Metabolic and immunological features of the failing islet-transplanted patient

Diabetes Care

Volumn 31, Issue 3, 2008, Pages 436-438

  Fiorina, Paolo ^a,b   Vergani, Andrea ^a,b   Petrelli, Alessandra ^a   D'Addio, Francesca ^b   Monti, Lucilla ^a   Abdi, Reza ^b   Bosi, Emanuele ^a   Maffi, Paola ^a,c   Secchi, Antonio ^a,c  

^a SAN RAFFAELE HOSPITAL   (Italy)

^b BOSTON CHILDREN S HOSPITAL   (United States)

^c VITA SALUTE SAN RAFFAELE UNIVERSITY   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

C PEPTIDE; FAS LIGAND; INSULIN; SOLUBLE INTERLEUKIN 2 RECEPTOR; FASLG PROTEIN, HUMAN; LIPOCORTIN 5;

APOPTOSIS; ARTICLE; CLINICAL ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; FOLLOW UP; GRAFT REJECTION; HUMAN; IMMUNE RESPONSE; INSULIN RELEASE; INSULIN RESISTANCE; PANCREAS ISLET TRANSPLANTATION; POSTOPERATIVE PERIOD; PROTEIN SECRETION; T LYMPHOCYTE ACTIVATION; ADULT; BLOOD; GRAFT SURVIVAL; IMMUNOLOGY; METABOLISM; POSTOPERATIVE COMPLICATION; RETROSPECTIVE STUDY; TIME;

ADULT; ANNEXIN A5; C-PEPTIDE; FAS LIGAND PROTEIN; GRAFT REJECTION; GRAFT SURVIVAL; HUMANS; INSULIN; INSULIN RESISTANCE; ISLETS OF LANGERHANS TRANSPLANTATION; POSTOPERATIVE COMPLICATIONS; RETROSPECTIVE STUDIES; TIME FACTORS;

EID: 44449171511     PISSN: 01495992     EISSN: 19355548     Source Type: Journal    
DOI: 10.2337/dc07-1831     Document Type: Article

References (24)

1. Ricordi C: Islet transplantation: a brave new world. Diabetes 52:1595-1603, 2003
2. Ryan EA, Lakey JR, Rajotte RV, Korbutt GS, Kin T, Imes S, Rabinovitch A, Elliott JF, Bigam D, Kheteman NM, Warnock GL, Larsen I, Shapiro AM: Clinical outcomes and insulin secretion after islet transplantation with the Edmonton Protocol. Diabetes 50:710-719, 2001
3. Ryan EA, Paty BW, Senior PA, Bigam D, Alfadhli E, Kneteman NM, Lakey JR, Shapiro AM: Five-year follow-up after clinical islet transplantation. Diabetes 54:2060-2069, 2005
4. Shapiro AM, Lakey JR, Ryan EA, Korbutt GS, Toth E, Warnock GL, Kneteman NM, Rajotte RV: Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. N Engl J Med 343:230-238, 2000
5. Shapiro AM, Nanji SA, Lakey JR: Clinical islet transplant: current and future directions towards tolerance. Immunol Rev 196: 219-236, 2003
6. Hering BJ, Kandaswamy R, Ansite JD, Eckman PM, Nakano M, Sawada T, Matsumoto I, Ihm SH, Zhang HJ, Parkey J, Hunter DW, Sutherland DE: Single-donor, marginal-dose islet transplantation in patients with type 1 diabetes. JAMA 293:830-835, 2005
7. Fiorina P, Folli F, Bertuzzi F, Maffi P, Finzi G, Venturini M, Socci C, Davalli A, Orsenigo E, Monti L, Falqui L, Uccella S, La Rosa S, Usellini L, Properzi G, Di Carlo V, Del Maschio A, Capella C, Secchi A: Long-term beneficial effect of islet transplantation on diabetic macro-/microangiopathy in type 1 diabetic kidney-transplanted patients. Diabetes Care 26:1129-1136, 2003
8. Fiorina P, Folli F, Maffi P, Placidi C, Venturini M, Finzi G, Bertuzzi F, Davalli A, D'Angelo A, Socci C, Gremizzi C, Orsenigo E, La Rosa S, Ponzoni M, Cardillo M, Scalamogna M, Del Maschio A, Capella C, Di Carlo V, Secchi A: Islet transplantation improves vascular diabetic complications in patients with diabetes who underwent kidney transplantation: a comparison between kidney-pancreas and kidney-alone transplantation. Transplantation 75:1296-1301, 2003
9. Fiorina P, Folli F, Zerbini G, Maffi P, Gremizzi C, Di Carlo V, Socci C, Bertuzzi F, Kashgarian M, Secchi A: Islet transplantation is associated with improvement of renal function among uremic patients with type I diabetes mellitus and kidney transplants. J Am Soc Nephrol 14:21502158, 2003
10. Fiorina P, Gremizzi C, Maffi P, Caldara R, Tavano D, Monti L, Socci C, Folli F, Fazio F, Astorri E, Del Maschio A, Secchi A: Islet transplantation is associated with an improvement of cardiovascular function in type 1 diabetic kidney transplant patients. Diabetes Care 28:1358-1365, 2005
11. Davalli AM, Ogawa Y, Scaglia L, Wu YJ, Hollister J, Bonner-Weir S, Weir GC: Function, mass, and replication of porcine and rat islets transplanted into diabetic nude mice. Diabetes 44:104-111, 1995
12. Braghi S, Bonifacio E, Secchi A, Di Carlo V, Pozza G, Bosi E: Modulation of humoral islet autoimmunity by pancreas allotransplantation influences allograft outcome in patients with type 1 diabetes. Diabetes 49:218-224, 2000
13. Ricordi C, Strom TB: Clinical islet transplantation: advances and immunological challenges. Nat Rev Immunol 4:259-268, 2004
14. Shapiro AM, Ricordi C: Unraveling the secrets of single donor success in islet transplantation. Am J Transplant 4:295-298, 2004
15. Kenyon NS, Chatzipetrou M, Masetti M, Ranuncoli A, Oliveira M, Wagner JL, Kirk AD, Harlan DM, Burkly LC, Ricordi C: Long-term survival and function of intrahepatic islet allografts in rhesus monkeys treated with humanized anti-CD 154. Proc Natl Acad Sci USA 96:8132-8137, 1999
16. Yasuda H, Inoue K, Shibata H, Takeuchi T, Eto Y, Hasegawa Y, Sekine N, Totsuka Y, Mine T, Ogata E, et al: Existence of activin-A in A- and D-cells of rat pancreatic islet. Endocrinology 133:624-630, 1993
17. Ogawa K, Abe K, Kurosawa N, Kurohmaru M, Sugino H, Takahashi M, Hayashi Y: Expression of alpha, beta A and beta B subunits of inhibin or activin and follistatin in rat pancreatic islets. FEBS Lett 319: 217-220, 1993
18. Perseghin G, Caumo A, Sereni LP, Battezzati A, Luzi L: Fasting blood sample-based assessment of insulin sensitivity in kid-ney-pancreas-transplanted patients. Diabetes Care 25:2207-2211, 2002
19. Martin S, Pawlowski B, Greulich B, Ziegler AG, Mandrup-Poulsen T, Mahon J: Natural course of remission in IDDM during 1st yr after diagnosis. Diabetes Care 15:66-74, 1992
20. Finzi G, Davalli A, Placidi C, Finzi G, Davalli A, Placidi C, Usellini L, La Rosa S, Folli F, Capella C: Morphological and ultrastructural features of human islet grafts performed in diabetic nude mice. Ultrastruct Pathol 29:525-533, 2005
21. Ryan EA, LakeyJR, Paty BW, Imes S, Korbutt GS, Kneteman NM, Bigam D, Rajotte RV, Shapiro AM: Successful islet transplantation: continued insulin reserve provides long-term glycemie control. Diabetes 51:2148-2157, 2002
22. Jaeger C, Brendel MD, Hering BJ, Eckhard M, Bretzel RG: Progressive islet graft failure occurs significantly earlier in autoantibody-positive than in autoantibody-negative IDDM recipients of intrahepatic islet allografts. Diabetes 46:1907-1910, 1997
23. Han D, Xu X, Baidal D, LeithJ, Ricordi C, Alejandro R, Kenyon NS: Assessment of cytotoxic lymphocyte gene expression in the peripheral blood of human islet allograft recipients: elevation precedes clinical evidence of rejection. Diabetes 53: 2281-2290, 2004
24. Han D, Xu X, Pastori RL, Ricordi C, Kenyon NS: Elevation of cytotoxic lymphocyte gene expression is predictive of islet allograft rejection in nonhuman primates. Diabetes 51:562-566, 2002