MRNA transcripts as molecular biomarkers in medicine and nutrition

Journal of Nutritional Biochemistry

Volumn 21, Issue 8, 2010, Pages 665-670

  Sunde, Roger A ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

Individualized nutrition; MRNA; Quantitative real time PCR; Requirements; Selenium; Selenoprotein

Indexed keywords

BIOLOGICAL MARKER; GLUTATHIONE PEROXIDASE 1; MESSENGER RNA; SELENIUM; SELENOPROTEIN; SELENOPROTEIN H; SELENOPROTEIN W; TRANSCRIPTOME; UNCLASSIFIED DRUG;

BIOPSY; BLOOD ANALYSIS; DIAGNOSTIC ACCURACY; DIAGNOSTIC VALUE; DIET SUPPLEMENTATION; DISEASE COURSE; DOWN REGULATION; ERYTHROID CELL; HEALTH CARE COST; HUMAN; LIVER; MEDICINE; MICROARRAY ANALYSIS; NONHUMAN; NUTRIENT; NUTRITION; NUTRITIONAL ASSESSMENT; NUTRITIONAL STATUS; ORTHOLOGY; REVIEW; RISK ASSESSMENT; RNA ISOLATION; RNA TRANSCRIPTION; SELENIUM DEFICIENCY; TREATMENT PLANNING;

ANIMALS; BIOLOGICAL MARKERS; NUTRITIONAL STATUS; RATS; RNA, MESSENGER;

RATTUS;

EID: 77954660583     PISSN: 09552863     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jnutbio.2009.11.012     Document Type: Review

References (48)

1. Merriam-Webster's Medical Dictionary. [Internet] 2009 Available at:, Accessed 7/28/2009. http://www2.merriam-webster.com/cgi-bin/mwmedsamp?book=Medical&va=biomarker.
2. Biomarkers and surrogate endpoints: preferred definitions and conceptual framework. Clin Pharmacol Ther 2001, 69:89-95. Biomarkers Definitions Working Group.
3. Bell J. Predicting disease using genomics. Nature 2004, 429:453-456.
4. Winegarden N. Microarrays in cancer: moving from hype to clinical reality. Lancet 2003, 362:1428.
5. Gerszten R.E., Wang T.J. The search for new cardiovascular biomarkers. Nature 2008, 451:949-952.
6. de Leon J. Pharmacogenomics: the promise of personalized medicine for CNS disorders. Neuropsychopharmacology 2009, 34:159-172.
7. Mikhailovich V., Gryadunov D., Kolchinsky A., Makarov A.A., Zasedatelev A. DNA microarrays in the clinic: infectious diseases. Bioessays 2008, 30:673-682.
8. Sly P.D., Eskenazi B., Pronczuk J., Sram R., Diaz-Barriga F., Machin D.G., et al. Ethical issues in measuring biomarkers in children's environmental health. Environ Health Perspect 2009, 117:1185-1190.
9. Saiki T., Kawai T., Morita K., Ohta M., Saito T., Rokutan K., et al. Identification of marker genes for differential diagnosis of chronic fatigue syndrome. Mol Med 2008, 14:599-607.
10. Singh I., Rose N. Biomarkers in psychiatry. Nature 2009, 460:202-207.
11. Tian Z., Palmer N., Schmid P., Yao H., Galdzicki M., Berger B., et al. A practical platform for blood biomarker study by using global gene expression profiling of peripheral whole blood. PLoS ONE 2009, 4:e5157.
12. Kabanova S., Kleinbongard P., Volkmer J., Andree B., Kelm M., Jax T.W. Gene expression analysis of human red blood cells. Int J Med Sci 2009, 6:156-159.
13. Liew C.C., Ma J., Tang H.C., Zheng R., Dempsey A.A. The peripheral blood transcriptome dynamically reflects system wide biology: a potential diagnostic tool. J Lab Clin Med 2006, 147:126-132.
14. Lu Y.R., Wang L.N., Jin X., Chen Y.N., Cong C., Yuan Y., et al. A preliminary study on the feasibility of gene expression profile of rhesus monkey detected with human microarray. Transplant Proc 2008, 40:598-602.
15. Mohr S., Liew C.C. The peripheral-blood transcriptome: new insights into disease and risk assessment. Trends Mol Med 2007, 13:422-432.
16. DNA and RNA Profiling in Human Blood: Methods and Protocols. In: Methods in Molecular Biology, Vol. 496 2009, Humana Press, New York, NY. P. Burgert (Ed.).
17. Bushel P.R., Heinloth A.N., Li J., Huang L., Chou J.W., Boorman G.A., et al. Blood gene expression signatures predict exposure levels. Proc Natl Acad Sci U S A 2007, 104:18211-18216.
18. Cao J., Cousins R.J. Metallothionein mRNA in monocytes and peripheral blood mononuclear cells and in cells from dried blood spots increases after zinc supplementation of men. J Nutr 2000, 130:2180-2187.
19. Andree K.B., Kim J., Kirschke C.P., Gregg J.P., Paik H.Y., Joung H., et al. Investigation of lymphocyte gene expression for use as biomarkers for zinc status in humans. J Nutr 2004, 134:1716-1723.
20. Dakeshita S., Kawai T., Uemura H., Hiyoshi M., Oguma E., Horiguchi H., et al. Gene expression signatures in peripheral blood cells from Japanese women exposed to environmental cadmium. Toxicology 2009, 257:25-32.
21. Saedi M.S., Smith C.G., Frampton J., Chambers I., Harrison P.R., Sunde R.A. Effect of selenium status on mRNA levels for glutathione peroxidase in rat liver. Biochem Biophys Res Commun 1988, 153:855-861.
22. Weiss S.L., Sunde R.A. cis-Acting elements are required for selenium regulation of glutathione peroxidase-1 mRNA levels. RNA 1998, 4:816-827.
23. Moriarty P.M., Reddy C.C., Maquat L.E. Selenium deficiency reduces the abundance of mRNA for Se-dependent glutathione peroxidase 1 by a UGA-dependent mechanism likely to be nonsense codon-mediated decay of cytoplasmic mRNA. Mol Cell Biol 1998, 18:2932-2939.
24. Weiss S.L., Evenson J.K., Thompson K.M., Sunde R.A. Dietary selenium regulation of glutathione peroxidase mRNA and other selenium-dependent parameters in male rats. J Nutr Biochem 1997, 8:85-91.
25. Weiss S.L., Evenson J.K., Thompson K.M., Sunde R.A. The selenium requirement for glutathione peroxidase mRNA level is half of the selenium requirement for glutathione peroxidase activity in female rats. J Nutr 1996, 126:2260-2267.
26. Lei X.G., Evenson J.K., Thompson K.M., Sunde R.A. Glutathione peroxidase and phospholipid hydroperoxide glutathione peroxidase are differentially regulated in rats by dietary selenium. J Nutr 1995, 125:1438-1446.
27. Sunde R.A., Evenson J.K., Thompson K.M., Sachdev S.W. Dietary selenium requirements based on glutathione peroxidase-1 activity and mRNA levels and other selenium parameters are not increased by pregnancy and lactation in rats. J Nutr 2005, 135:2144-2150.
28. Sunde R.A., Raines A.M., Barnes K.M., Evenson J.K. Selenium status highly-regulates selenoprotein mRNA levels for only a subset of the selenoproteins in the selenoproteome. Biosci Rep 2009, 29:329-338.
29. Barnes K.M., Evenson J.K., Raines A.M., Sunde R.A. Transcript analysis of the selenoproteome indicates that dietary selenium requirements in rats based on selenium-regulated selenoprotein mRNA levels are uniformly less than those based on glutathione peroxidase activity. J Nutr 2009, 139:199-206.
30. Evenson J.K., Wheeler A.D., Blake S.M., Sunde R.A. Selenoprotein mRNA is expressed in blood at levels comparable to major tissues in rats. J Nutr 2004, 134:2640-2645.
31. Sunde R.A., Thompson K.M., Evenson J.K., Thompson B.M. Blood glutathione peroxidase-1 mRNA levels can be used as molecular biomarkers to determine selenium requirements in rats. Exp Biol Med 2009, 234:1271-1279.
32. Sunde R.A., Paterson E., Evenson J.K., Barnes K.M., Lovegrove J.A., Gordon M.H. Longitudinal selenium status in healthy British adults: assessment using biochemical and molecular biomarkers. Br J Nutr 2008, 99:S37-S47.
33. Food and Nutrition Board Selenium. Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium and Carotenoids 2000, 284-324. National Academy Press, Washington, DC.
34. Sunde R.A. Selenium. Present Knowledge in Nutrition 2006, 480-497. ILSI Press, Washington, DC. 9th ed. B.A. Bowman, R.M. Russell (Eds.).
35. Burk R.F., Norsworthy B.K., Hill K.E., Motley A.K., Byrne D.W. Effects of chemical form of selenium on plasma biomarkers in a high-dose human supplementation trial. Cancer Epidemiol Biomarkers Prev 2006, 15:804-810.
36. Kobayashi Y., Ogra Y., Ishiwata K., Takayama H., Aimi N., Suzuki K.T. Selenosugars are key and urinary metabolites for selenium excretion within the required to low-toxic range. Proc Natl Acad Sci 2002, 99:15932-15936.
37. Hsieh H.S., Ganther H.E. Biosynthesis of dimethyl selenide from sodium selenite in rat liver and kidney cell-free systems. Biochim Biophys Acta 1977, 497:205-217.
38. Lippman S.M., Klein E.A., Goodman P.J., Lucia M.S., Thompson I.M., Ford L.G., et al. Effect of selenium and vitamin E on risk of prostate cancer and other cancers: the Selenium and Vitamin E Cancer Prevention Trial (SELECT). JAMA 2009, 301:39-51.
39. Clark L.C., Combs G.F., Turnbull B.W., Slate E.H., Chalker D.K., Chow J., et al. Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin. JAMA 1996, 276:1957-1963.
40. Stranges S., Marshall J.R., Natarajan R., Donahue R.P., Trevisan M., Combs G.F., et al. Effects of long-term selenium supplementation on the incidence of type 2 diabetes: a randomized trial. Ann Intern Med 2007, 147:217-223.
41. Duffield-Lillico A.J., Slate E.H., Reid M.E., Turnbull B.W., Wilkins P.A., Combs G.F., et al. Selenium supplementation and secondary prevention of nonmelanoma skin cancer in a randomized trial. J Natl Cancer Inst 2003, 95:1477-1481.
42. Duffield-Lillico A.J., Reid M.E., Turnbull B.W., Combs G.F., Slate E.H., Fischbach L.A., et al. Baseline characteristics and the effect of selenium supplementation on cancer incidence in a randomized clinical trial: a summary report of the Nutritional Prevention of Cancer Trial. Cancer Epidemiol Biomarkers Prev 2002, 11:630-639.
43. Affymetrix GeneChip chicken array [Internet] 2009 Available from:. http://www.affymetrix.com/products_services/arrays/specific/chicken.affx.
44. FDA FDA finds hazardous levels of selenium in samples of "Total Body Formula" and "Total Body Mega Formula" [Internet] 2008 April 9 [cited 2008 May 5]. Available from:. http://www.fda.gov/bbs/topics/news/2008/new01818.html.
45. FDA FDA completes final analysis of "Total Body Formula" and "Total Body Mega Formula" products [Internet] 2008 May 1. Available from:. http://www.fda.gov/bbs/topics/news/2008/new01831.html.
46. Woolfe M., Primrose S. Food forensics: using DNA technology to combat misdescription and fraud. Trends Biotechnol 2004, 22:222-226.
47. Food and Nutrition Board Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium and Carotenoids 2000, National Academy Press, Washington, DC.
48. NIH State-of-the-Science Panel National Institutes of Health state-of-the-science conference statement: multivitamin/mineral supplements and chronic disease prevention. Am J Clin Nutr 2007, 85:257S-264S.