A novel phenylimidazo[1,2-a]pyridine core skeleton and pharmacophore model as hypoxia-inducible factor inhibitors

Bulletin of the Korean Chemical Society

Volumn 31, Issue 7, 2010, Pages 2039-2042

  Gong, Young Dae ^a   Kang, Nam Sook ^a,b  

^a Dongguk University   (South Korea)

^b Korea Research Institute of Chemical Technology   (South Korea)

Author keywords

Drug like core skeleton; Hypoxia inducible factor (HIF); Pharmacophore; Phenylimidazo 1,2 a pyridine

Indexed keywords

EID: 77954930604     PISSN: 02532964     EISSN: 12295949     Source Type: Journal    
DOI: 10.5012/bkcs.2010.31.7.2039     Document Type: Article

References (22)

1. Semenza, G. L. Drug Discov. Today 2007, 12, 853.
2. Jiang, B. H.; Rue, E.; Wang, R. Roe.; Semenza, G. L. J. Biol. Chem. 1996, 271, 17771.
3. Wang, G. L.; Semenza, G. L. J. Biol. Chem. 1995, 270, 1230.
4. Kaelin, W. G. Annu. Rev. Biochem. 2005, 74, 115.
5. Lee, K.; Lee, J. H.; Boovanahalil, S. K.; Jin, Y.; Lee, M.; Jin, X.; Kim, J. H.; Hong, Y.-S.; Lee, J. J. J. Med. Chem. 2007, 50, 1675.
6. Giaccia, A.; Siim, B. G.; Johnson, R. S. Nat. Rev. Drug Discovery 2003, 2, 1.
7. Choi, H. J.; Song, B.-J.; Gong, Y.-D.; Gwak, W. J.; Soh, Y. British J. Pharm. 2008, 154, 114.
8. Hwang, J. Y.; Choi, H.-S.; Seo, J.-S.; La, H.-J.; Yoo, S.-e.; Gong, Y. D. J. Comb. Chem. 2006, 8, 897.
9. Hwang, J. Y.; Gong, Y. D. J. Comb. Chem. 2006, 8, 297.
10. Hwang, J. Y.; Choi, H. S.; Lee, D. H.; Yoo, S.-e.; Gong, Y. D. J. Comb. Chem. 2005, 7, 136.
11. Hwang, J. Y.; Choi, H. S.; Lee, D. H.; Gong, Y. D. J. Comb. Chem. 2005, 7, 816.
12. Lee, I. Y.; Kim, S. Y.; Lee, J. Y.; Yu, C.-M.; Lee, D. H.; Gong, Y. D. Tetrahedron Lett. 2004, 45, 9319.
13. Concord; Tripos Inc., 1699 South Hanley Road, St. Louis, MO 63144.
14. Hert, J.; Willett, P.; Wilton, D. J.; Acklin, P.; Azzaoui, K.; Jacoby, E.; Schuffenhauer, A. J. Chem. Inf. Comp. Sci. 2004, 44, 1177.
15. Chalet, T.; Rita, G. N.; Anthony, J. R.; Beata, P.; Fatima, K.; Zhaobin, Z.; Huanchun, Z.; Quincy, T.; Ainsley, C. N.; Paraskevi, G.; Wei, Z.; Jeffrey, J. O.; Manuela, M. P.; Nicolaou, K. C.; Erwin, G. V. M. Cancer Res. 2005, 65, 605.
16. Amar, G. C.; Gundluru, M. K.; Kumar, P. B. C.; Yang, L.; Yu- Dong, Z.; Dale, G. N.; Mitchell, A. A. J. Med. Chem. 2007, 50, 6299.
17. Park, J. W.; Chun, Y. S.; Kenneth, B.; Sho, H. S. WO 2005030121. 2005.
18. Warshakoon, N. C.; Wu, S.; Boyer, A.; Kawamoto, R.; Renock, S.; Xu, K.; Pokross, M.; Evdokimov, A. G.; Zhou, S.; Winter, C.; Walter, R.; Mekel, M. Bioorg. Med. Chem. Lett. 2006, 16, 5687.
19. Ventosa-Andres, P.; Gonzalez-Vera, J. A.; Valdivielso, A. M.; Teresa Garcia-Lopez, M.; Herranz, R. Bioorg. Med. Chem. 2008, 16, 9313.
20. Sprague, P. W. Automated Chemical Hypothesis Generation and Database Searching with Catalyst. In Perspectives in Drug Discovery and Design; Müller, K., Ed.; ESCOM Science Publishers B. V.: Leiden, The Netherlands, 1995; Vol. 3, pp 1-20.
21. Leopoldo, M.; Lacivita, E.; Passafiume, E.; Contino, M.; Colabufo, N.; Berardi, F.; Perrone, Liu, R. J. Med. Chem. 2007, 50, 5043.
22. Han, Z. B.; Ren, H.; Zhao, H.; Chi, Y.; Chen, K.; Zhou, B.; Liu, Y. J.; Zhang, L.; Xu, B.; Liu, B.; Yang, R.; Han, Z. C. Carcinogenesis 2008, 29, 1853.