Quantitative structure activity relationship (QSAR) analysis of substituted 4-oxothiazolidines and 5-arylidines as lipoxygenase inhibitors

Mini-Reviews in Medicinal Chemistry

Volumn 10, Issue 8, 2010, Pages 705-714

  Choudhary, A N ^a   Kumar, A ^a   Juyal, V ^a  

^a KUMAUN UNIVERSITY   (India)

Author keywords

Anti inflammatory; Lipoxygenase inhibitors; QSAR; Quantitative structure activity relationship; Substituted 4 oxathiazolidines and 5 arylidines

Indexed keywords

4 OXOTHIAZOLIDINE; 5 ARYLIDINE; LIPOXYGENASE INHIBITOR; UNCLASSIFIED DRUG; 4-OXOTHIAZOLIDINE; ANTIINFLAMMATORY AGENT; LIPOXYGENASE; THIAZOLE DERIVATIVE;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; BINDING AFFINITY; BIOLOGICAL ACTIVITY; QUANTITATIVE STRUCTURE ACTIVITY RELATION; CHEMICAL MODEL; CHEMISTRY; METABOLISM; STATISTICAL MODEL;

ANTI-INFLAMMATORY AGENTS; LIPOXYGENASE; LIPOXYGENASE INHIBITORS; MODELS, CHEMICAL; MODELS, STATISTICAL; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES;

EID: 77954718420     PISSN: 13895575     EISSN: None     Source Type: Journal    
DOI: 10.2174/138955710791572505     Document Type: Article

References (24)

1. Krishna, D.H.; Reddy, M.S.; Rajnarayana, K; Krishna, D.R.; Prabhaker, M.C. Inflammation and therapeutic approaches for its management. Indian J. Pharm. Sci., 2003, 65, 565-575.
2. Hanke, P.K.; Wakefield, T. Thrombus resolution and vein wall injury dependence on chemokines and leukocytes. Thromb. Res., 2009, 123, S72-78.
3. Cheng, Y.; Wang, M.; Yu, Y.; Law, J.; Funk, C.D.; Fiitzgerald, G.A. Cycloxygenase, microsomal prostaglandin E-synthase and cardiovascular function. J. Clin. Invest., 2006, 116, 1391-1399.
4. Belton, O.A.; Duffy, A.; Toomey, S.; Fitzgerald, D.J. Cycloxygenase isoforms and platelet vessels wall interactions in the apolipoprotiens E knockout mouse model of atherosclerosis. Circulation, 2003, 108, 3017-3023.
5. Hishinuma, T.; Nakamura, H.; Sawai, T. Analysis of urinary prostacycline and thromboxane/prostacycline ratio in patients with rheumatoid arthritis using gas chromatography/selected ion monitoring. Prostaglandins Leukot. Essent. Fatty Acids, 2001, 65, 85-90.
6. Belton, O.; Byme, D.; Kearney, D.; Leahy, A; Fitzgerald, D.J. Cycloxygenase 1 and 2 dependent prostacycline formations in patients with atherosclerosis. Circulation, 2000, 102, 840-845.
7. Norel, X.; Walch, L.; Gascarel, J.P.; Demontpreville, V.; Brink, C. Prostacyclin release and receptor activation: Differential control of human pulmonary venous and arterial tone. Br. J. Pharmacol., 2004, 142, 788-796.
8. Kean, W.F.; Buchanan, W.W. The use of NSAIDS in rheumatic disorders: a global perspective. Inflammopharmacology, 2005, 13, 343-370.
9. Zochling, J.; Vaneler, H.D.; Dougados, M.; Braun, J. Current evidence for the management of ankylosing spondylitis: a systematic literature review for the ASAS/EULAR management recommendation in ankylosing spondylitis. Ann. Rheum. Dis., 2006, 65, 423-432.
10. Tetley, T.D. Inflammatory cells and chronic obstructive pulmonary disease. Curr Drug Targets Inflammation. Allergy, 2005, 4, 607-618.
11. Gadgil, A.; Daucan, S.R. Role of T-lymphocyte and proinflammatory mediators in the pathogenesis of COPD. Int. J. Chron. Obstruct. Pulm. Dis. 2008, 3(4), 531-41.
12. Laine, L. Approaches to non steroidal antinflammatory drug use in the high risk patient. Gastroenterology, 2001, 120, 594-606.
13. Simen, L.S. Biological effects of nonsteroidal antinflammatory drugs. Curr. Opin. Rheumatol., 1997, 9, 178-182.
14. Ofman, J.J.; Maclean, C.H.; Straus, W.L.; Morton, S.C.; Berger, M.L.; Roth, E.A.; Shekelle, P. A metaanalysis of severe upper gastrointestinal complications of non steroidal antinflammatory drugs. J. Rheumatol, 2002, 29, 804-812.
15. Flavin, D.F. Lipoxygenase inhibitors in breast cancer brain metastases. J. Neurooncol., 2007, 82, 91-93.
16. Wanare, R.; Babu, M.A.; Kaskhedikar, S.G. A 3D-QSAR study of some substituted napthols as 5-lipoxygenase inhibitors. Indian J. Pharma. Sci., 2003, 65, 351-357.
17. Yadav, R.; Srivastava, S.D.; Srivastava, S.K. Synthesis, antimicrobial and antiinflammatory activities of 4-oxothazolidines and their 5-arylidenes. Indian J. Chem., 2005, 44, 1262-1266.
18. Chem. Soft. Office, Version 10.0 Cambridge soft corporation; Software Publishers Association; 1730-M Street; NW; Suite 700; Washington DC. USA, 20036(202) 452-1600.
19. Besler, B.H; Merz, J.K.M.; Kollman, P.A. Atomic charges derived from semiempirical methods. J. Comput. Chem., 1990, 11, 431-439.
20. st ed, Weinheim, New York; 1993.
21. M. Petitjean: Application of the radius-diameter diagram to the classification of topological and geometrical shapes of chemical compounds. J. Chem. Inf. Comput. Sci., 1992, 32, 331-337.
22. Gupta, A.K.; Babu, M.A.; Kaskhedikar, S.G. VALSTAT: Validation program for Quantitative Structure Activity Relationship Activity Relationship Studies. Indian J. Pharm. Sci., 2004, 66, 396-402.
23. nd ed, John Wiley & sons, New York; 1983.
24. nd ed, Prentice-Hall of India Pvt. Ltd., New Delhi; 1991.