Stimulation of the extracellular matrix production in dermal fibroblasts by velvet antler extract

Annals of Dermatology

Volumn 22, Issue 2, 2010, Pages 173-179

  Roh, Seok Seon ^a   Lee, Min Ho ^b   Hwang, Yul Lye ^b   Song, Hyun Hee ^b   Jin, Mu Hyun ^c   Park, Sun Gyoo ^c   Lee, Cheon Koo ^c   Kim, Chang Deok ^a   Yoon, Tae Jin ^d   Lee, Jeung Hoon ^a  

^a Chungnam National University   (South Korea)

^b Oriental BioMed Lab   (South Korea)

^c LG Household and Healthcare Ltd   (South Korea)

^d Gyeongsang National University School of Medicine   (South Korea)

Author keywords

CDNA microarray; Extracellular matrix; Fibroblast; Velvet antler extract

Indexed keywords

EID: 77954718663     PISSN: 10139087     EISSN: None     Source Type: Journal    
DOI: 10.5021/ad.2010.22.2.173     Document Type: Article

References (18)

1. Pieraggi MT, Bouissou H, Angelier C, Uhart D, Magnol JP, Kokolo J. The fibroblast. Ann Pathol 1985;5:65-76.
2. Uitto J. Connective tissue biochemistry of the aging dermis. Age-related alterations in collagen and elastin. Dermatol Clin 1986;4:433-446.
3. Chan JC, Duszczyszyn DA, Castellino FJ, Ploplis VA. Accelerated skin wound healing in plasminogen activator inhibitor-1-deficient mice. Am J Pathol 2001;159:1681-1688.
4. Ignotz RA, Massague J. Transforming growth factor-beta stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix. J Biol Chem 1986;261:4337-4345.
5. Jhon GJ, Park SY, Han SY, Lee S, Kim Y, Chang YS. Studies of the chemical structure of gangliosides in deer antler, Cervus nippon. Chem Pharm Bull (Tokyo) 1999;47:123-127.
6. Kang SK, Kim KS, Kim SI, Chung KH, Lee IS, Kim CH. Immunosuppressive activity of deer antler extracts of Cervus korean TEMMINCK var. mantchuricus Swinhoe, on type II collagen-induced arthritis. In Vitro Cell Dev Biol Anim 2006;42:100-107.
7. Li YJ, Kim TH, Kwak HB, Lee ZH, Lee SY, Jhon GJ. Chloroform extract of deer antler inhibits osteoclast differentiation and bone resorption. J Ethnopharmacol 2007;113: 191-198.
8. Yang HO, Kim SH, Cho SH, Kim MG, Seo JY, Park JS, et al. Purification and structural determination of hematopoietic stem cell-stimulating monoacetyldiglycerides from Cervus nippon (deer antler). Chem Pharm Bull (Tokyo) 2004;52: 874-878.
9. Guan SW, Duan LX, Li YY, Wang BX, Zhou QL. A novel polypeptide from Cervus nippon Temminck proliferation of epidermal cells and NIH3T3 cell line. Acta Biochim Pol 2006;53:395-397.
10. Mikler JR, Theoret CL, High JC. Effects of topical elk velvet antler on cutaneous wound healing in streptozotocin-induced diabetic rats. J Altern Complement Med 2004;10: 835-840.
11. Liang CC, Park AY, Guan JL. In vitro scratch assay: a convenient and inexpensive method for analysis of cell migration in vitro. Nat Protoc 2007;2:329-333.
12. Lim IJ, Phan TT, Tan EK, Nguyen TT, Tran E, Longaker MT, et al. Synchronous activation of ERK and phosphatidylinositol 3-kinase pathways is required for collagen and extracellular matrix production in keloids. J Biol Chem 2003;278:40851-40858.
13. Lee DJ, Rosenfeldt H, Grinnell F. Activation of ERK and p38 MAP kinases in human fibroblasts during collagen matrix contraction. Exp Cell Res 2000;257:190-197.
14. Kanzaki T, Morisaki N, Shiina R, Saito Y. Role of transforming growth factor-beta pathway in the mechanism of wound healing by saponin from Ginseng Radix rubra. Br J Pharmacol 1998;125:255-262.
15. Quan T, He T, Kang S, Voorhees JJ, Fisher GJ. Solar ultraviolet irradiation reduces collagen in photoaged human skin by blocking transforming growth factor-beta type II receptor/Smad signaling. Am J Pathol 2004;165:741-751.
16. Sephel GC, Davidson JM. Elastin production in human skin fibroblast cultures and its decline with age. J Invest Dermatol 1986;86:279-285.
17. Falanga V, Isaacs C, Paquette D, Downing G, Kouttab N, Butmarc J, et al. Wounding of bioengineered skin: cellular and molecular aspects after injury. J Invest Dermatol 2002;119:653-660.
18. Ferrara N, Davis-Smyth T. The biology of vascular endothelial growth factor. Endocr Rev 1997;18:4-25.