Mechanism of retinal ganglion cells death in secondary degeneration of the optic nerve

Experimental Eye Research

Volumn 91, Issue 2, 2010, Pages 127-134

  Levkovitch Verbin, Hani ^a   Dardik, Rima ^a   Vander, Shelly ^a   Melamed, Shlomo ^a  

^a TEL AVIV UNIVERSITY   (Israel)

Author keywords

Apoptosis; Bcl 2; Glaucoma; Optic nerve; Secondary degeneration

Indexed keywords

CASPASE 3; PROTEIN BAD; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL XL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DEATH; CELL STRUCTURE; ENZYME ACTIVATION; GENE EXPRESSION; IMMUNOHISTOCHEMISTRY; NERVE DEGENERATION; NERVE TRANSECTION; NONHUMAN; OPTIC NERVE DISEASE; PRIORITY JOURNAL; RAT; RETINA GANGLION CELL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION;

ANIMALS; APOPTOSIS; CASPASE 3; IMMUNOHISTOCHEMISTRY; NERVE DEGENERATION; OPTIC NERVE; OPTIC NERVE DISEASES; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RATS, WISTAR; RETINAL GANGLION CELLS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 77954960116     PISSN: 00144835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exer.2009.11.014     Document Type: Article

References (24)

1. Blair M., et al. Effect of glatiramer acetate on primary and secondary degeneration of retinal ganglion cells in the rat. Invest. Ophthalmol. Vis. Sci. 2005, 46:884-890.
2. Bodeutsch N., et al. Unilateral injury to the adult rat optic nerve causes multiple cellular responses in the contralateral site. J. Neurobiol. 1999, 38:116-128.
3. Dusart I., Schwab M.E. Secondary cell death and the inflammatory reaction after dorsal hemisection of the rat spinal cord. Eur. J. Neurosci. 1994, 6:712-724.
4. Ferrer I., et al. Caspase-dependent and caspase-independent signalling of apoptosis in the penumbra following middle cerebral artery occlusion in the adult rat. Neuropathol. Appl. Neurobiol. 2003, 29:472-481.
5. Ferrer I., et al. Early modifications in the expression of mitogen-activated protein kinase (MAPK/ERK), stress-activated kinases SAPK/JNK and p38, and their phosphorylated substrates following focal cerebral ischemia. Acta Neuropathol. (Berl) 2003, 105:425-437.
6. Ferrer I., Planas A.M. Signaling of cell death and cell survival following focal cerebral ischemia: life and death struggle in the penumbra. J. Neuropathol. Exp. Neurol. 2003, 62:329-339.
7. Johnson E.C., et al. Chronology of optic nerve head and retinal responses to elevated intraocular pressure. Invest. Ophthalmol. Vis. Sci. 2000, 41:431-442.
8. Kerrigan L.A., et al. TUNEL-positive ganglion cells in human primary open-angle glaucoma. Arch. Ophthalmol. 1997, 115:1031-1035.
9. Levkovitch-Verbin H., et al. Experimental glaucoma and optic nerve transection induce simultaneous upregulation of proapoptotic and prosurvival genes. Invest. Ophthalmol. Vis. Sci. 2006, 47:2491-2497.
10. Levkovitch-Verbin H., et al. Regulation of cell death and survival pathways in experimental glaucoma. Exp. Eye Res. 2007, 85:250-258.
11. Levkovitch-Verbin H., et al. Optic nerve transection in monkeys may result in secondary degeneration of retinal ganglion cells. Invest. Ophthalmol. Vis. Sci. 2001, 42:975-982.
12. Levkovitch-Verbin H., et al. A model to study differences between primary and secondary degeneration of retinal ganglion cells in rats by partial optic nerve transection. Invest. Ophthalmol. Vis. Sci. 2003, 44:3388-3393.
13. McKinnon S.J., et al. Current management of glaucoma and the need for complete therapy. Am. J. Manag. Care 2008, 14:S20-S27.
14. McKinnon S.J., et al. Caspase activation and amyloid precursor protein cleavage in rat ocular hypertension. Invest. Ophthalmol. Vis. Sci. 2002, 43:1077-1087.
15. Moalem G., et al. Autoimmune T cells protect neurons from secondary degeneration after central nervous system axotomy. Nat. Med. 1999, 5:49-55.
16. Nevo U., et al. Diffusion anisotropy MRI for quantitative assessment of recovery in injured rat spinal cord. Magn. Reson. Med. 2001, 45:1-9.
17. Nishioka T., et al. Sequential and spatial profiles of apoptosis in ischemic penumbra after two-vein occlusion in rats. J. Neurosurg. 2006, 104:938-944.
18. Quigley H.A. Neuronal death in glaucoma. Prog. Retin. Eye Res. 1999, 18:39-57.
19. Quigley H.A., et al. Retinal ganglion cell death in experimental glaucoma and after axotomy occurs by apoptosis. Invest. Ophthalmol. Vis. Sci. 1995, 36:774-786.
20. Schaller B.J., et al. Pathophysiology of brain ischemia: penumbra, gene expression, and future therapeutic options. Eur. Neurol. 2005, 54:179-180.
21. Schwartz M., Yoles E. Optic nerve degeneration and potential neuroprotection: implications for glaucoma. Eur. J. Ophthalmol. 1999, 9(Suppl. 1):S9-S11.
22. Weinstein P.R., et al. Molecular identification of the ischemic penumbra. Stroke 2004, 35:2666-2670.
23. Yao H., et al. DNA fragmentation in ischemic core and penumbra in focal cerebral ischemia in rats. Brain Res. Mol. Brain Res. 2001, 91:112-118.
24. Yoles E., Schwartz M. Degeneration of spared axons following partial white matter lesion: implications for optic nerve neuropathies. Exp. Neurol. 1998, 153:1-7.