Immunopathological effects of ochratoxin A and T-2 toxin combination on broilers

Poultry Science

Volumn 89, Issue 6, 2010, Pages 1162-1166

  Xue, C Y ^a   Wang, G H ^b   Chen, F ^b   Zhang, X B ^b   Bi, Y Z ^b   Cao, Y C ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b SOUTH CHINA AGRICULTURAL UNIVERSITY   (China)

Author keywords

Broiler; Immunopathological effect; Ochratoxin A; T 2 toxin

Indexed keywords

ANIMALIA; NEWCASTLE DISEASE VIRUS;

EXCIPIENT; OCHRATOXIN; T 2 TOXIN;

ANIMAL; ANIMAL DISEASE; ANIMAL FOOD; ARTICLE; BIRD DISEASE; CHEMICALLY INDUCED DISORDER; CHICKEN; DIET; FOOD CONTAMINATION;

ANIMAL FEED; ANIMALS; CHICKENS; DIET; EXCIPIENTS; FOOD CONTAMINATION; OCHRATOXINS; POULTRY DISEASES; T-2 TOXIN;

EID: 77954655579     PISSN: 00325791     EISSN: 15253171     Source Type: Journal    
DOI: 10.3382/ps.2009-00609     Document Type: Article

References (22)

1. Al-Anati, L., and E. Petzinger. 2006. Immunotoxic activity of ochratoxin A. J. Vet. Pharmacol. Ther. 29: 79-90.
2. Alexander, D. J. 1988. Newcastle disease diagnosis. Pages 11-22 in Newcastle Disease. D. J. Alexander, ed. Kluwer Academic Publishers, Boston, MA.
3. Bamburg, J. R., F. M. Strong, and E. B. Smalley. 1970. Toxins from moldy feed cereals. J. Agric. Food Chem. 17: 443-450.
4. CAST. 2003. Mycotoxins risks in plant, animal and human systems. Pages 1-191 in Task Force Report No. 139. Council for Agricultural Science and Technology, Ames, IA.
5. Chen, F., Y. Ma, C. Xue, J. Ma, Q. Xie, G. Wang, Y. Bi, and Y. Cao. 2008. The combination of deoxynivalenol and zearalenone at permitted feed concentrations causes serious physiological effects in young pigs. J. Vet. Sci. 9: 39-44.
6. Cheng, Y. H., S. T. Ding, and M. H. Chang. 2006. Effect of fumonisins on macrophage immune functions and gene expression of cytokines in broilers. Arch. Anim. Nutr. 60: 267-276.
7. Chi, M. S., C. J. Mirocha, H. J. Kurtz, G. Weaver, F. Bates, and W. Shimoda. 1977. Subacute toxicity of T-2 toxin in broiler chicks. Poult. Sci. 56: 306-313.
8. Dänicke, S., S. Matthes, I. Halle, K. H. Ueberschar, S. Doll, and H. Valenta. 2003. Effects of graded levels of Fusarium toxin-contaminated wheat and of a detoxifying agent in broiler diets on performance, nutrient digestibility and blood chemical parameters. Br. Poult. Sci. 44: 113-126.
9. García, A. R., E. Avila, R. Rosiles, and V. M. Petrone. 2003. Evaluation of two mycotoxin binders to reduce toxicity of broiler diets containing ochratoxin A and T-2 toxin contaminated grain. Avian Dis. 47: 691-699.
10. Hanif, N. Q., G. Muhammad, M. Siddique, A. Khanum, T. Ahmed, J. A. Gadahai, and G. Kaukab. 2008. Clinico-pathomorphological, serum biochemical and histological studies in broilers fed ochratoxin A and a toxin deactivator (Mycofix Plus). Br. Poult. Sci. 49: 632-642.
11. Huff, W. E., L. F. Kubena, and R. B. Harvey. 1988. Progression of ochratoxicosis in broiler chickens. Poult. Sci. 67: 1139-1146.
12. Kubena, L. F., W. E. Huff, R. B. Harvey, D. E. Corrier, T. D. Phillips, and C. R. Creger. 1988. Influence of ochratoxin A and deoxynivalenol on growing broiler broilers. Poult. Sci. 67: 253-260.
13. Li, M., C. F. Cuff, and J. J. Pestka. 2006. T-2 toxin impairment of enteric reovirus clearance in the mouse associated with suppressed immunoglobulin and IFN-γ responses. Toxicol. Appl. Pharmacol. 214: 318-325.
14. NRC. 1994. Nutrient Requirements of Poultry. Natl. Acad. Press, Washington, DC.
15. Pestka, J. J., H. R. Zhou, Y. Moon, and Y. J. Chung. 2004. Cellular and molecular mechanisms for immune modulation by deoxynivalenol and other trichothecenes: Unraveling a paradox. Toxicol. Lett. 153: 61-73.
16. SAS Institute. 1994. SAS User's Guide: Statistics. Version 6. SAS Institute Inc., Cary, NC.
17. Sklan, D., E. Klipper, A. Friedman, M. Shelly, and B. Makovsky. 2001. The effect of chronic feeding of diacetoxyscirpenol, T-2 toxin, and aflatoxin on performance, health, and antibody production in broilers. J. Appl. Poult. Res. 10: 79-85.
18. Sokolović, M., V. Garaj-Vrhovac, and B. Simpraga. 2008. T-2 toxin: Incidence and toxicity in poultry. Arh. Hig. Rada Toksikol. 59: 43-52.
19. Verma, J., T. S. Johri, B. K. Swain, and S. Ameena. 2004. Effect of graded levels of aflatoxin, ochratoxin and their combinations on the performance and immune response of broilers. Br. Poult. Sci. 45: 512-518.
20. Wang, G. H., C. Y. Xue, F. Chen, Y. L. Ma, X. B. Zhang, Y. Z. Bi, and Y. C. Cao. 2009. Effects of combinations of ochratoxin A and T-2 toxin on immune function of yellow-feathered broiler broilers. Poult. Sci. 88: 504-510.
21. Wyatt, R. D., P. B. Hamilton, and H. R. Burmeister. 1973. The effects of T-2 toxin in broiler chickens. Poult. Sci. 52: 1853-1859.
22. Yuan, J. M., T. X. Wang, H. Pan, J. K. Shen, and W. Gu. 2009. Clinical significance of serum interferon-γ and signal transducer and activator of transcription 1 in patients with gastric carcinoma. World Chin. J. Digestology 17: 3048-3051. (In Chinese)