메뉴 건너뛰기




Volumn 395, Issue 4, 2010, Pages 395-405

Deregulation of HIF1-alpha and hypoxia-regulated pathways in hepatocellular carcinoma and corresponding non-malignant liver tissue-influence of a modulated host stroma on the prognosis of HCC

Author keywords

Carcinogenesis; Hepatocellular carcinoma; HIF1A; Host stroma

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1ALPHA; MYC PROTEIN; PROTEIN P21; HIF1A PROTEIN, HUMAN;

EID: 77954667202     PISSN: 14352443     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00423-009-0590-9     Document Type: Article
Times cited : (40)

References (36)
  • 2
    • 68149141442 scopus 로고    scopus 로고
    • Epidemiology, screening, diagnosis and treatment of hepatocellular carcinoma
    • Hussain K, El-Serag HB (2009) Epidemiology, screening, diagnosis and treatment of hepatocellular carcinoma. Minerva Gastroenterol Dietol 55:123-138
    • (2009) Minerva Gastroenterol Dietol , vol.55 , pp. 123-138
    • Hussain, K.1    El-Serag, H.B.2
  • 4
    • 67649497434 scopus 로고    scopus 로고
    • Predictors of survival after resection of early hepatocellular carcinoma
    • Nathan H, Schulick RD, Choti MA, Pawlik TM (2009) Predictors of survival after resection of early hepatocellular carcinoma. Ann Surg 249:799-805
    • (2009) Ann Surg , vol.249 , pp. 799-805
    • Nathan, H.1    Schulick, R.D.2    Choti, M.A.3    Pawlik, T.M.4
  • 6
    • 58149504413 scopus 로고    scopus 로고
    • Prognosis of patients with intrahepatic recurrence after hepatic resection for hepatocellular carcinoma: A retrospective study
    • Kawano Y, Sasaki A, Kai S, Endo Y, Iwaki K, Uchida H, Shibata K, Ohta M, Kitano S (2009) Prognosis of patients with intrahepatic recurrence after hepatic resection for hepatocellular carcinoma: a retrospective study. Eur J Surg Oncol 35:174-179
    • (2009) Eur J Surg Oncol , vol.35 , pp. 174-179
    • Kawano, Y.1    Sasaki, A.2    Kai, S.3    Endo, Y.4    Iwaki, K.5    Uchida, H.6    Shibata, K.7    Ohta, M.8    Kitano, S.9
  • 7
    • 36549013178 scopus 로고    scopus 로고
    • Activation of the ERK and AKT signalling pathway predicts poor prognosis in hepatocellular carcinoma and ERK activation in cancer tissue is associated with hepatitis C virus infection
    • Schmitz KJ, Wohlschlaeger J, Lang H, Sotiropoulos GC, Malago M, Steveling K, Reis H, Cicinnati VR, Schmid KW, Baba HA (2008) Activation of the ERK and AKT signalling pathway predicts poor prognosis in hepatocellular carcinoma and ERK activation in cancer tissue is associated with hepatitis C virus infection. J Hepatol 48:83-90
    • (2008) J Hepatol , vol.48 , pp. 83-90
    • Schmitz, K.J.1    Wohlschlaeger, J.2    Lang, H.3    Sotiropoulos, G.C.4    Malago, M.5    Steveling, K.6    Reis, H.7    Cicinnati, V.R.8    Schmid, K.W.9    Baba, H.A.10
  • 9
    • 26844502441 scopus 로고    scopus 로고
    • HIF1-alpha overexpression indicates a good prognosis in early stage squamous cell carcinomas of the oral floor
    • Fillies T, Werkmeister R, van Diest PJ, Brandt B, Joos U, Buerger H (2005) HIF1-alpha overexpression indicates a good prognosis in early stage squamous cell carcinomas of the oral floor. BMC Cancer 5:84
    • (2005) BMC Cancer , vol.5 , pp. 84
    • Fillies, T.1    Werkmeister, R.2    Van Diest, P.J.3    Brandt, B.4    Joos, U.5    Buerger, H.6
  • 10
    • 33646764243 scopus 로고    scopus 로고
    • Hypoxia-inducible factors, hypoxia, and tumor angiogenesis
    • Gruber M, Simon MC (2006) Hypoxia-inducible factors, hypoxia, and tumor angiogenesis. Curr Opin Hematol 13:169-174
    • (2006) Curr Opin Hematol , vol.13 , pp. 169-174
    • Gruber, M.1    Simon, M.C.2
  • 12
    • 76349095132 scopus 로고    scopus 로고
    • Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics
    • Semenza GL (2010) Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics. Oncogene 29:625-634
    • (2010) Oncogene , vol.29 , pp. 625-634
    • Semenza, G.L.1
  • 14
    • 34249815207 scopus 로고    scopus 로고
    • Stromal expression of hypoxia regulated proteins is an adverse prognostic factor in colorectal carcinomas
    • Cleven AH, van Engeland M, Wouters BG, de Bruine AP (2007) Stromal expression of hypoxia regulated proteins is an adverse prognostic factor in colorectal carcinomas. Cell Oncol 29:229-240
    • (2007) Cell Oncol , vol.29 , pp. 229-240
    • Cleven, A.H.1    Van Engeland, M.2    Wouters, B.G.3    De Bruine, A.P.4
  • 15
    • 17144364359 scopus 로고    scopus 로고
    • Expression of hypoxiainducible factor 1alpha and vascular endothelial growth factor in hepatocellular carcinoma: Impact on neovascularization and survival
    • Huang GW, Yang LY, Lu WQ (2005) Expression of hypoxiainducible factor 1alpha and vascular endothelial growth factor in hepatocellular carcinoma: impact on neovascularization and survival. World J Gastroenterol 11:1705-1708
    • (2005) World J Gastroenterol , vol.11 , pp. 1705-1708
    • Huang, G.W.1    Yang, L.Y.2    Lu, W.Q.3
  • 16
    • 33646885230 scopus 로고    scopus 로고
    • Total-genome analysis of BRCA1/2-related invasive carcinomas of the breast identifies tumor stroma as potential landscaper for neoplastic initiation
    • Weber F, Shen L, Fukino K, Patocs A, Mutter GL, Caldes T, Eng C (2006) Total-genome analysis of BRCA1/2-related invasive carcinomas of the breast identifies tumor stroma as potential landscaper for neoplastic initiation. Am J Hum Genet 78:961-972
    • (2006) Am J Hum Genet , vol.78 , pp. 961-972
    • Weber, F.1    Shen, L.2    Fukino, K.3    Patocs, A.4    Mutter, G.L.5    Caldes, T.6    Eng, C.7
  • 17
    • 33846144441 scopus 로고    scopus 로고
    • Microenvironmental genomic alterations and clinicopathological behavior in head and neck squamous cell carcinoma
    • Weber F, Xu Y, Zhang L, Patocs A, Shen L, Platzer P, Eng C (2007) Microenvironmental genomic alterations and clinicopathological behavior in head and neck squamous cell carcinoma. JAMA 297:187-195
    • (2007) JAMA , vol.297 , pp. 187-195
    • Weber, F.1    Xu, Y.2    Zhang, L.3    Patocs, A.4    Shen, L.5    Platzer, P.6    Eng, C.7
  • 20
    • 0043192611 scopus 로고    scopus 로고
    • Selection of optimal internal controls for gene expression profiling of liver disease
    • Kim S, Kim T (2003) Selection of optimal internal controls for gene expression profiling of liver disease. Biotechniques 35(456- 458):460
    • (2003) Biotechniques , vol.35 , Issue.456-458 , pp. 460
    • Kim, S.1    Kim, T.2
  • 21
    • 58149087247 scopus 로고    scopus 로고
    • Validation of putative reference genes for gene expression studies in human hepatocellular carcinoma using real-time quantitative RT-PCR
    • Cicinnati VR, Shen Q, Sotiropoulos GC, Radtke A, Gerken G, Beckebaum S (2008) Validation of putative reference genes for gene expression studies in human hepatocellular carcinoma using real-time quantitative RT-PCR. BMC Cancer 8:350
    • (2008) BMC Cancer , vol.8 , pp. 350
    • Cicinnati, V.R.1    Shen, Q.2    Sotiropoulos, G.C.3    Radtke, A.4    Gerken, G.5    Beckebaum, S.6
  • 22
    • 67649233100 scopus 로고    scopus 로고
    • A mouse mammary gland involution mRNA signature identifies biological pathways potentially associated with breast cancer metastasis
    • Stein T, Salomonis N, Nuyten DS, van de Vijver MJ, Gusterson BA (2009) A mouse mammary gland involution mRNA signature identifies biological pathways potentially associated with breast cancer metastasis. J Mammary Gland Biol Neoplasia 14:99-116
    • (2009) J Mammary Gland Biol Neoplasia , vol.14 , pp. 99-116
    • Stein, T.1    Salomonis, N.2    Nuyten, D.S.3    Van De Vijver, M.J.4    Gusterson, B.A.5
  • 23
    • 40849124295 scopus 로고    scopus 로고
    • Novel advancements in the management of hepatocellular carcinoma in 2008
    • Llovet JM, Bruix J (2008) Novel advancements in the management of hepatocellular carcinoma in 2008. J Hepatol 48(Suppl 1): S20-S37
    • (2008) J Hepatol , vol.48 , Issue.SUPPL. 1
    • Llovet, J.M.1    Bruix, J.2
  • 24
    • 0037371516 scopus 로고    scopus 로고
    • ICAM-1 triggers liver regeneration through leukocyte recruitment and Kupffer cell-dependent release of TNFalpha/ IL-6 in mice
    • Selzner N, Selzner M, Odermatt B, Tian Y, Van Rooijen N, Clavien PA (2003) ICAM-1 triggers liver regeneration through leukocyte recruitment and Kupffer cell-dependent release of TNFalpha/ IL-6 in mice. Gastroenterology 124:692-700
    • (2003) Gastroenterology , vol.124 , pp. 692-700
    • Selzner, N.1    Selzner, M.2    Odermatt, B.3    Tian, Y.4    Van Rooijen, N.5    Clavien, P.A.6
  • 26
    • 0035872451 scopus 로고    scopus 로고
    • Stimulation of tumor growth by human soluble intercellular adhesion molecule-1
    • Gho YS, Kim PN, Li HC, Elkin M, Kleinman HK (2001) Stimulation of tumor growth by human soluble intercellular adhesion molecule-1. Cancer Res 61:4253-4257
    • (2001) Cancer Res , vol.61 , pp. 4253-4257
    • Gho, Y.S.1    Kim, P.N.2    Li, H.C.3    Elkin, M.4    Kleinman, H.K.5
  • 27
    • 0033192573 scopus 로고    scopus 로고
    • Oxidant stress regulation of IL-8 and ICAM- 1 gene expression: Differential activation and binding of the transcription factors AP-1 and NF-kappaB (Review
    • Roebuck KA (1999) Oxidant stress regulation of IL-8 and ICAM- 1 gene expression: differential activation and binding of the transcription factors AP-1 and NF-kappaB (Review). Int J Mol Med 4:223-230
    • (1999) Int J Mol Med , vol.4 , pp. 223-230
    • Roebuck, K.A.1
  • 28
    • 0032880526 scopus 로고    scopus 로고
    • CXC-chemokines stimulate invasion and chemotaxis in prostate carcinoma cells through the CXCR2 receptor
    • Reiland J, Furcht LT, McCarthy JB (1999) CXC-chemokines stimulate invasion and chemotaxis in prostate carcinoma cells through the CXCR2 receptor. Prostate 41:78-88
    • (1999) Prostate , vol.41 , pp. 78-88
    • Reiland, J.1    Furcht, L.T.2    McCarthy, J.B.3
  • 29
    • 67650022084 scopus 로고    scopus 로고
    • The chemokine CCL20 and its receptor CCR6 in human malignancy with focus on colorectal cancer
    • Ghadjar P, Rubie C, Aebersold DM, Keilholz U (2009) The chemokine CCL20 and its receptor CCR6 in human malignancy with focus on colorectal cancer. Int J Cancer 125:741-745
    • (2009) Int J Cancer , vol.125 , pp. 741-745
    • Ghadjar, P.1    Rubie, C.2    Aebersold, D.M.3    Keilholz, U.4
  • 32
    • 70349734599 scopus 로고    scopus 로고
    • Down-regulation of suppressor of cytokine signaling-3 causes prostate cancer cell death through activation of the extrinsic and intrinsic apoptosis pathways
    • Puhr M, Santer FR, Neuwirt H, Susani M, Nemeth JA, Hobisch A, Kenner L, Culig Z (2009) Down-regulation of suppressor of cytokine signaling-3 causes prostate cancer cell death through activation of the extrinsic and intrinsic apoptosis pathways. Cancer Res 69:7375-7384
    • (2009) Cancer Res , vol.69 , pp. 7375-7384
    • Puhr, M.1    Santer, F.R.2    Neuwirt, H.3    Susani, M.4    Nemeth, J.A.5    Hobisch, A.6    Kenner, L.7    Culig, Z.8
  • 33
    • 50449106127 scopus 로고    scopus 로고
    • SOCS-3 is associated with vascular invasion and overall survival in hepatocellular carcinoma
    • Yang SF, Yeh YT, Wang SN, Hung SC, Chen WT, Huang CH, Chai CY (2008) SOCS-3 is associated with vascular invasion and overall survival in hepatocellular carcinoma. Pathology 40:558-563
    • (2008) Pathology , vol.40 , pp. 558-563
    • Yang, S.F.1    Yeh, Y.T.2    Wang, S.N.3    Hung, S.C.4    Chen, W.T.5    Huang, C.H.6    Chai, C.Y.7
  • 34
    • 0742289555 scopus 로고    scopus 로고
    • Homing and mobilization of hematopoietic stem cells and hematopoietic cancer cells are mirror image processes, utilizing similar signaling pathways and occurring concurrently: Circulating cancer cells constitute an ideal target for concurrent treatment with chemotherapy and antilineage-specific antibodies
    • Gazitt Y (2004) Homing and mobilization of hematopoietic stem cells and hematopoietic cancer cells are mirror image processes, utilizing similar signaling pathways and occurring concurrently: circulating cancer cells constitute an ideal target for concurrent treatment with chemotherapy and antilineage-specific antibodies. Leukemia 18:1-10
    • (2004) Leukemia , vol.18 , pp. 1-10
    • Gazitt, Y.1
  • 36
    • 73249152662 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1 alpha, in association with inflammation, angiogenesis and MYC, is a critical prognostic factor in patients with HCC after surgery
    • Dai CX, Gao Q, Qiu SJ, Ju MJ, Cai MY, Xu YF, Zhou J, Zhang BH, Fan J (2009) Hypoxia-inducible factor-1 alpha, in association with inflammation, angiogenesis and MYC, is a critical prognostic factor in patients with HCC after surgery. BMC Cancer 9:418
    • (2009) BMC Cancer , vol.9 , pp. 418
    • Dai, C.X.1    Gao, Q.2    Qiu, S.J.3    Ju, M.J.4    Cai, M.Y.5    Xu, Y.F.6    Zhou, J.7    Zhang, B.H.8    Fan, J.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.