Role of NADPH-insensitive nitroreductase gene to metronidazole resistance of Helicobacter pylori strains

Daru

Volumn 18, Issue 2, 2010, Pages 137-140

  Kargar, M ^a   Baghernejad, M ^a   Doosti, A ^b  

^a ISLAMIC AZAD UNIVERSITY   (Iran)

^b ISLAMIC AZAD UNIVERSITY   (Iran)

Author keywords

Helicobacter pylori; Metronidazole resistance rdxA gene

Indexed keywords

CATALASE; METRONIDAZOLE; NITROREDUCTASE; OXIDOREDUCTASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; UREASE;

ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL STRAIN; BACTERIUM CULTURE; BACTERIUM IDENTIFICATION; BACTERIUM ISOLATION; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; ENZYME ACTIVITY; FEMALE; GENE MUTATION; GRAM STAINING; HELICOBACTER PYLORI; HUMAN; HUMAN TISSUE; IRAN; MALE; NONHUMAN; POLYMERASE CHAIN REACTION; PROTEIN FUNCTION; SEQUENCE ANALYSIS;

EID: 77954820696     PISSN: 15608115     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. 14 urea breath test for the diagnosis of Helicobacter pylori: A survey in Iranian population, DARU 2005;13:6-10.
2. Houben, MH., Beek D, Hensen EF, Caen AJ, Rauws EA and Tytgat GNA. systematic review of Helicobacter pylori eradication rates. Alimentary Pharmacology and Therapeutics, 1999; 13: 1047-1055.
3. Goodwin A, Kersulyte D, Sisson G, Zanten SJ, Berg DE, Hoffman PS.Metronidazole resistance in Helicobacter pylori is due to null mutations in a gene (rdxA) that encodes an oxygen-insensitive NADPH nitroreductase. Molecular Microbiology, 1998;28:383-393.
4. Edwards DI. Nitroimidazole drugs-action and resistance mechanisms. I. Mechanism of action. Journal of Antimicrobial Chemothrapy, 1993;31:37-41.
5. Megraud F and Lehours PH. Helicobacter pylori detection and antimicrobial susceptibility testing. Clin Microbiol Rev, 2007; 20(2): 280-322.
6. Smith SI, Oyedeji KS, Arigbabu AO, Cantet F, Ojo OO, Uwaifo AO, Otegbayo JA, Ola SO, Coker AO. Comprasion of three PCR methods for detection of Helicobacter pylori DNA and detection of cagA gene in gastric biopsy specimens. World Journal of Gastroenterology, 2004; 13: 1958-1960.
7. Kato S, Fujimura S, Udagawa H, Shimizu T, Maisawa S, Ozawa K et al. Antibiotic resistance of Helicobacter pylori strains in Japanese children. Journal of Clinical Microbiology, 2002; 2: 649-653.
8. Debets-Ossenkopp YJ, Pot RGJ, Westerloo DJ, Goodwin A, Vandenbrouke Grauls CMJE, Berg DE, Hoffman PS, Kusters JH. Insertion of mini-IS605 and deletion of adjacent sequences in the nitroreductase (rdxA) gene cause metronidazole resistance in Helicobacter pylori NCTC11637. Antimicrob Agents and Chemother, 1999;43: 2657-2662.
9. Woll K, Leodolter A,Malfertheiner P,Koing W. Antibiotic susceptibility of Helicobacter pylori in Germany: stable praimary resistance from 1995 to 2000. Med Microbiol, 2002;51:705-709.
10. Megraud F. Helicobacter pylori antibiotic resistance: prevalence, importance, and advances in testing.Gut. 2004; 53: 1374-1384.
11. Suerbaum S, Michetti P. Helicobacter pylori infection. NEJ Med, 2002; 347: 1175-1186.
12. Doosti A, Rahimian GH. A, Nasiri J, Rahimi Foroushani A. Prevalence of the cag A-positive Helicobacter pylori strains isolated from gastric biopsy specimens in Shahrekord. Armaghan Danesh, 2007; 12: 29-38.
13. Nakhai Moghadam M, Khajeh Karamaldini M, Malekzadeh F, Khoshnavanaye Fumani A. Prevalence of Helicobacter pylori in biopsy specimens and determine sensitivity and specifity of its diagnostic methods. Ofoghe Danesh, 2005; 11(2): 37-40.
14. Emami M.H, Taheri H, Tavakoli H, Esmaeili A. Are endoscopic findings predictive for the presence of Helicobacter pylori infection? What about indirect histologic findings? Journal of reaserch in Med Sciences, 2007; 12(2): 80-85.
15. Moradi A, Rashidipour A. Seroepidemiology of Helicobacter pylori infection in Semnan. Koomesh, 2000; 1(3): 53-57.