Silver-loaded seaweed-based cellulosic fiber improves epidermal skin physiology in atopic dermatitis: Safety assessment, mode of action and controlled, randomized single-blinded exploratory in vivo study

Experimental Dermatology

Volumn 19, Issue 8, 2010, Pages

  Fluhr, Joachim W ^a,b   Breternitz, Maria ^a   Kowatzki, Doreen ^a   Bauer, Andrea ^a   Bossert, Joerg ^a   Elsner, Peter ^a   Hipler, Uta Christina ^a  

^a FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^b Bioskin   (Germany)

Author keywords

Antibacterial activity; Epidermal barrier function; Reactive oxygen species; Silver ions; Silver loaded cellulose fibre; Stratum corneum hydration; Surface pH

Indexed keywords

CELLULOSE; REACTIVE OXYGEN METABOLITE; SILVER;

ADULT; ARTICLE; ATOPIC DERMATITIS; BACTERIAL COLONIZATION; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; COTTON; ECZEMA; EPIDERMIS; EX VIVO STUDY; FEMALE; HUMAN; IN VITRO STUDY; IN VIVO STUDY; MALE; PATCH TEST; PATIENT SAFETY; RANDOMIZED CONTROLLED TRIAL; SEAWEED; SENSITIZATION; SINGLE BLIND PROCEDURE; SKIN WATER LOSS; STAPHYLOCOCCUS AUREUS; TEXTILE FIBER;

ADOLESCENT; ADULT; ANTIOXIDANTS; CELLULOSE; CLOTHING; DERMATITIS, ATOPIC; DOSE-RESPONSE RELATIONSHIP, DRUG; ECZEMA; EPIDERMIS; FEMALE; HUMANS; MALE; MIDDLE AGED; PATCH TESTS; REACTIVE OXYGEN SPECIES; SEAWEED; SILVER; SINGLE-BLIND METHOD; STAPHYLOCOCCUS AUREUS; TEXTILES; TREATMENT OUTCOME; YOUNG ADULT;

EID: 77954849667     PISSN: 09066705     EISSN: 16000625     Source Type: Journal    
DOI: 10.1111/j.1600-0625.2009.00943.x     Document Type: Article

References (46)

1. Dhabhar F S. Acute stress enhances while chronic stress suppresses skin immunity. The role of stress hormones and leukocyte trafficking. Ann N Y Acad Sci 2000, 917:876-893.
2. Friedman E M, Lawrence D A. Environmental stress mediates changes in neuroimmunological interactions. Toxicol Sci 2002, 67:4-10.
3. Fluhr J W, Behne M J, Brown B E. Stratum corneum acidification in neonatal skin: secretory phospholipase A2 and the sodium/hydrogen antiporter-1 acidify neonatal rat stratum corneum. J Invest Dermatol 2004, 122:320-329.
4. Hachem J P, Crumrine D, Fluhr J, Brown B E, Feingold K R, Elias P M. pH directly regulates epidermal permeability barrier homeostasis, and stratum corneum integrity/cohesion. J Invest Dermatol 2003, 121:345-353.
5. Elsner P. What textile engineers should know about the human skin. Curr Probl Dermatol 2003, 31:24-34.
6. Bolognia J L. Aging skin. Am J Med 1995, 98:99S-103S.
7. Fenske N A, Lober C W. Skin changes of aging: pathological implications. Geriatrics 1990, 45:27-35.
8. Fisher G J, Kang S, Varani J. Mechanisms of photoaging and chronological skin aging. Arch Dermatol 2002, 138:1462-1470.
9. Romagnani S. The increased prevalence of allergy and the hygiene hypothesis: missing immune deviation, reduced immune suppression, or both? Immunology 2004, 112:352-363.
10. Zikeli S. SeaCell® Active: a new cellulosic fiber with antimicrobial properties. International Forum and Symposium for High-tech Apparel Textiles 2002
11. Bauer R T E, Zikeli S. Seminar cellulosic man-made fibers in the new millenium. ALCERU - Manufacture of Cellulosic Materials by Using Organic Solvent Process 2000, Stenungsund
12. Strasburger E N F, Scheneck H, Schimper A F W. Lehrbuch der Botanik für Hochschulen 1991, Stuttgart, Gustav Fischer Verlag
13. Zikeli S. Lyocell fibers with health-promoting effect through incorporation of seaweed. Chem Fibers Int 2001, 51:272-276.
14. Zikeli S. Lyocell Fasern mit gesundheitsfördernder Wirkung durch Inkorporation von Algen. 7 Symposium Nachwachsende Rohstoffe für die Chemi 2001
15. Zikeli S E T, Martl M G. Polymer compositions and moulded bodies made therefrom.
16. Zikeli S E T, Martl M G. Cellulose shaped body and method for the production thereof.
17. Gorban E N, Kuprash L P, Gorban N E. Spirulina: perspectives of the application in medicine. Lik Sprava 2003, 100-110.
18. Hoppe H A L T, Tanaka Y. Marine Algae in Pharmaceutical Science 1979, Berlin, Walter de Gruyter & Co.
19. Kang H S, Chung H Y, Kim J Y, Son B W, Jung H A, Choi J S. Inhibitory phlorotannins from the edible brown alga Ecklonia stolonifera on total reactive oxygen species (ROS) generation. Arch Pharm Res 2004, 27:194-198.
20. Linares A F, Loikkanen J, Jorge M F, Soria R B, Novoa A V. Antioxidant and neuroprotective activity of the extract from the seaweed, Halimeda incrassata (Ellis) Lamouroux, against in vitro and in vivo toxicity induced by methyl-mercury. Vet Hum Toxicol 2004, 46:1-5.
21. Ramazanov Z, Jimenez del Rio M, Ziegenfuss T. Sulfated polysaccharides of brown seaweed Cystoseira canariensis bind to serum myostatin protein. Acta Physiol Pharmacol Bulg 2003, 27:101-106.
22. Gauger A, Mempel M, Schekatz A, Schafer T, Ring J, Abeck D. Silver-coated textiles reduce Staphylococcus aureus colonization in patients with atopic eczema. Dermatology 2003, 207:15-21.
23. Mundy G R, Guise T A. Hormonal control of calcium homeostasis. Clin Chem 1999, 45:1347-1352.
24. Hipler U C, Elsner P, Fluhr J W. Antifungal and Antibacterial Properties of a Silver-Loaded Cellulosic Fiber: J Biomed Mater Res Res B Appl Biomater 2006, 77:156-163.
25. Diepgen T L, Fartasch M, Hornstein O P. Evaluation and relevance of atopic basic and minor features in patients with atopic dermatitis and in the general population. Acta Derm Venereol Suppl (Stockh) 1989, 144:50-54.
26. Pinnagoda J, Tupker R A, Agner T, Serup J. Guidelines for transepidermal water loss (TEWL) measurement. Contact Derm 1990, 22:164-178.
27. Berardesca E. EEMCO guidance for the assessment of stratum corneum hydration: electrical methods. Skin Res Technol 1997, 3:126-132.
28. Rogiers V. EEMCO guidance for the assessment of transepidermal water loss in cosmetic sciences. Skin Pharmacol Appl Skin Physiol 2001, 14:117-128.
29. Parra J L, Paye M. EEMCO guidance for the in vivo assessment of skin surface pH. Skin Pharmacol Appl Skin Physiol 2003, 16:188-202.
30. Pierard G E, Pierard-Franchimont C, Marks R, Paye M, Rogiers V. EEMCO guidance for the in vivo assessment of skin greasiness. Skin Pharmacol Appl Skin Physiol 2000, 13:372-389.
31. Williamson P, Kligman A M. A new method for the quantitative investigation of cutaneous bacteria. J Invest Dermatol 1965, 45:498-503.
32. Zikeli S. Production process of a new cellulosic fiber with antimicrobial properties. Curr Probl Dermatol 2006, 33:110-126.
33. Proksch E, Brandner J M, Jensen J M. The skin: an indispensable barrier. Exp Dermatol 2008, 17:1063-1072.
34. Gauger A. Silver-coated textiles in the therapy of atopic eczema. Curr Probl Dermatol 2006, 33:152-164.
35. Haug S, Roll A, Schmid-Grendelmeier P. Coated textiles in the treatment of atopic dermatitis. Curr Probl Dermatol 2006, 33:144-151.
36. Hipler U C, Elsner P, Fluhr J W. A new silver-loaded cellulosic fiber with antifungal and antibacterial properties. Curr Probl Dermatol 2006, 33:165-178.
37. Kramer A, Guggenbichler P, Heldt P. Hygienic relevance and risk assessment of antimicrobial-impregnated textiles. Curr Probl Dermatol 2006, 33:78-109.
38. Ricci G, Patrizi A, Bellini F, Medri M. Use of textiles in atopic dermatitis: care of atopic dermatitis. Curr Probl Dermatol 2006, 33:127-143.
39. Juenger M, Ladwig A, Staecker S. Efficacy and safety of silver textile in the treatment of atopic dermatitis (AD). Curr Med Res Opin 2006, 22:739-750.
40. Gauger A, Fischer S, Mempel M. Efficacy and functionality of silver-coated textiles in patients with atopic eczema. J Eur Acad Dermatol Venereol 2006, 20:771.
41. Modak S M, Fox C L. Binding of silver sulfadiazine to the cellular components of Pseudomonas aeruginosa. Biochem Pharmacol 1973, 22:2391-2404.
42. Rosenkranz H S, Rosenkranz S. Silver sulfadiazine: interaction with isolated deoxyribonucleic acid. Antimicrob Agents Chemother 1972, 2:373-383.
43. Bragg P D, Rainnie D J. The effect of silver ions on the respiratory chain of Escherichia coli. Can J Microbiol 1974, 20:883-889.
44. Klasen H J. A historical review of the use of silver in the treatment of burns. II. Renewed interest for silver. Burns 2000, 26:131-138.
45. Hipler U C, Elsner P, Fluhr J W. Antifungal and antibacterial properties of a silver-loaded cellulosic fiber. J Biomed Mater Res B Appl Biomater 2006, 77:156-163.
46. Thiele J J, Traber M G, Podda M, Tsang K, Cross C E, Packer L. Ozone depletes tocopherols and tocotrienols topically applied to murine skin. FEBS Lett 1997, 401:167-170.