The relationship between Lewis/Secretor genotypes and serum carbohydrate antigen 19-9 levels in a Korean population

Korean Journal of Laboratory Medicine

Volumn 30, Issue 1, 2010, Pages 51-57

  Park, Hyung Doo ^a   Park, Kyoung Un ^b,c   Song, Junghan ^b,c   Ki, Chang Seok ^a   Han, Kyou Sup ^b   Kim, Jin Q ^b  

^a Sungkyunkwan University School of Medicine   (South Korea)

^b Seoul National University College of Medicine   (South Korea)

^c Seoul National University Bundang Hospital   (South Korea)

Author keywords

CA 19 9; Korean population; Lewis genotype; Lewis Secretor genotype

Indexed keywords

CA 19-9 ANTIGEN;

ADULT; AGED; ALLELE; ARTICLE; ASIAN; BLOOD; BLOOD GROUP LEWIS SYSTEM; CHEMOLUMINESCENCE; FEMALE; GENE FREQUENCY; GENETIC POLYMORPHISM; GENETICS; GENOTYPE; HUMAN; IMMUNOASSAY; MALE; METHODOLOGY; MIDDLE AGED; PHENOTYPE; SOUTH KOREA;

ADULT; AGED; ALLELES; ASIAN CONTINENTAL ANCESTRY GROUP; CA-19-9 ANTIGEN; CHEMILUMINESCENT MEASUREMENTS; FEMALE; GENE FREQUENCY; GENOTYPE; HUMANS; IMMUNOASSAY; LEWIS BLOOD-GROUP SYSTEM; MALE; MIDDLE AGED; PHENOTYPE; POLYMORPHISM, GENETIC; REPUBLIC OF KOREA;

EID: 77954839783     PISSN: 15986535     EISSN: None     Source Type: Journal    
DOI: 10.3343/kjlm.2010.30.1.51     Document Type: Article

References (22)

1. Mollicone R, Reguigne I, Kelly RJ, Fletcher A, Watt J, Chatfield S, et al. Molecular basis for Lewis alpha(1,3/1,4)-fucosyltransferase gene deficiency (FUT3) found in Lewis-negative Indonesian pedigrees. J Biol Chem 1994;269:20987-94.
2. Nishihara S, Narimatsu H, Iwasaki H, Yazawa S, Akamatsu S, Ando T, et al. Molecular genetic analysis of the human Lewis histo-blood group system. J Biol Chem 1994;269:29271-8.
3. Kelly RJ, Rouquier S, Giorgi D, Lennon GG, Lowe JB. Sequence and expression of a candidate for the human Secretor blood group alpha (1,2)fucosyltransferase gene (FUT2). Homozygosity for an enzymeinactivating nonsense mutation commonly correlates with the nonsecretor phenotype. J Biol Chem 1995;270:4640-9.
4. Kudo T, Iwasaki H, Nishihara S, Shinya N, Ando T, Narimatsu I, et al. Molecular genetic analysis of the human Lewis histo-blood group system. II. Secretor gene inactivation by a novel single missense mutation A385T in Japanese nonsecretor individuals. J Biol Chem 1996; 271:9830-7.
5. Koda Y, Soejima M, Liu Y, Kimura H. Molecular basis for secretor type alpha(1,2)-fucosyltransferase gene deficiency in a Japanese population: a fusion gene generated by unequal crossover responsible for the enzyme deficiency. Am J Hum Genet 1996;59:343-50.
6. Rouquier S, Lowe JB, Kelly RJ, Fertitta AL, Lennon GG, Giorgi D. Molecular cloning of a human genomic region containing the H blood group alpha(1,2)fucosyltransferase gene and two H locusrelated DNA restriction fragments. Isolation of a candidate for the human Secretor blood group locus. J Biol Chem 1995;270:4632-9.
7. Liu Y, Koda Y, Soejima M, Uchida N, Kimura H. PCR analysis of Lewis-negative gene mutations and the distribution of Lewis alleles in a Japanese population. J Forensic Sci 1996;41:1018-21.
8. Song SY, An SS, Ryu SW, Kim JS, Suh IB. Evaluation of the genotypes of the Lewis blood group in a Korean population using direct sequencing. Korean J Hematol 2008;43:34-42.
9. Kim MJ, Kim HS, Song KS, Noh SH, Kim HG, Paik YK, et al. Altered expression of Lewis antigen on tissue and erythrocytes in gastric cancer patients. Yonsei Med J 2002;43:427-34.
10. Hayashi N, Nakamori S, Okami J, Nagano H, Dono K, Umeshita K, et al. Association between expression levels of CA 19-9 and Nacetylglucosamine-beta;1,3-galactosyltransferase 5 gene in human pancreatic cancer tissue. Pathobiology 2004;71:26-34.
11. Lamerz R. Role of tumour markers, cytogenetics. Ann Oncol 1999; 10:145-9.
12. Hamajima N, Saito T, Matsuo K, Tajima K. Competitive amplification and unspecific amplification in polymerase chain reaction with confronting two-pair primers. J Mol Diagn 2002;4:103-7.
13. Shibata A, Hamajima N, Ikehara Y, Saito T, Matsuo K, Katsuda N, et al. ABO blood type, Lewis and Secretor genotypes, and chronic atrophic gastritis: a cross-sectional study in Japan. Gastric Cancer 2003;6:8-16.
14. Hamajima N, Shibata A, Ikehara Y, Katsuda N, Mori S, Ito H, et al. Lack of consistency in the associations of Helicobacter pylori seropositivity with Se and Le polymorphisms among Japanese. Gastric Cancer 2002;5:194-200.
15. Park KU, Song J, Han KS, Kim JQ. The fusion allele of the FUT2 (secretor type alpha(1,2)-fucosyltransferase) gene at a high frequency and a new se385 allele in a Korean population. Ann Hematol 2005; 84:656-60.
16. Pang H, Liu Y, Koda Y, Soejima M, Jia J, Schlaphoff T, et al. Five novel missense mutations of the Lewis gene (FUT3) in African (Xhosa) and Caucasian populations in South Africa. Hum Genet 1998;102: 675-80.
17. Liu TC, Chang JG, Lin SF, Chang WC, Yang TY, Lin CL, et al. Lewis (FUT3) genotypes in Taiwanese, Thai, and Filipino populations. Ann Hematol 2000;79:599-603.
18. Liu YH, Koda Y, Soejima M, Pang H, Wang BJ, Kim DS, et al. The fusion gene at the ABO-secretor locus (FUT2): absence in Chinese populations. J Hum Genet 1999;44:181-4.
19. Liu Y, Koda Y, Soejima M, Pang H, Schlaphoff T, du Toit ED, et al. Extensive polymorphism of the FUT2 gene in an African (Xhosa) population of South Africa. Hum Genet 1998;103:204-10.
20. Narimatsu H, Iwasaki H, Nakayama F, Ikehara Y, Kudo T, Nishihara S, et al. Lewis and secretor gene dosages affect CA19-9 and DUPAN-2 serum levels in normal individuals and colorectal cancer patients. Cancer Res 1998;58:512-8.
21. Vestergaard EM, Hein HO, Meyer H, Grunnet N, Jorgensen J, Wolf H, et al. Reference values and biological variation for tumor marker CA 19-9 in serum for different Lewis and secretor genotypes and evaluation of secretor and Lewis genotyping in a Caucasian population. Clin Chem 1999;45:54-61.
22. Liu YH, Koda Y, Soejima M, Pang H, Wang B, Kimura H. Lewis (FUT3) genotypes in two different Chinese populations. J Forensic Sci 1999;44:82-6.