Effect of selective estrogen receptor modulator/raloxifene analogue on proliferation and collagen metabolism of tendon fibroblast

Connective Tissue Research

Volumn 51, Issue 3, 2010, Pages 179-187

  Irie, Toru ^a   Takahata, Masahiko ^a   Majima, Tokifumi ^a   Abe, Yuichiro ^a   Komatsu, Miki ^a   Iwasaki, Norimasa ^a   Minami, Akio ^a  

^a HOKKAIDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Collagen; Estrogen; Raloxifene; Selective Estrogen Receptor Modulator; Tendon Fibroblast

Indexed keywords

6 HYDROXY 2 (4 HYDROXYPHENYL) 3 [4 [2 (1 PYRROLIDINYL)ETHOXY]BENZOYL]BENZO[B]THIOPHENE; BROXURIDINE; COLLAGEN; COLLAGEN TYPE 1; COLLAGEN TYPE 3; COLLAGENASE 3; ELASTIN; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; MATRIX METALLOPROTEINASE; 2 (2 METHOXY 4 NITROPHENYL) 3 (4 NITROPHENYL) 5 (2,4 DISULFOPHENYL) 2H TETRAZOLIUM MONOSODIUM SALT; 2-(2-METHOXY-4-NITROPHENYL)-3-(4-NITROPHENYL)-5-(2,4-DISULFOPHENYL)-2H TETRAZOLIUM MONOSODIUM SALT; ANTIESTROGEN; DRUG DERIVATIVE; FULVESTRANT; PYRROLIDINE DERIVATIVE; RALOXIFENE; SELECTIVE ESTROGEN RECEPTOR MODULATOR; TETRAZOLIUM; THIOPHENE DERIVATIVE;

ACHILLES TENDON; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; COLLAGEN DEGRADATION; COLLAGEN METABOLISM; COLORIMETRY; CONTROLLED STUDY; ELASTICITY; ESTROGEN ACTIVITY; ESTROGEN DEFICIENCY; FEMALE; FIBROBLAST; NONHUMAN; PROTEIN EXPRESSION; RAT; TENDON; ANIMAL; CELL CULTURE; CELL SURVIVAL; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; EXTRACELLULAR MATRIX; METABOLISM; PATHOLOGY;

RATTUS;

ACHILLES TENDON; ANIMALS; BROMODEOXYURIDINE; CELL PROLIFERATION; CELL SURVIVAL; CELLS, CULTURED; COLLAGEN TYPE I; COLLAGEN TYPE III; ELASTIN; ESTRADIOL; ESTROGEN ANTAGONISTS; EXTRACELLULAR MATRIX; FEMALE; FIBROBLASTS; MATRIX METALLOPROTEINASE 13; PYRROLIDINES; RALOXIFENE; RATS; SELECTIVE ESTROGEN RECEPTOR MODULATORS; TETRAZOLIUM SALTS; THIOPHENES;

EID: 77954672058     PISSN: 03008207     EISSN: 16078438     Source Type: Journal    
DOI: 10.3109/03008200903204669     Document Type: Article

References (48)

1. Kim, I.Y., Kim, B.C., Seong, D.H., Lee, D.K., Seo, J.M., Hong, Y.J., Kim, H.T., Morton, R.A., and Kim, S.J. (2002). Raloxifene, a mixed estrogen agonist/antagonist, induces apoptosis in androgen-independent human prostate cancer cell lines. Cancer Res., 62, 5365-5369.
2. Body, J.J. (2008). [Update on treatment of postmenopausal osteoporosisö. Rev. Med. Brux., 29, 301-309.
3. Goldstein, S.R., Duvernoy, C.S., Calaf, J., Adachi, J.D., Mershon, J.L., Dowsett, S.A., Agnusdei, D., and Stuenkel, C.A. (2008). Raloxifene use in clinical practice: efficacy and safety. Menopause, Epub ahead of print, Dec. 13, 2008.
4. Sumino, H., Ichikawa, S., Kasama, S., Takahashi, T., Kumakura, H., Takayama, Y., Kanda, T., Murakami, M., and Kurabayashi, M. (2009). Effects of raloxifene and hormone replacement therapy on forearm skin elasticity in postmenopausal women. Maturitas, 20, 53-57.
5. Choi, B.G., Vilahur, G., Zafar, M.U., Cardoso, L., Yadegar, D., Ibanez, B., Tunstead, J., Viles-Gonzalez, J.F., Schaffler, M.B., Fuster, V., and Badimon, J.J. (2008). Selective estrogen receptor modulation influences atherosclerotic plaque composition in a rabbit menopause model. Atherosclerosis, Epub ahead of print, Feb. 21, 2008.
6. Abu-Fanne,R., Brzezinski, A., Golomb,M., Grad, E., Foldes, A.J., Shufaro, Y., Varon, D., Brill, A., Lotan, C., and Danenberg, H.D. (2008). Effects of estradiol and raloxifene on arterial thrombosis in ovariectomized mice. Menopause, 15, 98-104.
7. Verdier-Sevrain, S., Bonte, F., and Gilchrest,B. (2006).Biology of estrogens in skin: implications for skin aging. Exp. Dermatol., 15, 83-94.
8. Stevenson, J.C. (2009). HRT and cardiovascular disease. Best Pract. Res. Clin. Obstet. Gynaecol., 23, 109-120.
9. Pal, L., Hailpern, S.M., Santoro, N.F., Freeman, R., Barad, D., Kipersztok, S., Barnabei, V.M., and Wassertheil-Smoller, S. (2008). Association of pelvic organ prolapse and fractures in postmenopausal women: analysis of baseline data from the Women's Health Initiative Estrogen Plus Progestin trial. Menopause, 15, 59-66.
10. Orsatti, F.L., Nahas, E.A., Maesta, N., Nahas-Neto, J., and Burini, R.C. (2008). Plasma hormones, muscle mass and strength in resistance-trained postmenopausal women. Maturitas, 59, 394-404.
11. Surazynski, A., Jarzabek, K., Haczynski, J., Laudanski, P., Palka, J., and Wolczynski, S. (2003). Differential effects of estradiol and raloxifene on collagen biosynthesis in cultured human skin fibroblasts. Int. J. Mol. Med., 12, 803-809.
12. Takeyama, N., Sakai, H., Ohtake, H., Mashitori, H.,Tamai, K., and Saotome, K. (2007). Effects of hyperbaric oxygen on gene expressions of procollagen, matrix metalloproteinase and tissue inhibitor ofmetalloproteinase in injured medial collateral ligament and anterior cruciate ligament. Knee Surg. Sports Traumatol. Arthrosc., 15, 443-452.
13. Miller, B.F., Hansen,M., Olesen, J.L., Schwarz, P., Babraj, J.A., Smith, K., Rennie, M.J., and Kjaer, M. (2007). Tendon collagen synthesis at rest and after exercise in women. J. Appl. Physiol., 102, 541-546.
14. Wentorf, F.A., Sudoh, K., Moses, C.,Arendt, E.A., andCarlson, C.S. (2006). The effects of estrogen on material and mechanical properties of the intraand extra-articular knee structures. Am. J. Sports Med., 34, 1948-1952.
15. Warden, S.J., Saxon, L.K., Castillo, A.B., and Turner, C.H. (2006). Knee ligament mechanical properties are not influenced by estrogen or its receptors. Am. J. Physiol. Endocrinol. Metab., 290, E1034-E1040.
16. Komatsuda, T., Sugita, T., Sano, H., Kusakabe, T., Watanuki, M., Yoshizumi,Y., Murakami,T., Hashimoto, M., andKokubun, S. (2006).Does estrogen alter the mechanical properties of the anterior cruciate ligament? An experimental study in rabbits. Acta Orthop., 77, 973-980.
17. Slauterbeck, J., Clevenger, C., Lundberg,W., and Burchfield, D.M. (1999). Estrogen level alters the failure load of the rabbit anterior cruciate ligament. J. Orthop. Res., 17, 405-408.
18. Sciore, P., Frank, C.B., and Hart, D.A. (1998). Identification of sex hormone receptors in human and rabbit ligaments of the knee by reverse transcriptionpolymerase chain reaction: evidence that receptors are present in tissue from both male and female subjects. J. Orthop. Res., 16, 604-610.
19. Faryniarz, D.A., Bhargava, M., Lajam, C., Attia, E.T., and Hannafin, J.A. (2006). Quantitation of estrogen receptors and relaxin binding in human anterior cruciate ligament fibroblasts. In Vitro Cell Dev. Biol. Anim., 42, 176-181.
20. Wojtys, E.M., Huston, L.J., Lindenfeld, T.N., Hewett, T.E., and Greenfield, M.L. (1998). Association between the menstrual cycle and anterior cruciate ligament injuries in female athletes. Am. J. Sports Med., 26, 614-619.
21. Slauterbeck, J.R., Fuzie, S.F., Smith,M.P., Clark, R.J.,Xu, K., Starch, D.W., and Hardy, D.M. (2002). The menstrual cycle, sex hormones, and anterior cruciate ligament injury. J. Athl. Train., 37, 275-278.
22. Wojtys, E.M., Huston, L.J., Boynton, M.D., Spindler, K.P., and Lindenfeld, T.N. (2002). The effect of the menstrual cycle on anterior cruciate ligament injuries in women as determined by hormone levels. Am. J. Sports Med., 30, 182-188.
23. Sun, H.B., Li, Y., Fung, D.T., Majeska, R.J., Schaffler, M.B., and Flatow, E.L. (2008). Coordinate regulation of IL-1beta and MMP-13 in rat tendons following subrupture fatigue damage. Clin. Orthop. Relat. Res., 466, 1555-1561.
24. Cook, J.L., Bass, S.L., and Black, J.E. (2007). Hormone therapy is associated with smaller Achilles tendon diameter in active post-menopausal women. Scand. J. Med. Sci. Sports, 17, 128-132.
25. Nahm, D.S., Kim, H.J., Mah, J., and Baek, S.H. (2004). In vitro expression of matrix metalloproteinase-1, tissue inhibitor of metalloproteinase-1 and transforming growth factor-beta1 in human periodontal ligament fibroblasts. Eur. J. Orthod., 26, 129-135.
26. Sullivan, B.E., Carroll, C.C., Jemiolo, B., Trappe, S.W., Magnusson, S.P., Dossing, S., Kjaer, M., and Trappe, T.A. (2009). Effect of acute resistance exercise and sex on human patellar tendon structural and regulatory mRNA expression. J. Appl. Physiol., 106, 468-475.
27. Gazoti Debessa, C.R., Mesiano Maifrino, L.B., and Rodrigues de Souza, R. (2001). Age related changes of the collagen network of the human heart. Mech. Ageing Dev., 122, 1049-1058.
28. Liu, X., Wu, H., Byrne, M., Krane, S., and Jaenisch, R. (1997). Type III collagen is crucial for collagen I fibrillogenesis and for normal cardiovascular development. Proc. Natl. Acad. Sci. USA, 94, 1852-1856.
29. Birk, D.E., and Mayne, R. (1997). Localization of collagen types I, III and V during tendon development. Changes in collagen types I and III are correlated with changes in fibril diameter. Eur. J. Cell Biol., 72, 352-361.
30. Banos, C.C., Thomas, A.H., and Kuo, C.K. (2008). Collagen fibrillogenesis in tendon development: current models and regulation of fibril assembly. Birth Defects. Res. C Embryo Today, 84, 228-244.
31. Mariotti, A.J. (2005). Estrogen and extracellular matrix influence human gingival fibroblast proliferation and protein production. J. Periodontol., 76, 1391-1397.
32. Liu, S.H., Al-Shaikh, R.A., Panossian, V., Finerman, G.A., and Lane, J.M. (1997). Estrogen affects the cellular metabolism of the anterior cruciate ligament. A potential explanation for female athletic injury. Am. J. Sports Med., 25, 704-709.
33. Yu,W.D., Liu, S.H., Hatch, J.D., Panossian, V., and Finerman, G.A. (1999). Effect of estrogen on cellular metabolism of the human anterior cruciate ligament. Clin. Orthop. Relat. Res., 336, 229-238.
34. Townley, W.A., Cambrey, A.D., Khaw, P.T., and Grobbelaar, A.O. (2008). Matrix metalloproteinase inhibition reduces contraction by dupuytren fibroblasts. J. Hand Surg. [Amö, 33, 1608-1616.
35. Pearce, S.T., and Jordan, V.C. (2004). The biological role of estrogen receptors alpha and beta in cancer. Crit. Rev. Oncol. Hematol., 50, 3-22.
36. Thornton, G.M., Shrive, N.G., and Frank, C.B. (2003). Healing ligaments have decreased cyclic modulus compared to normal ligaments and immobilization further compromises healing ligament response to cyclic loading. J. Orthop. Res., 21, 716-722.
37. Kim, S.G., Akaike, T., Sasagaw, T., Atomi, Y., and Kurosawa, H. (2002). Gene expression of type I and type III collagen by mechanical stretch in anterior cruciate ligament cells. Cell Struct. Funct., 27, 139-144.
38. Park, S.A., Kim, I.A., Lee, Y.J., Shin, J.W., Kim, C.R., Kim, J.K., Yang, Y.I., and Shin, J.W. (2006). Biological responses of ligament fibroblasts and gene expression profiling on micropatterned silicone substrates subjected to mechanical stimuli. J. Biosci. Bioeng., 102, 402-412.
39. Majima, T., Marchuk, L.L., Sciore, P., Shrive, N.G., Frank, C.B., and Hart, D.A. (2000). Compressive compared with tensile loading of medial collateral ligament scar in vitro uniquely influences mRNA levels for aggrecan, collagen type II, and collagenase. J. Orthop. Res., 18, 524-531.
40. Majima, T., Yasuda, K., Yamamoto, N., Kaneda, K., and Hayashi, K. (1994).Deterioration ofmechanical properties of the autograft in controlled stress-shielded augmentation procedures.An experimental study with rabbit patellar tendon. Am. J. Sports Med., 22, 821-829.
41. Lee, C.Y., Liu, X., Smith, C.L., Zhang, X., Hsu, H.C., Wang, D.Y., and Luo, Z.P. (2004). The combined regulation of estrogen and cyclic tension on fibroblast biosynthesis derived from anterior cruciate ligament. Matrix Biol., 23, 323-329.
42. Lee, C.Y., Smith, C.L., Zhang, X., Hsu, H.C., Wang, D.Y., and Luo, Z.P. (2004). Tensile forces attenuate estrogen-stimulated collagen synthesis in the ACL. Biochem. Biophys. Res. Commun., 317, 1221-1225.
43. Shibayama, H., Hisama, M., Matsuda, S., Kawase, A., Ohtsuki, M., Hanada, K., and Iwaki, M. (2008). Effect of a novel ascorbic derivative, disodium isostearyl 2-O-L-ascorbyl phosphate, on normal human dermal fibroblasts against reactive oxygen species. Biosci. Biotechnol. Biochem., 72, 1015-1022. (Pubitemid 351679356)
44. Amano, S., Ogura, Y., Akutsu, N., Nishiyama, and T. (2007). Quantitative analysis of the synthesis and secretion of type VII colagen in cultured human dermal fibroblast with a sensitive sandwich enzyme-linked immunoassay. Exp. Dermatol., 16, 151-155.
45. Shiga, M., Kapila, Y.L., Zhang, Q., Hayashi, T., and Kapila, S. (2003). Ascorbic acid induces collagenase-1 in human periodontal ligament cells but not in MC3T3-E1 osteoblast-like cells: potential association between collagenase expression and changes in alkaline phosphatase phenotype. J. Bone Miner. Res., 18, 67-77.
46. Qiao, H., Bell, J., Juliao, S., Li, L., and May, J.M. (2009) Ascorbic acid uptake and regulation of type I collagen synthesis in cultured vascular smooth muscle cells. J. Vasc. Res., 46, 15-24.
47. Azuma, H., Yasuda, K., Tohyama, H., Sakai, T., Majima, T., Aoki, Y., and Minami,A. (2003). Timing of administration of transforming growth factorbeta and epidermal growth factor influences the effect on material properties of the in situ frozen-thawed anterior cruciate ligament. J. Biomech., 36, 373-381.
48. Strickland, S.M., Belknap, T.W., Turner, S.A., Wright, T.M., and Hannafin, J.A. (2003). Lack of hormonal influences on mechanical properties of sheep knee ligaments. Am. J. Sports Med., 31, 210-215.