FGF signalling in prostate development, tissue homoeostasis and tumorigenesis

Bioscience Reports

Volumn 30, Issue 5, 2010, Pages 285-291

  Lin, Yongshun ^a   Wang, Fen ^b  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UNIVERSITY OF TEXAS   (United States)

Author keywords

Development; Fibroblast growth factor (FGF); Fibroblast growth factor receptor (FGFR); Prostate; Tissue homoeostasis; Tumorigenesis

Indexed keywords

ANDROGEN; FIBROBLAST GROWTH FACTOR; FIBROBLAST GROWTH FACTOR RECEPTOR;

CARCINOGENESIS; EPITHELIAL MESENCHYMAL TRANSITION; GAIN OF FUNCTION MUTATION; GENE MUTATION; HOMEOSTASIS; HORMONE ACTION; HORMONE DEPENDENCE; HUMAN; LOSS OF FUNCTION MUTATION; MOLECULAR INTERACTION; NONHUMAN; ORGANOGENESIS; PARACRINE SIGNALING; PROSTATE CANCER; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVIEW; SIGNAL TRANSDUCTION; ANIMAL; GENETICS; GROWTH, DEVELOPMENT AND AGING; MALE; METABOLISM; PATHOLOGY; PHYSIOLOGY; PROSTATE; PROSTATE TUMOR;

ANDROGENS; ANIMALS; FIBROBLAST GROWTH FACTORS; HOMEOSTASIS; HUMANS; MALE; PROSTATE; PROSTATIC NEOPLASMS; RECEPTORS, FIBROBLAST GROWTH FACTOR; SIGNAL TRANSDUCTION;

EID: 77954746538     PISSN: 01448463     EISSN: None     Source Type: Journal    
DOI: 10.1042/BSR20100020     Document Type: Review

References (52)

1. McKeehan, W. L., Wang, F. and Kan, M (1998) The heparan sulfate-fibroblast growth factor family: diversity of structure and function. Prog. Nucleic Acid Res. Mol. Biol. 59, 135-176
2. Powers, C. J., McLeskey, S. W. and Wellstein, A. (2000) Fibroblast growth factors, their receptors and signaling. Endocr. Relat. Cancer 7, 165-197
3. Ornitz, D. M. and Itoh, N. (2001) Fibroblast growth factors. Genome Biol. 2, REVIEWS3005
4. Thomson, A. A. (2001) Role of androgens and fibroblast growth factors in prostatic development. Reproduction 121, 187-195 (Pubitemid 32175541)
5. Lu, W., Luo, Y., Kan, M. and McKeehan, W. L. (1999) Fibroblast growth factor-10. A second candidate stromal to epithelial cell andromedin in prostate. J. Biol. Chem. 274, 12827-12834
6. Thomson, A. A. and Cunha, G. R. (1999) Prostatic growth and development are regulated by FGF10. Development 126, 3693-3701
7. Huang, L., Pu, Y., Alam, S., Birch, L. and Prins, G. S. (2005) The role of Fgf10 signaling in branching morphogenesis and gene expression of the rat prostate gland: lobe-specific suppression by neonatal estrogens. Dev. Biol. 278, 396-414
8. Lin, Y., Liu, G., Zhang, Y., Hu, Y P., Yu, K., Lin, C., McKeehan, K., Xuan, J. W., Ornitz, D. M., Shen, M. M. et al. (2007) Fibroblast growth factor receptor 2 tyrosine kinase is required for prostatic morphogenesis and the acquisition of strict androgen dependency for adult tissue homeostasis. Development 134, 723-734
9. Donjacour, A. A., Thomson, A. A. and Cunha, G. R. (2003) FGF-10 plays an essential role in the growth of the fetal prostate. Dev. Biol. 261, 39-54
10. Acevedo, V. D., Gangula, R. D., Freeman, K. W., Li, R., Zhang, Y., Wang, F., Ayala, G. E., Peterson, L. E., Ittmann, M. and Spencer, D. M. (2007) Inducible FGFR-1 activation leads to irreversible prostate adenocarcinoma and an epithelial-to-mesenchymal transition. Cancer Cell 12, 559-571
11. Memarzadeh, S., Xin, L., Mulholland, D. J., Mansukhani, A., Wu, H., Teitell, M. A. and Witte, O. N. (2007) Enhanced paracrine FGF10 expression promotes formation of multifocal prostate adenocarcinoma and an increase in epithelial androgen receptor. Cancer Cell 12, 572-585
12. Zhang, Y., Zhang, J., Lin, Y., Lan, Y., Lin, C., Xuan, J. W., Shen, M. M., McKeehan, W. L., Greenberg, N. M. and Wang, F. (2008) Role of epithelial cell fibroblast growth factor receptor substrate 2α in prostate development, regeneration and tumorigenesis. Development 135, 775-784
13. Itoh, N. and Ornitz, D. M. (2004) Evolution of the Fgf and Fgfr gene families. Trends Genet. 20, 563-569
14. Bottcher, R. T. and Niehrs, C. (2005) Fibroblast growth factor signaling during early vertebrate development. Endocr. Rev. 26, 63-77
15. Linhardt, R. J. (2003) 2003 Claude S. Hudson Award address in carbohydrate chemistry. Heparin: structure and activity. J. Med. Chem. 46, 2551-2564
16. Kan, M., Wang, F., Xu, J., Crabb, J. W., Hou, J. and McKeehan, W. L. (1993) An essential heparin-binding domain in the fibroblast growth factor receptor kinase. Science 259, 1918-1921
17. Nurcombe, V., Ford, M. D., Wildschut, J. A. and Bartlett, P. F. (1993) Developmental regulation of neural response to FGF-1 and FGF-2 by heparan sulfate proteoglycan. Science 260, 103-106
18. Ornitz, D. M. (2000) FGFs, heparan sulfate and FGFRs: complex interactions essential for development. Bioessays 22, 108-112
19. Luo, Y., Ye, S., Kan, M. and McKeehan, W. L. (2006) Control of fibroblast growth factor (FGF) 7- and FGF1-induced mitogenesis and downstream signaling by distinct heparin octasaccharide motifs. J. Biol. Chem. 281, 21052-21061
20. Eswarakumar, V. P., Lax, I. and Schlessinger, J. (2005) Cellular signaling by fibroblast growth factor receptors. Cytokine Growth Factor Rev. 16, 139-149
21. Wang, F., Kan, M., Xu, J., Yan, G. and McKeehan, W. L. (1995) Ligand-specific structural domains in the fibroblast growth factor receptor. J. Biol. Chem. 270, 10222-10230
22. 2-terminal immunoglobulin-like Loop I in the ectodomain of the fibroblast growth factor (FGF) receptor 1 lowers affinity for both heparin and FGF-1. J. Biol. Chem. 270, 10231-10235
23. Zhang, Y., Lin, Y., Bowles, C. and Wang, F. (2004) Direct cell cycle regulation by the fibroblast growth factor receptor (FGFR) kinase through phosphorylation-dependent release of Cks1 from FGFR substrate 2. J. Biol. Chem. 279, 55348-55354
24. Mohammadi, M., Dionne, C. A., Li, W., Li, N., Spivak, T., Honegger, A. M., Jaye, M. and Schlessinger, J. (1992) Point mutation in FGF receptor eliminates phosphatidylinositol hydrolysis without affecting mitogenesis. Nature 358, 681-684
25. Peters, K. G., Escobedo, J. A., Fantl, W. J. and Williams, L. T. (1992) Interactions of PDGF and FGF receptors with cytoplasmic signaling molecules. Cold Spring Harb. Symp. Quant. Biol. 57, 63-66
26. Hadari, Y. R., Gotoh, N., Kouhara, H., Lax, I. and Schlessinger, J. (2001) Critical role for the docking-protein FRS2α in FGF receptor-mediated signal transduction pathways. Proc. Natl. Acad. Sci. U.S.A. 98, 8578-8583
27. Wang, F., McKeehan, K., Yu, C. and McKeehan, W. L. (2002) Fibroblast growth factor receptor 1 phosphotyrosine 766: molecular target for prevention of progression of prostate tumors to malignancy. Cancer Res. 62, 1898-1903
28. Shen, MM. and Abate-Shen, C. (2003) Roles of the Nkx3.1 homeobox gene in prostate organogenesis and carcinogenesis. Dev. Dyn. 228, 767-778
29. Bhatia-Gaur, R., Donjacour, A. A., Sciavolino, P. J., Kim, M., Desai, N., Young, P., Norton, C. R., Gridley, T., Cardiff, R. D. and Cunha, G. R. et al (1999) Roles for Nkx3.1 in prostate development and cancer. Genes Dev. 13, 966-977
30. Cunha, G. R. and Baskin, L. (2004) Development of the penile urethra. Adv. Exp. Med. Biol. 545, 87-102
31. Hayward, S. W., Baskin, L. S., Haughney, P. C., Foster, B. A., Cunha, A. R., Dahiya, R., Prins, G. S. and Cunha, G. R. (1996) Stromal development in the ventral prostate, anterior prostate and seminal vesicle of the rat. Acta Anat. 155, 94-103
32. Cunha, G. R., Hayward, S. W., Dahiya, R. and Foster, B. A. (1996) Smooth muscle-epithelial interactions in normal and neoplastic prostatic development. Acta Anat. 155, 63-72
33. Baskin, L. S., Hayward, S. W., Young, P. F. and Cunha, G. R. (1996) Ontogeny of the rat bladder: smooth muscle and epithelial differentiation. Acta Anat. 155, 163-171
34. Sugimura, Y., Cunha, G. R. and Donjacour, A. A. (1986) Morphological and histological study of castration-induced degeneration and androgen-induced regeneration in the mouse prostate. Biol. Reprod. 34, 973-983
35. Heinlein, C. A. and Chang, C. (2004) Androgen receptor in prostate cancer. Endocr. Rev. 25, 276-308
36. Jin, C., Wang, F., Wu, X., Yu, C., Luo, Y. and McKeehan, W. L. (2004) Directionally specific paracrine communication mediated by epithelial FGF9 to stromal FGFR3 in two-compartment premalignant prostate tumors. Cancer Res. 64, 4555-4562
37. Yan, G., Fukabori, Y., McBride, G., Nikolaropolous, S. and McKeehan, W. L. (1993) Exon switching and activation of stromal and embryonic fibroblast growth factor (FGF)-FGF receptor genes in prostate epithelial cells accompany stromal independence and malignancy. Mol. Cell. Biol. 13, 4513-4522
38. Sugimura, Y., Foster, B. A., Hom, Y. K., Lipschutz, J. H., Rubin, J. S., Finch, P. W., Aaronson, S. A., Hayashi, N., Kawamura, J. and Cunha, G. R. (1996) Keratinocyte growth factor (KGF) can replace testosterone in the ductal branching morphogenesis of the rat ventral prostate. Int. J. Dev. Biol. 40, 941-951
39. Guo, L., Degenstein, L. and Fuchs, E. (1996) Keratinocyte growth factor is required for hair development but not for wound healing. Genes Dev. 10, 165-175 (Pubitemid 26044604)
40. Zhang, X., Ibrahimi, O. A., Olsen, S. K., Umemori, H., Mohammadi, M. and Ornitz, D. M. (2006) Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family. J. Biol. Chem. 281, 15694-15700
41. Peehl, D. M. and Rubin, J. S. (1995) Keratinocyte growth factor: an androgen-regulated mediator of stromal-epithelial interactions in the prostate. World J. Urol. 13, 312-317
42. Yan, G., Fukabori, Y., Nikolaropoulos, S., Wang, F. and McKeehan, W. L. (1992) Heparin-binding keratinocyte growth factor is a candidate stromal-to-epithelial-cell andromedin. Mol. Endocrinol. 6, 2123-2128
43. Nishi, N., Oya, H., Matsumoto, K., Nakamura, T., Miyanaka, H. and Wada, F. (1996) Changes in gene expression of growth factors and their receptors during castration-induced involution and androgen-induced regrowth of rat prostates. Prostate 28, 139-152
44. Zhang, Y., McKeehan, K., Lin, Y., Zhang, J. and Wang, F. (2008) Fibroblast growth factor receptor 1 (FGFR1) tyrosine phosphorylation regulates binding of FGFR substrate 2α (FRS2α) but not FRS2 to the receptor. Mol. Endocrinol. 22, 167-175
45. Dorkin, T. J., Robinson, M. C., Marsh, C., Bjartell, A., Neal, D. E. and Leung, H. Y. (1999) FGF8 over-expression in prostate cancer is associated with decreased patient survival and persists in androgen independent disease. Oncogene 18, 2755-2761
46. Giri, D. and Ittmann, M. (1999) Inactivation of the PTEN tumor suppressor gene is associated with increased angiogenesis in clinically localized prostate carcinoma. Hum. Pathol. 30, 419-424
47. Feng, S., Wang, F., Matsubara, A., Kan, M. and McKeehan, W.L. (1997) Fibroblast growth factor receptor 2 limits and receptor 1 accelerates tumorigenicity of prostate epithelial cells. Cancer Res. 57, 5369-5378
48. Wu, X., Jin, C., Wang, F., Yu, C. and McKeehan, W. L. (2003) Stromal cell heterogeneity in fibroblast growth factor-mediated stromal-epithelial cell cross-talk in premalignant prostate tumors. Cancer Res. 63, 4936-4944
49. Naimi, B., Latil, A., Fournier, G., Mangin, P., Cussenot, O. and Berthon, P. (2002) Down-regulation of (IIIb) and (IIIc) isoforms of fibroblast growth factor receptor 2 (FGFR2) is associated with malignant progression in human prostate. Prostate 52, 245-252
50. Kwabi-Addo, B., Giri, D., Schmidt, K., Podsypanina, K., Parsons, R., Greenberg, N. and Ittmann, M. (2001) Haploinsufficiency of the Pten tumor suppressor gene promotes prostate cancer progression. Proc. Natl. Acad. Sci. U.S.A. 98, 11563-11568
51. Matsubara, A., Kan, M., Feng, S. and McKeehan, W. L. (1998) Inhibition of growth of malignant rat prostate tumor cells by restoration of fibroblast growth factor receptor 2. Cancer Res. 58, 1509-1514
52. Jin, C., McKeehan, K., Guo, W., Jauma, S., Ittmann, M. M., Foster, B., Greenberg, N. M., McKeehan, W. L. and Wang, F. (2003) Cooperation between ectopic FGFR1 and depression of FGFR2 in induction of prostatic intraepithelial neoplasia in the mouse prostate. Cancer Res. 63, 8784-8790 (Pubitemid 38064058)