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Volumn 10, Issue SUPPL. 1, 2010, Pages

Acetyl-l-carnitine improves aged brain function

Author keywords

Acetyl l carnitine; Aging; Behavior; Brain; Synapses

Indexed keywords

ACETYLCHOLINE; CALCIUM ION; CHOLINE; LEVACECARNINE; ACETYLCARNITINE; CARNITINE; VITAMIN B COMPLEX;

EID: 77954676430     PISSN: 14441586     EISSN: 14470594     Source Type: Journal    
DOI: 10.1111/j.1447-0594.2010.00595.x     Document Type: Article
Times cited : (31)

References (43)
  • 1
    • 0019972810 scopus 로고
    • The cholinergic hypothesis of geriatric memory dysfunction
    • Bartus RT, Dean RL, Beer B, Lippa AS. The cholinergic hypothesis of geriatric memory dysfunction. Science 1982, 217:408-414.
    • (1982) Science , vol.217 , pp. 408-414
    • Bartus, R.T.1    Dean, R.L.2    Beer, B.3    Lippa, A.S.4
  • 2
    • 0022922249 scopus 로고
    • Age and sex-dependent decreases in ChAT in basal forebrain nuclei
    • Luine VN, Renner KJ, Heady S, Jones KJ. Age and sex-dependent decreases in ChAT in basal forebrain nuclei. Neurobiol Aging 1986, 7:193-198.
    • (1986) Neurobiol Aging , vol.7 , pp. 193-198
    • Luine, V.N.1    Renner, K.J.2    Heady, S.3    Jones, K.J.4
  • 3
    • 0019794025 scopus 로고
    • Brain acetylcholine synthesis declines with senescence
    • Gibson GE, Peterson C, Jenden DJ. Brain acetylcholine synthesis declines with senescence. Science 1981, 213:674-676.
    • (1981) Science , vol.213 , pp. 674-676
    • Gibson, G.E.1    Peterson, C.2    Jenden, D.J.3
  • 4
    • 0027759639 scopus 로고
    • The development of age-related deficits in several presynaptic processes associated with brain [3H]acetylcholine release
    • Meyer EM, Judkins JH. The development of age-related deficits in several presynaptic processes associated with brain [3H]acetylcholine release. Mech Ageing Dev 1993, 72:119-128.
    • (1993) Mech Ageing Dev , vol.72 , pp. 119-128
    • Meyer, E.M.1    Judkins, J.H.2
  • 5
    • 0343462068 scopus 로고
    • Galanin antagonizes acetylcholine on a memory task in basal forebrain-lesioned rats
    • Mastropaolo J, Nadi NS, Ostrowski NL, Crawley JN. Galanin antagonizes acetylcholine on a memory task in basal forebrain-lesioned rats. Proc Natl Acad Sci USA 1988, 85:9841-9845.
    • (1988) Proc Natl Acad Sci USA , vol.85 , pp. 9841-9845
    • Mastropaolo, J.1    Nadi, N.S.2    Ostrowski, N.L.3    Crawley, J.N.4
  • 6
    • 84923364625 scopus 로고
    • Zur Kenntnis der Extrktionsstofe der Muskeln. 2. Mitteilung uber das Carnitin
    • Gulewtisch W, Krimberg R. Zur Kenntnis der Extrktionsstofe der Muskeln. 2. Mitteilung uber das Carnitin. Hoppe Seylers Physiol Chem 1905, 45:326-330.
    • (1905) Hoppe Seylers Physiol Chem , vol.45 , pp. 326-330
    • Gulewtisch, W.1    Krimberg, R.2
  • 7
    • 0026948442 scopus 로고
    • L-carnitine: metabolism, functions and value in pathology
    • Jacob C, Belleville F. l-carnitine: metabolism, functions and value in pathology. Pathol Biol (Paris) 1992, 40:910-919.
    • (1992) Pathol Biol (Paris) , vol.40 , pp. 910-919
    • Jacob, C.1    Belleville, F.2
  • 8
    • 0030049889 scopus 로고    scopus 로고
    • Drug treatment of Alzheimer's disease. Effects on caregiver burden and patient quality of life
    • Hollister L, Gruber N. Drug treatment of Alzheimer's disease. Effects on caregiver burden and patient quality of life. Drugs Aging 1996, 8:47-55.
    • (1996) Drugs Aging , vol.8 , pp. 47-55
    • Hollister, L.1    Gruber, N.2
  • 9
    • 0022494388 scopus 로고
    • Study of the efficacy and tolerability of l-acetylcarnitine therapy in the senile brain
    • Bonavita E. Study of the efficacy and tolerability of l-acetylcarnitine therapy in the senile brain. Int J Clin Pharmacol Ther Toxicol 1986, 24:511-516.
    • (1986) Int J Clin Pharmacol Ther Toxicol , vol.24 , pp. 511-516
    • Bonavita, E.1
  • 10
    • 0025010733 scopus 로고
    • Role of acetyl-L-carnitine in the treatment of cognitive deficit in chronic alcoholism
    • Tempesta E, Troncon R, Janiri L. Role of acetyl-L-carnitine in the treatment of cognitive deficit in chronic alcoholism. Int J Clin Pharmacol Res 1990, 10:101-107.
    • (1990) Int J Clin Pharmacol Res , vol.10 , pp. 101-107
    • Tempesta, E.1    Troncon, R.2    Janiri, L.3
  • 11
    • 0032875579 scopus 로고    scopus 로고
    • Attenuation by acetyl-L-carnitine of neurological damage and biochemical derangement following brain ischemia and reperfusion
    • Calvani M, Arrigoni-Martelli E. Attenuation by acetyl-L-carnitine of neurological damage and biochemical derangement following brain ischemia and reperfusion. Int J Tissue React 1999, 21:1-6.
    • (1999) Int J Tissue React , vol.21 , pp. 1-6
    • Calvani, M.1    Arrigoni-Martelli, E.2
  • 12
    • 0000607131 scopus 로고
    • A closed field intelligence test for rats
    • Rabinovitch MS, Rosvold HE. A closed field intelligence test for rats. Can J Psychol 1951, 5:122-128.
    • (1951) Can J Psychol , vol.5 , pp. 122-128
    • Rabinovitch, M.S.1    Rosvold, H.E.2
  • 13
    • 0017862201 scopus 로고
    • A method for the rapid separation of cytosolic and particulate components of rat brain synaptosomes
    • Booth RF, Clark JB. A method for the rapid separation of cytosolic and particulate components of rat brain synaptosomes. Biochem Soc Trans 1978, 6:128-129.
    • (1978) Biochem Soc Trans , vol.6 , pp. 128-129
    • Booth, R.F.1    Clark, J.B.2
  • 14
    • 0030589030 scopus 로고    scopus 로고
    • Determination of l-carnitine, acetyl-L-carnitine, and propionyl-L-carnitine in human plasma by high-performance liquid chromatography after pre-column derivatization with l-aminoanthracene
    • Longo A, Bruno G, Curyi S, Mancinelli A, Miott G. Determination of l-carnitine, acetyl-L-carnitine, and propionyl-L-carnitine in human plasma by high-performance liquid chromatography after pre-column derivatization with l-aminoanthracene. J. Chromatogr B Biomed Appl 1996, 686:129-139.
    • (1996) J. Chromatogr B Biomed Appl , vol.686 , pp. 129-139
    • Longo, A.1    Bruno, G.2    Curyi, S.3    Mancinelli, A.4    Miott, G.5
  • 15
    • 1642328052 scopus 로고    scopus 로고
    • 100 years of mazes in psychology & neuroscience
    • Clements RL, Brown RE. 100 years of mazes in psychology & neuroscience. Soc Neurosci Abstr 1999, 25:261.
    • (1999) Soc Neurosci Abstr , vol.25 , pp. 261
    • Clements, R.L.1    Brown, R.E.2
  • 16
    • 0002320935 scopus 로고
    • A method of rating animal intelligence
    • Hebb DO, Williams KA. A method of rating animal intelligence. J Gen Psychol 1946, 34:59-65.
    • (1946) J Gen Psychol , vol.34 , pp. 59-65
    • Hebb, D.O.1    Williams, K.A.2
  • 17
    • 0002096713 scopus 로고
    • Studies in spatial learning. I. Orientation and the short-cut
    • Tolman EC, Ritchie BF, Kalish D. Studies in spatial learning. I. Orientation and the short-cut. J Exp Psychol 1946, 36:13-24.
    • (1946) J Exp Psychol , vol.36 , pp. 13-24
    • Tolman, E.C.1    Ritchie, B.F.2    Kalish, D.3
  • 18
    • 0025284835 scopus 로고
    • Acetyl-L-carnitine as a precursor of acetylcholine
    • White HL, Scates PW. Acetyl-L-carnitine as a precursor of acetylcholine. Neurochem Res 1990, 15:597-601.
    • (1990) Neurochem Res , vol.15 , pp. 597-601
    • White, H.L.1    Scates, P.W.2
  • 19
    • 0024500456 scopus 로고
    • Effect of aging and acetyl-L-carnitine on energetic and cholinergic metabolism in rat brain regions
    • Curti D, Dagani F, Galmozzi MR, Marzatico F. Effect of aging and acetyl-L-carnitine on energetic and cholinergic metabolism in rat brain regions. Mech Ageing Dev 1989, 47:39-45.
    • (1989) Mech Ageing Dev , vol.47 , pp. 39-45
    • Curti, D.1    Dagani, F.2    Galmozzi, M.R.3    Marzatico, F.4
  • 20
    • 0027500472 scopus 로고
    • Acetyl-L-carnitine: behavioral, electrophysiological, and neurochemical effects
    • Davis S, Markowska AL, Wenk GL, Barnes CA. Acetyl-L-carnitine: behavioral, electrophysiological, and neurochemical effects. Neurobiol Aging 1993, 14:107-115.
    • (1993) Neurobiol Aging , vol.14 , pp. 107-115
    • Davis, S.1    Markowska, A.L.2    Wenk, G.L.3    Barnes, C.A.4
  • 21
    • 20444380384 scopus 로고    scopus 로고
    • Function and dysfunction of synaptic calcium channels: insights from mouse models
    • Pietrobon D. Function and dysfunction of synaptic calcium channels: insights from mouse models. Curr Opin Neurobiol 2005, 15:257-265.
    • (2005) Curr Opin Neurobiol , vol.15 , pp. 257-265
    • Pietrobon, D.1
  • 22
    • 0026744863 scopus 로고
    • Age-dependence of effects of A1 adenosine receptor antagonism in rat hippocampal slices
    • Bauman LA, Mahle CD, Boissard CG, Gribkoff VK. Age-dependence of effects of A1 adenosine receptor antagonism in rat hippocampal slices. J Neurophysiol 1992, 68:629-638.
    • (1992) J Neurophysiol , vol.68 , pp. 629-638
    • Bauman, L.A.1    Mahle, C.D.2    Boissard, C.G.3    Gribkoff, V.K.4
  • 24
    • 0020004264 scopus 로고
    • Production of [14C]acetylcholine and [14C]carbon dioxide from [U-14C]glucose in tissue prisms from aging rat brain
    • Sims NR, Marek KL, Bowen DM, Davison AN. Production of [14C]acetylcholine and [14C]carbon dioxide from [U-14C]glucose in tissue prisms from aging rat brain. J Neurochem 1982, 38:488-492.
    • (1982) J Neurochem , vol.38 , pp. 488-492
    • Sims, N.R.1    Marek, K.L.2    Bowen, D.M.3    Davison, A.N.4
  • 25
    • 0020957423 scopus 로고
    • Acetylcholine release from rat cortical slices during postnatal development and aging
    • Pedata F, Slavikova J, Kotas A, Pepeu G. Acetylcholine release from rat cortical slices during postnatal development and aging. Neurobiol Aging 1983, 4:31-35.
    • (1983) Neurobiol Aging , vol.4 , pp. 31-35
    • Pedata, F.1    Slavikova, J.2    Kotas, A.3    Pepeu, G.4
  • 26
    • 0022517837 scopus 로고
    • Aging decreases the sensitivity of rat cortical synaptosomes to calcium ionophore-induced acetylcholine release
    • Meyer EM, Crews FT, Otero DH, Larsen K. Aging decreases the sensitivity of rat cortical synaptosomes to calcium ionophore-induced acetylcholine release. J Neurochem 1986, 47:1244-1246.
    • (1986) J Neurochem , vol.47 , pp. 1244-1246
    • Meyer, E.M.1    Crews, F.T.2    Otero, D.H.3    Larsen, K.4
  • 27
    • 0025124803 scopus 로고
    • Acetylcholine release from striatal slices of young adult and aged Fischer 344 rats
    • Weiler MH. Acetylcholine release from striatal slices of young adult and aged Fischer 344 rats. Neurobiol Aging 1990, 11:401-407.
    • (1990) Neurobiol Aging , vol.11 , pp. 401-407
    • Weiler, M.H.1
  • 28
    • 0027943770 scopus 로고
    • Age-related changes of cholinergic markers in the rat brain
    • Yufu F, Egashira T, Yamanaka Y. Age-related changes of cholinergic markers in the rat brain. Jpn J Pharmacol 1994, 66:247-255.
    • (1994) Jpn J Pharmacol , vol.66 , pp. 247-255
    • Yufu, F.1    Egashira, T.2    Yamanaka, Y.3
  • 29
    • 0026567917 scopus 로고
    • Progressive decline in spatial learning and integrity of forebrain cholinergic neurons in rats during aging
    • Fischer W, Chen KS, Gage FH, Björklund A. Progressive decline in spatial learning and integrity of forebrain cholinergic neurons in rats during aging. Neurobiol Aging 1992, 13:9-23.
    • (1992) Neurobiol Aging , vol.13 , pp. 9-23
    • Fischer, W.1    Chen, K.S.2    Gage, F.H.3    Björklund, A.4
  • 30
    • 0027432949 scopus 로고
    • Age-related behavioral and neurochemical deficits: the cholinergic system revisited
    • Gorman LK. Age-related behavioral and neurochemical deficits: the cholinergic system revisited. Neurobiol Aging 1993, 14:699-702.
    • (1993) Neurobiol Aging , vol.14 , pp. 699-702
    • Gorman, L.K.1
  • 31
    • 0027295385 scopus 로고
    • Morphologic alterations of choline acetyltransferase-positive neurons in the basal forebrain of aged behaviorally characterized Fisher 344 rats
    • Armstrong DM, Sheffield R, Buzsáki G. Morphologic alterations of choline acetyltransferase-positive neurons in the basal forebrain of aged behaviorally characterized Fisher 344 rats. Neurobiol Aging 1993, 14:457-470.
    • (1993) Neurobiol Aging , vol.14 , pp. 457-470
    • Armstrong, D.M.1    Sheffield, R.2    Buzsáki, G.3
  • 32
    • 0028287088 scopus 로고
    • Spatial learning deficits in the aged rat: neuroanatomical and neurochemical correlates
    • Lee JM, Ross ER, Gower A, Paris JM, Martensson R, Lorens SA. Spatial learning deficits in the aged rat: neuroanatomical and neurochemical correlates. Brain Res Bull 1994, 33:489-500.
    • (1994) Brain Res Bull , vol.33 , pp. 489-500
    • Lee, J.M.1    Ross, E.R.2    Gower, A.3    Paris, J.M.4    Martensson, R.5    Lorens, S.A.6
  • 33
    • 0031766282 scopus 로고    scopus 로고
    • Individual differences in spatial memory and striatal ChAT activity among young and aged rats
    • Colombo PJ, Gallagher M. Individual differences in spatial memory and striatal ChAT activity among young and aged rats. Neurobiol Learn Mem 1998, 70:314-327.
    • (1998) Neurobiol Learn Mem , vol.70 , pp. 314-327
    • Colombo, P.J.1    Gallagher, M.2
  • 34
    • 0033575467 scopus 로고    scopus 로고
    • Effects of age and sex on the water maze performance and hippocampal cholinergic fibers in rats
    • Lukoyanov NV, Andrade JP, Dulce Madeira M, Paula-Barbosa MM. Effects of age and sex on the water maze performance and hippocampal cholinergic fibers in rats. Neurosci Lett 1999, 269:141-144.
    • (1999) Neurosci Lett , vol.269 , pp. 141-144
    • Lukoyanov, N.V.1    Andrade, J.P.2    Dulce Madeira, M.3    Paula-Barbosa, M.M.4
  • 35
    • 0034647829 scopus 로고    scopus 로고
    • Hippocampal acetylcholine release correlates with spatial learning performance in freely moving rats
    • Fadda F, Cocco S, Stancampiano R. Hippocampal acetylcholine release correlates with spatial learning performance in freely moving rats. Neuroreport 2000, 11:2265-2269.
    • (2000) Neuroreport , vol.11 , pp. 2265-2269
    • Fadda, F.1    Cocco, S.2    Stancampiano, R.3
  • 36
    • 0033620903 scopus 로고    scopus 로고
    • Severe learning impairment caused by combined immunotoxic lesion of the cholinergic projections to the cortex and hippocampus in monkeys
    • Ridley RM, Pugh P, Maclean CJ, Baker HF. Severe learning impairment caused by combined immunotoxic lesion of the cholinergic projections to the cortex and hippocampus in monkeys. Brain Res 1999, 836:120-138.
    • (1999) Brain Res , vol.836 , pp. 120-138
    • Ridley, R.M.1    Pugh, P.2    Maclean, C.J.3    Baker, H.F.4
  • 37
    • 0032702092 scopus 로고    scopus 로고
    • Threshold relationship between lesion extent of the cholinergic basal forebrain in the rat and working memory impairment in the radial maze
    • Wrenn CC, Lappi DA, Wiley RG. Threshold relationship between lesion extent of the cholinergic basal forebrain in the rat and working memory impairment in the radial maze. Brain Res 1999, 847:284-298.
    • (1999) Brain Res , vol.847 , pp. 284-298
    • Wrenn, C.C.1    Lappi, D.A.2    Wiley, R.G.3
  • 38
    • 0028894038 scopus 로고
    • Maze learning in aged rats is enhanced by phenserine, a novel anticholinesterase
    • Ikari H, Spangler EL, Greig NH. Maze learning in aged rats is enhanced by phenserine, a novel anticholinesterase. Neuroreport 1995, 6:481-484.
    • (1995) Neuroreport , vol.6 , pp. 481-484
    • Ikari, H.1    Spangler, E.L.2    Greig, N.H.3
  • 39
    • 0028961267 scopus 로고
    • Cholinergic manipulations in the medial septal area: age-related effects on working memory and hippocampal electrophysiology
    • Markowska AL, Olton DS, Givens B. Cholinergic manipulations in the medial septal area: age-related effects on working memory and hippocampal electrophysiology. J Neurosci 1995, 15:2063-2073.
    • (1995) J Neurosci , vol.15 , pp. 2063-2073
    • Markowska, A.L.1    Olton, D.S.2    Givens, B.3
  • 40
    • 0020318261 scopus 로고
    • Carnitine transport in cultured muscle cells and skin fibroblasts from patients with primary systemic carnitine deficiency
    • Rebouche CJ, Engel AG. Carnitine transport in cultured muscle cells and skin fibroblasts from patients with primary systemic carnitine deficiency. In Vitro 1982, 18:495-500.
    • (1982) In Vitro , vol.18 , pp. 495-500
    • Rebouche, C.J.1    Engel, A.G.2
  • 42
    • 0032767691 scopus 로고    scopus 로고
    • Functional characteristics and tissue distribution pattern of organic cation transporter 2 (OCTN2), an organic cation/carnitine transporter
    • Wu X, Huang W, Prasad PD. Functional characteristics and tissue distribution pattern of organic cation transporter 2 (OCTN2), an organic cation/carnitine transporter. J Pharmacol Exp Ther 1999, 290:1482-1492.
    • (1999) J Pharmacol Exp Ther , vol.290 , pp. 1482-1492
    • Wu, X.1    Huang, W.2    Prasad, P.D.3


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