A disease-causing mutation in the active site of serine palmitoyltransferase causes catalytic promiscuity

Journal of Biological Chemistry

Volumn 285, Issue 30, 2010, Pages 22846-22852

  Gable, Kenneth ^a   Gupta, Sita D ^a   Han, Gongshe ^a   Niranjanakumari, Somashekarappa ^a   Harmon, Jeffrey M ^a   Dunn, Teresa M ^a  

^a UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; ACYL-COA; AUTOSOMAL DOMINANTS; ELEVATED LEVEL; ENDOPLASMIC RETICULUM STRESS; FUSION PROTEINS; GAIN-OF FUNCTION; GROWTH MEDIA; HETEROTRIMERS; IN-CELL; IN-VIVO; LONG CHAINS; MAMMALIAN CELLS; MUTANT ENZYMES; PERIPHERAL SENSORY; SERINE PALMITOYLTRANSFERASES; TRANSGENIC MICE; WILD TYPES; WILD-TYPE ENZYMES; YEAST CELL;

AMINO ACIDS; CATALYSTS; CONDENSATION; MAMMALS; PHOSPHATASES; YEAST;

ENZYMES;

1 DEOXYSPHINGANINE; ALANINE; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; SERINE; SERINE PALMITOYLTRANSFERASE; SERINE PALMITOYLTRANSFERASE LONG CHAIN BASE SUBUNIT; SERINE PALMITOYLTRANSFERASE LONG CHAIN BASE SUBUNIT 1; SERINE PALMITOYLTRANSFERASE LONG CHAIN BASE SUBUNIT 2B; SPHINGANINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DIMERIZATION; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVE SITE; ENZYME SPECIFICITY; GENE MUTATION; HEREDITARY SENSORY NEUROPATHY TYPE 1; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SENSORY NEUROPATHY; STOICHIOMETRY;

ALANINE; ANIMALS; BIOCATALYSIS; CATALYTIC DOMAIN; CHO CELLS; CRICETINAE; CRICETULUS; EXTRACELLULAR SPACE; HEREDITARY SENSORY AND AUTONOMIC NEUROPATHIES; HUMANS; ISOENZYMES; KINETICS; MICE; MUTATION; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, QUATERNARY; SERINE; SERINE C-PALMITOYLTRANSFERASE; SPHINGOSINE; SUBSTRATE SPECIFICITY;

MAMMALIA; MUS MUSCULUS;

EID: 77954898943     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.122259     Document Type: Article

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