Evidence for the conversion of docetaxel into 7′-epidocetaxel in patients receiving Taxotere®-based conventional chemotherapy

International Journal of Clinical Pharmacology and Therapeutics

Volumn 48, Issue 7, 2010, Pages 483-484

  Czejka, M ^a   Greil, R ^b   Ulsperger, E ^c   Schnait, H ^d   Kienesberger, K ^d   Brumnik, T ^a   Farkouh, A ^a   Schierholz, J ^d  

^a UNIVERSITY OF VIENNA   (Austria)

^b University Hospital/LKH Salzburg   (Austria)

^c Hietzing Hospital   (Austria)

^d Research Initiative Ebewe   (Austria)

Author keywords

7 epidocetaxel; Cancer chemotherapy; Docetaxel; Plasma concentration; Urine concentration

Indexed keywords

7' EPIDOCETAXEL; BICALUTAMIDE; DOCETAXEL; DRUG METABOLITE; EPIRUBICIN; UNCLASSIFIED DRUG;

BLOOD SAMPLING; BREAST CARCINOMA; CLINICAL ARTICLE; CONFERENCE PAPER; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG TRANSFORMATION; DRUG URINE LEVEL; EPIMERIZATION; HUMAN; LUNG CARCINOMA; PROSTATE CANCER; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SOLID PHASE EXTRACTION; SOLID TUMOR;

EID: 77954892595     PISSN: 09461965     EISSN: None     Source Type: Journal    
DOI: 10.5414/CPP48483     Document Type: Conference Paper

References (6)

1. Tian J, Stella VJ. Degradation of paclitaxel and related compounds in aqueous solutions I: epimerization. J Pharm Sci. 2008; 97: 1224-1235.
2. Kumar D, Tomar RS, Deolia SK. Isolation and characterization of degradation impurities in docetaxel drug substance and its formulation. J Pharm Biomed Analysis. 2007; 43: 1228-1235. (Pubitemid 46316818)
3. Royer I, Alvinerie P, Armand JP. Paclitaxel metabolites in human plasma and urine: identification of 6a-hydroxytaxol, 7-epitaxol and taxol hydrolysis products using liquid chromatography/Atmospheric-pressure chemical ionization mass spectrometry. Rapid commun mass spectrometry. 1995; 9: 495-502.
4. Vaclavikova R Soucek P, Svobodova L Anzenbacher P, Simek, Guengerich FP, Gut I. Different in-vitro metabolism of paclitaxel and docetaxel in humans, rats, pigs and minipigs. Drug Metab Dispos. 2004; 32: 666-674. (Pubitemid 38668160)
5. Hochegger K, Lhotta K, Mayer G, Czejka M, Hilbe W. Pharmacokinetic analysis of docetaxel during haemodialysis in a patient with locally advanced non-small cell lung cancer. J Nephrol Dial Transplant. 2007; 22: 289-290. (Pubitemid 46050373)
6. Sparrenboom A, Van Tellingen O, Scherrenburg EJ. Isolation, purification and biological activity of major docetaxel metabolites from human faeces. Drug Met Dispos. 1996; 24: 655-658. (Pubitemid 26000768)