Improvement in growth after 1 year of growth hormone therapy in well-nourished infants with growth retardation secondary to chronic renal failure: Results of a multicenter, controlled, randomized, open clinical trial

Clinical Journal of the American Society of Nephrology

Volumn 5, Issue 7, 2010, Pages 1190-1197

  Santos, Fernando ^a   Moreno, M Llanos ^b   Neto, Arlete ^c   Ariceta, Gema ^d   Vara, Julia ^e   Alonso, Angel ^f   Bueno, Alberto ^g   Afonso, Alberto Caldas ^h   Correia, António Jorge ⁱ   Muley, Rafael ^e   Barrios, Vicente ^j   Gómez, Carlos ^a   Argente, Jesús ^j  

^a HOSPITAL UNIVERSITARIO CENTRAL DE ASTURIAS   (Spain)

^b NOVO NORDISK A S   (Denmark)

^c HOSPITAL DONA ESTEFÂNIA   (Portugal)

^d HOSPITAL DE CRUCES   (Spain)

^e HOSPITAL UNIVERSITARIO 12 DE OCTUBRE   (Spain)

^f HOSPITAL INFANTIL LA PAZ   (Spain)

^g HOSPITAL REGIONAL UNIVERSITARIO DE MÁLAGA   (Spain)

^h HOSPITAL DE SÃO JOÃO   (Portugal)

ⁱ CENTRO HOSPITALAR E UNIVERSITÁRIO DE COIMBRA   (Portugal)

^j UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

more..

Author keywords

[No Author keywords available]

Indexed keywords

GHRELIN; GROWTH HORMONE BINDING PROTEIN; HUMAN GROWTH HORMONE; LEPTIN; NORDITROPIN SIMPLEXX; SOMATOMEDIN B; SOMATOMEDIN BINDING PROTEIN 1; SOMATOMEDIN BINDING PROTEIN 2; SOMATOMEDIN BINDING PROTEIN 3; SOMATOMEDIN C; UNCLASSIFIED DRUG; BIOLOGICAL MARKER;

ABDOMINAL PAIN; ACUTE GASTROENTERITIS; ACUTE OTITIS MEDIA; ARTICLE; BEDTIME DOSAGE; BODY HEIGHT; BODY WEIGHT; BONE MASS; BONE MATURATION; CHICKENPOX; CHILD; CHRONIC KIDNEY FAILURE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIETARY INTAKE; DISEASE COURSE; ERYTHEMA; FEMALE; FOREARM; GROWTH RETARDATION; GROWTH STIMULATION; HUMAN; INFANT; INFANT NUTRITION; KIDNEY FUNCTION; MALE; METABOLIC REGULATION; MULTICENTER STUDY; PORTUGAL; RANDOMIZED CONTROLLED TRIAL; RESPIRATORY TRACT INFECTION; SPAIN; TREATMENT DURATION; TREATMENT OUTCOME; URINARY TRACT INFECTION; BLOOD; BONE DENSITY; BONES OF THE ARM AND HAND; CHI SQUARE DISTRIBUTION; COMPLICATION; DRUG EFFECTS; ENZYME LINKED IMMUNOSORBENT ASSAY; GLOMERULUS FILTRATION RATE; GROWTH DISORDERS; GROWTH, DEVELOPMENT AND AGING; KIDNEY FAILURE, CHRONIC; NUTRITIONAL STATUS; PATHOPHYSIOLOGY; PHOTON ABSORPTIOMETRY; PROSPECTIVE STUDY; RADIOGRAPHY; RADIOIMMUNOASSAY; TARSAL BONE; TIME;

ABSORPTIOMETRY, PHOTON; ARM BONES; BIOLOGICAL MARKERS; BODY HEIGHT; BODY WEIGHT; BONE DENSITY; CHI-SQUARE DISTRIBUTION; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; GLOMERULAR FILTRATION RATE; GROWTH DISORDERS; HUMAN GROWTH HORMONE; HUMANS; INFANT; INFANT NUTRITIONAL PHYSIOLOGICAL PHENOMENA; KIDNEY FAILURE, CHRONIC; MALE; NUTRITIONAL STATUS; PORTUGAL; PROSPECTIVE STUDIES; RADIOIMMUNOASSAY; SPAIN; TARSAL BONES; TIME FACTORS; TREATMENT OUTCOME;

EID: 77954808566     PISSN: 15559041     EISSN: 1555905X     Source Type: Journal    
DOI: 10.2215/CJN.07791109     Document Type: Article

References (38)

1. NAPRTCS: NAPRTCS 2008 Annual Report. Available at: http://spitfire.emmes. com/study/ped/index.htm. Accessed June 3, 2009
2. Furth SL: Growth and nutrition in children with chronic kidney disease. Adv Chronic Kidney Dis 12: 366-371, 2005 (Pubitemid 41376494)
3. Kuizon BD, Salusky IB: Growth retardation in children with chronic renal failure. J Bone Miner Res 14: 1680-1690, 1999 (Pubitemid 29455816)
4. Karlberg J, Schaefer F, Hennicke M, Wingen AM, Rigden S, Mehls O: Early age-dependent growth impairment in chronic renal failure. European Study Group for Nutritional Treatment of Chronic Renal Failure in Childhood. Pediatr Nephrol 10: 283-287, 1996
5. Rees L, Shaw V: Nutrition in children with CRF and on dialysis. Pediatr Nephrol 22: 1689-1702, 2007
6. Kari JA, Gonzalez C, Ledermann SE, Shaw V, Rees L: Outcome and growth of infants with severe chronic renal failure. Kidney Int 57: 1681-1687, 2000 (Pubitemid 30207927)
7. Parekh RS, Flynn JT, Smoyer WE, Milne JL, Kershaw DB, Bunchman TE, Sedman AB: Improved growth in young children with severe chronic renal insufficiency who use specified nutritional therapy. J Am Soc Nephrol 12: 2418-2426, 2001
8. Abitbol CL, Zilleruelo G, Montane B, Strauss J: Growth of uremic infants on forced feeding regimens. Pediatr Nephrol 7: 173-177, 1993 (Pubitemid 23093700)
9. Brewer ED: Growth of small children managed with chronic peritoneal dialysis and nasogastric tube feedings: 203-Month experience in 14 patients. Adv Perit Dial 6: 269-272, 1990
10. Fine RN, Attie KM, Kuntze J, Brown DF, Kohaut EC: Recombinant human growth hormone in infants and young children with chronic renal insufficiency. Genentech Collaborative Study Group. Pediatr Nephrol 9: 451-457, 1995
11. Schwartz GJ, Brion LP, Spitzer A: The use of plasma creatinine concentration for estimating glomerular filtration rate in infants, children, and adolescents. Pediatr Clin North Am 34: 571-590, 1987
12. Hernández M, Fundación Francisco Orbegozo: Growth charts [in Spanish], 3rd Ed., Madrid, Ergon, 2002
13. Argente J, Barrios V, Chowen JA, Sinha MK, Considine RV: Leptin plasma levels in healthy Spanish children and adolescents, children with obesity, and adolescents with anorexia nervosa and bulimia nervosa. J Pediatr 131: 833-838, 1997 (Pubitemid 28027606)
14. Argente J, Barrios V, Pozo J, Munoz MT, Hervas F, Stene M, Hernandez M: Normative data for insulin-like growth factors (IGFs), IGF-binding proteins, and growth hormone-binding protein in a healthy Spanish pediatric population: age- and sex-related changes. J Clin Endocrinol Metab 77: 1522-1528, 1993 (Pubitemid 24000907)
15. Hernandez M, Sanchez E, Sobradillo B, Rincon JM, Narvaiza JL: A new method for assessment of skeletal maturity in the first 2 years of life. Pediatr Radiol 18: 484-489, 1988
16. Ledermann SE, Shaw V, Trompeter RS: Long-term enteral nutrition in infants and young children with chronic renal failure. Pediatr Nephrol 13: 870-875, 1999
17. Fine RN, Ho M, Tejani A, Blethen S: Adverse events with rhGH treatment of patients with chronic renal insufficiency and end-stage renal disease. J Pediatr 142: 539-545, 2003 (Pubitemid 36623565)
18. Mahan JD, Warady BA: Assessment and treatment of short stature in pediatric patients with chronic kidney disease: A consensus statement. Pediatr Nephrol 21: 917-930, 2006
19. Mencarelli F, Kiepe D, Leozappa G, Stringini G, Cappa M, Emma F: Growth hormone treatment started in the first year of life in infants with chronic renal failure. Pediatr Nephrol 24: 1039-1046, 2009
20. Karlberg J: On the modelling of human growth. Stat Med 6: 185-192, 1987
21. Tonshoff B, Kiepe D, Ciarmatori S: Growth hormone/insulin-like growth factor system in children with chronic renal failure. Pediatr Nephrol 20: 279-289, 2005 (Pubitemid 40309930)
22. Argente J, Caballo N, Barrios V, Munoz MT, Pozo J, Chowen JA, Morande G, Hernandez M: Multiple endocrine abnormalities of the growth hormone and insulin-like growth factor axis in patients with anorexia nervosa: Effect of short- and long-term weight recuperation. J Clin Endocrinol Metab 82: 2084-2092, 1997 (Pubitemid 27287565)
23. Argente J, Caballo N, Barrios V, Pozo J, Munoz MT, Chowen JA, Hernandez M: Multiple endocrine abnormalities of the growth hormone and insulin-like growth factor axis in prepubertal children with exogenous obesity: Effect of short- and long-term weight reduction. J Clin Endocrinol Metab 82: 2076-2083, 1997 (Pubitemid 27287564)
24. Lindblad YT, Axelsson J, Barany P, Celsi G, Lindholm B, Qureshi AR, Carrea A, Canepa A: Hyperinsulinemia and insulin resistance, early cardiovascular risk factors in children with chronic kidney disease. Blood Purif 26: 518-525, 2008
25. Mak RH, Haycock GB, Chantler C: Glucose intolerance in children with chronic renal failure. Kidney Int Suppl 15: S22-S26, 1983
26. Besbas N, Ozaltin F, Coskun T, Ozalp S, Saatci U, Bakkaloglu A, El Nahas AM: Relationship of leptin and insulin-like growth factor I to nutritional status in hemodialyzed children. Pediatr Nephrol 18: 1255-1259, 2003
27. Daschner M, Tonshoff B, Blum WF, Englaro P, Wingen AM, Schaefer F, Wuhl E, Rascher W, Mehls O: Inappropriate elevation of serum leptin levels in children with chronic renal failure. European Study Group for Nutritional Treatment of Chronic Renal Failure in Childhood. J Am Soc Nephrol 9: 1074-1079, 1998
28. Arbeiter AK, Buscher R, Petersenn S, Hauffa BP, Mann K, Hoyer PF: Ghrelin and other appetite-regulating hormones in paediatric patients with chronic renal failure during dialysis and following kidney transplantation. Nephrol Dial Transplant 24: 643-646, 2009
29. Szczepanska M, Szprynger K, Mazur B, Zwolinska D, Kilis-Pstrusinska K, Makulska I: Plasma ghrelin levels in children with chronic renal failure on peritoneal dialysis. Perit Dial Int 27: 61-66, 2007
30. Nusken KD, Groschl M, Rauh M, Stohr W, Rascher W, Dotsch J: Effect of renal failure and dialysis on circulating ghrelin concentration in children. Nephrol Dial Transplant 19: 2156-2157, 2004
31. Ozkaya O, Buyan N, Bideci A, Gonen S, Ortac E, Fidan K, Cinaz P, Soylemezoglu O: Osteoprotegerin and RANKL serum levels and their relationship with serum ghrelin in children with chronic renal failure and on dialysis. Nephron Clin Pract 105: c153-c158, 2007
32. Yoshimoto A, Mori K, Sugawara A, Mukoyama M, Yahata K, Suganami T, Takaya K, Hosoda H, Kojima M, Kangawa K, Nakao K: Plasma ghrelin and desacyl ghrelin concentrations in renal failure. J Am Soc Nephrol 13: 2748-2752, 2002
33. Asakawa A, Inui A, Fujimiya M, Sakamaki R, Shinfuku N, Ueta Y, Meguid MM, Kasuga M: Stomach regulates energy balance via acylated ghrelin and desacyl ghrelin. Gut 54: 18-24, 2005 (Pubitemid 40007213)
34. Patel L, Webb NJ, Bradbury MG, Zaman N, Smith P, Lewis MA, Postlethwaite RJ, Price DA, Clayton PE: Serum leptin and IGF-I during growth hormone treatment in chronic renal failure. Pediatr Nephrol 17: 643-647, 2002 (Pubitemid 36097340)
35. Mehls O, Ritz E, Hunziker EB, Eggli P, Heinrich U, Zapf J: Improvement of growth and food utilization by human recombinant growth hormone in uremia. Kidney Int 33: 45-52, 1988 (Pubitemid 18059653)
36. Santos F, Chan JC, Hanna JD, Niimi K, Krieg RJ Jr, Wellons MD: The effect of growth hormone on the growth failure of chronic renal failure. Pediatr Nephrol 6: 262-266, 1992
37. van der Sluis IM, Boot AM, Nauta J, Hop WC, de Jong MC, Lilien MR, Groothoff JW, van Wijk AE, Pols HA, Hokken-Koelega AC, de Muinck Keizer-Schrama SM: Bone density and body composition in chronic renal failure: Effects of growth hormone treatment. Pediatr Nephrol 15: 221-228, 2000
38. Boot AM, Nauta J, de Jong MC, Groothoff JW, Lilien MR, van Wijk JA, Kist-van Holthe JE, Hokken-Koelega AC, Pols HA, de Muinck Keizer-Schrama SM: Bone mineral density, bone metabolism and body composition of children with chronic renal failure, with and without growth hormone treatment. Clin Endocrinol (Oxf) 49: 665-672, 1998