The mechanical triggers of plaque rupture: Shear stress vs pressure gradient

British Journal of Radiology

Volumn 82, Issue SPEC. ISSUE 1, 2009, Pages

  Li, Z Y ^a,b   Taviani, V ^a   Tang, T ^a   Sadat, U ^a   Young, V ^a   Patterson, A ^a   Graves, M ^a   Gillard, J H ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b SOUTHEAST UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

AGED; ARTICLE; ATHEROSCLEROSIS; BIOLOGICAL MODEL; BLOOD FLOW VELOCITY; BLOOD PRESSURE; CAROTID ARTERY OBSTRUCTION; HUMAN; MAGNETIC RESONANCE ANGIOGRAPHY; MALE; MECHANICAL STRESS; METHODOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; PULSATILE FLOW; RUPTURE;

AGED; ATHEROSCLEROSIS; BLOOD FLOW VELOCITY; BLOOD PRESSURE; CAROTID STENOSIS; HUMANS; MAGNETIC RESONANCE ANGIOGRAPHY; MALE; MODELS, CARDIOVASCULAR; PULSATILE FLOW; RUPTURE, SPONTANEOUS; STRESS, MECHANICAL;

EID: 77954944556     PISSN: 00071285     EISSN: None     Source Type: Journal    
DOI: 10.1259/bjr/15036781     Document Type: Article

References (21)

1. Caro CG, Fitz-Gerald JM, Schroter RC. Atheroma and arterial wall shear. Observation, correlation and proposal of a shear dependent mass transfer mechanism for atherogenesis. Proc R Soc Lond B Biol Sci 1971;177:109-59.
2. Fry DL. Acute vascular endothelial changes associated with increased blood velocity gradients. Circ Res 1968;22:165-97.
3. Ku DN, Giddens DP, Zarins CK, Glagov S. Pulsatile flow and atherosclerosis in the human carotid bifurcation. Positive correlation between plaque location and low oscillating shear stress. Arteriosclerosis 1985;5:293-302.
4. Kornet L, Hoeks AP, Lambregts J, Reneman RS. In the femoral artery bifurcation, differences in mean wall shear stress within subjects are associated with different intimamedia thicknesses. Arterioscler Thromb Vasc Biol 1999;19: 2933-9.
5. Chatzizisis YS, Coskun AU, Jonas M, Edelman ER, Feldman CL, Stone PH. Role of endothelial shear stress in the natural history of coronary atherosclerosis and vascular remodeling: molecular, cellular, and vascular behavior. J Am Coll Cardiol 2007;49:2379-93.
6. Mattart M, Mazzolai L, Chambaz C, Hayoz D, Brunner HR, Silacci P. ET-1 and NOS III gene expression regulation by plaque-free and plaque-prone hemodynamic conditions. Biorheology 2003;40:289-97.
7. Groen HC, Gijsen FJ, van der Lugt A, Ferguson MS, Hatsukami TS, van der Steen AF, et al. Plaque rupture in the carotid artery is localized at the high shear stress region: a case report. Stroke 2007;38:2379-81.
8. Isaka N, Tanigawa T, Nishikawa M, Nakano T. High shear stress induced platelet aggregation (h-SIPA) and effects of antiplatelet therapy. Nippon Rinsho 1998;56:2624-9. (In Japanese).
9. Badimon L, Badimon JJ, Turitto VT, Vallabhajosula S, Fuster V. Platelet thrombus formation on collagen type I. A model of deep vessel injury. Influence of blood rheology, von Willebrand factor, and blood coagulation. Circulation 1988;78:1431-42.
10. Slager CJ, Wentzel JJ, Gijsen FJ, Schuurbiers JC, van der Wal AC, van der Steen AF, et al. The role of shear stress in the generation of rupture-prone vulnerable plaques. Nat Clin Pract Cardiovasc Med 2005;2:401-7.
11. Ku DN. Blood flow in arteries. Annu Rev Fluid Mech 1997;29:399-434.
12. Helderman F, Segers D, de Crom R, Hierck BP, Poelmann RE, Evans PC, et al. Effect of shear stress on vascular inflammation and plaque development. Curr Opin Lipidol 2007;18:527-533.
13. Dirksen MT, van der Wal AC, van den Berg FM, van der Loos CM, Becker AE. Distribution of inflammatory cells in atherosclerotic plaques relates to the direction of flow. Circulation 1998;98:2000-3.
14. Cheng C, Tempel D, van Haperen R, van der Baan A, Grosveld F, Daemen MJ, et al. Atherosclerotic lesion size and vulnerability are determined by patterns of fluid shear stress. Circulation 2006;113:2744-53.
15. Rodriguez-Granillo GA, Garcia-Garcia HM, Wentzel J, Valgimigli M, Tsuchida K, van der Giessen W, et al. Plaque composition and its relationship with acknowledged shear stress patterns in coronary arteries. J Am Coll Cardiol 2006;47:884-5.
16. Cheng GC, Loree HM, Kamm RD, Fishbein MC, Lee RT. Distribution of circumferential stress in ruptured and stable atherosclerotic lesions. A structural analysis with histopathological correlation. Circulation 1993;87:1179-87.
17. Loree HM, Kamm RD, Stringfellow RG, Lee RT. Effects of fibrous cap thickness on peak circumferential stress in model atherosclerotic vessels. Circ Res 1992;71:850-8.
18. Lee RT, Loree HM, Cheng GC, Lieberman EH, Jaramillo N, Schoen FJ. Computational structural analysis based on intravascular ultrasound imaging before in vitro angioplasty: prediction of plaque fracture locations. J Am Coll Cardiol 1993;21:777-82.
19. Li ZY, Howarth S, Trivedi RA, JM Uki, Graves MJ, Brown A, et al. Stress analysis of carotid plaque rupture based on in vivo high resolution MRI. J Biomech 2006;39:2611-22.
20. Li ZY, Howarth SP, Tang T, Graves MJ, J Uki, Trivedi RA, et al. Structural analysis and magnetic resonance imaging predict plaque vulnerability: a study comparing symptomatic and asymptomatic individuals. J Vasc Surg 2007;45:768-75.
21. Li ZY, Howarth SP, Tang T, Gillard JH. How critical is fibrous cap thickness to carotid plaque stability? A flowplaque interaction model. Stroke 2006;37:1195-9.