메뉴 건너뛰기




Volumn 89, Issue 12, 2009, Pages 855-859

Simvastatin prevents the development of pulmonary hypertension in the rats through reduction of inflammation

Author keywords

Hypertension, pulmonary; Inflammation; Monocrotaline; Rats, Sprague Dawley; Simvastatin

Indexed keywords

INTERLEUKIN 6; MONOCROTALINE; MONOCYTE CHEMOTACTIC PROTEIN 1; SIMVASTATIN; SODIUM CHLORIDE; TUMOR NECROSIS FACTOR ALPHA;

EID: 77954942100     PISSN: 03762491     EISSN: None     Source Type: Journal    
DOI: 10.3760/cma.j.issn.0376-2491.2009.12.016     Document Type: Article
Times cited : (2)

References (28)
  • 1
    • 77954949630 scopus 로고    scopus 로고
    • Chinese source
  • 2
    • 0028282859 scopus 로고
    • Exuberant endothelial cell growth and elements of inflammation are present in plexiform lesions of pulmonary hypertension
    • Tuder RM, Groves B, Badesch DB, et al. Exuberant endothelial cell growth and elements of inflammation are present in plexiform lesions of pulmonary hypertension. Am J Pathol, 1994,144:275-285.
    • (1994) Am J Pathol , vol.144 , pp. 275-285
    • Tuder, R.M.1    Groves, B.2    Badesch, D.B.3
  • 3
    • 0043028479 scopus 로고    scopus 로고
    • Inflammation in pulmonary arterial hypertension
    • Dorfmüller P, Perros F, Balabaniam K, et al. Inflammation in pulmonary arterial hypertension. Eur Respir J, 2003,22:358-363.
    • (2003) Eur Respir J , vol.22 , pp. 358-363
    • Dorfmüller, P.1    Perros, F.2    Balabaniam, K.3
  • 4
    • 28844506346 scopus 로고    scopus 로고
    • Potential vascular benefits of statins
    • Kinlay S. Potential vascular benefits of statins. Am J Med, 2005,118(Suppl 12A):62-67.
    • (2005) Am J Med , vol.118 , Issue.SUPPL. 12A , pp. 62-67
    • Kinlay, S.1
  • 5
    • 0035162266 scopus 로고    scopus 로고
    • Simvastatin has anti-imflammatory and antiatherosclerotic activities independent of plasma cholesterol lowering
    • Sparrow CP, Burton CA, Hernandez M, et al. Simvastatin has anti-imflammatory and antiatherosclerotic activities independent of plasma cholesterol lowering. Arterioscler Thromb Vasc Biol, 2001,21:115-121.
    • (2001) Arterioscler Thromb Vasc Biol , vol.21 , pp. 115-121
    • Sparrow, C.P.1    Burton, C.A.2    Hernandez, M.3
  • 6
    • 0034533147 scopus 로고    scopus 로고
    • Statins as a newly recognized type of immunomodulator
    • Kwak B, Mulhaupt F, Myit S, et al. Statins as a newly recognized type of immunomodulator. Nat Med, 2000,6:1399-1402.
    • (2000) Nat Med , vol.6 , pp. 1399-1402
    • Kwak, B.1    Mulhaupt, F.2    Myit, S.3
  • 7
    • 0035829849 scopus 로고    scopus 로고
    • Locking a leukocyte integrin with statins
    • Frenette PS. Locking a leukocyte integrin with statins. N Engl J Med, 2001,345:1419-1421.
    • (2001) N Engl J Med , vol.345 , pp. 1419-1421
    • Frenette, P.S.1
  • 8
    • 0038348392 scopus 로고    scopus 로고
    • HMG-CoA reductase inhibition: Anti-inflammatory effects beyond lipid lowering?
    • Marz W, Koenig W. HMG-CoA reductase inhibition: anti-inflammatory effects beyond lipid lowering? J Cardiovasc Risk, 2003,10:169-179.
    • (2003) J Cardiovasc Risk , vol.10 , pp. 169-179
    • Marz, W.1    Koenig, W.2
  • 9
    • 33748753564 scopus 로고    scopus 로고
    • How valid are animal models to evaluate treatments for pulmonary hypertension?
    • Campian ME, Hardziyenka M, Michel MC, et al. How valid are animal models to evaluate treatments for pulmonary hypertension? Naunyn Schmiedebergs Arch Pharmacol, 2006,373:391-400.
    • (2006) Naunyn Schmiedebergs Arch Pharmacol , vol.373 , pp. 391-400
    • Campian, M.E.1    Hardziyenka, M.2    Michel, M.C.3
  • 11
    • 0029062419 scopus 로고
    • Increased interleukin-1 and interleukin-6 serum concentration in severe primary pulmonary hypertension
    • Humbert M, Monti G, Brenot F, et al. Increased interleukin-1 and interleukin-6 serum concentration in severe primary pulmonary hypertension. Am J Respir Crit Care Med, 1995,151:1628-1631.
    • (1995) Am J Respir Crit Care Med , vol.151 , pp. 1628-1631
    • Humbert, M.1    Monti, G.2    Brenot, F.3
  • 12
    • 0031925331 scopus 로고    scopus 로고
    • Platelet-derived growth factor expression in primary pulmonary hypertension: Comparison of HIV seropositive and HIV seronegative patients
    • Humbert M, Monti G, Fartoukh M, et al. Platelet-derived growth factor expression in primary pulmonary hypertension: comparison of HIV seropositive and HIV seronegative patients. Eur Respir J, 1998,11:554-559.
    • (1998) Eur Respir J , vol.11 , pp. 554-559
    • Humbert, M.1    Monti, G.2    Fartoukh, M.3
  • 13
    • 0031857771 scopus 로고    scopus 로고
    • Chemokine macrophage inflammatory protein-1 alpha mRNA expression in lung biopsy specimens of primary pulmonary hypertension
    • Fartoukh M, Emilie D, Le Gall C, et al. Chemokine macrophage inflammatory protein-1 alpha mRNA expression in lung biopsy specimens of primary pulmonary hypertension. Chest, 1998,114:50-51.
    • (1998) Chest , vol.114 , pp. 50-51
    • Fartoukh, M.1    Emilie, D.2    Le Gall, C.3
  • 15
    • 0033048993 scopus 로고    scopus 로고
    • Treatment of pulmonary hypertension secondary to connective tissue diseases
    • Sanchez O, Humbert M, Sitbon O, et al. Treatment of pulmonary hypertension secondary to connective tissue diseases. Thorax, 1999,54:273-277.
    • (1999) Thorax , vol.54 , pp. 273-277
    • Sanchez, O.1    Humbert, M.2    Sitbon, O.3
  • 16
    • 0032986928 scopus 로고    scopus 로고
    • Effective immunosuppressive therapy in a patient with primary pulmonary hypertension
    • Bellotto F, Chiavacei P, Laveder F, et al. Effective immunosuppressive therapy in a patient with primary pulmonary hypertension. Thorax, 1999,54:372-374.
    • (1999) Thorax , vol.54 , pp. 372-374
    • Bellotto, F.1    Chiavacei, P.2    Laveder, F.3
  • 17
    • 0029938442 scopus 로고    scopus 로고
    • Improvement of severe pulmonary hypertension in a patient with SLE
    • Karmochkine M, Wechsler B, Godeau P, et al. Improvement of severe pulmonary hypertension in a patient with SLE. Ann Rheum Dis, 1996,55:561-562.
    • (1996) Ann Rheum Dis , vol.55 , pp. 561-562
    • Karmochkine, M.1    Wechsler, B.2    Godeau, P.3
  • 18
    • 0027746015 scopus 로고
    • Pulmonary arterial hypertension responsive to immunosuppressive therapy in systemic lupus erythematosus
    • Morelli S, Giordano M, De Marzio P, et al. Pulmonary arterial hypertension responsive to immunosuppressive therapy in systemic lupus erythematosus. Lupus, 1993,2:367-369.
    • (1993) Lupus , vol.2 , pp. 367-369
    • Morelli, S.1    Giordano, M.2    De Marzio, P.3
  • 19
    • 84916362625 scopus 로고
    • Pulmonary arteries produced in rats by feeding Crotolaria spectabilis
    • LALICH JJ, MERKOW L. Pulmonary arteries produced in rats by feeding Crotolaria spectabilis. Lab Invest, 1961,10:744-750.
    • (1961) Lab Invest , vol.10 , pp. 744-750
    • Lalich, J.J.1    Merkow, L.2
  • 20
    • 0034526932 scopus 로고    scopus 로고
    • Triptolide attenuates pulmonary arterial hypertension and neointimal formation in rats
    • Faul JL, Nishimura T, Berry GJ, et al. Triptolide attenuates pulmonary arterial hypertension and neointimal formation in rats. Am J Respir Crit Care Med, 2000,162:2252-2258.
    • (2000) Am J Respir Crit Care Med , vol.162 , pp. 2252-2258
    • Faul, J.L.1    Nishimura, T.2    Berry, G.J.3
  • 21
    • 0035131411 scopus 로고    scopus 로고
    • 40-O-(2-hydroxyethyl)-rapamycin attenuates pulmonary arterial hypertension and neointimal formation in rats
    • Nishimura T, Faul JL, Berry GJ, et al. 40-O-(2-hydroxyethyl)-rapamycin attenuates pulmonary arterial hypertension and neointimal formation in rats. Am J Respir Crit Care Med, 2001,163:498-502.
    • (2001) Am J Respir Crit Care Med , vol.163 , pp. 498-502
    • Nishimura, T.1    Faul, J.L.2    Berry, G.J.3
  • 22
    • 1942505215 scopus 로고    scopus 로고
    • Chemokine and atherosclerosis
    • Sheikine Y, Hansson GK. Chemokine and atherosclerosis. Ann Med, 2004,36:98-118.
    • (2004) Ann Med , vol.36 , pp. 98-118
    • Sheikine, Y.1    Hansson, G.K.2
  • 23
    • 0034928612 scopus 로고    scopus 로고
    • Tumor nercosis factor-alpha and cardiovascular diseases
    • Bellisarii FL, Gallina S, De Caterina R. Tumor nercosis factor-alpha and cardiovascular diseases. Ital Heart J, 2001,2:408-417.
    • (2001) Ital Heart J , vol.2 , pp. 408-417
    • Bellisarii, F.L.1    Gallina, S.2    De Caterina, R.3
  • 24
    • 0141730236 scopus 로고    scopus 로고
    • Simvastatin rescues rats from fatal pulmonary hypertension by inducing apoptosis of neointimal smooth muscle cells
    • Nishimura T, Vsazar LT, Faul JL, et al. Simvastatin rescues rats from fatal pulmonary hypertension by inducing apoptosis of neointimal smooth muscle cells. Circulation, 2003,108:1640-1645.
    • (2003) Circulation , vol.108 , pp. 1640-1645
    • Nishimura, T.1    Vsazar, L.T.2    Faul, J.L.3
  • 25
    • 0037111215 scopus 로고    scopus 로고
    • Simvastatin attenuates smooth muscle neointimal proliferation and pulmonary hypertension in rats
    • Nishimura T, Faul JL, Berry GJ, et al. Simvastatin attenuates smooth muscle neointimal proliferation and pulmonary hypertension in rats. Am J Respir Crit Care Med, 2002,166:1403-1408.
    • (2002) Am J Respir Crit Care Med , vol.166 , pp. 1403-1408
    • Nishimura, T.1    Faul, J.L.2    Berry, G.J.3
  • 26
    • 0347367306 scopus 로고    scopus 로고
    • Decreased endothelial nitric-oxide synthase (eNOS) activity resulting from abnormal interaction between eNOS and its regulatory proteins in hypoxia-induced pulmonary hypertension
    • Murata T, Sato K, Hori M, et al. Decreased endothelial nitric-oxide synthase (eNOS) activity resulting from abnormal interaction between eNOS and its regulatory proteins in hypoxia-induced pulmonary hypertension. J Biol Chem, 2002,277:44085-44092.
    • (2002) J Biol Chem , vol.277 , pp. 44085-44092
    • Murata, T.1    Sato, K.2    Hori, M.3
  • 27
    • 27644561714 scopus 로고    scopus 로고
    • Statin protects endothelial nitric oxide synthase activity in hypoxia-induced pulmonary hypertension
    • Murata T, Kinoshita K, Hori M, et al. Statin protects endothelial nitric oxide synthase activity in hypoxia-induced pulmonary hypertension. Arterioscler Thromb Vasc Biol, 2005,25:2335-2342.
    • (2005) Arterioscler Thromb Vasc Biol , vol.25 , pp. 2335-2342
    • Murata, T.1    Kinoshita, K.2    Hori, M.3
  • 28
    • 0041859249 scopus 로고    scopus 로고
    • Attenuation of chronic hypoxic pulmonary hypertension by simvastatin
    • Girgis RE, Li D, Zhan X, et al. Attenuation of chronic hypoxic pulmonary hypertension by simvastatin. Am J Physiol Heart Circ Physiol, 2003,285:H938-945.
    • (2003) Am J Physiol Heart Circ Physiol , vol.285
    • Girgis, R.E.1    Li, D.2    Zhan, X.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.