Deposition of inhaled ultrafine aerosols in replicas of nasal airways of infants

Aerosol Science and Technology

Volumn 44, Issue 9, 2010, Pages 741-752

  Golshahi, L ^a   Finlay, W H ^a   Olfert, J S ^a   Thompson, R B ^a   Noga, M L ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

APRIORI; CONDENSATION PARTICLE COUNTERS; CONSTANT FLOW RATES; DIFFERENTIAL MOBILITY ANALYZERS; DYNAMICAL PARAMETERS; EMPIRICAL EQUATIONS; EXPERIMENTAL PROCEDURE; GEOMETRICAL FEATURES; IN-VIVO; IN-VIVO MEASUREMENT; POLYDISPERSES; REYNOLDS; ULTRA-FINE AEROSOLS; ULTRAFINE PARTICLE; WOMERSLEY NUMBERS;

ATMOSPHERIC AEROSOLS; ATOMIZERS; POLYDISPERSITY; SODIUM; SODIUM CHLORIDE;

DEPOSITION;

SODIUM CHLORIDE;

ADULT; AEROSOL; AIRWAY; ARTICLE; BREATHING; FACE; FEMALE; HUMAN; IN VIVO STUDY; INFANT; INHALATION; MALE; NOSE; PRIORITY JOURNAL; RESPIRATORY AIRFLOW; TRACHEA;

EID: 77954701105     PISSN: 02786826     EISSN: 15217388     Source Type: Journal    
DOI: 10.1080/02786826.2010.488256     Document Type: Article

References (54)

1. Arens, R., Sin, S., McDonough, J. M., Palmer, J. M., Dominguez, T., Meyer, H., Wootton, D. M., and Pack, A. I. (2005). Changes in Upper Airway Size During Tidal Breathing in Children with Obstructive Sleep Apnea Syndrome. Am. J. Respir. Crit. Care Med. 171:1298-1304.
2. Blasius, H. (1911). The Similarity Law in Friction Processes. Phys. Z. 12:1175-1177.
3. Cheng, Y. S., Yamada, Y., Yeh, H. C., and Swift, D. L. (1988). Diffusional Deposition of Ultrafine Aerosols in a Human Nasal Cast. J Aerosol Sci. 19(6):741-751.
4. Cheng, Y. S., Yamada, Y., Yeh, H. C., and Swift, D. L. (1990). Deposition of Ultrafine Aerosols in a Human Oral Cast. Aerosol Sci. Technol. 12 (4):1075-1081.
5. Cheng,Y. S., Su,Y. F.,Yeh, H. C., and Swift, D. L. (1993).Deposition of Thoron Progeny in Human Head Airways. Aerosol Sci. Technol. 18(4):359-375.
6. Cheng, Y. S., Smith, S. M., Yeh, H. C., Kim, D. B., Cheng, K. H., and Swift, D. L. (1995). Deposition of Ultrafine Aerosols and Thoron Progeny in Replicas of Nasal Airways of Young Children. Aerosol Sci. Technol. 23:541-552.
7. Cheng, Y. S., Yeh, H. C., Guilmette, R. A., Simpson, S. Q., Cheng, K. H., and Swift, D. L. (1996). Nasal Deposition of Ultrafine Particles in Human Volunteers and its Relationship to Airway Geometry. Aerosol Sci. Technol. 25:274-291.
8. Cheng, K. H., Cheng, Y. S., Yeh, H. C., Guilmette, R. A., Simpson, S.Q., Yang, S. Q., and Swift, D. L. (1996). In vivo Measurements of Nasal Airway Dimensions and Ultrafine Aerosols Depositing in Human Nasal and Oral Airways. J Aerosol Sci. 27(5):785-801.
9. Cheng, Y. S. (2003). Aerosol Deposition in the Extrathoracic Region. Aerosol Sci. Technol. 37:659-671.
10. Finlay, W. H. (2008). At The Frontiers of Understanding: Inhaled Aerosols in Neonates. Pediatr. Res.64(2):121-122.
11. Finlay W. H., and Martin, A. R. (2008). Recent Advances in Predictive Understanding of Respiratory Tract Deposition. J. Aerosol Med. Pulm. Drug Deliv. 21(2):1-17.
12. Garcia, G. J. M., Tewksbury, E. W., Wong, B. A., and Kimbell, J. S. (2009). Interindividual Variability in Nasal Filtration as a Function of Nasal Cavity Geometry. J. Aerosol Med. Pulm. Drug Deliv. 22(2):139-155.
13. Gill, S., Lobenberg, R., Ku, T., Azarmi, S., Roa, W. and Prenner, E. J. (2007). Nanoparticles: Characteristics, Mechanisms of Action and Toxicity in Pulmonary Drug Delivery-A Review. J. Biomed Nanotech. 3:107-119.
14. Grgic, B., Finlay, W. H., Burnell, P. K. P., and Heenan, A. F. (2004). In Vitro Intersubject and Intrasubject Deposition Measurements in Realistic Mouth-Throat Geometries. J. Aerosol Sci. 35:1025-1040.
15. Grgic, B.,Martin, A. R., and FinlayW. H. (2006). The Effect of Unsteady Flow Rate Increase on in vitro Mouth-Throat Deposition of Inhaled Boluses. J Aerosol Sci. 37:1222-1233.
16. Guilmette, R. A., Cheng, Y. S., Yeh, H. C., and Swift, D. L. (1994). Deposition of 0.005-12 μm Monodisperse Particles in a Computer-Milled, MRI based Nasal Airway Replica. Inhal. Toxicol. 6(s1):395-399.
17. Halonen, J. I., Lanki, T., Yli-Tuomi, T., Tiittanen, P., Kulmala, M., and Pekkanen, J. (2009). Particulate air Pollution and Acute Cardiorespiratory Hospital Admissions and Mortality Among the Elderly. Epidemiol. 20(1):143-153.
18. Haussermann, S., Bailey, A. G., Bailey, M. R., Etherington, G., and Youngman, M. (2002). The Influence of Breathing Patterns on Particle Deposition in a Nasal Replicate Cast. J. Aerosol Sci. 33:923-933.
19. Heyder, J., and Rudolf, G. (1977). Deposition of Aerosol Particles in the Human Nose. In Inhaled Particles IV, W. H. Walton, ed., Pergamon Press, Oxford, UK, pp. 107-126.
20. Heyder, J., Gebhart, J., Stahlhofen, W., and Stuck, B. (1982). Biological Variability of Particle Deposition in the Human Respiratory Tract During Controlled and Spontaneous Mouth-Breathing. Ann. Occupat. Hyg. 26 (1-4): 137-147.
21. Hounam, R. F., Black, A., and Walsh, M. (1971). The Deposition of Aerosol Particles in the Nasopharyngeal Region of the Human Respiratory Tract. J. Aerosol Sci. 2:47-61.
22. Janssens, H.M., De Jongste, J. C., Fokkens,W. J., Robben, S. G. F.,Wouters, K., and Tiddens,H.A.W.M. (2001). The SophiaAnatomical Infant Nose-Throat (Saint). Model: A Valuable Tool to Study Aerosol Deposition in Infants. J Aerosol Med. 14(4):433-441.
23. Kelly, J. T., Asgharian, B., Kimbell, J. S., and Wong, B. (2004). Particle Deposition in Human Nasal Airway Replicas Manufactured by Different Methods. Part II: Ultrafine Particles, Aerosol Sci. Technol. 38:1072-1079. (Pubitemid 40075751)
24. Kreyling, W. G., Semmler-Behnke, M., and Moller, W. (2006). Ultrafine Particle-Lung Interactions: Does Size Matter? J. Aerosol Med. 19:74-83.
25. Martonen, T. B., and Zhang, Z. (1992). Comments on Recent Data for Particle Deposition in Human Nasal Passages. J Aerosol Sci. 23(6):667-674.
26. Minocchieri, S., Burren, J. M., Bachmann, M. A., Stern, G.,Wildhaber, J., Buob, S., Schindel, R., Kraemer, R., Frey, U. P., and Nelle, M. (2008). Development of the Premature Neonate for the Study of Aerosol Delivery. Pediatr. Res. 64(2):141-146.
27. National Research Council (NRC). (1988). Health Risks of Radon and Other Internally Deposited Alpha Emitters. Committee on the Biological Effects of Ionizing Radiations, National Academy Press, Washington, DC.
28. Oberdorster, G., Sharp, Z., Atudorei, V., Elder, A., Gelein, R., Kreyling, W., and Cox. C. (2004). Translocation of Inhaled Ultrafine Particles to the Brain. Inhal. Toxicol. 16:437-445.
29. Orr, C., Hurd, F. K., and Corbett, W. J. (1958). Aerosol Size and Relative Humidity. J. Colloid Sci. 13:472-482.
30. Park, S. H., Kim, H. O., Han, Y. T., Kwon, S. B., and Lee, K. W. (2001). Wall Loss Rate of Polydispersed Aerosols. Aerosol Sci. Technol. 35:710-717.
31. Pattle, R. E. (1961). The Retention of Gases and Particles in the Human Nose. In Inhaled Particles and Vapors, C. N. Davies ed., Pergamon Press, New York, pp. 302-309.
32. Phalen, R. F., Oldham, M. J., Beaucage, C. B., Crocker, T. T., and Mortensen, J. D. (1985). Postnatal Enlargement of Human Tracheobronchial Airways and Implications for Particle Deposition. Anat. Rec. 212:368-380.
33. Polgar, G., and Kong, G. P. (1965). The Nasal Resistance of Newborn Infants. J. Pediatr. 67:557-567.
34. Schlichting, H. (1968). Boundary Layer Theory (Trans. by Kestin, J.).McGraw-Hill, Stanford.
35. Schuepp, K. G., Jauernig, J., Janssens, H. M., Tiddens, H. A., Straub, D. A., Stangl, R., Keller, M., and Wildhaber, J. H. (2005). In Vitro Determination of the Optimal Particle Size for Nebulized Aerosol Delivery to Infants. J. Aerosol Med. 18:225-235.
36. Shi, H., Kleinstreuer, C., and Zhang, Z. (2006). Laminar Airflow and Nanoparticle or Vapor Deposition in a Human Nasal Cavity Model. J. Biomech. Eng. 128:697-706.
37. Stocks, J., and Godfrey, S. (1978). Nasal Resistance During Infancy. Respir. Physiol. 34:233-246.
38. Storey-Bishoff, J., Noga, M., and Finlay, W. H. (2008). Deposition of Micrometer-Sized Aerosol Particles in Infant Nasal Airway Replicas. J. Aerosol Sci. 39:1055-1065.
39. Swift, D. L., Cheng, Y. S., Su, Y. F., and Yeh, H. C. (1990). In Indoor Radon and Lung Cancer: Reality and Myth? (F. Cross, eds.). 29th Hanford Symposium on Health and the Environment, Richland, Washington, p. 213.
40. Swift, D. L. (1991). Inspiratory Inertial Deposition of Aerosols in Human Nasal Airway Replicate Casts: Implications for the Proposed NCRP Lung Model. Radiat. Prot. Dosimetry. 38:29-34.
41. Swift, D. L., Montassier, N., Hopke, P. K., Kim, K. H., Cheng, Y. S., Su, Y. F., Yeh, H. C., and Strong, J. C. (1992). Inspiratory Deposition of Ultrafine Particles in Human Nasal Replicate Cast. J. Aerosol Sci. 23(1):65-72.
42. Swift, D. L., and Strong, J. C. (1996). Nasal Deposition of ulTrafine 218Po Aerosols in Human Subjects. J. Aerosol Sci. 27(7):1125-1132.
43. Tang, I. N., and Murkelwitz, H. R. (1984). An Investigation of Solute Nucleation in Levitated Solution Droplets. J. Colloid Interface Sci. 98(2):430-438.
44. Trevelyan, P.M. J., Kalliadasis, S., Merkin, J. H., and Scott, S. K. (2002). Mass-Transport Enhancement in Regions Bounded by Rigid Walls. J. Eng Math. 42:45-64.
45. Van Woensel, J. B. M., Van Aalderen, W. M. C., and Kimpen, J. L. L. (2003).. Viral Lower Respiratory Tract Infection in Infants and Young Children. Br. Med. J. 327:36-40.
46. Vincent, J. H. (2005). Health-Related Aerosol Measurement: A Review of Existing Sampling Criteria and Proposals for New Ones. J. Environ. Monit. 7:1037-1053.
47. Wang, S. C., and Flagan, R. C. (1990). Scanning Electrical Mobility Spectrometer. Aerosol Sci. Technol. 13(2):230-240.
48. Wang, S. M., Inthavong, K.,Wen, J., Tu, J.Y., and Xue, C. L. (2009).Comparison of Micron- and Nanoparticle Deposition Patterns in a Realistic Human Nasal Cavity. Respir. Physiol. Neurobiol. 166:142-151.
49. Wiedensohler, A. (1988). An Approximation of the Bipolar Charge Distribution for Particles in the Submicron Size Range. J. Aerosol Sci. 19(3):387-389.
50. Xi, J., Longest, P. W. (2008). Effects of Oral Airway Geometry Characteristics on the Diffusional Deposition of Inhaled Nanoparticles. J. Biomech. Eng. 130:011008:1-16.
51. Xi, J., and Longest, P. W. (2008). Numerical Predictions of Submicrometer Aerosol Deposition in the Nasal Cavity Using a Novel Drift Flux Approach. Int. J. Heat Mass Transfer. 51:5562-5577.
52. Yamada, Y., Cheng, Y. S., Yeh, H. C., and Swift, D. L. (1988). Inspiratory and Expiratory Deposition of Ultrafine Particles in a Human Nasal Cast. Inhal. Toxicol. 1:1-11.
53. Yu, G., Zhang, Z., and Lessman, R. (1998). Fluid Flow and Particle Deposition in the Human Upper Respiratory System. Aerosol Sci. Technol. 28:146-158. (Pubitemid 28099025)
54. Zamankhan, P., Ahmadi, G., Wang, Z., Hopke, P. H., Cheng, Y. S., Su, W. C., and Leonard,D. (2006).Airflowand Deposition ofNano-Particles in aHuman Nasal Cavity. Aerosol Sci. Technol. 40:463-476.