Aging increases retinal vascular lesions characteristic of early diabetic retinopathy

Biogerontology

Volumn 11, Issue 4, 2010, Pages 447-455

  Roy, Sumon ^a   Tonkiss, John ^a   Roy, Sayon ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Aging; Apoptosis; Endothelial cells; Pericytes; Retinal vascular lesions

Indexed keywords

GLUCOSE; HEMOGLOBIN A1C; GLUCOSE BLOOD LEVEL;

AGING; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BODY WEIGHT; CELL LOSS; CHOROID; CONTROLLED STUDY; DIABETIC RETINOPATHY; FEMALE; GLUCOSE BLOOD LEVEL; HEMOGLOBIN BLOOD LEVEL; NICK END LABELING; NONHUMAN; PERICYTE; PRIORITY JOURNAL; RAT; VASCULAR LESION; AGED; ANIMAL; CYTOLOGY; EXPERIMENTAL DIABETES MELLITUS; HUMAN; LONG EVANS RAT; METABOLISM; PATHOLOGY; PHYSIOLOGY; RANDOMIZATION; RETINA BLOOD VESSEL;

AGED; AGING; ANIMALS; APOPTOSIS; BLOOD GLUCOSE; BODY WEIGHT; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC RETINOPATHY; FEMALE; HUMANS; IN SITU NICK-END LABELING; PERICYTES; RANDOM ALLOCATION; RATS; RATS, LONG-EVANS; RETINAL VESSELS;

EID: 77954955043     PISSN: 13895729     EISSN: 15736768     Source Type: Journal    
DOI: 10.1007/s10522-010-9263-x     Document Type: Article

References (54)

1. Abyad A (1997) In-office screening for age-related hearing and vision loss. Geriatrics 52(6):45-46, 51-44, 57
2. Ali TK, El-Remessy AB (2009) Diabetic retinopathy: current management and experimental therapeutic targets. Pharmacotherapy 29(2):182-192
3. American Macular Degeneration Foundation (2009) "What is Macular Degeneration?" http://www.macular.org/disease. html. Retrieved September 5, 2009
4. Ashcroft GS, Horan MA et al (1998) Aging alters the inflammatory and endothelial cell adhesion molecule profiles during human cutaneous wound healing. Lab Invest 78(1):47-58
5. Balantinou E, Trougakos IP et al (2009) Transcriptional and posttranslational regulation of clustering by the two main cellular proteolytic pathways. Free Radic Biol Med 46(9):1267-1274
6. Barcelo A, Rajpathak S (2001) Incidence and prevalence of diabetes mellitus in the Americas. Rev Panam Salud Publica 10(5):300-308
7. Brownlee M (1995) Advanced protein glycosylation in diabetes and aging. Annu Rev Med 46:223-234
8. Butler RN, Faye EE et al (1997) Keeping an eye on vision: primary care of age-related ocular disease Part 1. Geriatrics 52(8):30-41
9. Carter TL (1994) Age-related vision changes: a primary care guide. Geriatrics 49(9):37-42, 45; quiz 46-137
10. Cherian S, Roy S et al (2009) Tight glycemic control regulates fibronectin expression and basement membrane thickening in retinal and glomerular capillaries of diabetic rats. Invest Ophthalmol Vis Sci 50(2):943-949
11. Cogan DG, Kuwabara T (1984) Comparison of retinal and cerebral vasculature in trypsin digest preparations. Br J Ophthalmol 68(1):10-12
12. Cotter SA, Varma R et al (2006) Causes of low vision and blindness in adult Latinos: the Los Angeles Latino eye study. Ophthalmology 113(9):1574-1582 (Pubitemid 44292317)
13. Crawford TN, Alfaro DV III et al (2009) Diabetic retinopathy and angiogenesis. Curr Diabetes Rev 5(1):8-13
14. Curtis TM, Gardiner TA et al (2009) Microvascular lesions of diabetic retinopathy: clues towards understanding pathogenesis? Eye 23(7):1496-1508
15. Fagot-Campagna A, Bourdel-Marchasson I, et al. (2005) Burden of diabetes in an aging population: prevalence, incidence, mortality, characteristics and quality of care.Diabetes Metab 31 Spec No 2:5S35-35S52
16. Diabetes Metab 31 Spec No 2:5S35-35S52 Galli F, Piroddi M et al (2005) Oxidative stress and reactive oxygen species. Contrib Nephrol 149:240-260
17. Gimeno SG, Ferreira SR et al (2002) Prevalence and 7-year incidence of Type II diabetes mellitus in a Japanese- Brazilian population: an alarming public health problem. Diabetologia 45(12):1635-1638
18. Haffner SM, Hazuda HP et al (1991) Increased incidence of type II diabetes mellitus in Mexican Americans. Diabetes Care 14(2):102-108
19. Kalina RE (1997) Seeing into the future. Vision and aging. West J Med 167(4):253-257
20. Kallman H and Vernon MS (1987) The aging eye. A family physician discusses some inevitable changes and suggests methods for dealing with them. Postgrad Med 81(2):108- 109, 112-1108, 123 passim
21. Kempen JH, O'Colmain BJ et al (2004) The prevalence of diabetic retinopathy among adults in the United States. Arch Ophthalmol 122(4):552-563
22. Kern TS, Engerman RL (1995) Galactose-induced retinal microangiopathy in rats. Invest Ophthalmol Vis Sci 36(2):490-496
23. Kilo C, Vogler N et al (1972) Muscle capillary basement membrane changes related to aging and to diabetes mellitus. Diabetes 21(8):881-905
24. Krishnaiah S, Das T et al (2007) Risk factors for diabetic retinopathy: Findings from the Andhra Pradesh eye disease study. Clin Ophthalmol 1(4):475-482
25. Lee PP, Feldman ZW et al (2003) Longitudinal prevalence of major eye diseases. Arch Ophthalmol 121(9):1303-1310
26. Loh KY, Ogle J (2004) Age related visual impairment in the elderly. Med J Malaysia 59(4):562-568 (quiz 569)
27. Ludvigsson J (2006) Why diabetes incidence increases-a unifying theory. Ann N Y Acad Sci 1079:374-382
28. Madsen-Bouterse SA, Kowluru RA (2008) Oxidative stress and diabetic retinopathy: pathophysiological mechanisms and treatment perspectives. Rev Endocr Metab Disord 9(4):315-327
29. McGuire LC, Ford ES et al (2006) The impact of cognitive functioning on mortality and the development of functional disability in older adults with diabetes: the second longitudinal study on aging. BMC Geriatr 6:8
30. Mehnert H (1997) Diabetes mellitus as a clinical model of the process of aging. Eur J Med Res 2(10):441-444
31. Messier C (2005) Impact of impaired glucose tolerance and type 2 diabetes on cognitive aging. Neurobiol Aging 26(Suppl 1):26-30
32. Minaker KL (1987) Aging and diabetes mellitus as risk factors for vascular disease. Am J Med 82(1B):47-53
33. Miyahara S, Kiryu J et al (2006) Alteration of leukocyteendothelial cell interaction during aging in retinal microcirculation of hypertensive rats. Jpn J Ophthalmol 50(6):509-514
34. Morello CM (2007) Etiology and natural history of diabetic retinopathy: an overview. Am J Health Syst Pharm 64(17 Suppl 12):S3-S7
35. Morley JE (2008) Diabetes and aging: epidemiologic overview. Clin Geriatr Med 24(3):395-405
36. Nathan DM, Singer DE et al (1986) Non-insulin-dependent diabetes in older patients. Complications and risk factors. Am J Med 81(5):837-842
37. Ng JS (2009) Specific medical intervention for diabetic retinopathy. Med Hypotheses 73(2):158-160
38. Nsiah-Kumi P, Ortmeier SR et al (2009) Disparities in diabetic retinopathy screening and disease for racial and ethnic minority populations-a literature review. J Natl Med Assoc 101(5):430-437
39. Ohnuma I (2001) Quantitative assessment of macular appearance with a scanning laser ophthalmoscope in aging or diabetic retinopathy patients. Nippon Ganka Gakkai Zasshi 105(2):88-95
40. Park SW, Goodpaster BH et al (2007) Accelerated loss of skeletal muscle strength in older adults with type 2 diabetes: the health, aging, and body composition study. Diabetes Care 30(6):1507-1512
41. Diabetes Care 30(6):1507-1512 Paulus YM, Gariano RF (2009) Diabetic retinopathy: a growing concern in an aging population. Geriatrics 64(2):16-20
42. Peter S (2007) Trends in the incidence of type I diabetes mellitus worldwide. West Indian Med J 56(3):264-269
43. Pieczenik SR, Neustadt J (2007) Mitochondrial dysfunction and molecular pathways of disease. Exp Mol Pathol 83(1):84-92
44. Pizzarello LD (1987) The dimensions of the problem of eye disease among the elderly. Ophthalmology 94(9): 1191-1195
45. Radomski JS, Jarrell BE et al (1989) Effects of in vitro aging on human endothelial cell adherence to dacron vascular graft material. J Surg Res 47(2):173-177
46. Rota M, LeCapitaine N et al (2006) Diabetes promotes cardiac stem cell aging and heart failure, which are prevented by deletion of the p66shc gene. Circ Res 99(1):42-52
47. Roy S, Sato T (2000) Role of vascular basement membrane components in diabetic microangiopathy. Drug News Perspect 13(2):91-98
48. Roy S, Sato T et al (2003) Downregulation of fibronectin overexpression reduces basement membrane thickening and vascular lesions in retinas of galactose-fed rats. Diabetes 52(5):1229-1234
49. Shah CA (2008) Diabetic retinopathy: A comprehensive review. Indian J Med Sci 62(12):500-519
50. Tagawa H, McMeel JW et al (1986) Role of the vitreous in diabetic retinopathy. I. Vitreous changes in diabetic retinopathy and in physiologic aging. Ophthalmology 93(5):596-601 (Pubitemid 16086711)
51. Tsai CY, Woung LC et al (2005) The current status of visual disability in the elderly population of Taiwan. Jpn J Ophthalmol 49(2):166-172
52. Vannini N, Pfeffer U et al (2008) Endothelial cell aging and apoptosis in prevention and disease: E-selectin expression and modulation as a model. Curr Pharm Des 14(3):221-225
53. Yamagishi S, Ueda S et al (2008) Role of advanced glycation end products (AGEs) and oxidative stress in diabetic retinopathy. Curr Pharm Des 14(10):962-968
54. Yoshida M (2006) Cell adhesion and endothelial function in aging and atherosclerosis. Nippon Ronen Igakkai Zasshi 43(3):345-346