Characterization of a monoclonal antibody cell culture production process using a quality by design approach

Molecular Biotechnology

Volumn 45, Issue 3, 2010, Pages 203-206

  Horvath, Brian ^a   Mun, Melissa ^a   Laird, Michael W ^a  

^a GENENTECH INC   (United States)

Author keywords

Chinese hamster ovary; Ion exchange chromatography; Monoclonal antibody; Process characterization; Process validation; Quality by Design

Indexed keywords

CHINESE HAMSTER OVARY; ION-EXCHANGE CHROMATOGRAPHY; PROCESS CHARACTERIZATION; PROCESS VALIDATION; QUALITY BY DESIGNS;

BENCHMARKING; CELL CULTURE; DESIGN OF EXPERIMENTS; FLEXIBLE MANUFACTURING SYSTEMS; ION EXCHANGE; ION EXCHANGERS; IONS; MONOCLONAL ANTIBODIES; PRODUCTION ENGINEERING; SURFACE PLASMON RESONANCE;

CHROMATOGRAPHY;

MONOCLONAL ANTIBODY;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL HETEROGENEITY; CONTROLLED STUDY; INOCULATION; ION EXCHANGE CHROMATOGRAPHY; NONHUMAN; PH MEASUREMENT; TEMPERATURE SENSITIVITY;

ACIDS; ANALYSIS OF VARIANCE; ANIMALS; ANTIBODIES, MONOCLONAL; BIOREACTORS; CELL CULTURE TECHNIQUES; CHO CELLS; CHROMATOGRAPHY, ION EXCHANGE; CRICETINAE; CRICETULUS; CULTURE MEDIA; HYDROGEN-ION CONCENTRATION; REPRODUCIBILITY OF RESULTS; RESEARCH DESIGN; TEMPERATURE;

CRICETULUS GRISEUS;

EID: 77954914066     PISSN: 10736085     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12033-010-9267-4     Document Type: Article

References (7)

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