Potent and selective inhibition of the open-channel conformation of AMPA receptors by an RNA aptamer

Biochemistry

Volumn 49, Issue 27, 2010, Pages 5790-5798

  Huang, Zhen ^a   Han, Yan ^a   Wang, Congzhou ^a   Niu, Li ^a  

^a STATE UNIVERSITY OF NEW YORK   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMPA-RECEPTOR; APTAMERS; DRUG CANDIDATES; IN-VITRO; NANOMOLAR AFFINITY; NEUROLOGICAL DISORDERS; OPEN CHANNELS; RATE PROCESS; RNA APTAMER; SELECTIVE INHIBITION; SMALL MOLECULE INHIBITOR; STRUCTURE-FUNCTION STUDIES; TIME DOMAIN; WATERSOLUBLE;

CONFORMATIONS; PHOTOLYSIS; QUANTUM CHEMISTRY; RNA;

TIME DOMAIN ANALYSIS;

AMPA RECEPTOR; APTAMER; RNA;

ARTICLE; CELL STRAIN HEK293; CHANNEL GATING; CONTROLLED STUDY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN CONFORMATION; RNA SEQUENCE; SEQUENCE ANALYSIS; TIME; ANIMAL; CONFORMATION; GENETICS; METABOLISM; PHOTOLYSIS; PHYSIOLOGY; RAT; SPRAGUE DAWLEY RAT;

ANIMALS; APTAMERS, NUCLEOTIDE; MOLECULAR CONFORMATION; PHOTOLYSIS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, AMPA;

EID: 77954740502     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi100690k     Document Type: Article

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