Characterization and transfer studies of macrolide resistance genes in Streptococcus pneumoniae from Denmark

Scandinavian Journal of Infectious Diseases

Volumn 42, Issue 8, 2010, Pages 586-593

  Nielsen, Karen L ^a   Hammerum, Anette M ^a   Lambertsen, Lotte M ^a   Lester, Camilla H ^a   Arpi, Magnus ^b   Knudsen, Jenny D ^c   Stegger, Marc ^a   Tolker Nielsen, Tim ^d   Frimodt Møller, Niels ^a  

^a STATENS SERUM INSTITUT   (Denmark)

^b GENTOFTE UNIVERSITY HOSPITAL   (Denmark)

^c HVIDOVRE HOSPITAL   (Denmark)

^d UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

CHLORAMPHENICOL; CLINDAMYCIN; ERYTHROMYCIN; GENE PRODUCT; MACROLIDE; PENICILLIN G; SULFONAMIDE; TETRACYCLINE; TRIMETHOPRIM; VANCOMYCIN; ANTIINFECTIVE AGENT; BACTERIAL DNA;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL GENE; BACTERIUM DETECTION; BACTERIUM ISOLATE; BACTERIUM TRANSFORMATION; CONJUGATION; CONTROLLED STUDY; DENMARK; ERM GENE; GENE MUTATION; GENE SEQUENCE; GENE TRANSFER; GENOTYPE; MEF GENE; NONHUMAN; NUCLEOTIDE SEQUENCE; SEROTYPING; STREPTOCOCCUS PNEUMONIAE; BACTERIUM CONJUGATION; CHEMISTRY; DNA SEQUENCE; DRUG EFFECTS; GENETICS; HORIZONTAL GENE TRANSFER; HUMAN; ISOLATION AND PURIFICATION; MICROBIAL SENSITIVITY TEST; MICROBIOLOGY; PNEUMOCOCCAL INFECTION; POINT MUTATION;

ANTI-BACTERIAL AGENTS; CONJUGATION, GENETIC; DENMARK; DNA, BACTERIAL; DRUG RESISTANCE, BACTERIAL; GENE TRANSFER, HORIZONTAL; HUMANS; MACROLIDES; MICROBIAL SENSITIVITY TESTS; PNEUMOCOCCAL INFECTIONS; POINT MUTATION; SEQUENCE ANALYSIS, DNA; STREPTOCOCCUS PNEUMONIAE; TRANSFORMATION, BACTERIAL;

EID: 77954789453     PISSN: 00365548     EISSN: 16511980     Source Type: Journal    
DOI: 10.3109/00365541003754451     Document Type: Article

References (26)

1. DANMAP 2007. Use of antimicrobial agents and occurrence of antimicrobial resistance in bacteria from food animals, foods and humans in Denmark; 2007. Available at: http:// www.danmap.org/pdfFiles/Danmap-2007.pdf (accessed August 2009).
2. ESAC-European Surveillance of Antimicrobial Consumption. ESAC Yearbook 2007. Available at: http://www.esac. ua.ac.be/main.aspx?c=*ESAC2&n= 50036 (accessed October 2009).
3. Littauer P, Sangvik A, Caugant DA, Hoiby EA, Simonsen GS, Sundsfjord A. Molecular epidemiology of macrolideresistant isolates of Streptococcus pneumoniae collected from blood and respiratory specimens in Norway. J Clin Microbiol 2005;43:2125-2132
4. Cochetti I, Vecchi M, Mingoia M, Tili E, Catania MR, Manzin A, et al. Molecular characterization of pneumococci with efflux-mediated erythromycin resistance and identification of a novel mef gene subclass, mef (I). Antimicrob Agents Chemother 2005;49:4999-5006.
5. Siira L, Rantala M, Jalava J, Hakanen AJ, Huovinen P, Kaijalainen T, et al. Temporal trends of antimicrobial resistance and clonality of invasive Streptococcus pneumoniae isolates in Finland, 2002 to 2006. Antimicrob Agents Chemother 2009;53:2066-2073
6. Calatayud L, Ardanuy C, Cercenado E, Fenoll A, Bouza E, Pallares R, et al. Serotypes, clones, and mechanisms of resistance of erythromycin-resistant Streptococcus pneumoniae isolates collected in Spain. Antimicrob Agents Chemother 2007;51:3240-3246
7. de la Pedrosa EG, Baquero F, Loza E, Nadal-Serrano JM, Fenoll A, Del Campo R, et al. High clonal diversity in erythromycin- resistant Streptococcus pneumoniae invasive isolates in Madrid, Spain (2000-2007). J Antimicrob Chemother 2009;64:1165-1169
8. Lambertsen LM, Harboe ZB, Konradsen HB, Christensen JJ, Hammerum AM. Non-invasive erythromycin-resistant pneumococcal isolates are more often non-susceptible to more antimicrobial agents than invasive isolates. Int J Antimicrob Agents 2010;35:72-75
9. Goossens H. Antibiotic consumption and link to resistance. Clin Microbiol Infect 2009;15(Suppl 3):12-15
10. Gaustad P, Morrison DA. Induction of transformation in streptococci by synthetic competence stimulating peptides. Methods Cell Sci 1998;20:65-70.
11. Rosco. Neosensitabs susceptibility testing: users guide. 18t h ed. Taastrup, Denmark: Rosco; 2005.
12. Fiebelkorn KR, Crawford SA, McElmeel ML, Jorgensen JH. Practical disk diffusion method for detection of inducible clindamycin resistance in Staphylococcus aureus and coagulase- negative staphylococci. J Clin Microbiol 2003;41: 4740-4744
13. Clinical and Laboratory Standards Institute. Performance standards for antimicrobial susceptility testing. 17 th Informational Supplement. CLSI document M100-S17. Wayne, PA: CLSI; 2007.
14. Nielsen HU, Hammerum AM, Ekelund K, Bang D, Pallesen LV, Frimodt-Moller N. Tetracycline and macrolide co-resistance in Streptococcus pyogenes: co-selection as a reason for increase in macrolide-resistant S. pyogenes? Microb Drug Resist 2004;10:231-238
15. Del Grosso M, Iannelli F, Messina C, Santagati M, Petrosillo N, Stefani S, et al. Macrolide efflux genes mef (A) and mef (E) are carried by different genetic elements in Streptococcus pneumoniae. J Clin Microbiol 2002;40:774-778
16. Aarestrup FM, Agerso Y, Gerner-Smidt P, Madsen M, Jensen LB. Comparison of antimicrobial resistance phenotypes and resistance genes in Enterococcus faecalis and Enterococcus faecium from humans in the community, broilers, and pigs in Denmark. Diagn Microbiol Infect Dis 2000;37:127-137
17. Lester CH, Frimodt-Moller N, Hammerum AM. Conjugal transfer of aminoglycoside and macrolide, resistance between Enterococcus faecium isolates in the intestine of streptomycin-treated mice. FEMS Microbiol Lett 2004;235:385-391
18. Luna VA, Roberts MC. The presence of the t etO gene in a variety of tetracycline-resistant Streptococcus pneumoniae serotypes from Washington State. J Antimicrob Chemother 1998;42:613-619
19. Giovanetti E, Magi G, Brenciani A, Spinaci C, Lupidi R, Facinelli B, et al. Conjugative transfer of the erm (A) gene from erythromycin-resistant Streptococcus pyogenes to macrolide- susceptible S. pyogenes, Enterococcus faecalis and Listeria innocua. J Antimicrob Chemother 2002;50:249-252
20. Havarstein LS, Coomaraswamy G, Morrison DA. An unmodified heptadecapeptide pheromone induces competence for genetic-transformation in Streptococcus pneumoniae. Proc Natl Acad Sci U S A 1995;92:11140-11144
21. Amezaga MR, Carter PE, Cash P, McKenzie H. Molecular epidemiology of erythromycin resistance in Streptococcus pneumoniae isolates from blood and noninvasive sites. J Clin Microbiol 2002;40:3313-3318
22. Foster D, Knox K, Walker AS, Griffiths DT, Moore H, Haworth E, et al. Invasive pneumococcal disease: epidemiology in children and adults prior to implementation of the conjugate vaccine in the Oxfordshire region, England. J Med Microbiol 2008;57(Pt 4):480-487
23. Del Grosso M, d' A busco AS, Iannelli F, Pozzi G, Pantosti A. Tn2009, a Tn916-like element containing mef (E) in Streptococcus pneumoniae. Antimicrob Agents Chemother 2004;48:2037-2042
24. Macrina FL, Archer GL. Conjugation and broad host range plasmids in streptococci and staphylococci. In: Clewell DB, editor. Bacterial conjugation. New York: Plenum Press; 1993.
25. Tenover FC. Development and spread of bacterial resistance to antimicrobial agents: an overview. Clin Infect Dis 2001; 33:S108-15.
26. Mingoia M, Vecchi M, Cochetti I, et al. Composite structure of Streptococcus pneumoniae containing the erythromycin efflux resistance gene mef (I) and the chloramphenicol resistance gene catQ . Antimicrob Agents Chemother 2007;51: 3983-3987