Liver focal fatty changes at ultrasound after islet transplantation: An early sign of altered graft function?

Diabetic Medicine

Volumn 27, Issue 8, 2010, Pages 960-964

  Venturini, M ^a   Angeli, E ^a   Maffi, P ^a   Losio, C ^a   Pozzi, P ^a   Paties, C ^b   Cellina, M ^a   De Cobelli, F ^a,d   Fiorina, P ^a,c   Secchi, A ^a,c   Del Maschio, A ^a,c  

^a Transplant Unit   (Italy)

^b SAN RAFFAELE HOSPITAL   (Italy)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

^d VITA SALUTE SAN RAFFAELE UNIVERSITY   (Italy)

Author keywords

insulin action; islet; ultrasound

Indexed keywords

C PEPTIDE; CHOLESTEROL; TRIACYLGLYCEROL;

ADULT; ARTICLE; FATTY LIVER; FEMALE; FOLLOW UP; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; KIDNEY TRANSPLANTATION; LIVER BIOPSY; MAJOR CLINICAL STUDY; MALE; PANCREAS ISLET TRANSPLANTATION; POSTOPERATIVE PERIOD; PREVALENCE; RETROSPECTIVE STUDY; ULTRASOUND;

ADULT; BLOOD GLUCOSE; DIABETES MELLITUS, TYPE 1; FATTY LIVER; FEMALE; HUMANS; ISLETS OF LANGERHANS TRANSPLANTATION; MALE; MIDDLE AGED;

EID: 77954804620     PISSN: 07423071     EISSN: 14645491     Source Type: Journal    
DOI: 10.1111/j.1464-5491.2010.03035.x     Document Type: Article

References (11)

1. Markmann JF, Rosen M, Siegelman ES, Soulen MC, Deng S, Barker CS et al. Magnetic resonance-defined periportal steatosis following intraportal islet transplantation. A functional footprint of islet graft survival? Diabetes 2003 52 : 1591 1594.
2. Bhargava R, Senior PA, Ackerman TE, Ryan EA, Paty BW, Lakey JR et al. Prevalence of hepatic steatosis after islet transplantation and its relation to graft function. Diabetes 2004 53 : 1311 1317.
3. Venturini M, Angeli E, Maffi P, Fiorina P, Bertuzzi F, Salvioni M et al. Technique, complications, and therapeutic efficacy in percutaneous transplantation of human pancreatic islet cells in type 1 diabetes: the role of US. Radiology 2005 234 : 617 624.
4. Maffi P, Angeli E, Bertuzzi F, Paties C, Socci C, Fedeli C et al. Minimal focal steatosis of liver after islet transplantation in humans: a long-term study. Cell Transplant 2005 14 : 727 733.
5. Kilworth L, Crane D, Masters C. The influence of insulin on the flux of lipid metabolism in vivo. Biochem Int 1985 10 : 539 547.
6. Shapiro AMJ, Lakey JRT, Ryan EA, Kortbutt JS, Toth E, Warnock GL et al. Insulin independence after solitary islet transplantation in seven patients with type I diabetes mellitus using a glucocorticoid-free immuno-suppressive regimen. N Engl J Med 2000 343 : 230 238.
7. Luzi L, Perseghin G, Brendel MD, Terruzzi I, Battezzati A, Eckard M et al. Metabolic effects of restoring partial beta-cell function after islet allotransplantation in type 1 diabetic patients. Diabetes 2001 50 : 277 282.
8. Ong SL, Pollard C, Rees Y, Garcea G, Webb M, Illouz S et al. Ultrasound changes within the liver after total pancreatectomy and intrahepatic islet cell autotransplantation. Transplantation 2008 85 : 1773 1777.
9. Eckhard M, Lommel D, Hackstein N, Winter D, Ziegler A, Rau W et al. Disseminated periportal fatty generation after allogeneic intraportal islet transplantation in a patient with type 1 diabetes mellitus: a case report. Transplant Proc 2004 36 : 1111 1116.
10. Fiorina P, Vergani A, Petrelli A, D'addio F, Monti L, Abdi R et al. Metabolic and immunological features of the failing islet-transplanted patient. Diabetes Care 2008 31 : 1 3.
11. Lee Y, Ravazzola M, Park BH, Bashmakov YK, Orci L, Unger RH. Metabolic mechanisms of failure of intraportally transplanted pancreatic β-cells in rats. Role of lipotoxicity and prevention by leptin. Diabetes 2007 56 : 2295 2301.