Prevention of naturally occurring infectious bovine keratoconjunctivitis with a recombinant Moraxella bovis pilin-Moraxella bovis cytotoxin-ISCOM matrix adjuvanted vaccine

Veterinary Microbiology

Volumn 125, Issue 3-4, 2007, Pages 274-283

  Angelos, John A ^a   Bonifacio, Robert G ^a   Ball, Louise M ^a   Hess, John F ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Cytotoxin; Infectious bovine keratoconjunctivitis; Moraxella bovis; Pilin

Indexed keywords

BACTERIAL TOXIN; BACTERIAL VACCINE; CYTOTOXIN; IMMUNOLOGICAL ADJUVANT; ISCOM; PILIN; RECOMBINANT PILIN CYTOTOXIN VACCINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL STRAIN; BACTERIUM CULTURE; BEEF CATTLE; CARBOXY TERMINAL SEQUENCE; CATTLE DISEASE; CONTROLLED STUDY; CORNEA ULCER; DRUG EFFICACY; DRUG FORMULATION; KERATOCONJUNCTIVITIS; MALE; MORAXELLA BOVIS; MORAXELLA BOVOCULI; NONHUMAN; NUCLEOTIDE SEQUENCE; TREATMENT OUTCOME; VACCINATION;

ANIMALS; ANTIBODIES, BACTERIAL; BACTERIAL VACCINES; BASE SEQUENCE; CATTLE; CATTLE DISEASES; CHEMOTACTIC FACTORS; FIMBRIAE PROTEINS; ISCOMS; KERATOCONJUNCTIVITIS, INFECTIOUS; MALE; MOLECULAR SEQUENCE DATA; MORAXELLA (MORAXELLA) BOVIS; MORAXELLACEAE INFECTIONS; VACCINATION; VACCINES, SYNTHETIC;

BOS; BOVINAE; MORAXELLA BOVIS;

EID: 35348904930     PISSN: 03781135     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vetmic.2007.05.028     Document Type: Article

References (35)

1. Angelos J.A., Hess J.F., and George L.W. Cloning and characterization of a Moraxella bovis cytotoxin gene. Am. J. Vet. Res. 62 (2001) 1222-1228
2. Angelos J.A., Hess J.F., and George L.W. An RTX operon in hemolytic Moraxella bovis is absent from nonhemolytic strains. Vet. Microbiol. 92 (2003) 363-377
3. Angelos J.A., Hess J.F., and George L.W. Prevention of naturally occurring infectious bovine keratoconjunctivitis with a recombinant Moraxella bovis cytotoxin-ISCOM matrix adjuvanted vaccine. Vaccine 23 (2004) 537-545
4. Angelos J.A., Spinks P.Q., Ball L.M., and George L.W. Moraxella bovoculi sp. nov., isolated from calves with infectious bovine keratoconjunctivitis. Int. J. Syst. Evol. Micro. 57 (2007) 789-795
5. Atwell J.L., Tennent J.M., Lepper A.W., and Elleman T.C. Characterization of pilin genes from seven serologically defined prototype strains of Moraxella bovis. J. Bacteriol. 176 (1994) 4875-4882
6. Beard M.K., and Moore L.J. Reproduction of bovine keratoconjunctivitis with a purified haemolytic and cytotoxic fraction of Moraxella bovis. Vet. Microbiol. 42 (1994) 15-33
7. Billson F.M., Hodgson J.L., Egerton J.R., Lepper A.W., Michalski W.P., Schwartzkoff C.L., Lehrbach P.R., and Tennent J.M. A haemolytic cell-free preparation of Moraxella bovis confers protection against infectious bovine keratoconjunctivitis. FEMS Microbiol. Lett. 124 (1994) 69-74
8. Elad D., Yeruham I., and Bernstein M. Moraxella ovis in cases of infectious bovine keratoconjunctivitis (IBK) in Israel. Zentralbl Veterinarmed [B] 35 (1988) 431-434
9. Fairlie G. The isolation of a haemolytic Neisseria from cattle and sheep in the North of Scotland. Vet. Rec. 78 (1966) 649-650
10. George L.W., Angelos J.A., and Ruehl W.W. Stability, antigenicity, and aggregation of Moraxella bovis cytolysin after purification and storage. Am. J. Vet. Res. 65 (2004) 977-983
11. George L.W., Borrowman A.J., and Angelos J.A. Effectiveness of a cytolysin-enriched vaccine for protection of cattle against infectious bovine keratoconjunctivitis. Am. J. Vet. Res. 66 (2005) 136-142
12. Gray J.T., Fedorka-Cray P.J., and Rogers D.G. Partial characterization of a Moraxella bovis cytolysin. Vet. Microbiol. 43 (1995) 183-196
13. Greene W.H., Grubbs S.T., and Potgieter L.N. Detection of shared antigenic determinants on whole Moraxella bovis pili by use of antisera to cyanogen bromide-cleaved M. bovis pilus protein. Am. J. Vet. Res. 62 (2001) 1279-1284
14. Greene W.H., Grubbs S.T., and Potgieter L.N. Immunoblot analysis of cyanogen bromide-cleaved Moraxella bovis pilin reveals presence of shared antigenic determinants on pili from heterologous strains. Vet. Microbiol. 80 (2001) 365-372
15. Henson J.B., and Grumbles L.C. Infectious Bovine Keratoconjunctivitis. I. Etiology. Am. J. Vet. Res. 21 (1960) 761-766
16. Hess J.F., and Angelos J.A. The Moraxella bovis RTX toxin locus mbx defines a pathogenicity island. J. Med. Microbiol. 55 (2006) 443-449
17. Hoien-Dalen P.S., Rosenbusch R.F., and Roth J.A. Comparative characterization of the leukocidic and hemolytic activity of Moraxella bovis. Am. J. Vet. Res. 51 (1990) 191-196
18. Kagonyera G.M., George L.W., and Munn R. Cytopathic effects of Moraxella bovis on cultured bovine neutrophils and corneal epithelial cells. Am. J. Vet. Res. 50 (1989) 10-17
19. Lehr C., Jayappa H.G., and Goodnow R.A. Serologic and protective characterization of Moraxella bovis pili. Cornell Vet. 75 (1985) 484-492
20. Lepper A.W. Vaccination against infectious bovine keratoconjunctivitis: protective efficacy and antibody response induced by pili of homologous and heterologous strains of Moraxella bovis. Aust. Vet. J. 65 (1988) 310-316
21. Marrs C.F., Ruehl W.W., Schoolnik G.K., and Falkow S. Pilin-gene phase variation of Moraxella bovis is caused by an inversion of the pilin genes. J. Bacteriol. 170 (1988) 3032-3039
22. Moore L.J., and Lepper A.W. A unified serotyping scheme for Moraxella bovis. Vet. Microbiol. 29 (1991) 75-83
23. Nayar P.S., and Saunders J.R. Infectious bovine keratoconjunctivitis II. Antibodies in lacrimal secretions of cattle naturally or experimentally infected with Moraxella bovis. Can. J. Comp. Med. 39 (1975) 32-40
24. Ostle A.G., and Rosenbusch R.F. Immunogenicity of Moraxella bovis hemolysin. Am. J. Vet. Res. 46 (1985) 1011-1014
25. Pedersen K.B. The origin of immunoglobulin-G in bovine tears. Acta Pathol. Microbiol. Scand. [B] Microbiol. Immunol. 81 (1973) 245-252
26. Pugh Jr. G.W., Hughes D.E., and McDonald T.J. The isolation and characterization of Moraxella bovis. Am. J. Vet. Res. 27 (1966) 957-962
27. Rozsa F.W., and Marrs C.F. Interesting sequence differences between the pilin gene inversion regions of Moraxella lacunata ATCC 17956 and Moraxella bovis Epp63. J. Bacteriol. 173 (1991) 4000-4006
28. Ruehl W.W., Marrs C., Beard M.K., Shokooki V., Hinojoza J.R., Banks S., Bieber D., and Mattick J.S. Q pili enhance the attachment of Moraxella bovis to bovine corneas in vitro. Mol. Microbiol. 7 (1993) 285-288
29. Ruehl W.W., Marrs C.F., George L., Banks S.J., and Schoolnik G.K. Infection rates, disease frequency, pilin gene rearrangement, and pilin expression in calves inoculated with Moraxella bovis pilin-specific isogenic variants. Am. J. Vet. Res. 54 (1993) 248-253
30. Smith P.C., Greene W.H., and Allen J.W. Antibodies related to resistance in bovine pinkeye. California Vet. (1989) 18 (July/August, 7-10)
31. Spradbrow P.B. A microbiological study of bovine conjunctivitis and keratoconjunctivitis. Aust. Vet. J. 43 (1967) 55-58
32. Vandergaast N., and Rosenbusch R.F. Infectious bovine keratoconjunctivitis epizootic associated with area-wide emergence of a new Moraxella bovis pilus type. Am. J. Vet. Res. 50 (1989) 1437-1441
33. Weyant R.S., Wayne Moss C., Weaver R.E., Hollis D.G., Jordan J.G., Cook E.C., and Daneshvar M.I. Identification of Unusual Pathogenic Gram-negative Aerobic and Facultatively Anaerobic Bacteria. 2nd ed. (1996), Williams and Wilkins, Baltimore
34. Wilcox G.E. Bacterial flora of the bovine eye with special reference to the Moraxella and Neisseria. Aust. Vet. J. 46 (1970) 253-256
35. Yeruham I., Perl S., and Elad D. Infectious bovine keratoconjunctivitis and lymphofollicular hyperplasia of the third eyelid in heifers. J. Vet. Med. B Infect. Dis. Vet. Public Health 48 (2001) 137-141