Mesangial Cells Stimulated by Immunoglobin A1 from IgA Nephropathy Upregulates Transforming Growth Factor-β1 Synthesis in Podocytes Via Renin-Angiotensin System Activation

Archives of Medical Research

Volumn 41, Issue 4, 2010, Pages 255-260

  Wang, Cheng ^a   Liu, Xun ^a   Peng, Hui ^a   Tang, Ying ^a   Tang, Hua ^a   Chen, Zhujiang ^a   Lou, Tanqi ^a   Zhang, Hui ^b  

^a SUN YAT SEN UNIVERSITY   (China)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

IgA nephropathy; IgA1; Mesangial cells; Podocyte; Renin angiotensin system; Transforming growth factor 1

Indexed keywords

ANGIOTENSIN II; ANGIOTENSINOGEN; DIPEPTIDYL CARBOXYPEPTIDASE; ENALAPRILAT; IMMUNOGLOBULIN A1; JACALIN; MESSENGER RNA; TRANSFORMING GROWTH FACTOR BETA1; VALSARTAN; CULTURE MEDIUM; IMMUNOGLOBULIN A; PRIMER DNA;

AFFINITY CHROMATOGRAPHY; ANIMAL CELL; ARTICLE; BLOOD; CELL STIMULATION; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; IMMUNOGLOBULIN A NEPHROPATHY; MESANGIUM CELL; MOLECULAR INTERACTION; MOUSE; NONHUMAN; PODOCYTE; PROTEIN EXPRESSION; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION; ANIMAL; BIOSYNTHESIS; CULTURE MEDIUM; DRUG EFFECTS; MESANGIUM; METABOLISM; NUCLEOTIDE SEQUENCE; PATHOLOGY; POLYMERASE CHAIN REACTION;

ANIMALS; BASE SEQUENCE; CULTURE MEDIA; DNA PRIMERS; ENZYME-LINKED IMMUNOSORBENT ASSAY; GLOMERULAR MESANGIUM; GLOMERULONEPHRITIS, IGA; HUMANS; IMMUNOGLOBULIN A; MICE; PODOCYTES; POLYMERASE CHAIN REACTION; RENIN-ANGIOTENSIN SYSTEM; TRANSFORMING GROWTH FACTOR BETA1; UP-REGULATION;

EID: 77954655588     PISSN: 01884409     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.arcmed.2010.05.003     Document Type: Article

References (27)

1. Chen H., Tang Z., Zeng C., et al. Pathological demography of native patients in a nephropathy in a nephrology center in China. Chin Med J 2003, 116:1377-1381.
2. Julian B.A., Tomana M., Novak J., et al. Progesson in the pathogenesis of IgA nephropathy. Adv Nephrol Necker Hosp 1999, 29:53-72.
3. Shen P., He L., Li Y., et al. Natural history and prognostic factors of IgA nephropathy presented with isolated microscopic hematuria in Chinese patients. Nephron Clin Pract 2007, 106:c157-c161.
4. Paul J.M., Boog Vander, van Kottten Cees, et al. Role of macromolecular IgA in IgA nephropathy. Kidney Int 2005, 67:813-821.
5. Arrizaabalaga P., Sole M., Quinto I.L., et al. Intercellular adhesion molecule-1 mediated interaction and leucocyte infiltration in IgA nephropathy. Nephrol Dial Transplant 1997, 12:2258-2262.
6. Xu L.X., Zhao M.H. Aberrantly glycosylated IgA1 are closed associated with pathologic phenotype of IgA nephropathy. Kidney Int 2005, 68:167-172.
7. Ding J.X., Xu L.X., Lv J.C., et al. Aberrant sialylation of serum IgA1 was associated with prognosis of patients with IgA nephropathy. Clin Immunol 2007, 125:268-274.
8. Peng A.I., Yong Gu, Tao Xiao, et al. Clinicopathological characteristics of IgA nephropathy with urinary podocyte excretion. Chin J Nephrol 2007, 23:283-285.
9. Lemley K.V., Lafayette R.A., Safai M., et al. Podocytopenia and disease severity in IgA nephropathy. Kidney Int 2002, 61:1475-1485.
10. Border W.A., Noble N.A. Transforming growth factor-β in tissue fibrosis. N Engl J Med 1994, 331:1286-1292.
11. Yamamoto T., Noble N.A., Miller D.E., et al. Sustained expression of TGF-ß1 underlies development of progressive kidney fibrosis. Kidney Int 1994, 45:916-927.
12. Yamamoto T., Noble N.A., Cohen A.H., et al. Expression of TGF-β isoforms in human glomerular diseases. Kidney Int 1996, 49:461-469.
13. Niemir Z.I., Stein H., Noronha I.L., et al. PDGF and TGF-β contribute to the natural course of human IgA glomerulonephritis. Kidney Int 1995, 48:1530-1541.
14. Wang C.H., Peng H., Tang H., et al. Serum IgA1 from IgA nephropathy induces apoptosis in podocytes through direct and indirect pathway. Clin Invest Med 2007, 30:E240-E249.
15. Wang Y., Zhao M.H., Zhang Y.K., et al. Binding capacity and pathophysiological effects of IgA1 from patients with IgA nephropathy on human glomerular mesangial cells. Clin Exp Immunol 2004, 136:168-175.
16. Wang Y., Zhao M.H., Zhang Y., et al. Serum IgA1 from patients with IgA nephropathy induces phosphorylation of extracellular signal-regulated kinase and proliferation of human mesangial cells. Zhonghua Yi Xue Za Zhi 2002, 82:1406-1409.
17. Kobori H., Katurada A., Ozawa Y., et al. Enhanced intrarenal oxidative sress and angiotensinogen in IgA nephropathy. Biochem Biophys Res Commun 2007, 358:156-163.
18. Kashiwagi M., Shinozaki M., Hirakata H., et al. Locally activated renin-angiotensin system associated with TGF-β1 as a major factor for renal injury Induced by chronic inhibition of nitric oxide synthase in rats. J Am Soc Nephrol 2000, 11:616-624.
19. Zoja C., Abbate M., Corna D., et al. Pharmacologic control of angiotensin II ameliorates renal disease while reducing renal TGF-β1 in experimental mesangioproliferative glomerulonephritis. Am J Kidney Dis 1998, 31:453-463.
20. Monteiro de Freitas A.S., Coimbra T.M., Costa R.S., et al. Urinary transforming growth factor-beta (TGF-beta) excretion and renal production of TGF-beta in rats with subtotal renal ablation: effect of enalapril and nifedipine. Nephron 1998, 78:302-309.
21. Song J.H., Cha S.H., Lee H.J., et al. Effect of low-dose dual blockade of renin-angiotensin system on urinary TGF-beta in type 2 diabetic patients with advanced kidney disease. Nephrol Dial Transplant 2006, 21:683-689.
22. Russo D., Minutolo R., Pisani A., et al. Coadministration of losartan and enalapril exerts additive antiproteinuric effect in IgA nephropathy. Am J Kidney Dis 2001, 38:18-25.
23. Ellis D., Forrest K.Y., Erbey J., et al. Urinary measurement of transforming growth factor-β and type IV collagen as new markers of renal injury: application in diabetic nephropathy. Clin Chem 1998, 44:50-956.
24. Chihara Y., Ono H., Ishimitsu T., et al. Roles of TGF-beta1 and apoptosis in the progression of glomerulosclerosis in human IgA nephropathy. Clin Nephrol 2006, 65:385-392.
25. Han S.Y., Ihm C.G., Cha D.R., et al. Effect of IgA aggregates on transforming growth factor-beta1 production in human mesangial cells and the intraglomerular expression of transforming growth factor-beta1 in patients with IgA nephropathy. Korean J Intern Med 2005, 20:40-47.
26. Lai K.N., Tang S.C., Guh J.Y., et al. Polymeric IgA1 from patients with IgA nephropathy upregulates transforming growth factor-synthesis and signal transduction in human mesangial cells via the renin-angiotensin system. J Am Soc Nephrol 2003, 14:3127-3137.
27. Chan L.Y., Leung J.C., Tsang A.W., et al. Activation of tubular epithelial cells by mesangial-derived TNF-α: glomerulotubular communication in IgA nephropathy. Kidney Int 2005, 67:602-612.