FOXL2 interacts with steroidogenic factor-1 (SF-1) and represses SF-1-induced CYP17 transcription in granulosa cells

Molecular Endocrinology

Volumn 24, Issue 5, 2010, Pages 1024-1036

  Park, Mira ^a   Shin, Eunkyoung ^b   Won, Miae ^a   Kim, Jae Hong ^a   Go, Hayoung ^b   Kim, Hyun Lee ^a   Ko, Jeong Jae ^a   Lee, Kangseok ^b   Bae, Jeehyeon ^a  

^a CHA University   (South Korea)

^b Chung Ang University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450 17; MUTANT PROTEIN; PROTEIN; PROTEIN FOXL2; STEROIDOGENIC FACTOR 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BLEPHAROPHIMOSIS; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DNA LIBRARY; EPICANTHUS; FEMALE; GEL MOBILITY SHIFT ASSAY; GENE INDUCTION; GENE REPRESSION; GRANULOSA CELL; HUMAN; HUMAN CELL; NONHUMAN; OVARY FOLLICLE DEVELOPMENT; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN PROTEIN INTERACTION; PTOSIS; RAT; TRANSCRIPTION INITIATION; TWO HYBRID SYSTEM;

ANIMALS; BLOTTING, WESTERN; CELL LINE; CHROMATIN IMMUNOPRECIPITATION; ELECTROPHORETIC MOBILITY SHIFT ASSAY; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; GRANULOSA CELLS; HUMANS; IMMUNOPRECIPITATION; MICE; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; RATS; RATS, SPRAGUE-DAWLEY; STEROID 17-ALPHA-HYDROXYLASE; STEROIDOGENIC FACTOR 1; TRANSCRIPTION, GENETIC;

MUS; RATTUS;

EID: 77954839635     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/me.2009-0375     Document Type: Article

References (24)

1. Crisponi L, Deiana M, Loi A, Chiappe F, Uda M, Amati P, Bisceglia L, Zelante L, Nagaraja R, Porcu S, Ristaldi MS, Marzella R, Rocchi M, Nicolino M, Lienhardt-Roussie A, Nivelon A, Verloes A, Schlessinger D, Gasparini P, Bonneau D, Cao A, Pilia G 2001 The putative forkhead transcription factor FOXL2 is mutated in blepharophimosis/ptosis/ epicanthus inversus syndrome. Nat Genet 27:159-166
2. Pisarska MD, Bae J, Klein C, Hsueh AJ 2004 Forkhead l2 is expressed in the ovary and represses the promoter activity of the steroidogenic acute regulatory gene. Endocrinology 145:3424-3433
3. Uda M, Ottolenghi C, Crisponi L, Garcia JE, Deiana M, Kimber W, Forabosco A, Cao A, Schlessinger D, Pilia G 2004 Foxl2 disruption causes mouse ovarian failure by pervasive blockage of follicle development. Hum Mol Genet 13:1171-1181
4. Schmidt D, Ovitt CE, Anlag K, Fehsenfeld S, Gredsted L, Treier AC, Treier M 2004 The murine winged-helix transcription factor Foxl2 is required for granulosa cell differentiation and ovary maintenance. Development 131:933-942 (Pubitemid 38263207)
5. Wang DS, Kobayashi T, Zhou LY, Paul-Prasanth B, Ijiri S, Sakai F, Okubo K, Morohashi K, Nagahama Y 2007 Foxl2 up-regulates aromatase gene transcription in a female-specific manner by binding to the promoter as well as interacting with ad4 binding protein/ steroidogenic factor 1. Mol Endocrinol 21:712-725
6. Luo X, Ikeda Y, Parker KL 1994 A cell-specific nuclear receptor is essential for adrenal and gonadal development and sexual differentiation. Cell 77:481-490 (Pubitemid 24153989)
7. Falender AE, Lanz R, Malenfant D, Belanger L, Richards JS 2003 Differential expression of steroidogenic factor-1 and FTF/LRH-1 in the rodent ovary. Endocrinology 144:3598-3610
8. Parker KL, Rice DA, Lala DS, Ikeda Y, Luo X, Wong M, Bakke M, Zhao L, Frigeri C, Hanley NA, Stallings N, Schimmer BP 2002 Steroidogenic factor 1: an essential mediator of endocrine development. Recent Prog Horm Res 57:19-36
9. Lee K, Pisarska MD, Ko JJ, Kang Y, Yoon S, Ryou SM, Cha KY, Bae J 2005 Transcriptional factor FOXL2 interacts with DP103 and induces apoptosis. Biochem Biophys Res Commun 336:876-881
10. Nishi Y, Yanase T, Mu Y, Oba K, Ichino I, Saito M, Nomura M, Mukasa C, Okabe T, Goto K, Takayanagi R, Kashimura Y, Haji M, Nawata H 2001 Establishment and characterization of a steroidogenic human granulosa-like tumor cell line, KGN, that expresses functional follicle-stimulating hormone receptor. Endocrinology 142:437-445
11. Beysen D, Moumné L, Veitia R, Peters H, Leroy BP, De Paepe A, De Baere E 2008 Missense mutations in the forkhead domain of FOXL2 lead to subcellular mislocalization, protein aggregation and impaired transactivation. Hum Mol Genet 17:2030-2038
12. Gurates B, Amsterdam A, Tamura M, Yang S, Zhou J, Fang Z, Amin S, Sebastian S, Bulun SE 2003 WT1 and DAX-1 regulate SF-1-mediated human P450arom gene expression in gonadal cells. Mol Cell Endocrinol 208:61-75
13. Michael MD, Kilgore MW, Morohashi K, Simpson ER 1995 Ad4BP/SF-1 regulates cyclic AMP-induced transcription from the proximal promoter (PII) of the human aromatase P450 (CYP19) gene in the ovary. J Biol Chem 270:13561-13566
14. Pannetier M, Fabre S, Batista F, Kocer A, Renault L, Jolivet G, Mandon-Pépin B, Cotinot C, Veitia R, Pailhoux E 2006 FOXL2 activates P450 aromatase gene transcription: towards a better characterization of the early steps of mammalian ovarian development. J Mol Endocrinol 36:399-413
15. Zhang P, Mellon SH 1996 The orphan nuclear receptor steroidogenic factor-1 regulates the cyclic adenosine 3′,5′-monophosphate-mediated transcriptional activation of rat cytochrome P450c17 (17α-hydroxylase/ c17-20 lyase). Mol Endocrinol 10:147-158
16. Jeyasuria P, Ikeda Y, Jamin SP, Zhao L, De Rooij DG, Themmen AP, Behringer RR, Parker KL 2004 Cell-specific knockout of steroidogenic factor 1 reveals its essential roles in gonadal function. Mol Endocrinol 18:1610-1619
17. Zhou LY, Wang DS, Shibata Y, Paul-Prasanth B, Suzuki A, Nagahama Y 2007 Characterization, expression and transcriptional regulation of P450c17-I and -II in the medaka, Oryzias latipes. Biochem Biophys Res Commun 362:619-625
18. De Baere E, Beysen D, Oley C, Lorenz B, Cocquet J, De Sutter P, Devriendt K, Dixon M, Fellous M, Fryns JP, Garza A, Jonsrud C, Koivisto PA, Krause A, Leroy BP, Meire F, Plomp A, Van Maldergem L, De Paepe A, Veitia R, Messiaen L 2003 FOXL2 and BPES: mutational hotspots, phenotypic variability, and revision of the genotypephenotype correlation. Am J Hum Genet 72:478-487
19. Simpson JL 2008 Genetic and phenotypic heterogeneity in ovarian failure: overview of selected candidate genes. Ann NY Acad Sci 1135:146-154
20. Santoro N 2001 Research on the mechanisms of premature ovarian failure. J Soc Gynecol Investig 8:S10-S12
21. Jagarlamudi K, Reddy P, Adhikari D, Liu K 2010 Genetically modified mouse models for premature ovarian failure (POF). Mol Cell Endocrinol 315:1-10
22. Matzuk MM, Lamb DJ 2002 Genetic dissection of mammalian fertility pathways. Nat Cell Biol 4(Suppl):s41-s49
23. Shapiro DB, Pappalardo A, White BA, Peluso JJ 1996 Steroidogenic factor-1 as a positive regulator of rat granulosa cell differentiation and a negative regulator of mitosis. Endocrinology 137:1187-1195 (Pubitemid 26095230)
24. Suzuki T, Sasano H, Tamura M, Aoki H, Fukaya T, Yajima A, Nagura H, Mason JI 1993 Temporal and spatial localization of steroidogenic enzymes in premenopausal human ovaries: in situ hybridization and immunohistochemical study. Mol Cell Endocrinol 97:135-143