Document Type: Article

References (29)

1. Amaral D.G., Schumann C.M., Nordahl C.W. Neuroanatomy of autism. Trends in Neurosciences 2008, 31:137-145.
2. Bauman M.L., Kemper T.L. Structural brain anatomy in autism: what is the evidence?. The Neurobiology of Autism 2005, 121-135. Johns Hopkins University Press, Baltimore, Maryland. 2nd ed. M.L. Bauman, T.L. Kemper (Eds.).
3. Birken D.L., Oldendorf W.H. N-acetyl-L-aspartic acid: a literature review of a compound prominent in 1H-NMR spectroscopic studies of brain. Neuroscience and Biobehavioral Reviews 1989, 13:23-31.
4. Bradley S.L., Dodelzon K., Sandhu H.K., Philibert R.A. Relationship of serotonin transporter gene polymorphisms and haplotypes to mRNA transcription. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics 2005, 136:58-61.
5. Brune C.W., Kim S.J., Salt J., Leventhal B.L., Lord C., Cook E.H. 5-HTTLPR genotype-specific phenotype in children and adolescents with autism. American Journal of Psychiatry 2006, 163:2148-2156.
6. Canli T., Omura K., Haas B.W., Fallgatter A., Constable R.T., Lesch K.P. Beyond affect: a role for genetic variation of the serotonin transporter in neural activation during a cognitive attention task. Proceedings of the National Academy of Sciences of the United States of America 2005, 102:12224-12229.
7. Chugani D.C., Sundram B.S., Behen M., Lee M.L., Moore G.J. Evidence of altered energy metabolism in autistic children. Progress in Neuropsychopharmacology & Biological Psychiatry 1999, 23:635-641.
8. Chugani D.C., Muzik O., Behen M., Rothermel R., Janisse J.J., Lee J., Chugani H.T. Developmental change in brain serotonin synthesis capacity in autistic and nonautistic children. Annals of Neurology 1999, 45:287-295.
9. Clark J.B. N-acetyl aspartate: a marker for neuronal loss or mitochondrial dysfunction. Developmental Neuroscience 1998, 20:271-276.
10. DeVito T.J., Drost D.J., Neufeld R.W., Rajakumar N., Pavlosky W., Williamson P., Nicolson R. Evidence for cortical dysfunction in autism: a proton magnetic resonance spectroscopic imaging study. Biological Psychiatry 2007, 61:465-473.
11. Endo T., Shioiri T., Kitamura H., Kimura T., Endo S., Masuzawa N., Someya T. Altered chemical metabolites in the amygdala-hippocampus region contribute to autistic symptoms of autism spectrum disorders. Biological Psychiatry 2007, 62:1030-1037.
12. Friedman S.D., Shaw D.W., Artru A.A., Dawson G., Petropoulos H., Dager S.R. Gray and white matter brain chemistry in young children with autism. Archives of General Psychiatry 2006, 63:786-794.
13. Frodl T., Koutsouleris N., Bottlender R., Born C., Jäger M., Mörgenthaler M., Scheuerecker J., Zill P., Baghai T., Schüle C., Rupprecht R., Bondy B., Reiser M., Möller H.J., Meisenzahl E.M. Reduced gray matter brain volumes are associated with variants of the serotonin transporter gene in major depression. Molecular Psychiatry 2008, 13:1093-1101.
14. Gabis L., Wei H., Azzian A., DeVincent C., Tudorica A., Kesner-Baruch Y., Roche P., Pomeroy J. 1H-magnetc resonance spectroscopy markers of cognitive and language ability in clinical subtypes of autism spectrum disorders. Journal of Child Neurology 2008, 23:766-774.
15. Gallinat J., Ströhle A., Lang U.E., Bajbouj M., Kalus P., Montag C., Seifert F., Wernicke C., Rommelspacher H., Rinneberg H., Schubert F. Association of human hippocampal neurochemistry, serotonin transporter genetic variation, and anxiety. Neuroimage 2005, 15(26):123-131.
16. Hisaoka S., Harada M., Nishitani H., Mori K. Regional magnetic resonance spectroscopy of the brain in autistic individuals. Neuroradiology 2001, 43:496-498.
17. Huang C.H., Santangelo S.L. Autism and serotonin transporter gene polymorphisms: a systematic review and meta-analysis. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics 2008, 5(147B):903-913.
18. Kim S.J., Cox N., Courchesne R., Lord C., Corsello C., Akshoomoff N., Guter S., Leventhal B.L., Courchesne E., Cook E.H. Transmission disequilibrium mapping at the serotonin transporter gene (SLC6A4) region in autistic disorder. Molecular Psychiatry 2002, 7:278-288.
19. Kurita H., Miyake Y., Katsuno K. Reliability and validity of the Childhood Autism Rating Scale-Tokyo version (CARS-TV). Journal of Autism and Developmental Disorders 1989, 19:389-396.
20. Murphy D.G., Critchley H.D., Schmitz N., McAlonan G., Van Amelsvoort T., Robertson D., Daly E., Rowe A., Russell A., Simmons A., Murphy K.C., Howlin P. Asperger syndrome: a proton magnetic resonance spectroscopy study of brain. Archives of General Psychiatry 2002, 59:885-891.
21. Oldfield R.C. The assessment and analysis of handedness: the Edinburgh inventory. Neuropsychologia 1971, 9:97-113.
22. Otsuka H., Harada M., Mori K., Hisaoka S., Nishitani H. Brain metabolites in the hippocampus-amygdala region and cerebellum in autism: an 1H-MR spectroscopy study. Neuroradiology 1999, 41:517-519.
23. Pezawas L., Meyer-Lindenberg A., Drabant E.M., Verchinski B.A., Munoz K.E., Kolachana B.S., Egan M.F., Mattay V.S., Hariri A.R., Weinberger D.R. 5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: a genetic susceptibility mechanism for depression. Nature Neuroscience 2005, 8:828-834.
24. Salmond C.H., Ashburner J., Connelly A., Friston K.J., Gadian D.G., Vargha-Khadem F. The role of the medial temporal lobe in autistic spectrum disorders. European Journal of Neuroscience 2005, 22:764-772.
25. Sodhi M.S., Sanders-Bush E. Serotonin and brain development. International Review of Neurobiology 2004, 59:111-174.
26. Sokol D.K., Dunn D.W., Edwards-Brown M., Feinberg J. Hydrogen proton magnetic resonance spectroscopy in autism: preliminary evidence of elevated choline/creatine ratio. Journal of Child Neurology 2002, 17:245-249.
27. Taylor W.D., Steffens D.C., Payne M.E., MacFall J.R., Marchuk D.A., Svenson I.K., Krishnan K.R. Influence of serotonin transporter promoter region polymorphisms on hippocampal volumes in late-life depression. Archives of General Psychiatry 2005, 62:537-544.
28. Urenjak J., Williams S.R., Gardian D.G., Noble M. Proton nuclear magnetic resonance spectroscopy unambiguously identifies different neural cell types. Journal of Neuroscience 1993, 13:981-989.
29. Wassink T.H., Hazlett H.C., Epping E.A., Arndt S., Dager S.R., Schellenberg G.D., Dawson G., Piven J. Cerebral cortical gray matter overgrowth and functional variation of the serotonin transporter gene in autism. Archives of General Psychiatry 2007, 64:709-717.