A PAT approach to enhance process understanding of fluid bed granulation using in-line particle size characterization and multivariate analysis

Journal of Pharmaceutical Innovation

Volumn 5, Issue 1-2, 2010, Pages 58-68

  Huang, Jun ^a   Goolcharran, Chimanlall ^a   Utz, Julia ^b   Hernandez Abad, Pedro ^a   Ghosh, Krishnendu ^a   Nagi, Arwinder ^a  

^a PFIZER INC   (United States)

^b Excella GmbH   (Germany)

Author keywords

Fluid bed granulation; Multivariate statistical process control (MSPC); Parsum; Particle size distribution (PSD); Process analytical technology (PAT); Quality by design (QbD)

Indexed keywords

ARTICLE; DRUG DESIGN; DRUG GRANULATION; DRUG MANUFACTURE; DRUG QUALITY; FLUID BED GRANULATION; MEASUREMENT; MULTIVARIATE ANALYSIS; NEAR INFRARED SPECTROSCOPY; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; PROCESS CONTROL; PROCESS TECHNOLOGY; QUALITY CONTROL;

EID: 77954661285     PISSN: 18725120     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12247-010-9079-x     Document Type: Article

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