Natalizumab and regulation of cerebral blood flow: Results from an observational study

European Neurology

Volumn 64, Issue 2, 2010, Pages 124-128

  Reinhard, Matthias ^a   Rosengarten, Bernhard ^b   Kirchhoff, Luise ^a   Hetzel, Andreas ^a   Rauer, Sebastian ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

^b JUSTUS LIEBIG UNIVERSITY   (Germany)

Author keywords

Cerebral autoregulation; Cerebral blood flow; Multiple sclerosis; Natalizumab; Neurovascular coupling

Indexed keywords

NATALIZUMAB;

ADULT; ARTICLE; AUTOREGULATION; BLOOD FLOW VELOCITY; BRAIN BLOOD FLOW; CLINICAL ARTICLE; CONTROLLED STUDY; DOPPLER ECHOGRAPHY; FEMALE; HUMAN; MALE; MIDDLE CEREBRAL ARTERY; MULTIPLE SCLEROSIS; NEUROVASCULAR COUPLING; POSTERIOR CEREBRAL ARTERY; PRIORITY JOURNAL; PULSATILE FLOW; VISUAL STIMULATION;

ADULT; ANALYSIS OF VARIANCE; ANTIBODIES, MONOCLONAL; BLOOD FLOW VELOCITY; CEREBROVASCULAR CIRCULATION; FEMALE; HUMANS; INFUSIONS, INTRAVENOUS; MALE; MIDDLE AGED; MULTIPLE SCLEROSIS; OBSERVATION; STATISTICS, NONPARAMETRIC; TIME FACTORS; ULTRASONOGRAPHY, DOPPLER, TRANSCRANIAL;

EID: 77954662059     PISSN: 00143022     EISSN: None     Source Type: Journal    
DOI: 10.1159/000316765     Document Type: Article

References (18)

1. Iadecola C: Neurovascular regulation in the normal brain and in Alzheimer's disease. Nat Rev Neurosci 2004; 5: 347-360.
2. Hill MA, Sun Z, Martinez-Lemus L, Meininger GA: New technologies for dissecting the arteriolar myogenic response. Trends Pharmacol Sci 2007; 28: 308-315.
3. Morton J, Coles B, Wright K, Gallimore A, Morrow JD, Terry ES, Anning PB, Morgan BP, Dioszeghy V, Kuhn H, Chaitidis P, Hobbs AJ, Jones SA, O'Donnell VB: Circulating neutrophils maintain physiological blood pressure by suppressing bacteria and IFNγ -dependent iNOS expression in the vasculature of healthy mice. Blood 2008; 111: 5187-5194.
4. Gavins F, Yilmaz G, Granger DN: The evolving paradigm for blood cell-endothelial cell interactions in the cerebral microcirculation. Microcirculation 2007; 14: 667-681.
5. Polman CH, O'Connor PW, Havrdova E, Hutchinson M, Kappos L, Miller DH, Phillips JT, Lublin FD, Giovannoni G, Wajgt A, Toal M, Lynn F, Panzara MA, Sandrock AW: A randomized, placebo-controlled trial of natalizumab for relapsing multiple sclerosis. N Engl J Med 2006; 354: 899-910.
6. Rosengarten B, Osthaus S, Auch D, Kaps M: Effects of acute hyperhomocysteinemia on the neurovascular coupling mechanism in healthy young adults. Stroke 2003; 34: 446-451.
7. Rosengarten B, Paulsen S, Molnar S, Kaschel R, Gallhofer B, Kaps M: Acetylcholine esterase inhibitor donepezil improves dynamic cerebrovascular regulation in Alzheimer patients. J Neurol 2006; 253: 58-64.
8. Uzuner N, Ozkan S, Gucuyener D, Ozdemir G: Cerebral blood flow velocity changes to visual stimuli in patients with multiple sclerosis. Mult Scler 2002; 8: 217-221.
9. Buerk DG, Ances BM, Greenberg JH, Detre JA: Temporal dynamics of brain tissue nitric oxide during functional forepaw stimulation in rats. Neuroimage 2003; 18: 1-9.
10. Engelhardt B: Immune cell entry into the central nervous system: involvement of adhesion molecules and chemokines. J Neurol Sci 2008; 274: 23-26.
11. Barkalow FJ, Goodman MJ, Gerritsen ME, Mayadas TN: Brain endothelium lack one of two pathways of P-selectin-mediated neutrophil adhesion. Blood 1996; 88: 4585-4593.
12. Kaul S, Padgett RC, Heistad DD: Role of platelets and leukocytes in modulation of vascular tone. Ann NY Acad Sci 1994; 714: 122-135.
13. Zhang R, Wilson TE, Witkowski S, Cui J, Crandall GG, Levine BD: Inhibition of nitric oxide synthase does not alter dynamic cerebral autoregulation in humans. Am J Physiol Heart Circ Physiol 2004; 286:H863-H869.
14. Reinhard M, Waldkircher Z, Timmer J, Weiller C, Hetzel A: Cerebellar autoregulation dynamics in humans. J Cereb Blood Flow Metab 2008; 28: 1605-1612.
15. Sheremata WA, Vollmer TL, Stone LA, Willmer-Hulme AJ, Koller M: A safety and pharmacokinetic study of intravenous natalizumab in patients with MS. Neurology 1999; 52: 1072-1074.
16. Calabresi PA, Giovannoni G, Confavreux C, Galetta SL, Havrdova E, Hutchinson M, Kappos L, Miller DH, O'Connor PW, Phillips JT, Polman CH, Radue EW, Rudick RA, Stuart WH, Lublin FD, Wajgt A, Weinstock-Guttman B, Wynn DR, Lynn F, Panzara MA: The incidence and significance of anti-natalizumab antibodies: results from AFFIRM and SENTINEL. Neurology 2007; 69: 1391-1403.
17. Hutchinson M: Natalizumab: a new treatment for relapsing remitting multiple sclerosis. Ther Clin Risk Manag 2007; 3: 259-268.
18. Stich O, Janowitz D, Rauer S: Spontaneous intracerebral hemorrhage in a patient with multiple sclerosis and tumefactive demyelinating lesion. Mult Scler 2009; 15: 517-519.