Immunologic and virologic analyses in pediatric liver transplant recipients with chronic high epstein-barr virus loads

Journal of Infectious Diseases

Volumn 202, Issue 3, 2010, Pages 461-469

  Gotoh, Kensei ^a   Ito, Yoshinori ^a   Ohta, Rieko ^a   Iwata, Seiko ^b   Nishiyma, Yukihiro ^b   Nakamura, Taro ^c   Kaneko, Kenitiro ^d   Kiuchi, Tetsuya ^c   Ando, Hisami ^d   Kimura, Hiroshi ^b  

^a Departments of Pediatrics   (United States)

^b Departments of Virology   (Australia)

^c Departments of Transplant Surgery   (United States)

^d NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ACICLOVIR; BAMH1 A RIGHTWARD TRANSCRIPT; CD19 ANTIBODY; CD56 ANTIGEN; EPSTEIN BARR VIRUS ENCODED SMALL RNA 1; INTERLEUKIN 10; LATENT MEMBRANE PROTEIN 2; LIVER ENZYME; PREDNISOLONE; TACROLIMUS; UNCLASSIFIED DRUG; VIRUS DNA; CD19 ANTIGEN; VIRUS PROTEIN;

ARTICLE; BLOOD LEVEL; CD3+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CERVICAL LYMPHADENOPATHY; CLINICAL ARTICLE; CONTROLLED STUDY; DIARRHEA; DISEASE ASSOCIATION; DISEASE COURSE; DNA EXTRACTION; EPSTEIN BARR VIRUS; FEMALE; FEVER; GENE EXPRESSION; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; LIVER GRAFT REJECTION; LIVER TRANSPLANTATION; LYMPHOCYTOSIS; LYMPHOPROLIFERATIVE DISEASE; MALE; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; RNA EXTRACTION; RNA PURIFICATION; SERODIAGNOSIS; VIRUS GENE; VIRUS LOAD; BIOSYNTHESIS; BLOOD; CHEMISTRY; EPSTEIN BARR VIRUS INFECTION; GENE EXPRESSION PROFILING; IMMUNOLOGY; INFANT; ISOLATION AND PURIFICATION; MONONUCLEAR CELL; PRESCHOOL CHILD; TRANSPLANTATION; VIROLOGY;

ANTIGENS, CD19; CD8-POSITIVE T-LYMPHOCYTES; CHILD, PRESCHOOL; DNA, VIRAL; EPSTEIN-BARR VIRUS INFECTIONS; FEMALE; GENE EXPRESSION PROFILING; HERPESVIRUS 4, HUMAN; HUMANS; INFANT; INTERLEUKIN-10; LEUKOCYTES, MONONUCLEAR; LIVER TRANSPLANTATION; MALE; TRANSPLANTATION; VIRAL LOAD; VIRAL PROTEINS;

EID: 77954694880     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/653737     Document Type: Article

References (32)

1. Rickinson AB, Kieff E. Epstein-Barr virus. In: Knipe DM, Howley PM, eds. Fields virology. Fifth ed. Philadelphia, PA: Lippincott Williams & Wilkins, 2007:2655-2700.
2. Cohen JI. Epstein-Barr virus infection. N Engl J Med 2000; 343:481-492.
3. Kis LL, Takahara M, Nagy N, Klein G, Klein E. Cytokine mediated induction of the major Epstein-Barr virus (EBV)-encoded transforming protein, LMP-1. Immunol Lett 2006; 104:83-88.
4. Williams H, Crawford DH. Epstein-Barr virus: the impact of scientific advances on clinical practice. Blood 2006; 107:862-869.
5. Wagner HJ, Wessel M, Jabs W, et al. Patients at risk for development of posttransplant lymphoproliferative disorder: plasma versus peripheral blood mononuclear cells as material for quantification of Epstein- Barr viral load by using real-time quantitative polymerase chain reaction. Transplantation 2001; 72:1012-1019.
6. Lee TC, Savoldo B, Rooney CM, et al. Quantitative EBV viral loads and immunosuppression alterations can decrease PTLD incidence in pediatric liver transplant recipients. Am J Transplant 2005; 5:2222-2228.
7. Kimura H, Morita M, Yabuta Y, et al. Quantitative analysis of Epstein- Barr virus load by using a real-time PCR assay. J Clin Microbiol 1999; 37:132-136.
8. Hopwood PA, Brooks L, Parratt R, et al. Persistent Epstein-Barr virus infection: unrestricted latent and lytic viral gene expression in healthy immunosuppressed transplant recipients. Transplantation 2002; 74:194-202.
9. Campe H, Jaeger G, Abou-Ajram C, et al. Serial detection of Epstein- Barr virus DNA in sera and peripheral blood leukocyte samples of pediatric renal allograft recipients with persistent mononucleosis-like symptoms defines patients at risk to develop post-transplant lymphoproliferative disease. Pediatr Transplant 2003; 7:46-52.
10. D'Antiga L, Del Rizzo M, Mengoli C, Cillo U, Guariso G, Zancan L. Sustained Epstein-Barr virus detection in paediatric liver transplantation: insights into the occurrence of late PTLD. Liver Transpl 2007;13: 343-348.
11. Bingler MA, Feingold B, Miller SA, et al. Chronic high Epstein-Barr viral load state and risk for late-onset posttransplant lymphoproliferative disease/lymphoma in children. Am J Transplant 2008; 8:442-445.
12. Green M, Soltys K, Rowe DT, Webber SA, Mazareigos G. Chronic high Epstein-Barr viral load carriage in pediatric liver transplant recipients. Pediatr Transplant 2009; 13:319-323.
13. Kamei H, Fujimoto Y, Nagai S, Suda R, Yamamoto H, Kiuchi T. Impact of non-congestive graft size in living donor liver transplantation: new indicator for additional vein reconstruction in right liver graft. Liver Transpl 2007; 13:1295-1301.
14. Kimura H, Hoshino Y, Kanegane H, et al. Clinical and virologic characteristics of chronic active Epstein-Barr virus infection. Blood 2001; 98:280-286.
15. Wada K, Kubota N, Ito Y, et al. Simultaneous quantification of Epstein- Barr virus, cytomegalovirus, and human herpesvirus 6 DNA in samples from transplant recipients by multiplex real-time PCR assay. J Clin Microbiol 2007; 45:1426-1432.
16. Kubota N, Wada K, Ito Y, et al. One-step multiplex real-time PCR assay to analyse the latency patterns of Epstein-Barr virus infection. J Virol Methods 2008; 147:26-36.
17. Patel K, Whelan PJ, Prescott S, et al. The use of real-time reverse transcription-PCR for prostate-specific antigen mRNA to discriminate between blood samples from healthy volunteers and from patients with metastatic prostate cancer. Clin Cancer Res 2004; 10:7511-7519.
18. Muti G, Klersy C, Baldanti F, et al. Epstein-Barr virus (EBV) load and interleukin-10 in EBV-positive and EBV-negative post-transplant lymphoproliferative disorders. Br J Haematol 2003; 122:927-933.
19. Stevens SJ, Verschuuren EA, Pronk I, et al. Frequent monitoring of Epstein-Barr virus DNA load in unfractionated whole blood is essential for early detection of posttransplant lymphoproliferative disease in high-risk patients. Blood 2001; 97:1165-1171.
20. Baldanti F, Grossi P, Furione M, et al. High levels of Epstein-Barr virus DNA in blood of solid-organ transplant recipients and their value in predicting posttransplant lymphoproliferative disorders. J Clin Microbiol 2000; 38:613-619.
21. Kimura H, Ito Y, Suzuki R, Nishiyama Y. Measuring Epstein-Barr virus (EBV) load: the significance and application for each EBV-associated disease. Rev Med Virol 2008; 18:305-319.
22. LaCasce AS. Post-transplant lymphoproliferative disorders. Oncologist 2006; 11:674-680.
23. Bakker NA, van Imhoff GW, Verschuuren EA, van Son WJ. Presentation and early detection of post-transplant lymphoproliferative disorder after solid organ transplantation. Transpl Int 2007; 20:207-218.
24. Hoshino Y, Kimura H, Tanaka N, et al. Prospective monitoring of the Epstein-Barr virus DNA by a real-time quantitative polymerase chain reaction after allogenic stem cell transplantation. Br J Haematol 2001; 115:105-111.
25. Rowe DT,Webber S, Schauer EM, Reyes J, Green M. Epstein-Barr virus load monitoring: its role in the prevention and management of posttransplant lymphoproliferative disease. Transpl Infect Dis 2001; 3:79-87.
26. Meij P, van Esser JW, Niesters HG, et al. Impaired recovery of Epstein- Barr virus (EBV)-specific CD8+ T lymphocytes after partially T-depleted allogeneic stem cell transplantation may identify patients at very high risk for progressive EBV reactivation and lymphoproliferative disease. Blood 2003; 101:4290-4297.
27. Macedo C, Donnenberg A, Popescu I, et al. EBV-specific memory CD8+ T cell phenotype and function in stable solid organ transplant patients. Transpl Immunol 2005; 14:109-116.
28. Smets F, Latinne D, Bazin H, et al. Ratio between Epstein-Barr viral load and anti-Epstein-Barr virus specific T-cell response as a predictive marker of posttransplant lymphoproliferative disease. Transplantation 2002; 73:1603-1610.
29. Yang J, Tao Q, Flinn IW, et al. Characterization of Epstein-Barr virusinfected B cells in patients with posttransplantation lymphoproliferative disease: disappearance after rituximab therapy does not predict clinical response. Blood 2000; 96:4055-4063.
30. Babcock GJ, Hochberg D, Thorley-Lawson AD. The expression pattern of Epstein-Barr virus latent genes in vivo is dependent upon the differentiation stage of the infected B cell. Immunity 2000; 13:497-506.
31. Qu L, Green M, Webber S, Reyes J, Ellis D, Rowe D. Epstein-Barr virus gene expression in the peripheral blood of transplant recipients with persistent circulating virus loads. J Infect Dis 2000; 182:1013-1021.
32. Thorley-Lawson DA, Gross A. Persistence of the Epstein-Barr virus and the origins of associated lymphomas. N Engl J Med 2004; 350: 1328-1337.