Recombinant Moraxella bovoculi cytotoxin-ISCOM matrix adjuvanted vaccine to prevent naturally occurring infectious bovine keratoconjunctivitis

Veterinary Research Communications

Volumn 34, Issue 3, 2010, Pages 229-239

  Angelos, John A ^a   Lane, V Michael ^a   Ball, Louise M ^a,c   Hess, John F ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

Author keywords

Cytotoxin; Infectious bovine keratoconjunctivitis; Moraxella bovis; Moraxella bovoculi; Subunit

Indexed keywords

BACTERIAL VACCINE; CYTOTOXIN; HEMOLYSIN; ISCOM; MORAXELLA BOVOCULI VACCINE; NEUTRALIZING ANTIBODY; UNCLASSIFIED DRUG; BACTERIAL TOXIN; IMMUNOLOGICAL ADJUVANT; RECOMBINANT VACCINE;

ANIMAL EXPERIMENT; ANTIBODY TITER; ARTICLE; BACTERIUM ISOLATION; BULLOCK; CATTLE; CONTROLLED STUDY; CORNEA ULCER; DRUG EFFICACY; EYE EXAMINATION; HERD; IMMUNE RESPONSE; INFECTIOUS BOVINE KERATOCONJUNCTIVITIS; MALE; MORAXELLA; MORAXELLA BOVIS; MORAXELLA BOVOCULI; NONHUMAN; TREATMENT OUTCOME; ANIMAL; ANIMAL DISEASE; CHEMISTRY; CLASSIFICATION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; IMMUNOLOGY; KERATOCONJUNCTIVITIS; MORAXELLACEAE INFECTION; RANDOMIZED CONTROLLED TRIAL;

BOS; BOVINAE; MORAXELLA BOVIS;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; BACTERIAL TOXINS; BACTERIAL VACCINES; CATTLE; CYTOTOXINS; ISCOMS; KERATOCONJUNCTIVITIS, INFECTIOUS; MORAXELLA; MORAXELLACEAE INFECTIONS; VACCINES, SYNTHETIC;

EID: 77954719735     PISSN: 01657380     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11259-010-9347-8     Document Type: Article

References (31)

1. Angelos JA, Ball LM (2007) Relatedness of cytotoxins from geographically diverse isolates of Moraxella bovis. Vet Microbiol 124, 382-386.
2. Angelos JA, Ball LM, Hess JF (2007a) Identification and characterization of complete RTX operons in Moraxella bovoculi and Moraxella ovis. Vet Microbiol 125, 73-79.
3. Angelos JA, Bonifacio RG, Ball LM, Hess JF (2007b) Prevention of naturally occurring infectious bovine keratoconjunctivitis with a recombinant Moraxella bovis pilin-Moraxella bovis cytotoxin-ISCOM matrix adjuvanted vaccine. Vet Microbiol 125, 274-283.
4. Angelos JA, Hess JF, George LW (2001) Cloning and characterization of a Moraxella bovis cytotoxin gene. Am J Vet Res 62, 1222-1228.
5. Angelos JA, Hess JF, George LW (2003) An RTX operon in hemolytic Moraxella bovis is absent from nonhemolytic strains. Vet Microbiol 92, 363-377.
6. Angelos JA, Hess JF, George LW (2004) Prevention of naturally occurring infectious bovine keratoconjunctivitis with a recombinant Moraxella bovis cytotoxin-ISCOM matrix adjuvanted vaccine. Vaccine 23, 537-545.
7. Angelos JA, Spinks PQ, Ball LM, George LW (2007c) Moraxella bovoculi sp. nov., isolated from calves with infectious bovine keratoconjunctivitis. Int J Syst Evol Microbiol 57, 789-795.
8. Annuar BO, Wilcox GE (1985) Adherence of Moraxella bovis to cell cultures of bovine origin. Res Vet Sci 39, 241-246.
9. Beard MK, Moore LJ (1994) Reproduction of bovine keratoconjunctivitis with a purified haemolytic and cytotoxic fraction of Moraxella bovis. Vet Microbiol 42, 15-33.
10. Dueger EL, George LW, Angelos JA, Tankersley NS, Luiz KM, Meyer JA, Portis ES, Lucas MJ (2004) Efficacy of a long-acting formulation of ceftiofur crystalline-free acid for the treatment of naturally occurring infectious bovine keratoconjunctivitis. Am J Vet Res 65, 1185-1188.
11. Elad D, Yeruham I, Bernstein M (1988) Moraxella ovis in cases of infectious bovine keratoconjunctivitis (IBK) in Israel. Zentralbl Veterinarmed [B] 35, 431-434.
12. Fairlie G (1966) The isolation of a haemolytic Neisseria from cattle and sheep in the North of Scotland. Vet Rec 78, 649-650.
13. Funk L, O'Connor AM, Maroney M, Engelken T, Cooper VL, Kinyon J, Plummer P (2009) A randomized and blinded field trial to assess the efficacy of an autogenous vaccine to prevent naturally occurring infectious bovine keratoconjunctivis (IBK) in beef calves. Vaccine 27, 4585-4590.
14. George LW, Angelos JA, Ruehl WW (2004) Stability, antigenicity, and aggregation of Moraxella bovis cytolysin after purification and storage. Am J Vet Res 65, 977-983.
15. George LW, Borrowman AJ, Angelos JA (2005) Effectiveness of a cytolysin-enriched vaccine for protection of cattle against infectious bovine keratoconjunctivitis. Am J Vet Res 66, 136-142.
16. Gray JT, Fedorka-Cray PJ, Rogers DG (1995) Partial characterization of a Moraxella bovis cytolysin. Vet Microbiol 43, 183-196.
17. Henson JB, Grumbles LC (1960) Infectious Bovine Keratoconjunctivitis. I. Etiology. Am J Vet Res 21, 761-766.
18. Hess JF, Angelos JA (2006) The Moraxella bovis RTX toxin locus mbx defines a pathogenicity island. J Med Microbiol 55, 443-449.
19. Hoien-Dalen PS, Rosenbusch RF, Roth JA (1990) Comparative characterization of the leukocidic and hemolytic activity of Moraxella bovis. Am J Vet Res 51, 191-196.
20. Ji GE, O'Hanley P (1990) Epitopes of Escherichia coli alpha-hemolysin: identification of monoclonal antibodies that prevent hemolysis. Infect Immun 58, 3029-3035.
21. Kagonyera GM, George L, Miller M (1989a) Effects of Moraxella bovis and culture filtrates on 51Cr-labeled bovine neutrophils. Am J Vet Res 50, 18-21.
22. Kagonyera GM, George LW, Munn R (1989b) Cytopathic effects of Moraxella bovis on cultured bovine neutrophils and corneal epithelial cells. Am J Vet Res 50, 10-17.
23. Lepper AW (1988) Vaccination against infectious bovine keratoconjunctivitis: Protective efficacy and antibody response induced by pili of homologous and heterologous strains of Moraxella bovis. Aust Vet J 65, 310-316.
24. Moore LJ, Rutter JM (1989) Attachment of Moraxella bovis to calf corneal cells and inhibition by antiserum. Aust Vet J 66, 39-42.
25. Pugh GW, Jr., Hughes DE (1971) Infectious bovine keratoconjunctivitis induced by different experimental methods. Cornell Vet 61, 23-45.
26. Ruehl WW, Marrs C, Beard MK, Shokooki V, Hinojoza JR, Banks S, Bieber D, Mattick JS (1993a) Q pili enhance the attachment of Moraxella bovis to bovine corneas in vitro. Mol Microbiol 7, 285-288.
27. Ruehl WW, Marrs CF, George L, Banks SJ, Schoolnik GK (1993b) Infection rates, disease frequency, pilin gene rearrangement, and pilin expression in calves inoculated with Moraxella bovis pilin-specific isogenic variants. Am J Vet Res 54, 248-253.
28. Spradbrow PB (1967) A microbiological study of bovine conjunctivitis and keratoconjunctivitis. Aust Vet J 43, 55-58.
29. Tryland M, Das Neves CG, Sunde M, Mork T (2009) Cervid herpesvirus 2, the primary agent in an outbreak of infectious keratoconjunctivitis in semidomesticated reindeer. J Clin Microbiol 47, 3707-3713.
30. Weyant RS, Wayne Moss C, Weaver RE, Hollis DG, Jordan JG, Cook EC, Daneshvar MI (1996) Identification of Unusual Pathogenic Gram-Negative Aerobic and Facultatively Anaerobic Bacteria. 2 Edn. Williams and Wilkins, Baltimore.
31. Wilcox GE (1970) Bacterial flora of the bovine eye with special reference to the Moraxella and Neisseria. Aust Vet J 46, 253-256.