Enantiomeric separation of ofloxacin by nano-liquid chromatography using a sulfated-β-cyclodextrin as a chiral selector in the mobile phase

Current Analytical Chemistry

Volumn 6, Issue 3, 2010, Pages 209-216

  Rosales Conrado, Noelia ^a,b   Leon Gonzalez, Maria E ^b   Rocco, Anna ^a   Fanali, Salvatore ^a  

^a CNR Consiglio Nazionale delle Ricerche   (Italy)

^b UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

Author keywords

Chiral separation; Fluoroquinolone antibiotics; Nano liquid chromatography; Ofloxacin; cyclodextrin

Indexed keywords

ANTIBIOTICS; CHIRALITY; ENANTIOMERS; LIQUID CHROMATOGRAPHY; SODIUM COMPOUNDS;

ANTI-BACTERIAL ACTIVITY; CHIRAL SELECTOR; CHIRAL SEPARATIONS; ENANTIOMERIC SEPARATION; FLUOROQUINOLONE ANTIBIOTICS; MOBILE PHASIS; NANO LIQUID CHROMATOGRAPHY; OFLOXACIN; S-ENANTIOMERS; Β-CYCLODEXTRIN;

CYCLODEXTRINS;

EID: 77954680992     PISSN: 15734110     EISSN: None     Source Type: Journal    
DOI: 10.2174/157341110791516972     Document Type: Article

References (28)

1. Hooper, D.C. Clinical applications of quinolones. Biochim. Biophys. Acta, 1998, 1400, 45-61.
2. Morissey, I.; Kazuki, H.; Sato, K.; Yoshida, A.; Hayakawa, I.; Bures, M.G.; Shen, L.L. Mechanism of differential activities of ofloxacin enantiomers. Antimicrob. Agents Chem., 1996, 40(8), 1775-1784.
3. FDA policy statement for the development of new stereoisomer drugs. Chirality, 1992, 4, 3238-3340.
4. Zhou, S.; Ouyang, J.; Baeyens, W.G.R.; Zhao, H.; Yang, Y. Chiral separation of four fluoroquinolone compounds using capillary electrophoresis with hydroxypropyl--cyclodextrin as chiral selector. J. Chromatogr. A, 2006, 1130, 296-301.
5. Elbashir, A.A.; Saad, B.; Ali, A.S.M.; Saleh, M.I.; Aboul-Enein, H.Y. Determination of ofloxacin enantiomers in pharmaceutical formulations by capillary electrophoresis. J. Liq. Chromatogr. R. T., 2008, 31(3), 348-360.
6. Wang, W.; Lu, J.; Fu, X.; Chen, Y. Carboxymethyl- -cyclodextrin for chiral separation of basic drugs by capillary electrophoresis. Anal. Lett., 2001, 34(4), 569-578.
7. Awadallah, B.; Schmidt, P.C.; Wahl, M.A. Quantitation of the enantiomers of ofloxacin by capillary electrophoresis in the parts per billon concentration range for in vitro drug absorption studies. J. Chromatogr. A, 2003, 988(1), 135-143.
8. Boer, T.; Mol, R.; Zeeuw, R.A.; Jong, G.J.; Ensing, K. Enantioseparation of ofloxacin by capillary electrokinetic chromatography using charged cyclodextrins as chiral selectors and assessment of enantioconversion, Electrophoresis, 2001, 22, 1413-1418.
9. Arai, T.; Nimura, N.K.; Kinoshita, T. Investigation of enantioselective separation of quinolonecarboxylic acids by capillary zone electrophoresis using vancomycin as a chiral selector. J. Chromatogr. A, 1996, 736, 303-311.
10. Grellet, J.; Ba, B.; Saux, M.C. High-performance liquid chromatography separation of fluoroquinolone enantiomers: a review. J. Biochem. Biophys. Methods, 2002, 54, 221-233.
11. Lehr, K.H.; Damm, P. Quantification of the enantiomers of ofloxacin in biological fluids by high-performance liquid chromatography. J. Chromatogr., 1988, 425, 153-161.
12. Arai, T.; Koike, H.; Hirata, K.; Oizumi, H. Separation of pyridoxine carboxylic acid enantiomers by high-performance liquid chromatography using copper (II)-L-amino acid as eluent. J. Chromatogr., 1988, 448, 439-444.
13. Zeng, S.; Zhong, J.; Pan, L.; Li, Y. High-performance liquid chromatography separation and quantification of ofloxacin enantiomers in rat microsomes. J. Chromatogr. B, 1999, 728, 151-155.
14. Shao, B.; Sun, X.; Zhang, J.; Hu, J.; Dong, H.; Yanh, Y. Determination of ofloxacin enantiomers in sewage using two-step solidphase extraction and liquid chromatography with fluorescence detection. J. Chromatogr. A, 2008, 1182, 77-84.
15. Rabaa, L.; Dautrey, S.; Colas-Linhart, N.; Carbon, C.; Farinotti, R. Absorption of ofloxacin isomers in the rat small intestine. Antimicrob. Agents Chem., 1997, 41(10), 2274-2277
16. Sun, X.; Shao, B.; Dong, H.; Hu, J. Analysis of ofloxacin enantiomers in sewage by high performance liquid chromatography. J. Univ. Sci. Technol. B., 2008, 35, 20-23.
17. Karlsson, K.E.; Novotny, M. Separation efficiency of slurry-packed LC microcolumns with very small inner diameters. Anal. Chem., 1988, 60, 1662-1665.
18. Vissers, J.P.C.; Claessens, H.A.; Cramers, C.A. Microcolumn liquid chromatography: instrumentation, detection and applications. J. Chromatogr. A, 1997, 779, 1-28.
19. Takeuchi, T.; Nagae, N. Enantiomeric resolution of dansyl phenylalanine and analogs by microcolumn liquid chromatography with -cyclodextrin as mobile phase additive. J. High Res. Chromatogr., 1992, 15, 121-123.
20. Takeuchi, T. Separation of 1,1'-binaphthyl-2,2'-diyl hydrogen phosphate enantiomers by microcolumn liquid chromatography with -cyclodextrin as mobile phase additive. J. High Res. Chromatogr., 1991, 14, 560-561.
21. Hu, R.; Takeuchi, T.; Jin, J.Y.; Miwa, T. Separation of enantiomers by microcolumn liquid chromatography with methylated cyclodextrin as mobile phase additive. Anal. Chim. Acta, 1994, 295, 173-179.
22. Healy, L.O.; Murrihy, J.P.; Tan, A.; Cocker, D.; McEnery, M.; Glenon, J.D. Enantiomeric separation of R,S-naxopren by conventional and nano-liquid chromatography with methyl- -cyclodextrin as mobile phase additive. J. Chromatogr. A, 2001, 924, 459-464.
23. Rocco, A.; Fanali, S. Enantiomeric separation of acidic compounds by nano-liquid chromatography with methylated- -cyclodextrin as a mobile phase additive. J. Sep. Sci., 2009, 32, 1696-1703.
24. Aturki, Z.; D'Orazio, G.; Fanali, S. Rapid assay of vitamin E in vegetable oils by reversed phase capillary electrochromatography. Electrophoresis, 2005, 26, 798-803.
25. Hernandez-Borges, J.; D'Orazio, G.; Aturki, Z.; Fanali, S. Nanoliquid chromatography analysis of dansylated biogenic amines in wines. J. Chromatogr. A, 2007, 1147, 192-199.
26. Rosales-Conrado, N.; Leon-Gonzalez, M.E.; D'Orazio, G.; Fanali, S. Enantiomeric separation of chlorophenoxy acid herbicides by nano liquid chromatography-UV detection on a vancomycin based chiral stationary phase. J. Sep. Sci., 2004, 27, 1303-1308.
27. Johnson, G.; Westwood, S.; Houghton, R. A generic approach for the HPLC separation of quinolone antibiotics. Chromatographia, 2002, 55, 127-131.
28. Chankvetadze, B. Capillary electrophoresis in chiral analysis, John Wiley and Sons Ltd: England, 1997, pp. 157-167.