Involvement of JNK signal transduction pathway in endothelial cell apoptosis induced by intermittent high glucose

Journal of Central South University (Medical Sciences)

Volumn 35, Issue 6, 2010, Pages 616-621

  Lei, Minxiang ^a   Tang, Zhimin ^a,b  

^a CENTRAL SOUTH UNIVERSITY   (China)

^b First People's Hospital of Yueyang   (China)

Author keywords

Apoptosis; Intermittent high glucose; Oxidative stress; Vascular endothelial cells

Indexed keywords

GLUCOSE; STRESS ACTIVATED PROTEIN KINASE;

APOPTOSIS; ARTICLE; CELL CULTURE; CYTOLOGY; DRUG EFFECT; ENDOTHELIUM CELL; GENETICS; HUMAN; PATHOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION; UMBILICAL VEIN;

APOPTOSIS; CELLS, CULTURED; ENDOTHELIAL CELLS; GLUCOSE; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; SIGNAL TRANSDUCTION; UMBILICAL VEINS;

EID: 77954781366     PISSN: 16727347     EISSN: None     Source Type: Journal    
DOI: 10.3969/j.issn.1672-7347.2010.06.013     Document Type: Article

References (10)

1. Del Prato S. In search of normoglycemia in diabetes: controlling postprandial glucose [J]. Int J Obes, 2002, 26 (Suppl 3): S9-S17.
2. Azuma K, Kawamori R, Toyofuku Y, et al. Repetitive fluctuations in blood glucose enhance monocyte adhesion to the endothelium of rat troracic aorta [J]. Arterioscler Thromb Vase Biol, 2006, 26(10): 2275-2280.
3. Geiss L S, Herman W H, Smith P J. Mortality in non-insulin-dependent diabetes [M]//Diabetes in America. 2nd ed. Washington, DC: US Government Printing Office, 1995: 233-257.
4. Mita T, Otsuka A, Azuma K, et al. Swings in blood glucose levels accelerate atherogenesis in apolipoprotein E2 deficient mice [J]. Biochem Biophys Res Commun, 2007, 358 (3): 679-685.
5. Dimmeler S, Zeiher A M. Endothelial cell apoptosis in an- giogenesis and vessel regression [J]. Circulation Res, 2000, 87(6): 434-439.
6. Irani K. Oxidant signaling in vascular cell growth, death, and survival: A review of the roles of reactive oxygen species in smooth muscle and endothelial cell autogenic and apoptotic signaling [J]. Circ Res, 2000, 87(3): 197-1183
7. Piconi L, Corgnali M, Da Ros R, et al. The protective effect of rosuvastatin in human umbilical endothelial cells exposed to constant or intermittent high glucose [J]. J Diabetes Complications, 2008, 22(1): 38-45.
8. Beckman J A, Goldfine A B, Gordon M B, et al. Ascor-bate restores endothelium-dependent vasodilation impaired by acute hyperglycemia in humans [J]. Circulation, 2001, 103(12): 1618-1623.
9. Chen Y R, Tan T H. The c-Jun N-terminal kinase pathway and apoptotic signaling [J]. Int J Oncol, 2000, 16(4): 651-662.
10. Piconi L, Quagliaro L, Assaloni R, et al. Constant and intermittent high glucose enhances endothelial cell apoptosis through mitochondrial superoxide overproduction [J]. Diabetes Metab Res Rev, 2006, 22(3): 198-203.