Regulation and role of myocyte cyclic GMP-dependent protein kinase-1

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 24, 2010, Pages

  Kass, David A ^a   Takimoto, Eiki ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCINEURIN; CYCLIC GMP ACTIVATED KINASE 1ALPHA; CYCLIC GMP ACTIVATED KINASE 1BETA; G ALPHA Q PROTEIN; ISOPRENALINE; NATRIURETIC PEPTIDE RECEPTOR A; NITRIC OXIDE; PHOSPHODIESTERASE V; PROTEIN; PROTEIN KINASE; RGS2 PROTEIN; SILDENAFIL; TADALAFIL; TRANSCRIPTION FACTOR NFAT; TROPONIN I; UNCLASSIFIED DRUG;

CELL STRESS; ENZYME ACTIVITY; ENZYME REGULATION; FIBROBLAST; GENE SILENCING; HEART LEFT VENTRICLE MASS; HEART LEFT VENTRICLE OVERLOAD; HEART MUSCLE CELL; HUMAN; LETTER; MORTALITY; MUSCLE HYPERTROPHY; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SARCOMERE; VASCULARIZATION; WILD TYPE;

ANIMALS; CARDIOMEGALY; CYCLIC GMP-DEPENDENT PROTEIN KINASES; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 5; MICE; MICE, KNOCKOUT; MODELS, CARDIOVASCULAR; MYOCYTES, CARDIAC; PHOSPHODIESTERASE INHIBITORS; PIPERAZINES; PURINES; SIGNAL TRANSDUCTION; SULFONES;

EID: 77954651393     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1003889107     Document Type: Letter

References (5)

1. Lukowski R, et al. (2010) Cardiac hypertrophy is not amplified by deletion of cGMP-dependent protein kinase I in cardiomyocytes. Proc Natl Acad Sci USA 107:5646-5651.
2. Nagayama T, et al. (2009) Pressure-overload magnitude-dependence of the anti-hypertrophic efficacy of PDE5A inhibition. J Mol Cell Cardiol 46:560-567.
3. Zhang M, et al. (2008) Expression, activity, and pro-hypertrophic effects of PDE5A in cardiac myocytes. Cell Signal 20:2231-2236.
4. Koitabashi N, et al. (2010) Cyclic GMP/PKG-dependent inhibition of TRPC6 channel activity and expression negatively regulates cardiomyocyte NFAT activation novel mechanism of cardiac stress modulation by PDE5 inhibition. J Mol Cell Cardiol 48: 713-724.
5. Miller CL, et al. (2009) Role of Ca2+/calmodulin-stimulated cyclic nucleotide phosphodiesterase 1 in mediating cardiomyocyte hypertrophy. Circ Res 105:956-964.