Degradation of paclitaxel and related compounds in aqueous solutions I: Epimerization

Journal of Pharmaceutical Sciences

Volumn 97, Issue 3, 2008, Pages 1224-1235

  Tian, Jiaher ^a,b   Stella, Valentino J ^a  

^a UNIVERSITY OF KANSAS   (United States)

^b WYETH RESEARCH   (United States)

Author keywords

7 epi taxol; Baccatin III; Degradation; Epimerization; Paclitaxel; Stability; Taxol

Indexed keywords

10 DEACETYLBACCATIN III; 10 DEACETYLTAXOL; 7 EPI 10 DEACETYLTAXOL; 7 EPI TAXOL; BACCATIN III; PACLITAXEL; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; WATER;

ALDOL REACTION; AQUEOUS SOLUTION; ARTICLE; DRUG DEGRADATION; DRUG STRUCTURE; EPIMERIZATION; EQUILIBRIUM CONSTANT; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PROTON TRANSPORT; THERMODYNAMICS; CHEMISTRY; PH; SOLUTION AND SOLUBILITY;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HYDROGEN-ION CONCENTRATION; MASS SPECTROMETRY; PACLITAXEL; SOLUTIONS; WATER;

EID: 42949156285     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.21112     Document Type: Article

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