메뉴 건너뛰기




Volumn 1, Issue 1, 2009, Pages

β-arrestin-biased parathyroid hormone ligands: A new approach to the development of agents that stimulate bone formation

Author keywords

[No Author keywords available]

Indexed keywords

BETA ARRESTIN; LIGAND; PARATHYROID HORMONE; RETINA S ANTIGEN;

EID: 77954672681     PISSN: 19466234     EISSN: 19466242     Source Type: Journal    
DOI: 10.1126/scitranslmed.3000268     Document Type: Review
Times cited : (9)

References (19)
  • 1
    • 73949084919 scopus 로고    scopus 로고
    • A β-arrestin-biased agonist of the parathyroid hormone receptor (PTH1R) promotes bone formation independent of G protein activation
    • D. Gesty-Palmer et al., A β-arrestin-biased agonist of the parathyroid hormone receptor (PTH1R) promotes bone formation independent of G protein activation. Sci. Transl. Med. 1, 1ra1 (2009).
    • (2009) Sci. Transl. Med. , vol.1
    • Gesty-Palmer, D.1
  • 2
    • 1642444847 scopus 로고    scopus 로고
    • PTH diff erentially regulates expression of RANKL and OPG
    • J. C. Huang et al., PTH diff erentially regulates expression of RANKL and OPG. J. Bone Miner. Res. 19, 235-244 (2004).
    • (2004) J. Bone Miner. Res. , vol.19 , pp. 235-244
    • Huang, J.C.1
  • 3
    • 42749095019 scopus 로고    scopus 로고
    • Studies on the mechanisms of the skeletal anabolic action of endogenous and exogenous parathyroid hormone
    • D. Goltzman, Studies on the mechanisms of the skeletal anabolic action of endogenous and exogenous parathyroid hormone. Arch. Biochem. Biophys. 473, 218-224 (2008).
    • (2008) Arch. Biochem. Biophys. , vol.473 , pp. 218-224
    • Goltzman, D.1
  • 4
    • 21844467220 scopus 로고    scopus 로고
    • SOST is a target gene for PTH in bone
    • H. Keller, M. Kneissel, SOST is a target gene for PTH in bone. Bone 37, 148-158 (2005).
    • (2005) Bone , vol.37 , pp. 148-158
    • Keller, H.1    Kneissel, M.2
  • 5
    • 0035837553 scopus 로고    scopus 로고
    • Eff ect of parathyroid hormone (1-34) on fractures and bone mineral density in postmenopausal women with osteoporosis
    • R. M. Neer et al., Eff ect of parathyroid hormone (1-34) on fractures and bone mineral density in postmenopausal women with osteoporosis. N. Engl. J. Med. 344, 1434-1441 (2001).
    • (2001) N. Engl. J. Med. , vol.344 , pp. 1434-1441
    • Neer, R.M.1
  • 6
    • 0033345813 scopus 로고    scopus 로고
    • On the mechanism of cancellous bone preservation in postmenopausal women with mild primary hyperparathyroidism
    • D. W. Dempster et al., On the mechanism of cancellous bone preservation in postmenopausal women with mild primary hyperparathyroidism. J. Clin. Endocrinol. Metab. 84, 1562-1566 (1999).
    • (1999) J. Clin. Endocrinol. Metab. , vol.84 , pp. 1562-1566
    • Dempster, D.W.1
  • 7
    • 0035138914 scopus 로고    scopus 로고
    • Activated parathyroid hormone/parathyroid hormone-related protein receptor in osteoblastic cells diff erentially aff ects cortical and trabecular bone
    • L. M. Calvi et al., Activated parathyroid hormone/parathyroid hormone-related protein receptor in osteoblastic cells diff erentially aff ects cortical and trabecular bone. J. Clin. Invest. 107, 277-286 (2001).
    • (2001) J. Clin. Invest. , vol.107 , pp. 277-286
    • Calvi, L.M.1
  • 8
    • 0033570107 scopus 로고    scopus 로고
    • Endocytosis of ligand-human parathyroid hormone receptor 1 complexes is protein kinase C-dependent and involves β-arrestin2. Real-time monitoring by fluorescence microscopy
    • S. L. Ferrari, V. Behar, M. Chorev, M. Rosenblatt, A. Bisello, Endocytosis of ligand-human parathyroid hormone receptor 1 complexes is protein kinase C-dependent and involves β-arrestin2. Real-time monitoring by fluorescence microscopy. J. Biol. Chem. 274, 29968-29975 (1999).
    • (1999) J. Biol. Chem. , vol.274 , pp. 29968-29975
    • Ferrari, S.L.1    Behar, V.2    Chorev, M.3    Rosenblatt, M.4    Bisello, A.5
  • 9
    • 0035137316 scopus 로고    scopus 로고
    • Cellular distribution of constitutively active mutant parathyroid hormone (PTH)/PTHrelated protein receptors and regulation of cyclic adenosine 3′,5′-monophosphate signaling by β-arrestin2
    • S. L. Ferrari, A. Bisello, Cellular distribution of constitutively active mutant parathyroid hormone (PTH)/PTHrelated protein receptors and regulation of cyclic adenosine 3′,5′-monophosphate signaling by β-arrestin2. Mol. Endocrinol. 15, 149-163 (2001).
    • (2001) Mol. Endocrinol. , vol.15 , pp. 149-163
    • Ferrari, S.L.1    Bisello, A.2
  • 10
    • 0037064132 scopus 로고    scopus 로고
    • Selective ligand-induced stabilization of active and desensitized parathyroid hormone type 1 receptor conformations
    • A. Bisello et al., Selective ligand-induced stabilization of active and desensitized parathyroid hormone type 1 receptor conformations. J. Biol. Chem. 277, 38524-38530 (2002).
    • (2002) J. Biol. Chem. , vol.277 , pp. 38524-38530
    • Bisello, A.1
  • 11
    • 68949173918 scopus 로고    scopus 로고
    • β-arrestin2 regulates parathyroid hormone eff ects on a p38 MAPK and NFkappaB gene expression network in osteoblasts
    • E. N. Bianchi, S. L. Ferrari, β-arrestin2 regulates parathyroid hormone eff ects on a p38 MAPK and NFkappaB gene expression network in osteoblasts. Bone 45, 716-725 (2009).
    • (2009) Bone , vol.45 , pp. 716-725
    • Bianchi, E.N.1    Ferrari, S.L.2
  • 12
    • 65949091145 scopus 로고    scopus 로고
    • β-arrestin2 regulates RANKL and ephrins gene expression in response to bone remodeling in mice
    • D. D. Pierroz et al., β-arrestin2 regulates RANKL and ephrins gene expression in response to bone remodeling in mice. J. Bone Miner. Res. 24, 775-784 (2009).
    • (2009) J. Bone Miner. Res. , vol.24 , pp. 775-784
    • Pierroz, D.D.1
  • 13
    • 15444367508 scopus 로고    scopus 로고
    • Bone response to intermittent parathyroid hormone is altered in mice null for β-arrestin2
    • S. L. Ferrari et al., Bone response to intermittent parathyroid hormone is altered in mice null for β-arrestin2. Endocrinology 146, 1854-1862 (2005).
    • (2005) Endocrinology , vol.146 , pp. 1854-1862
    • Ferrari, S.L.1
  • 14
    • 15344347049 scopus 로고    scopus 로고
    • β-arrestin2 regulates the diff erential response of cortical and trabecular bone to intermittent PTH in female mice
    • M. L. Bouxsein et al., β-arrestin2 regulates the diff erential response of cortical and trabecular bone to intermittent PTH in female mice. J. Bone Miner. Res. 20, 635-643 (2005).
    • (2005) J. Bone Miner. Res. , vol.20 , pp. 635-643
    • Bouxsein, M.L.1
  • 15
    • 33845967852 scopus 로고    scopus 로고
    • Proline-rich motifs in the parathyroid hormone (PTH)/PTH-related protein receptor C terminus mediate scaffolding of c-Src with â-arrestin2 for ERK1/2 activation
    • A. Rey, D. Manen, R. Rizzoli, J. Caverzasio, S. L. Ferrari, Proline-rich motifs in the parathyroid hormone (PTH)/PTH-related protein receptor C terminus mediate scaffolding of c-Src with â-arrestin2 for ERK1/2 activation. J. Biol. Chem. 281, 38181-38188 (2006).
    • (2006) J. Biol. Chem. , vol.281 , pp. 38181-38188
    • Rey, A.1    Manen, D.2    Rizzoli, R.3    Caverzasio, J.4    Ferrari, S.L.5
  • 16
    • 33744957160 scopus 로고    scopus 로고
    • Distinct β-arrestin- and G protein-dependent pathways for parathyroid hormone receptorstimulated ERK1/2 activation
    • D. Gesty-Palmer et al., Distinct β-arrestin- and G protein-dependent pathways for parathyroid hormone receptorstimulated ERK1/2 activation. J. Biol. Chem. 281, 10856-10864 (2006).
    • (2006) J. Biol. Chem. , vol.281 , pp. 10856-10864
    • Gesty-Palmer, D.1
  • 17
    • 34250029687 scopus 로고    scopus 로고
    • Evidences for a role of p38 MAP kinase in the stimulation of alkaline phosphatase and matrix mineralization induced by parathyroid hormone in osteoblastic cells
    • A. Rey, D. Manen, R. Rizzoli, S. L. Ferrari, J. Caverzasio, Evidences for a role of p38 MAP kinase in the stimulation of alkaline phosphatase and matrix mineralization induced by parathyroid hormone in osteoblastic cells. Bone 41, 59-67 (2007).
    • (2007) Bone , vol.41 , pp. 59-67
    • Rey, A.1    Manen, D.2    Rizzoli, R.3    Ferrari, S.L.4    Caverzasio, J.5
  • 18
    • 34447649922 scopus 로고    scopus 로고
    • β-arrestin-biased ligands at seven-transmembrane receptors
    • J. D. Violin, R. J. Lefkowitz, β-arrestin-biased ligands at seven-transmembrane receptors. Trends Pharmacol. Sci. 28, 416-422 (2007).
    • (2007) Trends Pharmacol. Sci. , vol.28 , pp. 416-422
    • Violin, J.D.1    Lefkowitz, R.J.2
  • 19
    • 38449105300 scopus 로고    scopus 로고
    • Infrequent delivery of a long-acting PTH-Fc fusion protein has potent anabolic eff ects on cortical and cancellous bone
    • P. J. Kostenuik et al., Infrequent delivery of a long-acting PTH-Fc fusion protein has potent anabolic eff ects on cortical and cancellous bone. J. Bone Miner. Res. 22, 1534-1547 (2007).
    • (2007) J. Bone Miner. Res. , vol.22 , pp. 1534-1547
    • Kostenuik, P.J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.