PKC-δ and-η, MEKK-1, MEK-6, MEK-3, and p38-δ Are essential mediators of the response of normal human epidermal keratinocytes to differentiating agents

Journal of Investigative Dermatology

Volumn 130, Issue 8, 2010, Pages 2017-2030

  Adhikary, Gautam ^a   Chew, Yap Ching ^a   Reece, E Albert ^a   Eckert, Richard L ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; INVOLUCRIN; MITOGEN ACTIVATED PROTEIN KINASE 13; MITOGEN ACTIVATED PROTEIN KINASE KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE 6; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE 1; PHORBOL 13 ACETATE 12 MYRISTATE; POLYPHENOL; PROTEIN KINASE C DELTA; PROTEIN KINASE C ETA; SMALL INTERFERING RNA;

ARTICLE; CELL DIFFERENTIATION; CELL STRUCTURE; CONTROLLED STUDY; DNA BINDING; GENE SILENCING; HUMAN; HUMAN CELL; KERATINOCYTE; MEDIATOR; PRIORITY JOURNAL; PROMOTER REGION; TEA;

ANTICARCINOGENIC AGENTS; CALCIUM; CARCINOGENS; CATECHIN; CELL DIFFERENTIATION; CELLS, CULTURED; EPIDERMIS; HUMANS; KERATINOCYTES; MAP KINASE KINASE 3; MAP KINASE KINASE 6; MAP KINASE KINASE KINASE 1; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASE 13; PROMOTER REGIONS, GENETIC; PROTEIN KINASE C; PROTEIN KINASE C-DELTA; PROTEIN PRECURSORS; RNA, SMALL INTERFERING; TETRADECANOYLPHORBOL ACETATE; TRANSCRIPTION FACTOR AP-1;

EID: 77954758155     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2010.108     Document Type: Article

References (60)

1. Acs P, Beheshti M, Szallasi Z et al. (2000) Effect of a tyrosine 155 to phenylalanine mutation of protein kinase cdelta on the proliferative and tumorigenic properties of NIH 3T3 fibroblasts. Carcinogenesis 21:887-891
2. Alt A, Ohba M, Li L et al. (2001) Protein kinase Cdelta-mediated phosphorylation of alpha6beta4 is associated with reduced integrin localization to the hemidesmosome and decreased keratinocyte attachment. Cancer Res 61:4591-4598
3. Amar LS, Shabana A, Oboeuf M et al. (1998) Desmosomes are regulated by protein kinase C in primary rat epithelial cells. Cell Adhes Commun 5:1-12
4. Ashendel CL (1985) The phorbol ester receptor: a phospholipid-regulated protein kinase. Biochim Biophys Acta 822:21 9
5. AzizMH, Sundling KE, Dreckschmidt NE, et al. (2009) Protein kinase Cepsilon inhibits UVR-induced expression of FADD, an adaptor protein, linked to both Fas- and TNFR1-mediated apoptosis. J Invest Dermatol 129:2011-2021
6. Balasubramanian S, Eckert RL (2004) Green tea polyphenol and curcumin inversely regulate human involucrin promoter activity via opposing effects on CCAAT/enhancer-binding protein function. J Biol Chem 279:24007-24014
7. Balasubramanian S, Efimova T, Eckert RL (2002) Green tea polyphenol stimulates a Ras, MEKK1, MEK3, and p38 cascade to increase activator protein 1 factor-dependent involucrin gene expression in normal human keratinocytes. J Biol Chem 277:1828-1836
8. Balasubramanian S, Sturniolo MT, Dubyak GR et al. (2005) Human epidermal keratinocytes undergo (-)-epigallocatechin-3-gallate-dependent differentiation but not apoptosis. Carcinogenesis 26:1100-1108
9. Bikle DD, Ng D, Oda Y et al. (2002) The vitamin D response element of the involucrin gene mediates its regulation by 1,25-dihydroxyvitamin D3. ; Invest Dermatol 119:1109-1113
10. Bikle DD, Ng D, Tu CL et al. (2001) Calcium- and vitamin D-regulated keratinocyte differentiation. Mol Cell Endocrinol 177:161-171
11. Chang L, Karin M (2001) Mammalian MAP kinase signalling cascades. Nature 410:37-0
12. Chen Z, Gibson TB, Robinson F et al. (2001) MAP kinases. Chem Rev 101:2449-2476
13. Cobb MH (1999) MAP kinase pathways. Prog Biophys Mol Biol 71: 479-500
14. CobbMH, Goldsmith EJ (2000) Dimerization in MAP-kinase signaling. Trends Biochem Sci 25:7-9
15. DCosta AM, Denning MF (2005) A caspase-resistant mutant of PKC-delta protects keratinocytes from UV-induced apoptosis. Cell Death Differ 12:224-232
16. DCosta AM, Robinson JK, Maududi T et al. (2005) The proapoptotic tumor suppressor protein kinase C-delta is lost in human squamous cell carcinomas. Oncogene 25:378-386
17. Dashti SR, Efimova T, Eckert RL (2001a) MEK6 regulates human involucrin gene expression via a p38alpha- and p38delta-dependent mechanism. ; Biol Chem 276:27214-27220
18. Denning MF, Dlugosz AA, Cheng C et al. (2000) Cross-talk between epidermal growth factor receptor and protein kinase C during calcium-induced differentiation of keratinocytes. Exp Dermatol 9:192-199
19. Deucher A, Efimova T, Eckert RL (2002) Calcium-dependent involucrin expression is inversely regulated by protein kinase C (PKC)alpha and PKCdelta. ; Biol Chem 277:17032-0
20. Dlugosz AA, Mischak H, Mushinski JF et al. (1992) Transcripts encoding protein kinase C-alpha, -delta, -epsilon, -zeta, and -eta are expressed in basal and differentiating mouse keratinocytes in vitro and exhibit quantitative changes in neoplastic cells. Mol Carcinog 5:286-292
21. Dlugosz AA, Yuspa SH (1994) Protein kinase C regulates keratinocyte transglutaminase (TGK) gene expression in cultured primary mouse epidermal keratinocytes induced to terminally differentiate by calcium. ; Invest Dermatol 102:409-414
22. Eckert RL, Crish JF, Efimova T et al. (2006) Opposing action of curcumin and green tea polyphenol in human keratinocytes. Mol Nutr Food Res 50:123-129
23. Eckert RL, Crish JF, Efimova T et al. (2004) Regulation of involucrin gene expression. J Invest Dermatol 123:13-22
24. Eckert RL, Efimova T, Balasubramanian S, et al. (2003) p38 Mitogen-activated protein kinases on the body surface - a function for p38delta. J Invest Dermatol 120:823-828
25. Eckert RL, Efimova T, Dashti SR et al. (2002) Keratinocyte survival, differentiation, and death: many roads lead to mitogen-activated protein kinase. J Invest Dermatol Symp Proc 73-A0
26. Efimova T, Broome AM, Eckert RL (2003) A regulatory role for p38 delta MAPK in keratinocyte differentiation. Evidence for p38 delta-ERK1/2 complex formation. J Biol Chem 278:34277-34285
27. Efimova T, Broome AM, Eckert RL (2004) Protein kinase Cdelta regulates keratinocyte death and survival by regulating activity and subcellular localization of a p38delta-extracellular signal-regulated kinase 1/2 complex. Mol Cell Biol 24:8167-8183
28. Efimova T, Deucher A, Kuroki T, et al. (2002) Novel protein kinase C isoforms regulate human keratinocyte differentiation by activating a p38 delta mitogen-activated protein kinase cascade that targets CCAAT/enhancer-binding protein alpha. J Biol Chem 277:31753-31760
29. Efimova T, Eckert RL (2000) Regulation of human involucrin promoter activity by novel protein kinase C isoforms. J Biol Chem 275:1601-1607
30. Efimova T, LaCelle P, Welter JF, et al. (1998) Regulation of human involucrin promoter activity by a protein kinase C, Ras, MEKK1, MEK3, p38/RK, AP1 signal transduction pathway. J Biol Chem 273:24387-24395
31. Fisher GJ, Tavakkol A, Leach K et al. (1993) Differential expression of protein kinase C isoenzymes in normal and psoriatic adult human skin: reduced expression of protein kinase C-beta II in psoriasis. J Invest Dermatol 101:553-559
32. Gherzi R, Sparatore B, Patrone M, et al. (1992) Protein kinase C mRNA levels and activity in reconstituted normal human epidermis: relationships to cell differentiation. Biochem Biophys Res Commun 184:283-291
33. Gschwendt M, Kielbassa K, Kittstein W et al. (1994) Tyrosine phosphorylation and stimulation of protein kinase C delta from porcine spleen by src in vitro. Dependence on the activated state of protein kinase C delta. FEBS Lett 347′:8S-9
34. Hara T, Saito Y, Hirai T et al. (2005) Deficiency of protein kinase Calpha in mice results in impairment of epidermal hyperplasia and enhancement of tumor formation in two-stage skin carcinogenesis. Cancer Res 65:7356-7362
35. Jerome-Morais A, Rahn HR, Tibudan SS, et al. (2009) Role for protein kinase C-alpha in keratinocyte growth arrest. J Invest Dermatol 129:2365-2375
36. Kazanietz MG (2005) Targeting protein kinase C and "non-kinase" phorbol ester receptors: emerging concepts and therapeutic implications. Biochim Biophys Acta 1754:296-304
37. Kimura TE, Merritt AJ, Garrod DR (2007) Calcium-independent desmosomes of keratinocytes are hyper-adhesive. J Invest Dermatol 127:775-781
38. Kitajima Y, Aoyama Y, Seishima M (1999) Transmembrane signaling for adhesive regulation of desmosomes and hemidesmosomes, and for cell-cell detachment induced by pemphigus IgG in cultured keratinocytes: involvement of protein kinase C. J Investig Dermatol Symp Proc 4:137-4
39. Kraft CA, Efimova T, Eckert RL (2007) Activation of PKCdelta and p38delta MAPK during okadaic acid dependent keratinocyte apoptosis. Arch Dermatol Res 299:71-83
40. LaCelle PT, Lambert A, Ekambaram MC et al. (1998) In vitro cross-linking of recombinant human involucrin. Skin Pharmacol Appl Skin Physiol 11:214-226
41. 2+inhibits murine keratinocyte differentiation in vitro.I Cell Physiol 163: 105-114
42. Mellor H, Parker PJ (1998) The extended protein kinase C superfamily. Biochem J 332(Part 2):281-292
43. Newton AC (1997) Regulation of protein kinase C. Curr Opin Cell Biol 9:161-167
44. Nishizuka Y (1992) Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. Science 258:607-614
45. Ono Y, Fujii T, Ogita K, et al. (1 989) Protein kinase C zeta subspecies from rat brain: its structure, expression, and properties. Proc Natl Acad Sci USA 86:3099-3103
46. Osada S, Mizuno K, Saido TC et al. (1990) A phorbol ester receptor/protein kinase, nPKC eta, a new member of the protein kinase C family predominantly expressed in lung and skin. J Biol Chem 265:22434-1-0
47. Raman M, Chen W, Cobb MH (2007) Differential regulation and properties of MAPKs. Oncogene 26:3100-3112
48. Rosse C, Linch M, Kermorgant S, et al. (2010) PKC and the control of localized signal dynamics. Nat Rev Mol Cell Biol 11:103-112
49. Sharkey NA, Leach KL, Blumberg PM (1984) Competitive inhibition by diacylglycerol of specific phorbol ester binding. Proc Natl Acad Sci USA 81:607-610
50. Shen S, Alt A, Wertheimer E et al. (2001) PKCdelta activation: a divergence point in the signaling of insulin and IGF-1-induced proliferation of skin keratinocytes. Diabetes 50:255-264
51. Sheu HM, Kitajima Y, Yaoita H (1989) Involvement of protein kinase C in translocation of desmoplakins from cytosol to plasma membrane during desmosome formation in human squamous cell carcinoma cells grown in low to normal calcium concentration. Exp Cell Res 185:176-190
52. Sitailo LA, Tibudan SS, Denning MF (2006) The protein kinase C delta catalytic fragment targets Mcl-1 for degradation to trigger apoptosis. ; Biol Chem 281:29703-29710
53. Uhlik MT, Abell AN, Cuevas BD et al. (2004) Wiring diagrams of MAPK regulation by MEKK1, 2, and 3. Biochem Cell Biol 82:658-663
54. Verma AK, Wheeler DL, Aziz MH, et al. (2006) Protein kinase Cepsilon and development of squamous cell carcinoma, the nonmelanoma human skin cancer. Mol Carcinog 45:381-388
55. Welter JF, Crish JF, Agarwal C et al. (1995) Fos-related antigen (Fra-1), junB, and junD activate human involucrin promoter transcription by binding to proximal and distal AP1 sites to mediate phorbol ester effects on promoter activity. J Biol Chem 270:12614-12622
56. Welter JF, Eckert RL (1995) Differential expression of fos and jun family members c-fos, fosB, Fra-1, Fra-2, c-jun, junB and junD during human epidermal keratinocyte differentiation. Oncogene 11:2681-2687
57. Welter JF, Gali H, Crish JF et al. (1996) Regulation of human involucrin promoter activity by POU domain proteins. J Biol Chem 271:14727-14733
58. Wheeler DL, Reddig PJ, Dreckschmidt NE, et al. (2002) Protein kinase Cdelta-mediated signal to ornithine decarboxylase induction is independent of skin tumor suppression. Oncogene 21:3620-3630
59. Yaar M, Gilani A, DiBenedetto PJ et al. (1993) Gene modulation accompanying differentiation of normal versus malignant keratinocytes. Exp Cell Res 206:235-3
60. Zhu L, Brodie C, Balasubramanian S, et al. (2008) Multiple PKCdelta tyrosine residues are required for PKCdelta-dependent activation of involucrin expression-a key role of PKCdelta-Y(311). J Invest Dermatol 128:833:1-5