Photodynamic therapy with topical methyl- and hexylaminolevulinate for prophylaxis and treatment of UV-induced SCC in hairless mice

Experimental Dermatology

Volumn 19, Issue 8, 2010, Pages

  Togsverd Bo, Katrine ^a   Lerche, Catharina M ^a   Poulsen, Thomas ^b   Wulf, Hans Christian ^a   Hædersdal, Merete ^a  

^a BISPEBJERG HOSPITAL   (Denmark)

^b Soenderborg Hospital   (Denmark)

Author keywords

Hairless mice; Hexyl aminolevulinate; Methyl aminolevulinate; Photodynamic therapy; SCC

Indexed keywords

AMINOLEVULINIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARCINOGENESIS; DRUG EFFICACY; HAIRLESS MOUSE; MOUSE; NONHUMAN; PHOTODYNAMIC THERAPY; PROPHYLAXIS; SKIN PIGMENTATION; SQUAMOUS CELL CARCINOMA; ULTRAVIOLET IRRADIATION;

ADMINISTRATION, TOPICAL; AMINOLEVULINIC ACID; ANIMALS; CARCINOMA, SQUAMOUS CELL; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; MICE; MICE, HAIRLESS; NEOPLASMS, RADIATION-INDUCED; PHOTOCHEMOTHERAPY; PHOTOSENSITIZING AGENTS; SKIN NEOPLASMS; TREATMENT OUTCOME; ULTRAVIOLET RAYS;

EID: 77954856211     PISSN: 09066705     EISSN: 16000625     Source Type: Journal    
DOI: 10.1111/j.1600-0625.2009.01035.x     Document Type: Article

References (31)

1. Cancerregisteret 2004 2008, Copenhagen
2. Brewster D H, Bhatti L A, Inglis J H, Nairn E R, Doherty V R. Recent trends in incidence of nonmelanoma skin cancer in the East of Scotland 1992-2003. Br J Dermatol 2007, 156:1295-3000.
3. Faurschou A, Wulf H C. Ecologic analysis of the relation between sunbeds and skin cancer. Photodermatol Photoimmunol Photomed 2007, 23:20-25.
4. Basset-Seguin N, Ibbotson S, Emtestam L. Photodynamic therapy using Metvix is as efficacious as cryotherapy in BCC, with better cosmetic results. J Eur Acad Dermatol Venerol 2001, 15(Suppl. 2):226-227.
5. Morton C, Horn M, Lehman J. A 24-month update of a placebo controlled European study comparing MAL-PDT with cryotherapy and 5-fluorouracil in patients with Bowen's disease. J Eur Acad Dermatol Venerol 2005, 19(Suppl. 2):766-771.
6. Hauschild A, Popp G, Stockfleth E. Effective photodynamic therapy of actinic keratoses on the head and face with a novel, self-adhesive 5-aminolaevulinic acid patch. Exp Dermatol 2009, 18:116-121. Epub 2008 July 17
7. Horn M, Wolf P, Wulf H C. Topical methyl aminolevulinate photodynamic therapy in patients with basal cell carcinoma prone to complications and poor cosmetic outcome with conventional therapy. Br J Dermatol 2003, 149:1242-1249.
8. Braathen L R, Szeimies R M, Basset-Seguin N. Guidelines on the use of photodynamic therapy for nonmelanoma skin cancer: An international consensus. J Am Acad Dermatol 2007, 56:125-143.
9. Soler A M, Warloe T, Berner A, Giercksky K E. A follow-up study of recurrence and cosmesis in completely responding superficial and nodular basal cell carcinomas treated with methyl 5-aminolaevulinate-based photodynamic therapy alone and with prior curettage. Br J Dermatol 2001, 145:467-471.
10. Szeimies R, Ibbotson S, Murrell D. A clinical study comparing methyl aminolevulinate photodynamic therapy and surgery in small superficial basal cell carcinoma (8-20 mm), with a 12-month follow-up. J Eur Acad Dermatol Venerol 2008, 22:1302-1311.
11. Rhodes L E, de Rie M A, Leifsdottir R. Five-year follow-up of a randomized, prospective trial of topical methyl aminolevulinate photodynamic therapy vs. surgery for nodular basal cell carcinoma. Arch Dermatol 2007, 143:1131-1136.
12. Vinciullo C, Elliott T, Gebauer K, Spelman L, Ngyen R. Photodynamic therapy with topical methyl aminolevulinate for " difficult-to-treat" basal cell carcinoma. Br J Dermatol 2005, 152:765-772.
13. Peng Q, Soler A M, Warloe T, Nesland J M, Giercksky K E. Selective distribution of porphyrins in skin thick basal cell carcinoma after topical application of methyl 5-aminolevulinate. Photochem Photobiol B 2001, 62:140-145.
14. Martin A, Tope W D, Grevelink J M. Lack of selectivity of protoporphyrin IX fluorescence for basal cell carcinoma after topical application of 5-aminolevulinic acid: implications for photodynamic therapy. Arch Dermatol 1995, 287:665-674.
15. Angell-Petersen E, Sørensen R, Warloe T. Porphyrin formation in actinic keratosis and basal cell carcinoma after topical application of methyl 5-aminolevulinate. J Invest Dermatol 2006, 126:265-271.
16. Fritsch C, Homey B, Stahl W, Lehrmann P, Ruzicka T, Sies H. Preferential relative porphyrin enrichment in solar keratoses upon topical application of δ-aminolevulinic acid methylester. Photochem Photobiol 1998, 68:218-221.
17. Juzeniene A, Juzenas P, Iani V, Moan J. Topical application of 5-aminolevulinic acid and its methylester, hexylester and octylester derivatives: considerations for dosimetry in mouse skin models. Photochem Photobiol 2002, 76:329-334.
18. Casas A, Perotti C, Fukuda H, Rogers L, Butler A R, Batlle A. ALA and ALA hexyl ester-induced porphyrin synthesis in chemically induced skin tumours: the role of different vehicles on improving photosensitization. Br J Cancer 2001, 85:1794-1800.
19. de Bruijn H S, Meijers C, van der Ploeg-van den Heuvel A, Sterenborg H J C M, Robinson D J. Microscopic localisation of protoporphyrin IX in normal mouse skin after topical application of 5-aminolevulinic acid or methyl 5-aminolevulinate. J Photochem Photobiol B 2008, 39:91-97.
20. Sandberg C, Halldin C B, Ericson M B, Larkö O, Krogstad A L, Wennberg A M. Bioavailability of aminolaevulinic acid and methylaminolaevulinate in basal cell carcinomas: a perfusion study using microdialysis in vivo. Br J Dermatol 2008, 159:1170-1176.
21. van den Akker J T H M, Iani V, Star W M, Sterenborg H J C M, Moan J. Topical application of 5-aminolevulinic acid hexyl ester and 5-aminolevulinic acid to normal nude mouse skin: Differences in protoporphyrin IX fluorescence kinetics and the role of the stratum corneum. Photochem Photobiol 2000, 72:681-689.
22. Juzeniene A, Juzenas P, Ma L W, Iani V, Moan J. Topical application of 5-aminolevulinic acid, methyl 5-aminolevulinate and hexyl 5-aminolevulinate on normal human skin. Br J Dermatol 2006, 155:791-799.
23. Stender I M, Bech-Thomsen N, Poulsen T, Wulf H C. Photodynamic therapy with topical δ-aminolevulinic acid delays UV photocarcinogenesis in hairless mice. Photochem Photobiol 1997, 66:493-496.
24. Sharfaei S, Juzenas P, Moan J, Bissonnette R. Weekly topical application of methyl aminolevulinate followed by light exposure delays the appearance of UV-induced skin tumours in mice. Arch Dermatol Res 2002, 294:237-242.
25. Sharfaei S, Viau G, Lui H, Bouffard D, Bissonnette R. Systemic photodynamic therapy with aminolevulinic acid delays the appearance of ultraviolet-induced skin tumours in mice. Br J Dermatol 2001, 144:1207-1214.
26. Lui Y, Viau G, Bissonnette R. Multiple large-surface photodynamic therapy sessions with topical or systemic aminolevulinic acid and blue light in UV-exposed hairless mice. J Cutan Med Surg 2004, 8:131-139.
27. Diffey B L, Jansen C T, Urbach F, Wulf H C. The standard erythema dose: a new photobiological concept. Photodermatol Photoimmunol Photomed 1997, 13:64-66.
28. Wulf H C, Poulsen T, Brodthagen H, Hou-Jensen K. Sunscreens for delay of ultraviolet induction of skin tumors. J Am Acad Dermatol 1982, 7:194-202.
29. Hansen A B, Bech-Thomsen N, Wulf H C. In vivo estimation of pigmentation in ultra-violet exposed hairless mice. Photodermatol Photoimmnol Photomed 1995, 11:14-17.
30. Calzavara-Pinton P G, Venturini M, Sala R. Methylaminolevulinate-based photodynamic therapy of Bowen's disease and squamous cell carcinoma. BJDermatol 2008, 159:137-144.
31. Fink-Puches R, Soyer H P, Hofer A, Kerl H, Wolf P. Long-term follow-up and histological changes of superficial nonmelanoma skin cancers treated with topical δ-aminolevulinic acid photodynamic therapy. Arch Dermatol 1998, 134:821-826.