Mechanical stimulation mediates gene expression in MC3T3 osteoblastic cells differently in 2D and 3D environments

Journal of Biomechanical Engineering

Volumn 132, Issue 4, 2010, Pages

  Barron, Matthew J ^a   Tsai, Chung Jui ^b   Donahue, Seth W ^a  

^a Michigan Technological University   (United States)

^b University of Georgia ^*  (United States)

Author keywords

Bone tissue engineering; Gene expression; Mechanotransduction; Shear stress

Indexed keywords

3-D ENVIRONMENTS; 3D CULTURE; 3D SCAFFOLDS; BONE TISSUE ENGINEERING; CALCIUM PHOSPHATE SCAFFOLDS; CELLULAR ACTIVITIES; FLUID FLOW; GLASS SLIDES; MC3T3-E1; MECHANICAL LOADING; MECHANICAL STIMULATION; MECHANOTRANSDUCTION; OSTEOBLAST CULTURES; OSTEOBLAST-LIKE CELLS; OSTEOBLASTIC CELLS; PERFUSION CULTURES; STATIC CONDITIONS; STATIC CULTURE; THREE-DIMENSIONAL (3D);

BONE; CALCIUM; CALCIUM PHOSPHATE; CELL CULTURE; FLOW OF FLUIDS; OSTEOBLASTS; SCAFFOLDS; SHEAR STRESS; STRENGTH OF MATERIALS; THREE DIMENSIONAL; TISSUE ENGINEERING;

GENE EXPRESSION;

CALCIUM PHOSPHATE; COLLAGEN TYPE 1; FIBROBLAST GROWTH FACTOR 2; OSTEOPONTIN; PROTEOME;

ANIMAL CELL; ARTICLE; CELL STIMULATION; DOWN REGULATION; GENE EXPRESSION; MECHANICAL STIMULATION; MOUSE; NONHUMAN; OSTEOBLAST; UPREGULATION; ANIMAL; CELL STRAIN 3T3; GENE EXPRESSION REGULATION; MECHANICAL STRESS; MECHANOTRANSDUCTION; METABOLISM; METHODOLOGY; PHYSIOLOGY; STIMULATION; TISSUE ENGINEERING;

3T3 CELLS; ANIMALS; GENE EXPRESSION REGULATION; MECHANOTRANSDUCTION, CELLULAR; MICE; OSTEOBLASTS; PHYSICAL STIMULATION; PROTEOME; STRESS, MECHANICAL; TISSUE ENGINEERING;

EID: 77954902368     PISSN: 01480731     EISSN: 15288951     Source Type: Journal    
DOI: 10.1115/1.4001162     Document Type: Article

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