Acute humoral rejection in a zero mismatch deceased donor renal transplant due to an antibody to an HLA-DP α

Transplantation

Volumn 90, Issue 2, 2010, Pages 220-221

  Singh, Pooja ^a   Colombe, Beth W ^a   Francos, George C ^a   Martinez Cantarin, Maria P ^a   Frank, Adam M ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CREATININE; HLA DP ANTIGEN; IMMUNOGLOBULIN; METHYLPREDNISOLONE; PANEL REACTIVE ANTIBODY; RITUXIMAB; STEROID; THYMOCYTE ANTIBODY;

ACUTE HUMORAL REJECTION; ADULT; AFRICAN AMERICAN; ANTIBODY TITER; B LYMPHOCYTE; BLOOD GROUP TYPING; CASE REPORT; CHROMOSOME 6; CREATININE BLOOD LEVEL; CYTOTOXICITY TEST; DELAYED GRAFT FUNCTION; DRUG MEGADOSE; FLOW CYTOMETRY; GRAFT RECIPIENT; GRAFT REJECTION; GRAFT SURVIVAL; HLA MATCHING; HUMAN; IMMUNE RESPONSE; IMMUNOFLUORESCENCE; IMMUNOSUPPRESSIVE TREATMENT; KIDNEY BIOPSY; KIDNEY GRAFT; LETTER; MAJOR HISTOCOMPATIBILITY COMPLEX; MALE; OLIGURIA; ORGAN DONOR; PLASMAPHERESIS; PRIORITY JOURNAL; T LYMPHOCYTE;

ADULT; B-LYMPHOCYTES; GRAFT REJECTION; HISTOCOMPATIBILITY TESTING; HLA-DP ANTIGENS; HUMANS; ISOANTIBODIES; KIDNEY TRANSPLANTATION; MALE; MIDDLE AGED; T-LYMPHOCYTES; TISSUE DONORS;

EID: 77954893258     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/TP.0b013e3181e1177d     Document Type: Letter

References (12)

1. Marsh SGE, ed. IMGT/HLA sequence database. Available at: http://www.ebi.ac.uk/imgt/hla. Accessed January 26 2010.
2. Shaw S, Johnson AH, Shearer GM. Evidence for a new segregant series of B cell antigens that are encoded in the HLA-D region and that stimulate secondary allogenic prolifera-tive and cytotoxic responses. J Exp Med 1980; 152: 565.
3. Mytilineos J, Deufel A, Opelz G. Clinical relevance of HLA-DPB locus matching for cadaver kidney retransplants: A report of the Collaborative Transplant Study. Transplantation 1997; 63: 1351.
4. Qiu J, Cai J, Terasaki PI, et al. Detection of antibodiesto HLA-DPin renal transplant recipients using single antigen beads. Transplantation 2005; 80: 1511.
5. Laux G, Mansmann U, Deufel A, et al. A new epitope-based HLA DPB matching approach for cadaver kidney retransplants. Transplantation 2003; 75: 1527.
6. Flomenberg N, Baxter-Lowe LA, Confer D, et al. Impact of HLA class I and class II high-resolution matching on outcomes of unrelated donor bone marrow transplantation: HLA-C mismatching is associated with a strong adverse effect on transplant outcome. Blood 2004; 104: 1923.
7. Goral S, Prak EL, Kearns J, et al. Preformed donor-directed anti-HLA-DP antibodies may be an impediment to successful kidney transplantation. Nephrol Dial Transplant 2008; 23: 390.
8. Vaidya S, Hilson B, Sheldon S, et al. DP reactive antibody in a zero mismatch renal transplant pair. Hum Immunol 2007; 68: 947.
9. Samaniego M, Mezrich J, Torrealba J, et al. C4d-positive acute antibody-mediated rejection due to anti-HLA-DP antibody: A tale of one patient and a review of the University of Wisconsin experience. Clin Transpl 2006: 503.
10. Thaunat O, Hanf W, Dubois V, et al. Chronic humoral rejection mediated by anti-HLA-DP alloantibodies: Insights into the role of epitope sharing in donor-specific and non-donor specific alloantibodies generation. Transpl Immunol 2009; 20: 209.
11. Cano P, Fernández-Viña M. Two sequence dimorphisms of DPB1 define the immuno-dominant serologic epitopes of HLA-DP. Hum Immunol 2009; 70: 836.
12. Duquesnoy RJ, Awadalla Y, Lomago J, et al. Retransplant candidates have donor-specific antibodies that react with structurally defined HLA-DR, DQ, DP epitopes. Transpl Immunol 2008; 18: 352.