메뉴 건너뛰기




Volumn 31, Issue 3, 2010, Pages 281-287

LH and non-SHBG testosterone and estradiol levels during testosterone replacement of hypogonadal men: Further evidence that steroid negative feedback increases as men grow older

Author keywords

Androgen; Andropause; Luteinizing hormone; Male hypogonadism; Sex hormone binding globulin

Indexed keywords

ESTRADIOL; LUTEINIZING HORMONE; SEX HORMONE BINDING GLOBULIN; STEROID; TESTOSTERONE;

EID: 77954929048     PISSN: 01963635     EISSN: 19394640     Source Type: Journal    
DOI: 10.2164/jandrol.109.009035     Document Type: Article
Times cited : (10)

References (45)
  • 1
    • 45149127774 scopus 로고    scopus 로고
    • Correlations between serum testosterone, estradiol, and sex hormone-binding globulin and bone mineral density in a diverse sample of men
    • Araujo AB, Travison TG, Leder BZ, McKinlay JB. Correlations between serum testosterone, estradiol, and sex hormone-binding globulin and bone mineral density in a diverse sample of men. J Clin Endocrinol Metab. 2008;93:2135-2141.
    • (2008) J Clin Endocrinol Metab , vol.93 , pp. 2135-2141
    • Araujo, A.B.1    Travison, T.G.2    Leder, B.Z.3    McKinlay, J.B.4
  • 6
    • 33751529229 scopus 로고    scopus 로고
    • Differences in the apparent metabolic clearance rate of testosterone in young and older men with gonadotropin suppression receiving graded doses of testosterone
    • Coviello AD, Lakshman K, Mazer NA, Bhasin S. Differences in the apparent metabolic clearance rate of testosterone in young and older men with gonadotropin suppression receiving graded doses of testosterone. J Clin Endocrinol Metab. 2006;91:4669-4675.
    • (2006) J Clin Endocrinol Metab , vol.91 , pp. 4669-4675
    • Coviello, A.D.1    Lakshman, K.2    Mazer, N.A.3    Bhasin, S.4
  • 8
    • 0023143155 scopus 로고
    • Influence of age on pulsatile luteinizing hormone release and responsiveness of the gonadotrophs to sex hormone feedback in men
    • Deslypere JP, Kaufman JM, Vermeulen T, Vogelaers D, Vandalem JL, Vermeulen A. Influence of age on pulsatile luteinizing hormone release and responsiveness of the gonadotrophs to sex hormone feedback in men. J Clin Endocrinol Metab. 1987;64:68-73.
    • (1987) J Clin Endocrinol Metab , vol.64 , pp. 68-73
    • Deslypere, J.P.1    Kaufman, J.M.2    Vermeulen, T.3    Vogelaers, D.4    Vandalem, J.L.5    Vermeulen, A.6
  • 9
    • 0019759637 scopus 로고
    • Transport of steroid hormones: Binding of 21 endogenous steroids to both testosterone-binding globulin and corticosteroid-binding globulin in human plasma
    • Dunn JF, Nisula BC, Rodbard D. Transport of steroid hormones: binding of 21 endogenous steroids to both testosterone-binding globulin and corticosteroid-binding globulin in human plasma. J Clin Endocrinol Metab. 1981;53:58-68.
    • (1981) J Clin Endocrinol Metab , vol.53 , pp. 58-68
    • Dunn, J.F.1    Nisula, B.C.2    Rodbard, D.3
  • 10
    • 0026007087 scopus 로고
    • Sex steroid control of gonadotropin secretion in the human male. II. Effects of estradiol administration in normal and gonadotropin-releasing hormone-deficient men
    • Finkelstein JS, O'Dea LS, Whitcomb RW, Crowley WF Jr. Sex steroid control of gonadotropin secretion in the human male. II. Effects of estradiol administration in normal and gonadotropin-releasing hormone-deficient men. J Clin Endocrinol Metab. 1991;73:621-628.
    • (1991) J Clin Endocrinol Metab , vol.73 , pp. 621-628
    • Finkelstein, J.S.1    O'Dea, L.S.2    Whitcomb, R.W.3    Crowley Jr., W.F.4
  • 12
    • 0025884064 scopus 로고
    • Age, disease, and changing sex hormone levels in middle-aged men: Results of the Massachusetts Male Aging Study
    • Gray A, Feldman HA, McKinlay JB, Longcope C. Age, disease, and changing sex hormone levels in middle-aged men: results of the Massachusetts Male Aging Study. J Clin Endocrinol Metab. 1991;73:1016-1025.
    • (1991) J Clin Endocrinol Metab , vol.73 , pp. 1016-1025
    • Gray, A.1    Feldman, H.A.2    McKinlay, J.B.3    Longcope, C.4
  • 13
    • 0035097033 scopus 로고    scopus 로고
    • Longitudinal effects of aging on serum total and free testosterone levels in healthy men. Baltimore Longitudinal Study of Aging
    • Harman SM, Metter EJ, Tobin JD, Pearson J, Blackman MR. Longitudinal effects of aging on serum total and free testosterone levels in healthy men. Baltimore Longitudinal Study of Aging. J Clin Endocrinol Metab. 2001;86:724-731.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 724-731
    • Harman, S.M.1    Metter, E.J.2    Tobin, J.D.3    Pearson, J.4    Blackman, M.R.5
  • 14
    • 0020458001 scopus 로고
    • Reproductive hormones in aging men. II. Basal pituitary gonadotropins and gonadotropin responses to luteinizing hormone-releasing hormone
    • Harman SM, Tsitouras PD, Costa PT, Blackman MR. Reproductive hormones in aging men. II. Basal pituitary gonadotropins and gonadotropin responses to luteinizing hormone-releasing hormone. J Clin Endocrinol Metab. 1982;54:547-551.
    • (1982) J Clin Endocrinol Metab , vol.54 , pp. 547-551
    • Harman, S.M.1    Tsitouras, P.D.2    Costa, P.T.3    Blackman, M.R.4
  • 17
    • 0033305253 scopus 로고    scopus 로고
    • Regulation of lutenizing hormone secretion and subunit messenger ribonucleic acid expression by gonadal steroids in perifused pituitary cells from male monkeys and rats
    • Kawakami S, Winters SJ. Regulation of lutenizing hormone secretion and subunit messenger ribonucleic acid expression by gonadal steroids in perifused pituitary cells from male monkeys and rats. Endocrinology. 1999;140:3587-3593.
    • (1999) Endocrinology , vol.140 , pp. 3587-3593
    • Kawakami, S.1    Winters, S.J.2
  • 19
    • 0025601683 scopus 로고
    • Effect of testosterone on regulation of the level of sex steroid-binding protein mRNA in monkey (Macaca fascicularis) liver
    • Kottler ML, Dang CD, Salmon R, Counis R, Degrelle H. Effect of testosterone on regulation of the level of sex steroid-binding protein mRNA in monkey (Macaca fascicularis) liver. J Mol Endocrinol. 1990;5:253-257.
    • (1990) J Mol Endocrinol , vol.5 , pp. 253-257
    • Kottler, M.L.1    Dang, C.D.2    Salmon, R.3    Counis, R.4    Degrelle, H.5
  • 21
    • 33749561819 scopus 로고    scopus 로고
    • Age or factors associated with aging attenuate testosterone's concentration-dependent enhancement of the regularity of luteinizing hormone secretion in healthy men
    • Liu PY, Takahashi PY, Roebuck PD, Veldhuis JD. Age or factors associated with aging attenuate testosterone's concentration-dependent enhancement of the regularity of luteinizing hormone secretion in healthy men. J Clin Endocrinol Metab. 2006;91:4077-4084.
    • (2006) J Clin Endocrinol Metab , vol.91 , pp. 4077-4084
    • Liu, P.Y.1    Takahashi, P.Y.2    Roebuck, P.D.3    Veldhuis, J.D.4
  • 22
    • 0018600838 scopus 로고
    • Evidence that testosterone can suppress pituitary gonadotropin secretion independently of peripheral aromatization
    • Marynick SP, Loriaux DL, Sherins RJ, Pita JC Jr, Lipsett MB. Evidence that testosterone can suppress pituitary gonadotropin secretion independently of peripheral aromatization. J Clin Endocrinol Metab. 1979;49:396-398.
    • (1979) J Clin Endocrinol Metab , vol.49 , pp. 396-398
    • Marynick, S.P.1    Loriaux, D.L.2    Sherins, R.J.3    Pita Jr., J.C.4    Lipsett, M.B.5
  • 23
    • 0024430817 scopus 로고
    • The free hormone hypothesis: A physiologically based mathematical model
    • Mendel CM. The free hormone hypothesis: a physiologically based mathematical model. Endocr Rev. 1989;10:232-274.
    • (1989) Endocr Rev , vol.10 , pp. 232-274
    • Mendel, C.M.1
  • 24
    • 0028948069 scopus 로고
    • Age related changes in the pituitary-testicular axis in normal men; lower serum testosterone results from decreased bioactive LH drive
    • Mitchell R, Hollis S, Rothwell C, Robertson WR. Age related changes in the pituitary-testicular axis in normal men; lower serum testosterone results from decreased bioactive LH drive. Clin Endocrinol (Oxf). 1995;42:501-507.
    • (1995) Clin Endocrinol (Oxf) , vol.42 , pp. 501-507
    • Mitchell, R.1    Hollis, S.2    Rothwell, C.3    Robertson, W.R.4
  • 25
    • 0018909420 scopus 로고
    • Alteration in the metabolism of dihydrotestosterone in elderly men with prostate hyperplasia
    • Morimoto I, Edmiston A, Horton R. Alteration in the metabolism of dihydrotestosterone in elderly men with prostate hyperplasia. J Clin Invest. 1980;66:612-615.
    • (1980) J Clin Invest , vol.66 , pp. 612-615
    • Morimoto, I.1    Edmiston, A.2    Horton, R.3
  • 26
    • 0028792229 scopus 로고
    • Aromatase deficiency in male and female siblings caused by a novel mutation and the physiological role of estrogens
    • Morishima A, Grumbach MM, Simpson ER, Fisher C, Qin K. Aromatase deficiency in male and female siblings caused by a novel mutation and the physiological role of estrogens. J Clin Endocrinol Metab. 1995;80:3689-3698.
    • (1995) J Clin Endocrinol Metab , vol.80 , pp. 3689-3698
    • Morishima, A.1    Grumbach, M.M.2    Simpson, E.R.3    Fisher, C.4    Qin, K.5
  • 28
    • 0035187808 scopus 로고    scopus 로고
    • Pulsatile iv infusion of recombinant human LH in leuprolide-suppressed men unmasks impoverished Leydig-cell secretory responsiveness to midphysiological LH drive in the aging male
    • Mulligan T, Iranmanesh A, Veldhuis JD. Pulsatile iv infusion of recombinant human LH in leuprolide-suppressed men unmasks impoverished Leydig-cell secretory responsiveness to midphysiological LH drive in the aging male. J Clin Endocrinol Metab. 2001;86:5547-5553.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 5547-5553
    • Mulligan, T.1    Iranmanesh, A.2    Veldhuis, J.D.3
  • 29
    • 0019350631 scopus 로고
    • Age-related changes in the feedback regulation of gonadotrophin secretion by sex steroids in men
    • Muta K, Kato K, Akamine Y, Ibayashi H. Age-related changes in the feedback regulation of gonadotrophin secretion by sex steroids in men. Acta Endocrinol (Copenh). 1981;96:154-162.
    • (1981) Acta Endocrinol (Copenh) , vol.96 , pp. 154-162
    • Muta, K.1    Kato, K.2    Akamine, Y.3    Ibayashi, H.4
  • 30
    • 0021123879 scopus 로고
    • Leydig cell numbers, daily sperm production, and serum gonadotropin levels in aging men
    • Neaves WB, Johnson L, Porter JC, Parker CR Jr, Petty CS. Leydig cell numbers, daily sperm production, and serum gonadotropin levels in aging men. J Clin Endocrinol Metab. 1984;59:756-763. (Pubitemid 14012503)
    • (1984) Journal of Clinical Endocrinology and Metabolism , vol.59 , Issue.4 , pp. 756-763
    • Neaves, W.B.1    Johnson, L.2    Porter, J.C.3
  • 31
    • 40849087859 scopus 로고    scopus 로고
    • Inhibition of luteinizing hormone secretion by testosterone in men requires aromatization for its pituitary but not its hypothalamic effects: Evidence from the tandem study of normal and gonadotropin-releasing hormone-deficient men
    • Pitteloud N, Dwyer AA, DeCruz S, Lee H, Boepple PA, Crowley WF Jr, Hayes FJ. Inhibition of luteinizing hormone secretion by testosterone in men requires aromatization for its pituitary but not its hypothalamic effects: evidence from the tandem study of normal and gonadotropin-releasing hormone-deficient men. J Clin Endocrinol Metab. 2008;93:784-791.
    • (2008) J Clin Endocrinol Metab , vol.93 , pp. 784-791
    • Pitteloud, N.1    Dwyer, A.A.2    Decruz, S.3    Lee, H.4    Boepple, P.A.5    Crowley Jr., W.F.6    Hayes, F.J.7
  • 32
    • 33748756702 scopus 로고    scopus 로고
    • In men, peripheral estradiol levels directly reflect the action of estrogens at the hypothalamo-pituitary level to inhibit gonadotropin secretion
    • Raven G, de Jong FH, Kaufman JM, de Ronde W. In men, peripheral estradiol levels directly reflect the action of estrogens at the hypothalamo-pituitary level to inhibit gonadotropin secretion. J Clin Endocrinol Metab. 2006;91:3324-3328.
    • (2006) J Clin Endocrinol Metab , vol.91 , pp. 3324-3328
    • Raven, G.1    De Jong, F.H.2    Kaufman, J.M.3    De Ronde, W.4
  • 33
    • 0015619041 scopus 로고
    • Studies of the role of sex steroids in the feedback control of FSH concentrations in men
    • Sherins RJ, Loriaux DL. Studies of the role of sex steroids in the feedback control of FSH concentrations in men. J Clin Endocrinol Metab. 1973;36:886-893.
    • (1973) J Clin Endocrinol Metab , vol.36 , pp. 886-893
    • Sherins, R.J.1    Loriaux, D.L.2
  • 34
    • 33646232953 scopus 로고    scopus 로고
    • Regulation of the neuroendocrine reproductive axis by kisspeptin-GPR54 signaling
    • Smith JT, Clifton DK, Steiner RA. Regulation of the neuroendocrine reproductive axis by kisspeptin-GPR54 signaling. Reproduction. 2006;131:623-630.
    • (2006) Reproduction , vol.131 , pp. 623-630
    • Smith, J.T.1    Clifton, D.K.2    Steiner, R.A.3
  • 35
    • 0020417830 scopus 로고
    • Calculation of free and bound fractions of testosterone and estradiol-17 beta to human plasma proteins at body temperature
    • Sodergard R, Backstrom T, Shanbhag V, Carstensen H. Calculation of free and bound fractions of testosterone and estradiol-17 beta to human plasma proteins at body temperature. J Steroid Biochem. 1982;16:801-810.
    • (1982) J Steroid Biochem , vol.16 , pp. 801-810
    • Sodergard, R.1    Backstrom, T.2    Shanbhag, V.3    Carstensen, H.4
  • 36
    • 0023550187 scopus 로고
    • The effects of aging in normal men on bioavailable testosterone and luteinizing hormone secretion: Response to clomiphene citrate
    • Tenover JS, Matsumoto AM, Plymate SR, Bremner WJ. The effects of aging in normal men on bioavailable testosterone and luteinizing hormone secretion: response to clomiphene citrate. J Clin Endocrinol Metab. 1987;65:1118-1126.
    • (1987) J Clin Endocrinol Metab , vol.65 , pp. 1118-1126
    • Tenover, J.S.1    Matsumoto, A.M.2    Plymate, S.R.3    Bremner, W.J.4
  • 37
    • 0033678650 scopus 로고    scopus 로고
    • Measures of bioavailable serum testosterone and estradiol and their relationships with muscle strength, bone density, and body composition in elderly men
    • van den Beld AW, de Jong FH, Grobbee DE, Pols HA, Lamberts SW. Measures of bioavailable serum testosterone and estradiol and their relationships with muscle strength, bone density, and body composition in elderly men. J Clin Endocrinol Metab. 2000;85:3276-3282.
    • (2000) J Clin Endocrinol Metab , vol.85 , pp. 3276-3282
    • Van Den Beld, A.W.1    De Jong, F.H.2    Grobbee, D.E.3    Pols, H.A.4    Lamberts, S.W.5
  • 38
    • 8744234066 scopus 로고    scopus 로고
    • Erosion of endogenous testosterone-driven negative feedback on pulsatile luteinizing hormone secretion in healthy aging men
    • Veldhuis JD, Iranmanesh A, Keenan DM. Erosion of endogenous testosterone-driven negative feedback on pulsatile luteinizing hormone secretion in healthy aging men. J Clin Endocrinol Metab. 2004;89:5753-5761.
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 5753-5761
    • Veldhuis, J.D.1    Iranmanesh, A.2    Keenan, D.M.3
  • 39
    • 0026762786 scopus 로고
    • Attenuation of luteinizing hormone secretory burst amplitude as a proximate basis for the hypoandrogenism of healthy aging in men
    • Veldhuis JD, Urban RJ, Lizarralde G, Johnson ML, Iranmanesh A. Attenuation of luteinizing hormone secretory burst amplitude as a proximate basis for the hypoandrogenism of healthy aging in men. J Clin Endocrinol Metab. 1992;75:707-713.
    • (1992) J Clin Endocrinol Metab , vol.75 , pp. 707-713
    • Veldhuis, J.D.1    Urban, R.J.2    Lizarralde, G.3    Johnson, M.L.4    Iranmanesh, A.5
  • 40
    • 0029968711 scopus 로고    scopus 로고
    • Influence of some biological indexes on sex hormone-binding globulin and androgen levels in aging or obese males
    • Vermeulen A, Kaufman JM, Giagulli VA. Influence of some biological indexes on sex hormone-binding globulin and androgen levels in aging or obese males. J Clin Endocrinol Metab. 1996;81:1821-1826.
    • (1996) J Clin Endocrinol Metab , vol.81 , pp. 1821-1826
    • Vermeulen, A.1    Kaufman, J.M.2    Giagulli, V.A.3
  • 41
    • 0019165409 scopus 로고
    • Elevated testosterone-binding globulin in Klinefelter's syndrome
    • Wieland RG, Zorn EM, Johnson MW. Elevated testosterone-binding globulin in Klinefelter's syndrome. J Clin Endocrinol Metab. 1980;51:1199-1200.
    • (1980) J Clin Endocrinol Metab , vol.51 , pp. 1199-1200
    • Wieland, R.G.1    Zorn, E.M.2    Johnson, M.W.3
  • 42
    • 0030773411 scopus 로고    scopus 로고
    • Serum LH concentrations in hypogonadal men during transdermal testosterone replacement through scrotal skin: Further evidence that ageing enhances testosterone negative feedback
    • The Testoderm Study Group
    • Winters SJ, Atkinson L. Serum LH concentrations in hypogonadal men during transdermal testosterone replacement through scrotal skin: further evidence that ageing enhances testosterone negative feedback. The Testoderm Study Group. Clin Endocrinol (Oxf). 1997;47:317-322.
    • (1997) Clin Endocrinol (Oxf) , vol.47 , pp. 317-322
    • Winters, S.J.1    Atkinson, L.2
  • 43
    • 0021713004 scopus 로고
    • The gonadotropin-suppressive activity of androgen is increased in elderly men
    • Winters SJ, Sherins RJ, Troen P. The gonadotropin-suppressive activity of androgen is increased in elderly men. Metabolism. 1984;33:1052-1059.
    • (1984) Metabolism , vol.33 , pp. 1052-1059
    • Winters, S.J.1    Sherins, R.J.2    Troen, P.3
  • 44
    • 0020385669 scopus 로고
    • Episodic luteinizing hormone (LH) secretion and the response of LH and follicle-stimulating hormone to LH-releasing hormone in aged men: Evidence for coexistent primary testicular insufficiency and an impairment in gonadotropin secretion
    • Winters SJ, Troen P. Episodic luteinizing hormone (LH) secretion and the response of LH and follicle-stimulating hormone to LH-releasing hormone in aged men: evidence for coexistent primary testicular insufficiency and an impairment in gonadotropin secretion. J Clin Endocrinol Metab. 1982;55:560-565.
    • (1982) J Clin Endocrinol Metab , vol.55 , pp. 560-565
    • Winters, S.J.1    Troen, P.2
  • 45
    • 0022385468 scopus 로고
    • Evidence for a role of endogenous estrogen in the hypothalamic control of gonadotropin secretion in men
    • Winters SJ, Troen P. Evidence for a role of endogenous estrogen in the hypothalamic control of gonadotropin secretion in men. J Clin Endocrinol Metab. 1985;61:842-845.
    • (1985) J Clin Endocrinol Metab , vol.61 , pp. 842-845
    • Winters, S.J.1    Troen, P.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.