Altered Chemical Metabolites in the Amygdala-Hippocampus Region Contribute to Autistic Symptoms of Autism Spectrum Disorders

Biological Psychiatry

Volumn 62, Issue 9, 2007, Pages 1030-1037

  Endo, Taro ^a   Shioiri, Toshiki ^a   Kitamura, Hideaki ^a   Kimura, Teruo ^b,c   Endo, Sumio ^b,d   Masuzawa, Naio ^a   Someya, Toshiyuki ^a  

^a NIIGATA UNIVERSITY GRADUATE SCHOOL OF MEDICAL AND DENTAL SCIENCES   (Japan)

^b Niigata University   (Japan)

^c Dohtoh Neurosurgical Hospital   (Japan)

^d TOKYO ROSAI HOSPITAL   (Japan)

Author keywords

Amygdala; autism spectrum disorder; Childhood Autistic Rating Scale; hippocampus; proton magnetic resonance spectroscopy (1H MRS)

Indexed keywords

CHOLINE; CREATINE; N ACETYLASPARTIC ACID;

ADOLESCENT; ADULT; AGE DISTRIBUTION; AMYGDALOID NUCLEUS; ARTICLE; ASPERGER SYNDROME; AUTISM; BRAIN REGION; CEREBELLUM VERMIS; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HIPPOCAMPUS; HUMAN; MALE; NEUROIMAGING; PREFRONTAL CORTEX; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; RATING SCALE; SCORING SYSTEM; STATISTICAL SIGNIFICANCE; TEMPORAL LOBE;

ADOLESCENT; ADULT; AMYGDALA; ASPARTIC ACID; AUTISTIC DISORDER; BRAIN MAPPING; CHILD; FEMALE; HIPPOCAMPUS; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; PHOSPHOCREATINE; PROTONS;

EID: 35248832684     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biopsych.2007.05.015     Document Type: Article

References (54)

1. Wing L. The history of ideas on autism. Autism 1 (1997) 13-23
2. Jarbrink K., and Knapp M. The economic impact of autism in Britain. Autism 5 (2001) 7-22
3. Baird G., Simonoff E., Pickles A., Chandler S., Loucas T., Meldrum D., and Charman T. Prevalence of disorders of the autism spectrum in a population cohort of children in South Thames: The Special Needs and Autism Project (SNAP). Lancet 368 (2006) 210-215
4. Baron-Cohen S., Ring H.A., Wheelwright S., Bullmore E.T., Brammer M.J., Simmons A., and Williams S.C. Social intelligence in the normal and autistic brain: An fMRI study. Eur J Neurosci 11 (1999) 1891-1898
5. Bauman M.L., and Kemper T.L. Structural brain anatomy in autism: What is the evidence?. In: Bauman M.L., and Kemper T.L. (Eds). The Neurobiology of Autism. 2nd ed. (2005), Johns Hopkins University Press, Baltimore, Maryland 121-135
6. Palmen S.J., Van Engeland H., Hof P.R., and Schmitz C. Neuropathological findings in autism. Brain 127 (2004) 2572-2583
7. Sokol D.K., and Edwards-Brown M. Neuroimaging in autistic spectrum disorder (ASD). J Neuroimaging 14 (2004) 8-15 2004
8. Birken D.L., and Oldendorf W.H. N-acetyl-L-aspartic acid: A literature review of a compound prominent in 1H-NMR spectroscopic studies of brain. Neurosci Biobehav Rev 13 (1989) 23-31
9. Clark J.B. N-acetyl aspartate: a marker for neuronal loss or mitochondrial dysfunction. Dev Neurosci 20 (1998) 271-276
10. Urenjak J., Williams S.R., Gardian D.G., and Noble M. Proton nuclear magnetic resonance spectroscopy unambiguously identifies different neural cell types. J Neurosci 13 (1993) 981-989
11. Brand A., Richter-Landsberg C., and Leibfritz D. Multinuclear NMR studies on the energy metabolism of glial and neuronal cells. Dev Neurosci 15 (1993) 289-298
12. Gupta R.K., Cloughesy T.F., Sinha U., Garakian J., Lazareff J., Rubino G., et al. Relationships between choline magnetic resonance spectroscopy, apparent diffusion coefficient and quantitative histopathology in human glioma. J Neurooncol 50 (2000) 215-226
13. Gill S.S., Thomas D.G., Van Bruggen N., Gadian D.G., Peden C.J., Bell J.D., et al. Proton MR spectroscopy of intracranial tumors: In vivo and in vitro studies. J Comp Assist Tomogr 14 (1990) 497-504
14. Speck O., Thiel T., and Hennig J. Grading and therapy monitoring of astrocytomas with 1H-spectroscopy: preliminary study. Anticancer Res 16 (1996) 1581-1585
15. Tedeschi G., Bertolino A., Righini A., Campbell G., Raman R., Duyn J.H., et al. Brain regional distribution pattern of metabolite signal intensities in young adults by proton magnetic resonance spectroscopic imaging. Neurology 45 (1995) 1384-1391
16. Chugani D.C., Sundram B.S., Behen M., Lee M.L., and Moore G.J. Evidence of altered energy metabolism in autistic children. Prog Neuropsychopharmacol Biol Psychiatry 23 (1999) 635-641
17. Hisaoka S., Harada M., Nishitani H., and Mori K. Regional magnetic resonance spectroscopy of the brain in autistic individuals. Neuroradiology 43 (2001) 496-498
18. Otsuka H., Harada M., Mori K., Hisaoka S., and Nishitani H. Brain metabolites in the hippocampus-amygdala region and cerebellum in autism: An 1H-MR spectroscopy study. Neuroradiology 41 (1999) 517-519
19. Murphy D.G., Critchley H.D., Schmitz N., McAlonan G., Van Amelsvoort T., Robertson D., et al. Asperger syndrome: A proton magnetic resonance spectroscopy study of brain. Arch Gen Psychiatry 59 (2002) 885-891
20. Friedman S.D., Shaw D.W., Artru A.A., Richards T.L., Gardner J., Dawson G., et al. Regional brain chemical alterations in young children with autism spectrum disorder. Neurology 60 (2003) 100-107
21. Friedman S.D., Shaw D.W., Artru A.A., Dawson G., Petropoulos H., and Dager S.R. Gray and white matter brain chemistry in young children with autism. Arch Gen Psychiatry 63 (2006) 786-794
22. DeVito T.J., Drost D.J., Neufeld R.W., Rajakumar N., Pavlosky W., Williamson P., and Nicolson R. Evidence for cortical dysfunction in autism: A proton magnetic resonance spectroscopic imaging study. Biol Psychiatry 61 (2007) 465-473
23. Levitt J.G., O'Neill J., Blanton R.E., Smalley S., Fadale D., McCracken J.T., et al. Proton magnetic resonance spectroscopic imaging of the brain in childhood autism. Biol Psychiatry 54 (2003) 1355-1366
24. Sokol D.K., Dunn D.W., Edwards-Brown M., and Feinberg J. Hydrogen proton magnetic resonance spectroscopy in autism: preliminary evidence of elevated choline/creatine ratio. J Child Neurol 17 (2002) 245-249
25. Berument S.K., Rutter M., Lord C., Pickles A., and Bailey A. Autism screening questionnaire: Diagnostic validity. Br J Psychiatry 175 (1999) 444-451
26. rd ed. (1991), Psychological Corporation, New York
27. Weschler D. Weschler Adult Intelligence Scale-Revised (1981), Harcourt Brace Jovanovich, New York
28. Oldfield R.C. The assessment and analysis of handedness: The Edinburgh inventory. Neuropsychologia 9 (1971) 97-113
29. Kurita H., Miyake Y., and Katsuno K. Reliability and validity of the Childhood Autism Rating Scale-Tokyo version (CARS-TV). J Autism Dev Disord 19 (1989) 389-396
30. Webb P.G., Sailasuta N., Kohler S.J., Raidy T., Moats R.A., and Hurd R.E. Automated single-voxel proton MRS: technical development and multisite verification. Magn Reson Med 31 (1994) 365-373
31. Aylward E.H., Minshew N.J., Goldstein G., Honeycutt N.A., Augustine A.M., Yates K.O., et al. MRI volumes of amygdala and hippocampus in non-mentally retarded autistic adolescents and adults. Neurology 53 (1999) 2145-2150
32. Critchley H.D., Daly E.M., Bullmore E.T., Williams S.C., Van Amelsvoort T., Robertson D.M., et al. The functional neuroanatomy of social behaviour: Changes in cerebral blood flow when people with autistic disorder process facial expressions. Brain 123 (2000) 2203-2212
33. Howard M.A., Cowell P.E., Boucher J., Broks P., Mayes A., Farrant A., and Roberts N. Convergent neuroanatomical and behavioural evidence of an amygdala hypothesis of autism. Neuroreport 11 (2000) 2931-2935
34. Pierce K., Muller R.A., Ambrose J., Allen G., and Courchesne E. Face processing occurs outside the fusiform 'face area' in autism: Evidence from functional MRI. Brain 124 (2001) 2059-2073
35. Schumann C.M., Hamstra J., Goodlin-Jones B.L., Lotspeich L.J., Kwon H., Buonocore M.H., et al. The amygdala is enlarged in children but not adolescents with autism; the hippocampus is enlarged at all ages. J Neurosci 24 (2004) 6392-6401
36. Sparks B.F., Friedman S.D., Shaw D.W., Aylward E.H., Echelard D., Artru A.A., et al. Brain structural abnormalities in young children with autism spectrum disorder. Neurology 59 (2002) 184-192
37. Nacewicz B.M., Dalton K.M., Johnstone T., Long M.T., McAuliff E.M., Oakes T.R., et al. Amygdala volume and nonverbal social impairment in adolescent and adults males with autism. Arch Gen Psychiatry 63 (2006) 1417-1428
38. Salmond C.H., Ashburner J., Connelly A., Friston K.J., Gadian D.G., and Vargha-Khadem F. The role of the medial temporal lobe in autistic spectrum disorders. Eur J Neurosci 22 (2005) 764-772
39. Courchesne E., Saitoh O., Yeung-Courchesne R., Press G.A., Lincoln A.J., Haas R.H., and Schreibman L. Abnormality of cerebellar vermian lobules VI and VII in patients with infantile autism: Identification of hypoplastic and hyperplastic subgroups with MR imaging. AJR Am J Roentgenol 162 (1994) 123-130
40. Kwon H., Ow A.W., Pedatella K.E., Lotspeich L.J., and Reiss A.L. Voxel-based morphometry elucidates structural neuroanatomy of high-functioning autism and Asperger syndrome. Dev Med Child Neurol 46 (2004) 760-764
41. Rojas D.C., Peterson E., Winterrowd E., Reite M.L., Rogers S.J., and Tregellas J.R. Regional gray matter volumetric changes in autism associated with social and repetitive behavior symptoms. BMC Psychiatry 6 (2006) 56
42. Hazlett H.C., Poe M.D., Gerig G., Smith R.G., and Piven J. Cortical gray and white brain tissue volume in adolescents and adults with autism. Biol Psychiatry 59 (2006) 1-6
43. Page L.A., Daly E., Schmitz N., Simmons A., Toal F., Deeley Q., et al. In vivo 1H-magnetic resonance spectroscopy study of amygdala-hippocampal and parietal regions in autism. Am J Psychiatry 163 (2006) 2189-2192
44. Haznedar M.M., Buchsbaum M.S., Wei T.C., Hof P.R., Cartwright C., Bienstock C.A., and Hollander E. Limbic circuitry in patients with autism spectrum disorders studied with positron emission tomography and magnetic resonance imaging. Am J Psychiatry 157 (2000) 1994-2001
45. Palmen S.J., Durston S., Nederveen H., and Van Engeland H. No evidence for preferential involvement of medial temporal lobe structures in high-functioning autism. Psychol Med 36 (2006) 827-834
46. Piven J., Bailey J., Ranson B.J., and Arndt S. No difference in hippocampus volume detected on magnetic resonance imaging in autistic individuals. J Autism Dev Disord 28 (1998) 105-110
47. Lotspeich L.J., Kwon H., Schumann C.M., Fryer S.L., Goodlin-Jones B.L., Buonocore M.H., et al. Investigation of neuroanatomical differences between autism and Asperger syndrome. Arch Gen Psychiatry 51 (2004) 291-298
48. Schumann C.M., and Amaral D.G. Stereological analysis of amygdala neuron number in autism. J Neuroscience 26 (2006) 7674-7679
49. Brothers L., Ring B., and Kling A. Response of neurons in the macaque amygdala to complex social stimuli. Behav Brain Res 41 (1990) 199-213
50. Haxby J.V., Hoffman E.A., and Gobbini M.I. Human neural systems for face recognition and social communication. Biol Psychiatry 51 (2002) 59-67
51. Adolphs R., Tranel D., and Damasio A.R. Dissociable neural systems for recognizing emotions. Brain Cogn 52 (2003) 61-69
52. Piven J., Saliba K., Bailey J., and Arndt S. An MRI study of autism: The cerebellum revisited. Neurology 49 (1997) 546-551
53. Grachev I.D., and Apkarian A.V. Chemical heterogeneity of living human brain: A proton MR spectroscopy study on effects of sex, age, and brain region. Neuroimage 11 (2000) 554-563
54. Kadota T., Horinouchi T., and Kuroda C. Development and aging of the cerebrum: Assessment with proton MR spectroscopy. AJNR Am J Neuroradiol 22 (2001) 128-135