Effects of adenoviral-mediated melanoma differentiation associated gene-7/IL-24 on growth and apoptosis of breast cancer cells

National Medical Journal of China

Volumn 88, Issue 42, 2008, Pages 3008-3011

  Ni, Qi Chao ^a   Yang, Lin ^b   Zhang, Chun Hui ^b   Zhou, Feng ^b   Zhu, Hui Jun ^b   Huang, Jian Fei ^b  

^a NANTONG UNIVERSITY   (China)

^b NONE

Author keywords

Adenovirus; Apoptosis; Breast neoplasms; Growth inhibition; Mda 7 IL 24

Indexed keywords

ADENOVIRUS VECTOR; CRYSTAL VIOLET; INTERLEUKIN 24; LIPOCORTIN 5; INTERLEUKIN DERIVATIVE; INTERLEUKIN-24;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL; CANCER GROWTH; CONTROLLED STUDY; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PROTEIN EXPRESSION; TUMOR VOLUME; WESTERN BLOTTING; ADENOVIRUS; ANIMAL; CELL PROLIFERATION; EXPERIMENTAL NEOPLASM; FEMALE; GENE VECTOR; GENETICS; NUDE MOUSE; PATHOLOGY; TUMOR CELL LINE;

ADENOVIRIDAE; ANIMALS; APOPTOSIS; CELL LINE, TUMOR; CELL PROLIFERATION; FEMALE; GENETIC VECTORS; HUMANS; INTERLEUKINS; MAMMARY NEOPLASMS, EXPERIMENTAL; MICE; MICE, NUDE;

EID: 77954827036     PISSN: 03762491     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (14)

1. Jiang H, Lin JJ, Su ZZ, et al. Subtraction hybridization identifies a novel melanoma differentiation associated gene, mda-7, modulated during human melanoma differentiation, growth and progression. Oncogene, 1995, 11: 2477-2486.
2. Tong AW, Nemunaitis J, Su D, et al. Intratumoral injection of INGN241, a nonreplicating adenovector expressing the melanoma-differentiation associated gene-7 (mda-7/IL-24): biologic outcome in advanced cancer patients. Mol Ther, 2005, 11: 160-172.
3. Yotnda P, Savoldo B, Charlet-Berguerand N, et al. Targeted delivery of adenoviral vectors by cytotoxic T cells. Blood, 2004, 104: 2272-2280. (Pubitemid 39331823)
4. Su ZZ, Madireddi MT, Lin JJ, et al. The cancer growth suppressor gene mda-7 selectively induces apoptosis in human breast cancer cells and inhibits tumor growth in nude mice. Proc Natl Acad Sci U S A, 1998, 95: 14400-14405.
5. Mhashilkar AM, Schrock RD, Hindi M, et al. Melanoma differentiation associated gene-7 (mda-7): a novel anti-tumor gene for cancer gene therapy. Mol Med, 2001, 7: 271-282.
6. Lebedeva IV, Sauane M, Gopalkrishnan RV, et al. mda-7/IL-24: exploiting cancer's Achilles' heel. Mol Ther, 2005, 11: 4-18.
7. Lebedeva IV, Su ZZ, Sarkar D, et al. Induction of reactive oxygen species renders mutant and wild-type K-ras pancreatic carcinoma cells susceptible to Ad. mda-7-induced apoptosis. Oncogene, 2005, 24: 585-596.
8. Saeki T, Mhashilkar A, Chada S, et al. Tumor-suppressive effects by adenovirus-mediated mda-7 gene transfer in non-small cell lung cancer cell in vitro. Gene Ther, 2000, 7: 2051-2057.
9. Pataer A, Vorburger SA, Barber GN, et al. Adenoviral transfer of the melanoma differentiation-associated gene-7 (mda-7) induces apoptosis of lung cancer cells via up-regulation of the double-stranded RNA-dependent protein kinase (PKR). Cancer Res, 2002, 62: 2239-2243.
10. Lebedeva IV, Su ZZ, Chang Y, et al. The cancer growth suppressing gene mda-7 induces apoptosis selectively in human melanoma cells. Oncogene, 2002, 21: 708-718.
11. Saeki T, Mhashilkar A, Swanson X, et al. Inhibition of human lung cancer growth following adenovirus-mediated mda-7 gene expression in vivo. Oncogene, 2002, 21, 4558-4566.
12. Tong AW, Nemunaitis J, Su D, et al. Intratumoral injection of INGN241, a nonreplicating adenovector expressing the melanoma-differentiation associated gene-7 (mda-7/IL-24): biologic outcome in advanced cancer patients. Mol Ther, 2005, 11: 161-172.
13. Cunningham CC, Chada S, Merritt JA, et al. Clinical and local biological effects of an intratumoral injection of mda-7 (IL-24; INGN241) in patients with advanced carcinoma: a phase I study. Mol Ther, 2005, 11: 149-159.
14. Sarkar D, Lebedeva IV, Gupta P, et al. Melanoma differentiation associated gene-7 (mda-7)/IL-24: a 'magic bullet' for cancer therapy? Expert Opin Biol Ther, 2007, 7: 577-586.