A novel mechanism, uniquely dependent on mitochondrial calcium accumulation, whereby peroxynitrite promotes formation of superoxide/hydrogen peroxide and the ensuing strand scission of genomic DNA

Antioxidants and Redox Signaling

Volumn 13, Issue 6, 2010, Pages 745-756

  Guidarelli, Andrea ^a   Fiorani, Mara ^a   Azzolini, Catia ^a   Cantoni, Orazio ^a  

^a UNIVERSITY OF URBINO   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CAFFEINE; CALCIUM; GENOMIC DNA; HYDROGEN PEROXIDE; PEROXYNITRITE; RYANODINE RECEPTOR; SUPEROXIDE; DNA; PEROXYNITROUS ACID;

ARTICLE; CELL PERMEABILIZATION; CONTROLLED STUDY; DNA CLEAVAGE; DNA STRAND BREAKAGE; HUMAN; HUMAN CELL; INFLAMMATION; MITOCHONDRION; MONOCYTE; PRIORITY JOURNAL; RESPIRATORY CHAIN; GENOME; METABOLISM; TUMOR CELL LINE;

CALCIUM; CELL LINE, TUMOR; DNA; GENOME; HUMANS; HYDROGEN PEROXIDE; MITOCHONDRIA; PEROXYNITROUS ACID; SUPEROXIDES;

EID: 77954921253     PISSN: 15230864     EISSN: None     Source Type: Journal    
DOI: 10.1089/ars.2009.2845     Document Type: Article

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